Inhibition of calpain blocks platelet secretion, aggregation, and spreading

scientific article published on December 1999

Inhibition of calpain blocks platelet secretion, aggregation, and spreading is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.274.51.36321
P932PMC publication ID2727653
P698PubMed publication ID10593923
P5875ResearchGate publication ID12707282

P2093author name stringB C Furie
B Furie
D A Potter
I M Herman
R Flaumenhaft
K Croce
M Rivers
P2860cites workA new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filamentsQ24309448
Adducin is an in vivo substrate for protein kinase C: phosphorylation in the MARCKS-related domain inhibits activity in promoting spectrin-actin complexes and occurs in many cells, including dendritic spines of neuronsQ24682526
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human plateletsQ28235484
Purification and characterization of an alpha 1 beta 2 isoform of CapZ from human erythrocytes: cytosolic location and inability to bind to Mg2+ ghosts suggest that erythrocyte actin filaments are capped by adducinQ28253307
Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin geneQ28254525
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 SubunitQ28291851
Beta cap73: a novel beta actin-specific binding proteinQ28296489
Regulation of cell migration by the calcium-dependent protease calpainQ29391186
The endogenous lectin of human platelets is an alpha-granule componentQ70788259
Involvement of calpain in integrin-mediated signal transductionQ71097810
A platelet membrane protein expressed during platelet activation and secretion. Studies using a monoclonal antibody specific for thrombin-activated plateletsQ71430992
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clotsQ71984999
Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human plateletsQ72033892
pp60src is an endogenous substrate for calpain in human blood plateletsQ72083293
Mechanism of shape change in chilled human plateletsQ72126140
Platelet alpha-granule and plasma membrane share two new components: CD9 and PECAM-1Q72175900
Membrane binding properties of the factor IX gamma-carboxyglutamic acid-rich domain prepared by chemical synthesisQ72724316
Domain structure of calpain: mapping the binding site for calpastatinQ72773438
Proteolysis of synaptobrevin, syntaxin, and SNAP-25 in alveolar epithelial type II cellsQ73347983
An antisense oligodeoxyribonucleotide to m-calpain mRNA inhibits secretion from alveolar epithelial type II cellsQ74239800
Proteins of the exocytotic core complex mediate platelet alpha-granule secretion. Roles of vesicle-associated membrane protein, SNAP-23, and syntaxin 4Q77801139
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.Q34070941
Subcellular localization of moesin in dynamic filopodia, retraction fibers, and other structures involved in substrate exploration, attachment, and cell-cell contactsQ34301673
Biphasic activation of PKBalpha/Akt in platelets. Evidence for stimulation both by phosphatidylinositol 3,4-bisphosphate, produced via a novel pathway, and by phosphatidylinositol 3,4,5-trisphosphateQ34466007
Effects of the lonophore A23187 on blood platelets I. Influence on aggregation and secretionQ35875535
The cleaved peptide of the thrombin receptor is a strong platelet agonistQ35979576
Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIaQ36233149
Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositidesQ36237502
Calmodulin-binding domain of recombinant erythrocyte beta-adducinQ36242358
Calpain regulates actin remodeling during cell spreadingQ36255313
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3Q36256128
Role of calpain in skeletal-muscle protein degradationQ36517553
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceQ36707669
Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potentialQ36792198
Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogsQ37270758
Calcium-activated neutral protease (calpain) system: structure, function, and regulationQ37767409
Inhibition of secretion from isolated rat alveolar epithelial type II cells by the cell permeant calpain inhibitor II (N-acetyl-leucyl-leucyl-methioninal)Q41671897
Inhibition of protein degradation in isolated rat hepatocytesQ41980490
Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivityQ42053540
Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitorsQ42153402
Affinity labelling of the Ca(2+)-activated neutral proteinase (calpain) in intact human plateletsQ42796434
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathwaysQ42815473
LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpainQ42837762
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpainQ42983314
Identification of two protease inhibitors from bovine cardiac muscleQ44178959
Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activationQ44227887
The occurrence of an inhibitor of Ca2+-dependent neutral protease in rat liverQ45215140
Activation of protein kinase C precedes alpha 5 beta 1 integrin-mediated cell spreading on fibronectinQ46081423
Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN)Q47301366
A high molecular weight inhibitor of Ca2+-dependent neutral protease in rat brainQ47305358
Adducin preferentially recruits spectrin to the fast growing ends of actin filaments in a complex requiring the MARCKS-related domain and a newly defined oligomerization domain.Q47827809
Calpain: a protease in search of a function?Q47923112
Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinasesQ49133536
Moesin, the major ERM protein of lymphocytes and platelets, differs from ezrin in its insensitivity to calpain.Q54106494
Identification and characterization of inhibitory sequences in four repeating domains of the endogenous inhibitor for calcium-dependent protease.Q54726844
Ionophore a 23187: some effects on platelet aggregation and clot retractionQ67498837
Secretagogue-induced proteolysis of lung spectrin in alveolar epithelial type II cellsQ67571148
Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+Q67600371
Membrane expression of platelet calpainQ68723158
Rapid effects of phorbol ester on platelet shape change, cytoskeleton and calcium transientQ69617612
Analysis of structure-function relationship of pig calpastatin by expression of mutated cDNAs in Escherichia coliQ69831958
Calcium-dependent proteolysis occurs during platelet aggregationQ70158655
Human platelet calmodulin-binding proteins: identification and Ca2+-dependent proteolysis upon platelet activationQ70348098
In situ capture of mu-calpain activation in plateletsQ70636074
pH-dependent nonlysosomal proteolysis contributes to lethal anoxic injury of rat hepatocytesQ70666379
P433issue51
P407language of work or nameEnglishQ1860
P1104number of pages7
P304page(s)36321-36327
P577publication date1999-12-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of calpain blocks platelet secretion, aggregation, and spreading
P478volume274

Reverse relations

cites work (P2860)
Q24603193Actin dynamics in platelets
Q37990195All cut up! The consequences of calpain activation on platelet function
Q36785451Association between type 2 diabetes mellitus, biochemical factors and UCSNP-43 polymorphisms of CALPIN-10 gene in patients with atherosclerosis of coronary artery disease in Southern Iran population
Q35079180Calpain activator dibucaine induces platelet apoptosis
Q44140863Calpain is required for MMP-2 and u-PA expression in SV40 large T-antigen-immortalized cells.
Q38979394Calpain mediates epithelial cell microvillar effacement by enterohemorrhagic Escherichia coli
Q36242090Calpain proteases in cell adhesion and motility
Q33657916Calpain- and talin-dependent control of microvascular pericyte contractility and cellular stiffness
Q38161548Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future?
Q36783478Calpain-mediated regulation of platelet signaling pathways
Q40652159Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: enhancing cell permeability by conjugation with penetratin.
Q42668393Calpastatin subdomains A and C are activators of calpain
Q30550030Ca²⁺ and calpain control membrane expansion during the rapid cell spreading of neutrophils.
Q41616336Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa
Q47947432Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats
Q45868733Coordinated control of both insulin secretion and insulin action through calpain-10-mediated regulation of exocytosis?
Q36323239Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling
Q34537620Cutting to the chase: calpain proteases in cell motility
Q33967742Disruption of the mouse mu-calpain gene reveals an essential role in platelet function
Q35950307Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets
Q36342597Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active
Q43830350Genetic variation of the platelet- surface integrin GPIIb-IIIa (PIA1/A2-SNP) shows a high association with Type 2 diabetes mellitus
Q34997206Global analysis of the rat and human platelet proteome - the molecular blueprint for illustrating multi-functional platelets and cross-species function evolution.
Q40576080Human platelet 20S proteasome: inhibition of its chymotrypsin-like activity and identification of the proteasome activator PA28. A preliminary report
Q41970355Inhibit the calpain to climb the mountain
Q46398330Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion
Q22001543Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum
Q64056707Intercellular Vesicular Transfer by Exosomes, Microparticles and Oncosomes - Implications for Cancer Biology and Treatments
Q30300686Involvement of calpains in adult neurogenesis: implications for stroke
Q36890791Localization and quantification of platelet-rich thrombi in large blood vessels with near-infrared fluorescence imaging
Q91595903Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome
Q44055431Melatonin elevates intracellular free calcium in human platelets by inositol 1,4,5-trisphosphate independent mechanism
Q73372406Molecular Basis of Platelet Granule Secretion
Q47071712Molecular cloning and RNA expression of a novel Drosophila calpain, Calpain C.
Q40599716Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization.
Q90484536Procoagulant Phosphatidylserine-Exposing Platelets in vitro and in vivo
Q27693902Protein degradation systems in platelets
Q34168003Protein kinase C mediates translocation of type II phosphatidylinositol 5-phosphate 4-kinase required for platelet alpha-granule secretion
Q46427353Proteolysis leads to the appearance of the long form of beta3-endonexin in human platelets
Q40603207Receptor/transporter-independent targeting of functional peptides across the plasma membrane
Q37279026Replication of calpain-10 genetic association with carotid intima-media thickness
Q35989495SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane
Q30711945SNAP-23 is a target for calpain cleavage in activated platelets.
Q51313041Sitagliptin: anti-platelet effect in diabetes and healthy volunteers.
Q37641872Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading
Q37798968The role of calpain in diabetes-associated platelet hyperactivation.
Q42518733Thiosulfinates modulate platelet activation by reaction with surface free sulfhydryls and internal thiol-containing proteins.
Q44272977Thrombotic microangiopathy in blood and marrow transplant patients receiving tacrolimus or cyclosporine A.
Q36074745Two-wavelength near-infrared fluorescence for the quantitation of drug antiplatelet effects in large animal model systems
Q44965408Vinculin is proteolyzed by calpain during platelet aggregation: 95 kDa cleavage fragment associates with the platelet cytoskeleton.

Search more.