Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.

scientific article published on 04 February 2017

Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.15084
P932PMC publication ID5370029
P698PubMed publication ID28188308

P50authorFrancoise DegoulQ71376771
Shoukat DedharQ77130251
Ingrid MasseQ81193315
Arnaud de la FouchardiereQ50167271
P2093author name stringFrançois Le Naour
Nicolas Gadot
Paul C McDonald
Odile Berthier-Vergnes
Clément Robert
Emmanuelle Danty-Berger
Tiffany Witkowski
Laetitia Barbollat-Boutrand
Manale El Kharbili
P2860cites workRictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survivalQ24310871
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinaseQ24314398
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signalingQ27001701
Integrins: bidirectional, allosteric signaling machinesQ27860700
Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine 211 and serine 343Q28213632
Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathyQ28564140
The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formationQ28584267
CD151 restricts the α6 integrin diffusion modeQ30513779
Penetration of human metastatic melanoma cells through an authentic dermal-epidermal junction is associated with dissolution of native collagen types IV and VII.Q30970759
Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targetsQ33610587
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localizationQ34100459
Tetraspanin CO-029 inhibits colorectal cancer cell movement by deregulating cell-matrix and cell-cell adhesionsQ34297122
Lateral organization of membrane proteins: tetraspanins spin their web.Q34979935
Mapping functional residues onto integrin crystal structures.Q35119761
Tetraspanin 8-rictor-integrin α3 complex is required for glioma cell migrationQ35381006
MelanomaQ56428909
Profiling of the Tetraspanin Web of Human Colon Cancer CellsQ58044786
Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinaseQ67926191
Expression of peanut agglutinin-binding glycoconjugates in primary melanomas with high risk of metastasesQ72218710
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signalingQ35474544
Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemiaQ35827910
Integrin signalling during tumour progressionQ35906078
Regulation of integrin-mediated adhesions.Q36264774
Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signalingQ36301561
Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand bindingQ36380699
Localized lipid packing of transmembrane domains impedes integrin clusteringQ36684546
Integrin-linked kinase--essential roles in physiology and cancer biology.Q37272385
Systematic large-scale meta-analysis identifies a panel of two mRNAs as blood biomarkers for colorectal cancer detectionQ37327479
Tetraspanins: push and pull in suppressing and promoting metastasisQ37349647
Tetraspanin-enriched microdomains: a functional unit in cell plasma membranesQ37587580
Integrin-linked kinase: not so 'pseudo' after all.Q37878251
Mechanical control of integrin-mediated adhesion and signalingQ38031678
Tetraspanin proteins promote multiple cancer stagesQ38186043
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasisQ38235867
Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanomaQ38238524
Targeting RAS-ERK signalling in cancer: promises and challengesQ38272894
Integrins and cancer: regulators of cancer stemness, metastasis, and drug resistance.Q38311815
Combination therapy of melanoma using kinase inhibitorsQ38324817
Cytoplasmic accumulation of peanut agglutinin-binding glycoconjugates in the cells of primary melanoma correlates with clinical outcomeQ38468597
Over-expression of tetraspanin 8 in malignant glioma regulates tumor cell progressionQ38909910
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agentsQ39224151
Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway.Q39568919
Gene expression profiles of human melanoma cells with different invasive potential reveal TSPAN8 as a novel mediator of invasion.Q39630988
E-cadherin/p120-catenin and tetraspanin Co-029 cooperate for cell motility control in human colon carcinomaQ39653099
TM4SF3 promotes esophageal carcinoma metastasis via upregulating ADAM12m expressionQ39998630
Therapeutic targeting of tetraspanin8 in epithelial ovarian cancer invasion and metastasisQ40068293
Homophilic interactions of Tetraspanin CD151 up-regulate motility and matrix metalloproteinase-9 expression of human melanoma cells through adhesion-dependent c-Jun activation signaling pathwaysQ40263014
Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survivalQ40333076
Overexpression of hyperactive integrin-linked kinase leads to increased cellular radiosensitivity.Q40525063
Possible involvement of tetraspanin CO‐029 in hematogenous intrahepatic metastasis of liver cancer cellsQ40627661
Divalent cations and ligands induce conformational changes that are highly divergent among beta1 integrinsQ41050898
Expression of PNA-binding sites on specific glycoproteins by human melanoma cells is associated with a high metastatic potentialQ41490659
The focal adhesion kinase (P125FAK) is constitutively active in human malignant melanomaQ44010949
Surface distribution of wheat germ agglutinin binding sites of human melanoma cell lines with low and high tumorigenicityQ44992729
Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activityQ46670127
Increased expression of integrin-linked kinase is correlated with melanoma progression and poor patient survival.Q47446784
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)17140-17155
P577publication date2017-03-01
P1433published inOncotargetQ1573155
P1476titleTetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells
P478volume8

Reverse relations

cites work (P2860)
Q61799033Blood-based analysis of type-2 diabetes mellitus susceptibility genes identifies specific transcript variants with deregulated expression and association with disease risk
Q57385046Homeostasis, regeneration and tumour formation in the mammalian epidermis
Q55467140Immune Targeting of Tetraspanins Involved in Cell Invasion and Metastasis.
Q55513422New susceptibility loci for cutaneous melanoma risk and progression revealed using a porcine model.
Q90072427TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy
Q91211987Tspan8-β-catenin positive feedback loop promotes melanoma invasion

Search more.