Biochemical signals and biological responses elicited by the focal adhesion kinase

scientific article (publication date: 25 July 2001)

Biochemical signals and biological responses elicited by the focal adhesion kinase is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0167-4889(01)00123-9
P3181OpenCitations bibliographic resource ID4331634
P698PubMed publication ID11476890

P2093author name stringM D Schaller
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylationQ22011187
Integrin signalling: a new Cas(t) of characters enters the stageQ22253193
A phosphotyrosine displacement mechanism for activation of Src by PTPalphaQ22253266
Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migrationQ22254608
Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinasesQ24306594
Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAKQ24310862
CAS/Crk coupling serves as a "molecular switch" for induction of cell migrationQ24311510
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinasesQ24316242
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migrationQ24318859
Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-SrcQ24320223
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motilityQ24554511
Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinasesQ24558683
Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60srcQ24614033
Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinaseQ24619015
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteinsQ24647075
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinaseQ24648985
Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesionsQ24651203
Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domainsQ24672461
Disruption of epithelial cell-matrix interactions induces apoptosisQ24673611
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase bindingQ24681861
Suppression of Pyk2 kinase and cellular activities by FIP200Q24685945
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathwayQ28139300
Physiological signals and oncogenesis mediated through Crk family adapter proteinsQ28139609
A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytesQ28140846
Signalling through phosphoinositide 3-kinases: the lipids take centre stageQ28141934
Paxillin and focal adhesion signallingQ28142041
Association of focal adhesion kinase with Grb7 and its role in cell migrationQ28142084
FAK integrates growth-factor and integrin signals to promote cell migrationQ28144169
Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphataseQ28188457
Signaling through focal adhesion kinaseQ28198051
Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cellsQ28203628
Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesionQ28259880
Direct association of protein-tyrosine phosphatase PTP-PEST with paxillinQ28264272
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinaseQ28277700
Paxillin LD motifs may define a new family of protein recognition domainsQ28279153
The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membraneQ28284187
Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesionQ28289246
Interaction of focal adhesion kinase with cytoskeletal protein talinQ28294149
IAP family proteins--suppressors of apoptosisQ28297514
The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways.Q52539985
Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.Q52541492
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.Q52828045
Focal adhesion kinase (pp125FAK) expression, activation and association with paxillin and p50CSK in human metastatic prostate carcinomaQ71743152
Expression of focal adhesion kinase gene and invasive cancerQ72235296
Activation of the focal adhesion kinase signal transduction pathway in cervical carcinoma cell lines and human genital epithelial cells immortalized with human papillomavirus type 18Q73536146
Involvement of focal adhesion kinase in hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cellsQ73538283
Neuregulin induces the rapid association of focal adhesion kinase with the erbB2-erbB3 receptor complex in schwann cellsQ73754429
v-Src induces tyrosine phosphorylation of focal adhesion kinase independently of tyrosine 397 and formation of a complex with SrcQ73804963
Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanismQ73938784
Cell adhesion and focal adhesion kinase regulate insulin receptor substrate-1 expressionQ74248196
Collagen IV-dependent ERK activation in human Caco-2 intestinal epithelial cells requires focal adhesion kinaseQ74312742
Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migrationQ77353628
Dephosphorylation of focal adhesion kinase (FAK) and loss of focal contacts precede caspase-mediated cleavage of FAK during apoptosis in renal epithelial cellsQ77388211
Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migrationQ77726581
Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblastsQ77785363
ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cellsQ36621254
Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivoQ36778304
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferationQ37381921
Differential signaling by the focal adhesion kinase and cell adhesion kinase betaQ38342809
Focal adhesion kinase expression in oral cancersQ38470971
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPasesQ38525479
Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylationQ38612701
Anti-apoptotic role of focal adhesion kinase (FAK). Induction of inhibitor-of-apoptosis proteins and apoptosis suppression by the overexpression of FAK in a human leukemic cell line, HL-60.Q40878313
The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillinQ40912830
Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activationQ40923058
Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cellsQ40929976
Protein-tyrosine phosphatase Shp-2 regulates cell spreading, migration, and focal adhesionQ41018719
The focal adhesion kinaseQ41033938
Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinasesQ41040319
Focal adhesion kinase pp125FAK and the beta 1 integrin subunit are constitutively complexed in HaCaT cellsQ41055684
A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancerQ41133339
Role of focal adhesion kinase in integrin signalingQ41672451
Bombesin and platelet-derived growth factor induce association of endogenous focal adhesion kinase with Src in intact Swiss 3T3 cellsQ41692025
Association of beta 1 integrin with focal adhesion kinase and paxillin in differentiating Schwann cells.Q42487726
Guanosine 5'-3-O-(thio)triphosphate stimulates tyrosine phosphorylation of p125FAK and paxillin in permeabilized Swiss 3T3 cells. Role of p21rhoQ42490579
Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancerQ42554561
Distinct roles of the adaptor protein Shc and focal adhesion kinase in integrin signaling to ERK.Q42797662
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblastsQ42800311
The carboxyl-terminal tyrosine residue of protein-tyrosine phosphatase alpha mediates association with focal adhesion plaquesQ42806069
The adaptor protein Shc couples a class of integrins to the control of cell cycle progressionQ42807056
Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinaseQ42807633
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpainQ42983314
Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cellsQ43688564
Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptideQ47921393
The role of integrins in tumorigenesis and metastasisQ47971728
Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.Q52210113
Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma.Q52536710
The N-termini of FAK and JAKs contain divergent band 4.1 domainsQ33546886
Bidirectional signaling between the cytoskeleton and integrinsQ33597380
ERM proteins in cell adhesion and membrane dynamicsQ33632981
Role of integrins in cancer: survey of expression patternsQ33774941
Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteinsQ33780874
Focal adhesions - the cytoskeletal connectionQ33840319
The multiple roles of PTEN in tumor suppressionQ33849727
RAFTK/Pyk2-mediated cellular signallingQ33855347
Growth factor activation of MAP kinase requires cell adhesion.Q33887464
Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.Q33958568
Focal adhesion kinase promotes phospholipase C-gamma1 activity.Q35592844
DFak56 is a novel Drosophila melanogaster focal adhesion kinaseQ35989337
Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblastsQ36254663
Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.Q36255622
Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycleQ36256572
Impaired integrin-mediated adhesion and signaling in fibroblasts expressing a dominant-negative mutant PTP1B.Q36288200
Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinaseQ36294784
Regulation of the cell cycle by focal adhesion kinaseQ36328536
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in plateletsQ36532167
The role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylationQ28305581
Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumorsQ28306155
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130CasQ28367366
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation eventsQ28609216
Cleavage of focal adhesion kinase by caspases during apoptosisQ28610850
Structure, function, and control of phosphoinositide-specific phospholipase CQ28646117
Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinaseQ28646514
Cellular functions regulated by Src family kinasesQ29616038
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
Src family kinases are required for integrin but not PDGFR signal transduction.Q30014832
Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinaseQ30175136
Protein tyrosine phosphatase 1B negatively regulates integrin signalingQ30176257
SH2- and SH3-mediated interactions between focal adhesion kinase and Src.Q30176302
Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.Q30176957
c-Src, receptor tyrosine kinases, and human cancerQ30303932
Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinaseQ30304229
Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complQ30305582
Focal adhesion kinase: a regulator of focal adhesion dynamics and cell movementQ30306561
Cloning and characterization of Dfak56, a homolog of focal adhesion kinase, in Drosophila melanogaster.Q30322998
Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cellsQ30442000
Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talinQ30442047
Inhibition of pp125FAK in cultured fibroblasts results in apoptosisQ30442183
Control of adhesion-dependent cell survival by focal adhesion kinaseQ30442196
Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosisQ30442817
Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAKQ30450284
pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for CrkQ30452729
Regulation of early events in integrin signaling by protein tyrosine phosphatase SHP-2.Q30453611
Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinaseQ30453995
Paxillin binding is not the sole determinant of focal adhesion localization or dominant-negative activity of focal adhesion kinase/focal adhesion kinase-related nonkinaseQ30454453
A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.Q30468168
Regulation of cortical structure by the ezrin-radixin-moesin protein familyQ33536481
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)1-21
P577publication date2001-07-25
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleBiochemical signals and biological responses elicited by the focal adhesion kinase
P478volume1540

Reverse relations

cites work (P2860)
Q39245050A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes
Q30014833A renaissance for SRC
Q36763176A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.
Q56996309Abstracts of the XXVII Italian Society for the Study of Connective Tissues (SISC) Meeting, Bologna, Italy, 8-10 November 2007
Q34360478Activation of FAK and Src are receptor-proximal events required for netrin signaling
Q38292525Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells
Q44655907Activation of Platelet-activating Factor Receptor-coupled Gαq Leads to Stimulation of Src and Focal Adhesion Kinase via Two Separate Pathways in Human Umbilical Vein Endothelial Cells
Q40293038Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication.
Q37424063Activity of the multikinase inhibitor dasatinib against ovarian cancer cells
Q33815723Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis
Q93047085Adult stem cells at work: regenerating skeletal muscle
Q40063967An essential role of integrin-linked kinase in the cellular radiosensitivity of normal fibroblasts during the process of cell adhesion and spreading.
Q26852158Anoikis molecular pathways and its role in cancer progression
Q36308239Apoptosis of rat hepatic stellate cells induced by anti-focal adhesion kinase antibody
Q39937957Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells
Q84340267Article withdrawal: Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
Q50291125Autophosphorylation of PTK2 at Y397
Q39108742Benzo-[a]-pyrene induces FAK activation and cell migration in MDA-MB-231 breast cancer cells
Q44572786Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
Q29568324Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload
Q39919475Betaig-h3 interacts with alpha3beta1 integrin to promote adhesion and migration of human hepatoma cells
Q36801088Biologic effects of dopamine on tumor vasculature in ovarian carcinoma
Q35103303Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion
Q36530668Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer
Q28253381CAIR-1/BAG-3 modulates cell adhesion and migration by downregulating activity of focal adhesion proteins
Q40439589CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in small cell lung cancer (SCLC) cells.
Q44140863Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells.
Q39286100Cell matrix adhesions in cancer: The proteins that form the glue
Q42802409Cell self-patterning on uniform PDMS-surfaces with controlled mechanical cues.
Q36258255Cellular mechanisms of bacterial internalization counteracted by Yersinia
Q42136937Characterization of an activated mutant of focal adhesion kinase: 'SuperFAK'
Q24791433Chemoresistance in human ovarian cancer: the role of apoptotic regulators
Q28537860Chymase mediates injury and mitochondrial damage in cardiomyocytes during acute ischemia/reperfusion in the dog
Q30483685Clinical and biological significance of tissue transglutaminase in ovarian carcinoma
Q35677074Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts
Q39354437Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.
Q30431862Compensatory endocytosis in bladder umbrella cells occurs through an integrin-regulated and RhoA- and dynamin-dependent pathway
Q34998069Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity
Q37328857Conditional knockout of myocyte focal adhesion kinase abrogates ischemic preconditioning in adult murine hearts
Q30368603Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.
Q37147891Control of fibrotic changes through the synergistic effects of anti-fibronectin antibody and an RGDS-tagged form of the same antibody
Q24293554Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton
Q58579198Cortical Actin Dynamics in Endothelial Permeability
Q30160113Crystal structure of the FERM domain of focal adhesion kinase.
Q40241749Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2.
Q36427742Detecting cryptic epitopes created by nanoparticles.
Q40180678Differential FAK phosphorylation at Ser-910, Ser-843 and Tyr-397 induced by angiotensin II, LPA and EGF in intestinal epithelial cells.
Q30441862Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis
Q24673170Differential regulation of cell motility and invasion by FAK
Q44408512Direct Interaction of Focal Adhesion Kinase with p190RhoGEF
Q36261722Disintegrins: integrin selective ligands which activate integrin-coupled signaling and modulate leukocyte functions
Q36304120Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
Q31044872Dissecting the link between stress fibres and focal adhesions by CALI with EGFP fusion proteins.
Q54530712Distribution and Y397 phosphorylation of focal adhesion kinase on follicular development in the mouse ovary.
Q54568963Diverse effects of type II collagen on osteogenic and adipogenic differentiation of mesenchymal stem cells.
Q37357254Dual targeting of EphA2 and FAK in ovarian carcinoma
Q33784603Dysregulation of nuclear receptor COUP-TFII impairs skeletal muscle development
Q44449812ERK 1/2- and JNKs-dependent synthesis of interleukins 6 and 8 by fibroblast-like synoviocytes stimulated with protein I/II, a modulin from oral streptococci, requires focal adhesion kinase.
Q40559733Ectodomain shedding of SHPS-1 and its role in regulation of cell migration
Q58366514Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells
Q39256759Effect of FAK, DLC-1 gene expression on OVCAR-3 proliferation
Q40176556Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA.
Q39320426Effect of small interfering RNA transfection on FAK and DLC1 mRNA expression in OVCAR-3.
Q46833993Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia
Q38454275Elevated focal adhesion kinase expression facilitates oral tumor cell invasion
Q36638727Endogenous production of fibronectin is required for self-renewal of cultured mouse embryonic stem cells
Q42458003Endothelial barrier protection by FTY720 under hyperglycemic condition: involvement of focal adhesion kinase, small GTPases, and adherens junction proteins
Q33947958Endothelial cell-specific molecule 2 (ECSM2) localizes to cell-cell junctions and modulates bFGF-directed cell migration via the ERK-FAK pathway
Q36272883Endothelial focal adhesions and barrier function
Q35907062Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin
Q41828281Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement
Q44163225Erucylphosphocholine-induced apoptosis in glioma cells: involvement of death receptor signalling and caspase activation
Q40343167Exploring the interaction between human focal adhesion kinase and inhibitors: a molecular dynamic simulation and free energy calculations
Q44243431Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in human gliomas is associated with unfavorable overall survival
Q38450221Expression of focal adhesion kinase and phosphorylated focal adhesion kinase in squamous cell carcinoma of the larynx
Q36334823Expression of focal adhesion kinase in the eutopic endometrium of women with adenomyosis varies with dysmenorrhea and pelvic pain
Q42538360Expression of pY397 FAK promotes the development of non-small cell lung cancer
Q90191767FAK Deficiency in Bone Marrow Stromal Cells Alters Their Homeostasis and Drives Abnormal Proliferation and Differentiation of Haematopoietic Stem Cells
Q26765360FAK and paxillin, two potential targets in pancreatic cancer
Q30441881FAK induces expression of Prx1 to promote tenascin-C-dependent fibroblast migration.
Q39735864FAK is involved in invasion and metastasis of hepatocellular carcinoma
Q30445295FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX.
Q27325401FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing.
Q92979120FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication
Q47577382FAK, CD44v6, c-Met and EGFR in colorectal cancer parameters: tumour progression, metastasis, patient survival and receptor crosstalk
Q30449206FERM domain interaction promotes FAK signaling
Q34360984FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth
Q44554916Fibronectin enhances viability and alters cytoskeletal functions (with effects on the phosphatidylinositol 3-kinase pathway) in small cell lung cancer.
Q28645969Focal adhesion kinase (FAK) expression and activation during lens development
Q90060636Focal adhesion kinase (FAK) phosphorylation is a key regulator of embryonal rhabdomyosarcoma (ERMS) cell viability and migration
Q94468439Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments
Q40354738Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1.
Q37813854Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis
Q37761970Focal adhesion kinase and p53 signal transduction pathways in cancer
Q36921742Focal adhesion kinase and p53 signaling in cancer cells
Q54545359Focal adhesion kinase expression in ovarian endometriosis.
Q40345475Focal adhesion kinase is activated in invading fibrosarcoma cells and regulates metastasis
Q28301647Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells
Q42446877Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor
Q39985969Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation
Q35083482Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate
Q39942877Focal adhesion kinase regulates cell-cell contact formation in epithelial cells via modulation of Rho.
Q40164239Focal adhesion kinase regulates insulin resistance in skeletal muscle
Q38585374Focal adhesion kinase regulates metastatic adhesion of carcinoma cells within liver sinusoids
Q35269444Focal adhesion kinase regulation of neovascularization
Q35607224Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells
Q30488828Focal adhesion kinase signaling regulates the expression of caveolin 3 and beta1 integrin, genes essential for normal myoblast fusion.
Q35131712Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cells
Q35130437Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapy.
Q29615192Focal adhesion kinase: in command and control of cell motility
Q36579538Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
Q40280218Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay
Q47093770Future Directions and Molecular Basis of Ventilator Associated Pneumonia.
Q42815610G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II.
Q37248141Gene Array and Fluorescence In situ Hybridization Biomarkers of Activity of Saracatinib (AZD0530), a Src Inhibitor, in a Preclinical Model of Colorectal Cancer
Q40245187Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways
Q46546062Gleditsioside B, a triterpene saponin isolated from the anomalous fruits of Gleditsia sinensis Lam., abrogates bFGF-induced endothelial cell migration through preventing the activation of MMP-2 and FAK via inhibiting ERK and PI3K/AKT signaling pathw
Q44271951Gonadotropin releasing hormone analogue therapy alters signal transduction pathways involving mitogen-activated protein and focal adhesion kinases in leiomyoma
Q39007681Heparin-binding EGF-like growth factor (HB-EGF) promotes cell migration and adhesion via focal adhesion kinase
Q35544489Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function
Q80382891Homocysteine-induced biochemical stress predisposes to cytoskeletal remodeling in stretched endothelial cells
Q37871641Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells
Q28181407Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression
Q28591790Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice
Q30490856Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly
Q33306169Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line
Q30424344Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment
Q40262195Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties.
Q36403862Integr(at)in(g) EGFR therapy in HNSCC
Q43043490Integrin receptors play a role in the internalin B-dependent entry of Listeria monocytogenes into host cells.
Q39155496Integrin signaling in atherosclerosis.
Q33766299Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer
Q35875611Integrin signalling and the cellular response to ionizing radiation.
Q46438380Integrin stimulation-induced hypertrophy in neonatal rat cardiomyocytes is NO-dependent
Q39562168Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion
Q35089143Integrins and extracellular matrix: a novel mechanism of multidrug resistance
Q38423864Intracellular signaling of cardiac fibroblasts
Q44004516Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis.
Q40629835Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction.
Q33196392Ionizing radiation modules of the expression and tyrosine phosphorylation of the focal adhesion-associated proteins focal adhesion kinase (FAK) and its substrates p130cas and paxillin in A549 human lung carcinoma cells in vitro
Q40572745Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 envelope glycoprotein gB induces the integrin-dependent focal adhesion kinase-Src-phosphatidylinositol 3-kinase-rho GTPase signal pathways and cytoskeletal rearrangements
Q34081423LIM kinase regulation of cytoskeletal dynamics is required for salivary gland branching morphogenesis
Q46209451Laminin acts via focal adhesion kinase/phosphatidylinositol-3' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes
Q46734504Local calcium transients contribute to disappearance of pFAK, focal complex removal and deadhesion of neuronal growth cones and fibroblasts.
Q42814089Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading
Q37520973MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression
Q36178668Malignant transformation but not normal cell growth depends on signal transducer and activator of transcription 3.
Q39631250Mechanical stimuli on C2C12 myoblasts affect myoblast differentiation, focal adhesion kinase phosphorylation and galectin-1 expression: a proteomic approach
Q36703602Mechanisms of bone remodeling during weight-bearing exercise
Q34173950MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
Q30438510Minimal features of paxillin that are required for the tyrosine phosphorylation of focal adhesion kinase
Q39296251Modulation of alignment and differentiation of skeletal myoblasts by biomimetic materials
Q33560572Molecular biology of KSHV in relation to AIDS-associated oncogenesis
Q38698686Multifaceted ability of naturally occurring polyphenols against metastatic cancer
Q41856148Multiple paxillin binding sites regulate FAK function
Q46345355Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells
Q27642755NMR solution structure of the focal adhesion targeting domain of focal adhesion kinase in complex with a paxillin LD peptide: evidence for a two-site binding model
Q28214529Nck-2 interacts with focal adhesion kinase and modulates cell motility
Q36097785Negative regulation of FAK signaling by SOCS proteins
Q48381736Neuregulin-1 enhances motility and migration of human astrocytic glioma cells
Q37921866Neutrophil transmigration, focal adhesion kinase and endothelial barrier function
Q35255826New insights into FAK phosphorylation based on a FAT domain-defective mutation
Q36759212Nonreceptor tyrosine kinases in prostate cancer
Q49185323Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice
Q30451773Optimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin β1-mediated expression of phosphorylated focal adhesion kinase
Q40637647Ovarian cancer cell proliferation and motility is induced by engagement of integrin alpha(v)beta3/Vitronectin interaction
Q40604626Overexpression of profilin reduces the migration of invasive breast cancer cells
Q28204032PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation
Q28212534PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas
Q36323106PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration
Q36098165Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells
Q24306441Paxillin-beta-catenin interactions are involved in Rac/Cdc42-mediated endothelial barrier-protective response to oxidized phospholipids
Q27005573Pharmacological aspects of Vipera xantina palestinae venom
Q41963297Pharmacology of cell adhesion molecules of the nervous system
Q33285246Phosphorylation of FAK, PI-3K, and impaired actin organization in CK-positive micrometastatic breast cancer cells
Q34162284Phosphorylation of focal adhesion kinase at Tyr397 in gastric carcinomas and its clinical significance
Q50291126Phosphorylation of pPTK2 by SRC
Q42438652Phosphospecific site tyrosine phosphorylation of p125FAK and proline-rich kinase 2 is differentially regulated by cholecystokinin receptor type A activation in pancreatic acini
Q44459226Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets
Q50866086Polymorphisms in PTK2 are associated with skeletal muscle specific force: an independent replication study.
Q37656093Progress in researches about focal adhesion kinase in gastrointestinal tract
Q35127968Protein kinase signaling in the modulation of microvascular permeability
Q44510433Protein phosphatase-2A regulates protein tyrosine phosphatase activity in Lewis lung carcinoma tumor variants
Q39268132Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
Q36870441Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways
Q40426575Quantification of Type, Timing, and Extent of Cell Body and Nucleus Deformations Caused by the Dimensions and Hydrophilicity of Square Prism Micropillars
Q89376542Quantitative analysis of focal adhesion dynamics using photonic resonator outcoupler microscopy (PROM)
Q47717654Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research
Q40549095RACK1 inhibits the serum- and anchorage-independent growth of v-Src transformed cells
Q28282427RGD and YIGSR synthetic peptides facilitate cellular adhesion identical to that of laminin and fibronectin but alter the physiology of neonatal cardiac myocytes
Q40615849RNA interference targeting focal adhesion kinase enhances pancreatic adenocarcinoma gemcitabine chemosensitivity
Q93111040ROCK1 promotes migration and invasion of non‑small‑cell lung cancer cells through the PTEN/PI3K/FAK pathway
Q34401749Regulation of endothelial permeability by Src kinase signaling: vascular leakage versus transcellular transport of drugs and macromolecules
Q44376607Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus.
Q36873581Regulation of matrix assembly through rigidity-dependent fibronectin conformational changes
Q38963349Regulation of pulmonary endothelial barrier function by kinases
Q42129457Relationship between focal adhesion kinase and hepatic stellate cell proliferation during rat hepatic fibrogenesis
Q51486103Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1.
Q40648952Requirement of the p130CAS-Crk Coupling for Metastasis Suppressor KAI1/CD82-mediated Inhibition of Cell Migration
Q40478503Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.
Q34768276Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells
Q40658213Rigidity of collagen fibrils controls collagen gel-induced down-regulation of focal adhesion complex proteins mediated by alpha2beta1 integrin.
Q83774575Role of DDR1 in the gelatinases secretion induced by native type IV collagen in MDA-MB-231 breast cancer cells
Q54469665Role of LOXs and COX-2 on FAK activation and cell migration induced by linoleic acid in MDA-MB-231 breast cancer cells.
Q37152874Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis
Q33916059Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
Q28572050Role of protein-tyrosine phosphatase SHP2 in focal adhesion kinase down-regulation during neutrophil cathepsin G-induced cardiomyocytes anoikis
Q39758938Role of the CD47-SHPS-1 system in regulation of cell migration
Q92446503Semaphorin-7A on Exosomes: A Promigratory Signal in the Glioma Microenvironment
Q28586292Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration
Q51252966Shear stress with appropriate time-step and amplification enhances endothelial cell retention on vascular grafts.
Q37891706Signaling of the direction-sensing FAK/RACK1/PDE4D5 complex to the small GTPase Rap1
Q64377303Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes
Q24535035Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein
Q34274666Skeletal muscle unweighting: spaceflight and ground-based models
Q28567215Small GTPase Ras and Rho expression in rat osteoblasts during spaceflight
Q53851174Small inhibitory RNA--a tool for credentialing candidate genes.
Q40060648Spatial and temporal regulation of focal adhesion kinase activity in living cells.
Q37712330Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression.
Q36890026Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor
Q34959208Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530.
Q40152520Src kinase promotes adhesion-independent activation of FAK and enhances cellular migration in tamoxifen-resistant breast cancer cells.
Q36438267Src protein tyrosine kinase family and acute inflammatory responses.
Q40648094Src-/- Fibroblasts are Defective in Their Ability to Disassemble Focal Adhesions in Response to Phorbol Ester/Hyaluronan Treatment
Q34284022Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells
Q41510232Stem cells migration during skeletal muscle regeneration - the role of Sdf-1/Cxcr4 and Sdf-1/Cxcr7 axis
Q46970743Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants
Q90571172Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
Q33560115Structure and functional evaluation of tendon-skeletal muscle constructs engineered in vitro
Q27640105Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
Q36370653Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis
Q34973911Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog.
Q38175738Targeting FAK in human cancer: from finding to first clinical trials
Q37800284Targeting cytoskeleton reorganisation as antimetastatic treatment.
Q44814601Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation
Q89660060The Extracellular Matrix: An Accomplice in Gastric Cancer Development and Progression
Q33591096The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Q44132505The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology
Q37127317The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.
Q24676735The integrin-actin connection, an eternal love affair
Q42709950The miR-181d-regulated metalloproteinase Adamts1 enzymatically impairs adipogenesis via ECM remodeling
Q40578206The opioid agonist ethylketocyclazocine reverts the rapid, non-genomic effects of membrane testosterone receptors in the human prostate LNCaP cell line
Q36598516The role of Src in solid and hematologic malignancies: development of new-generation Src inhibitors
Q36216076The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
Q35906962The role of growth factors in the pathogenesis of diabetic retinopathy
Q34733172The role of integrin-β/FAK in cyclic mechanical stimulation in MG-63 cells.
Q24305947The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways
Q36659321Therapeutic effects of tyroservatide on metastasis of lung cancer and its mechanism affecting integrin-focal adhesion kinase signal transduction
Q37750751Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer
Q24628602Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor
Q42243895Transglutaminase-mediated oligomerization of the fibrin(ogen) alphaC domains promotes integrin-dependent cell adhesion and signaling.
Q50291124Translocation of PTK2 to Focal complexes
Q30429345Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading
Q38772631UM-164: a potent c-Src/p38 kinase inhibitor with in vivo activity against triple negative breast cancer
Q34811842Urokinase receptor counteracts vascular smooth muscle cell functional changes induced by surface topography
Q36724913Visualizing and manipulating focal adhesion kinase regulation in live cells
Q42818845Vitronectin absorbed on nanoparticles mediate cell viability/proliferation and uptake by 3T3 Swiss albino mouse fibroblasts: in vitro study
Q44559365Zoledronate sensitizes endothelial cells to tumor necrosis factor-induced programmed cell death: evidence for the suppression of sustained activation of focal adhesion kinase and protein kinase B/Akt
Q48717796beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury.
Q36054147p130CAS is required for netrin signaling and commissural axon guidance
Q44495344p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration
Q37604084p38 mitogen-activated protein kinase interacts with vinculin at focal adhesions during fatty acid-stimulated cell adhesion
Q30167613v-Src SH3-enhanced interaction with focal adhesion kinase at beta 1 integrin-containing invadopodia promotes cell invasion
Q38805605β1,6-branched complex-type N-glycans affect FAK signaling in metastatic melanoma cells
Q41207747β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis

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