Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells.

scientific article published in September 2002

Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0006-291X(02)02187-3
P698PubMed publication ID12237117

P50authorLynne-Marie PostovitQ57016909
P2093author name stringJohn S Elce
Peter A Greer
Nathalie Dourdin
Charles H Graham
Previn Dutt
Minwoo Park
P2860cites workCleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Matrix metalloproteinasesQ28140451
Matrix metalloproteinases in tumor invasionQ28144147
Biochemical signals and biological responses elicited by the focal adhesion kinaseQ28209463
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritisQ28343409
Urokinase-receptor/integrin complexes are functionally involved in adhesion and progression of human breast cancer in vivoQ28350698
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and divisionQ28512039
Matrix metalloproteinases: effectors of development and normal physiologyQ28679038
Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPasesQ30500235
The structure of calpain.Q30666576
Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrixQ34008810
The plasminogen activation system in tumor growth, invasion, and metastasisQ34008816
Cellular transformation by SV40 large T antigen: interaction with host proteinsQ34177960
Role of T antigen interactions with p53 in tumorigenesisQ34177970
Invited review: focal adhesion and small heat shock proteins in the regulation of actin remodeling and contractility in smooth muscleQ34310352
Cutting to the chase: calpain proteases in cell motilityQ34537620
Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectinQ36235530
Calpain regulates actin remodeling during cell spreadingQ36255313
Integrin-mediated signals regulated by members of the rho family of GTPasesQ36256316
Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become activeQ36342597
Inhibition of calpain blocks platelet secretion, aggregation, and spreadingQ37307187
v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.Q39675981
Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblastsQ40774527
Effect of hypoxia on cellular adhesion to vitronectin and fibronectinQ40779697
c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cellsQ40797906
Altered matrix metalloproteinase expression associated with oncogene-mediated cellular transformation and metastasis formationQ40799976
Does nitric oxide play a role in the aetiology of pre-eclampsia?Q40811453
Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells.Q40868315
Calpain mediates integrin-induced signaling at a point upstream of Rho family membersQ40941467
Downstream targets of urokinase-type plasminogen-activator-mediated signal transductionQ41027822
MMP-2: expression, activation and inhibitionQ41105675
Casein zymography: a method to study mu-calpain, m-calpain, and their inhibitory agentsQ41346294
Degradation of transcription factors, c-Jun and c-Fos, by calpainQ41670196
Decreased susceptibility to calpains of v-FosFBR but not of v-FosFBJ or v-JunASV17 retroviral proteins compared with their cellular counterparts.Q42986389
Inhibition of calpain-mediated apoptosis by E-64 d-reduced immediate early gene (IEG) expression and reactive astrogliosis in the lesion and penumbra following spinal cord injury in ratsQ43764329
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cellsQ46095406
The urokinase-type plasminogen activator receptor mediates tyrosine phosphorylation of focal adhesion proteins and activation of mitogen-activated protein kinase in cultured endothelial cellsQ47859760
Calpain: a protease in search of a function?Q47923112
Differential regulation of myelin gene expression in SV40 T antigen-transfected rat glioma C6 cellsQ48788339
Identification and characterization of two novel calpain large subunit genes.Q52128241
Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.Q52541492
Altered expression of gelatinase and surface-associated plasminogen activator activity by trophoblast cells isolated from placentas of preeclamptic patientsQ71583126
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clotsQ71984999
Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitorsQ72992856
Beta1 integrin-mediated T cell adhesion and cell spreading are regulated by calpainQ73199540
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrierQ73842972
Motility is rate-limiting for invasion of bladder carcinoma cell linesQ77931640
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)294-301
P577publication date2002-09-01
P1433published inBiochemical and Biophysical Research CommunicationsQ864228
P1476titleCalpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells
P478volume297

Reverse relations

cites work (P2860)
Q35995215Acute actions and novel targets of matrix metalloproteinases in the heart and vasculature
Q34425717Calpain 2 is required for glioblastoma cell invasion: regulation of matrix metalloproteinase 2.
Q42214621Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
Q37017926Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia.
Q33204255Gene profiling of cottontail rabbit papillomavirus-induced carcinomas identifies upregulated genes directly Involved in stroma invasion as shown by small interfering RNA-mediated gene silencing
Q57117017Genetic disruption of calpain-1 and calpain-2 attenuates tumorigenesis in mouse models of HER2+ breast cancer and sensitizes cancer cells to doxorubicin and lapatinib
Q34007987Human papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein
Q30843714Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells
Q39015599Increased expression of Capn4 is associated with the malignancy of human glioma.
Q37504520Prolonged androgen deprivation leads to overexpression of calpain 2: implications for prostate cancer progression
Q37867486The calpain system and cancer.
Q42445284The calpastatin-derived calpain inhibitor CP1B reduces mRNA expression of matrix metalloproteinase-2 and -9 and invasion by leukemic THP-1 cells
Q35588934mRNA expression of genes involved in lipid efflux and matrix degradation in occlusive and ectatic atherosclerotic disease.

Search more.