In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself.

scientific article published on 28 June 2018

In renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1105203800
P356DOI10.1186/S12964-018-0247-9
P932PMC publication ID6025732
P698PubMed publication ID29954386

P2093author name stringJoachim W Thüroff
Walburgis Brenner
Jonas Welter
Dirk Prawitt
Thorsten Enklaar
Annette Hasenburg
Sebastian Frees
Heide-Katharina Bauer
Ines Breuksch
P2860cites workThe tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionQ22010498
Loss of tumor suppressor protein PTEN during renal carcinogenesis.Q53390981
Reference genes for gene expression analysis by real-time reverse transcription polymerase chain reaction of renal cell carcinoma.Q54338989
Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growthQ79249861
Oncologic long-term outcome of elective nephron-sparing surgery versus radical nephrectomy in patients with renal cell carcinoma stage pT1b or greater in a matched-pair cohortQ82820786
Migration of renal tumor cells depends on dephosphorylation of Shc by PTENQ83130882
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseQ22253438
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein functionQ24295164
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationQ24677034
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
The functions and regulation of the PTEN tumour suppressorQ29615536
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathwaysQ31837554
Ligand binding to integrinsQ33912940
NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.Q35256204
Prognostic role of PPAR-γ and PTEN in the renal cell carcinomaQ36375196
Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesisQ36998831
New insights into PTEN.Q37011116
Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathwayQ37071666
PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signalingQ37116576
PTEN and the PI3-kinase pathway in cancerQ37259680
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathwaysQ37425090
PTEN function: the long and the short of it.Q38198345
Bone Metastasis in Renal Cell Carcinoma is Preprogrammed in the Primary Tumor and Caused by AKT and Integrin α5 SignalingQ38916214
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membraneQ39328325
Co-deleting Pten with Rb in retinal progenitor cells in mice results in fully penetrant bilateral retinoblastomasQ40000796
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migrationQ40002542
Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancerQ40325176
Regulation of cell migration by the C2 domain of the tumor suppressor PTEN.Q40587498
Alternative splicing of the human PTEN/MMAC1/TEP1 geneQ40836678
Differential inhibition of renal cancer cell invasion mediated by fibronectin, collagen IV and lamininQ40878251
Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockadeQ41549055
Characterization of two cell lines with distinct phenotypes and genotypes established from a patient with renal cell carcinoma.Q41758134
High calcium concentration in bones promotes bone metastasis in renal cell carcinomas expressing calcium-sensing receptorQ41857468
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.Q42807109
Pten loss causes hypertrophy and increased proliferation of astrocytes in vivoQ45134010
Integrin α5 triggers the metastatic potential in renal cell carcinomaQ47140682
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectrenal cell carcinomaQ1164529
P304page(s)35
P577publication date2018-06-28
P1433published inCell Communication and SignalingQ1254390
P1476titleIn renal cell carcinoma the PTEN splice variant PTEN-Δ shows similar function as the tumor suppressor PTEN itself.
P478volume16

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cites work (P2860)
Q92966885Cell death-related molecules and biomarkers for renal cell carcinoma targeted therapy
Q92125845Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B
Q64114534Precise definition of PTEN C-terminal epitopes and its implications in clinical oncology