The EHEC-host interactome reveals novel targets for the translocated intimin receptor

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The EHEC-host interactome reveals novel targets for the translocated intimin receptor is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1031682327
P356DOI10.1038/SREP07531
P8608Fatcat IDrelease_ntarmpuchrhvna3vhuxsozmgua
P3181OpenCitations bibliographic resource ID3858962
P932PMC publication ID4269881
P698PubMed publication ID25519916
P5875ResearchGate publication ID269770869

P50authorPeter UetzQ13220218
Patrick AloyQ37393265
Arnaud CeolQ54188165
Theresia StradalQ56606105
Stefan WuchtyQ87803920
P2093author name stringFrank Schwarz
Gabriella Siszler
M Alexander Schmidt
Manfred Koegl
Roman Häuser
Sonja Blasche
Stefan Arens
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F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosisQ22010738
Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1Q24291451
The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assemblyQ24293516
Increased levels of intracellular calcium are not required for the formation of attaching and effacing lesions by enteropathogenic and enterohemorrhagic Escherichia coli.Q39572505
Enterohemorrhagic Escherichia coli O157:H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylated.Q39610565
Differential modulation by Ca2+ of type III secretion of diffusely adhering enteropathogenic Escherichia coliQ39741576
Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cellsQ39775816
IRSp53 links the enterohemorrhagic E. coli effectors Tir and EspFU for actin pedestal formation.Q39872899
Tyrosine phosphorylation controls cortactin binding to two enterohaemorrhagic Escherichia coli effectors: Tir and EspFu/TccP.Q40142577
Inactivation of human MAD2B in nasopharyngeal carcinoma cells leads to chemosensitization to DNA-damaging agentsQ40291563
Cytokeratin 18 interacts with the enteropathogenic Escherichia coli secreted protein F (EspF) and is redistributed after infectionQ40520664
Enteropathogenic Escherichia coli infection leads to appearance of aberrant tight junctions strands in the lateral membrane of intestinal epithelial cellsQ40538742
The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.Q40887013
Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulinQ41177676
EspF Interacts with nucleation-promoting factors to recruit junctional proteins into pedestals for pedestal maturation and disruption of paracellular permeability.Q42406563
Interaction of the enteropathogenic Escherichia coli protein, translocated intimin receptor (Tir), with focal adhesion proteinsQ42638113
Calpain regulates enterocyte brush border actin assembly and pathogenic Escherichia coli-mediated effacementQ43068880
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.Q45986472
Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerizationQ46860903
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A DNA probe to identify enterohemorrhagic Escherichia coli of O157:H7 and other serotypes that cause hemorrhagic colitis and hemolytic uremic syndromeQ33449728
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Type III secretion-dependent cell cycle block caused in HeLa cells by enteropathogenic Escherichia coli O103.Q33552605
NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infectionQ33733678
Gut feelings: enteropathogenic E. coli (EPEC) interactions with the hostQ34059691
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EspG of enteropathogenic and enterohemorrhagic E. coli binds the Golgi matrix protein GM130 and disrupts the Golgi structure and functionQ34198962
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Binding to Na(+) /H(+) exchanger regulatory factor 2 (NHERF2) affects trafficking and function of the enteropathogenic Escherichia coli type III secretion system effectors Map, EspI and NleH.Q34462401
Potent diarrheagenic mechanism mediated by the cooperative action of three enteropathogenic Escherichia coli-injected effector proteinsQ34478656
RNAi knockdown of human kinetochore protein CENP-H.Q34552186
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The type III system-secreted effector EspZ localizes to host mitochondria and interacts with the translocase of inner mitochondrial membrane 17bQ35598118
ORFeome cloning and systems biology: standardized mass production of the parts from the parts-listQ35920606
NleB, a bacterial effector with glycosyltransferase activity, targets GAPDH function to inhibit NF-κB activationQ36557738
The enterohemorrhagic Escherichia coli effector protein NleF binds mammalian Tmp21.Q36808276
Elevation of intracellular free calcium levels in HEp-2 cells infected with enteropathogenic Escherichia coliQ36962955
Enteropathogenic Escherichia coli subverts phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate upon epithelial cell infectionQ37034994
Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteinsQ37319475
Cytoskeleton-modulating effectors of enteropathogenic and enterohaemorrhagic Escherichia coli: Tir, EspFU and actin pedestal assemblyQ37755414
The EspF effector, a bacterial pathogen's Swiss army knifeQ37777278
Sorting nexins provide diversity for retromer-dependent trafficking eventsQ37970882
CORUM: the comprehensive resource of mammalian protein complexes--2009Q38377952
Enteropathogenic Escherichia coli Tir recruits cellular SHP-2 through ITIM motifs to suppress host immune responseQ39147598
Recruitment and membrane interactions of host cell proteins during attachment of enteropathogenic and enterohaemorrhagic Escherichia coliQ39348067
Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifsQ24299272
A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosisQ24304013
Human FEM1B is required for Rad9 recruitment and CHK1 activation in response to replication stressQ24310827
EspF of enteropathogenic Escherichia coli binds sorting nexin 9Q24313541
Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formationQ24315675
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligasesQ24322407
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequencesQ24336098
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cyclingQ24338298
SNX9, SNX18 and SNX33 are required for progression through and completion of mitosisQ24338678
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.Q24522487
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Improving the yeast two-hybrid system with permutated fusions proteins: the Varicella Zoster Virus interactomeQ24633667
Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signallingQ24676146
An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their disseminationQ24678382
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signalingQ27001701
Ablation of RIC8A function in mouse neurons leads to a severe neuromuscular phenotype and postnatal deathQ27307146
Metalloprotease type III effectors that specifically cleave JNK and NF-κBQ28116010
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeresQ28235274
High-throughput mapping of a dynamic signaling network in mammalian cellsQ28239249
Functional contribution of Ca2+ and Mg2+ to the intermolecular interaction of visinin-like proteinsQ28240449
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteinsQ28343954
The neuronal calcium sensor family of Ca2+-binding proteinsQ28345058
In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush bordersQ28593765
The MIntAct project--IntAct as a common curation platform for 11 molecular interaction databasesQ28660703
Towards a knowledge-based Human Protein AtlasQ29617987
The E. coli effector protein NleF is a caspase inhibitorQ30456165
The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways.Q30480560
Involvement of the intermediate filament protein cytokeratin-18 in actin pedestal formation during EPEC infectionQ33196595
Automated yeast two-hybrid screening for nuclear receptor-interacting proteinsQ33209988
Exploitation of eukaryotic ubiquitin signaling pathways by effectors translocated by bacterial type III and type IV secretion systemsQ33270514
Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cellsQ33292526
Enteropathogenic Escherichia coli effector EspF interacts with host protein Abcf2.Q52574553
Analyses of ultraviolet-induced focus formation of hREV1 protein.Q53636260
A new route of transmission for Escherichia coli: infection from dry fermented salami.Q54584730
Exhaustive benchmarking of the yeast two-hybrid system.Q55053371
Escherichia coli O157:H7 strains associated with haemorrhagic colitis in the United States produce a Shigella dysenteriae 1 (SHIGA) like cytotoxinQ72548803
Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with alpha-actininQ73938788
Talin, a host cell protein, interacts directly with the translocated intimin receptor, Tir, of enteropathogenic Escherichia coli, and is essential for pedestal formationQ77128233
Analysis of protein-protein interactions using LUMIER assaysQ87344342
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 InternationalQ42553662
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)7531
P577publication date2014-01-01
P1433published inScientific ReportsQ2261792
P1476titleThe EHEC-host interactome reveals novel targets for the translocated intimin receptor
P478volume4

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cites work (P2860)
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