Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.

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Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8. is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..109.9539Z
P356DOI10.1073/PNAS.1207021109
P932PMC publication ID3386095
P698PubMed publication ID22647598
P5875ResearchGate publication ID225080649

P2093author name stringJun Zou
Monita P Wilson
Philip W Majerus
Chunfen Zhang
Marina V Kisseleva
Jasna Marjanovic
P2860cites workMyotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth diseaseQ24291963
Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphataseQ24299014
Myotubularin regulates the function of the late endosome through the gram domain-phosphatidylinositol 3,5-bisphosphate interactionQ24304808
Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAPQ24307476
Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9Q24313006
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to humanQ24313350
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagyQ24318098
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphataseQ24336782
PIKfyve: Partners, significance, debates and paradoxesQ24652827
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatasesQ28202357
Protein tyrosine phosphatases in the human genomeQ28265924
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeastQ28279868
Isolation and characterization of two 3-phosphatases that hydrolyze both phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphateQ28303561
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's diseaseQ28588314
Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2Q28590542
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell deathQ29547297
Autophagy in health and disease: a double-edged swordQ29618103
Control of autophagy initiation by phosphoinositide 3-phosphatase JumpyQ30489519
Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.Q33901232
The role of PI3P phosphatases in the regulation of autophagyQ33914205
Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15.Q34173425
Type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase regulates stress-induced apoptosisQ34701557
Disease-related Myotubularins Function in Endocytic Traffic inCaenorhabditis elegansQ34786070
Phosphoinositide phosphatases and diseaseQ34877679
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathwayQ36117201
The myotubularin family of lipid phosphatasesQ36302905
Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization moduleQ36348830
Regulation of membrane traffic by phosphoinositide 3-kinasesQ36391678
Myotubularin phosphatases: policing 3-phosphoinositidesQ36530570
The role of myotubularin-related phosphatases in the control of autophagy and programmed cell deathQ36589837
Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor traffickingQ36796937
Unveiling the roles of autophagy in innate and adaptive immunityQ36927499
Endosomal phosphoinositides and human diseasesQ37024588
Regulation of membrane biogenesis in autophagy via PI3P dynamicsQ37733856
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagyQ39754404
Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3.Q40433158
PTEN and myotubularins: families of phosphoinositide phosphatasesQ40607696
MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosisQ43195964
Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegansQ44467158
Association of single-nucleotide polymorphisms in MTMR9 gene with obesity.Q51463472
Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.Q52560509
P433issue24
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
Myotubularin related protein 9Q21107272
Myotubularin related protein 6Q21112660
phosphatidylinositol-3,5-bisphosphate phosphatase activityQ30105304
P304page(s)9539-9544
P577publication date2012-05-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMyotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8.
P478volume109

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cites work (P2860)
Q28082271A Drosophila-centric view of protein tyrosine phosphatases
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Q37215001MTMR4 Is Required for the Stability of the Salmonella-Containing Vacuole
Q50293932MTMR8 binds MTMR9
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Q50293938PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane
Q24313624PI(5)P regulates autophagosome biogenesis
Q50293933PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane
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