| scholarly article | Q13442814 |
| P2093 | author name string | Chishti AH | |
| Azam M | |||
| Kuliopulos A | |||
| Kamath L | |||
| Sahr KE | |||
| Andrabi SS | |||
| P2860 | cites work | The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium | Q22011092 |
| Mutations in the proteolytic enzyme calpain 3 cause limb-girdle muscular dystrophy type 2A | Q24314667 | ||
| Structure and physiological function of calpains | Q24530607 | ||
| A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance | Q24627086 | ||
| Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation | Q27620740 | ||
| Calpain: novel family members, activation, and physiologic function | Q28273311 | ||
| p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets | Q28284735 | ||
| Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit | Q28291851 | ||
| Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and division | Q28512039 | ||
| Outside-in integrin signal transduction. Alpha IIb beta 3-(GP IIb IIIa) tyrosine phosphorylation induced by platelet aggregation | Q28609213 | ||
| Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation | Q28610108 | ||
| Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | Q28771769 | ||
| Calpain and caspase: can you tell the difference? | Q33815206 | ||
| Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. | Q33835366 | ||
| The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation | Q33874977 | ||
| Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets | Q34000203 | ||
| Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. | Q36232656 | ||
| Calpain regulates actin remodeling during cell spreading | Q36255313 | ||
| Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets | Q36532167 | ||
| Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets | Q36676794 | ||
| Inhibition of calpain blocks platelet secretion, aggregation, and spreading | Q37307187 | ||
| Calcium-activated neutral protease (calpain) system: structure, function, and regulation | Q37767409 | ||
| Calpain 10: the first positional cloning of a gene for type 2 diabetes? | Q40735864 | ||
| New era of calpain research. Discovery of tissue-specific calpains | Q40743207 | ||
| Regulation of the calpain-calpastatin system by membranes (review). | Q41443012 | ||
| Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function | Q41700251 | ||
| Integrin signaling: the platelet paradigm | Q41733864 | ||
| Vinculin is a major platelet protein that undergoes Ca2+-dependent tyrosine phosphorylation | Q42120708 | ||
| The behavior of calpain-generated N- and C-terminal fragments of talin in integrin-mediated signaling pathways | Q42612929 | ||
| On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. | Q46799641 | ||
| Mapping, cloning, cDNA sequence, and expression of the gene encoding the mouse micromolar calpain large subunit | Q48038452 | ||
| Tyrosine phosphorylation of the novel protein-tyrosine kinase RAFTK during an early phase of platelet activation by an integrin glycoprotein IIb-IIIa-independent mechanism. | Q52524774 | ||
| Induction of protein tyrosine phosphorylation in human natural killer cells by triggering via alpha 4 beta 1 or alpha 5 beta 1 integrins | Q71685982 | ||
| Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots | Q71984999 | ||
| Regulation of protein tyrosine kinases in platelets | Q72545145 | ||
| Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3 | Q72808954 | ||
| Glycoprotein V-deficient platelets have undiminished thrombin responsiveness and Do not exhibit a Bernard-Soulier phenotype | Q73254101 | ||
| Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction | Q73617879 | ||
| Inhibition of platelet integrin alpha(IIb)beta(3) by peptides that interfere with protein kinases and the beta(3) tail | Q73876927 | ||
| Differential involvement of tyrosine and serine/threonine kinases in platelet integrin alphaIIbbeta3 exposure | Q74351449 | ||
| Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions | Q74567473 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2213-2220 | |
| P577 | publication date | 2001-03-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Disruption of the mouse mu-calpain gene reveals an essential role in platelet function | |
| P478 | volume | 21 |
| Q50194234 | A Gastrointestinal Calpain Complex, G-calpain, Is a Heterodimer of CAPN8 and CAPN9 Calpain Isoforms, Which Play Catalytic and Regulatory Roles, Respectively |
| Q30835134 | A calpain-like activity insensitive to calpastatin in Drosophila melanogaster |
| Q36119672 | A molecular switch that controls cell spreading and retraction |
| Q30465306 | A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs |
| Q44726076 | A novel water-soluble and cell-permeable calpain inhibitor protects myocardial and mitochondrial function in postischemic reperfusion |
| Q24603193 | Actin dynamics in platelets |
| Q41880057 | Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury |
| Q44512409 | Activation of transglutaminase in mu-calpain null erythrocytes |
| Q37990195 | All cut up! The consequences of calpain activation on platelet function |
| Q26781368 | An eccentric calpain, CAPN3/p94/calpain-3 |
| Q27656592 | Atomic Structures of Two Novel Immunoglobulin-like Domain Pairs in the Actin Cross-linking Protein Filamin |
| Q41438679 | BDA-410: a novel synthetic calpain inhibitor active against blood stage malaria |
| Q39780778 | CEACAM2 positively regulates integrin αIIbβ3-mediated platelet functions |
| Q48240860 | CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain. |
| Q34349686 | CalpB modulates border cell migration in Drosophila egg chambers |
| Q40046395 | Calpain 1 and 2 are required for RNA replication of echovirus 1. |
| Q28584194 | Calpain 1 and Calpastatin expression is developmentally regulated in rat brain |
| Q34213253 | Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats |
| Q42449806 | Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites |
| Q33888505 | Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies |
| Q33649868 | Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense |
| Q35079180 | Calpain activator dibucaine induces platelet apoptosis |
| Q31061887 | Calpain activity is essential in skin wound healing and contributes to scar formation |
| Q35157505 | Calpain chronicle--an enzyme family under multidisciplinary characterization |
| Q35040393 | Calpain is required for normal osteoclast function and is down-regulated by calcitonin |
| Q36242090 | Calpain proteases in cell adhesion and motility |
| Q33973418 | Calpain protects the heart from hemodynamic stress |
| Q91712731 | Calpain proteolytic systems counteract endothelial cell adaptation to inflammatory environments |
| Q39004902 | Calpain research for drug discovery: challenges and potential |
| Q38234563 | Calpain system and its involvement in myocardial ischemia and reperfusion injury |
| Q33684125 | Calpain-1 contributes to IgE-mediated mast cell activation |
| Q37638858 | Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology |
| Q47666229 | Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease. |
| Q34973686 | Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice |
| Q37240560 | Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis |
| Q45310677 | Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3). |
| Q36783478 | Calpain-mediated regulation of platelet signaling pathways |
| Q53088604 | Calpain2 protease: A new member of the Wnt/Ca(2+) pathway modulating convergent extension movements in Xenopus. |
| Q30454134 | Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice |
| Q36233171 | Capn5 is expressed in a subset of T cells and is dispensable for development |
| Q43003200 | Characterization of a new p94-like calpain form in human lymphocytes |
| Q34298023 | Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94. |
| Q36323239 | Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling |
| Q34537620 | Cutting to the chase: calpain proteases in cell motility |
| Q36296163 | Death penalty for keratinocytes: apoptosis versus cornification. |
| Q38485116 | Degradation systems in heart failure |
| Q37345165 | Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. |
| Q35950307 | Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets |
| Q47937998 | Dysregulation of Calpain Proteolytic Systems Underlies Degenerative Vascular Disorders |
| Q39255621 | Emerging roles of calpain proteolytic systems in macrophage cholesterol handling |
| Q39214141 | Endothelial cell calpain as a critical modulator of angiogenesis |
| Q47907916 | Erythrocyte calpain is dispensable for malaria parasite invasion and growth |
| Q57223169 | Erythrocytes: death of a mummy |
| Q40855297 | Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension |
| Q42388542 | Genetic inactivation of calpain-1 attenuates pain sensitivity in a humanized mouse model of sickle cell disease |
| Q34997206 | Global analysis of the rat and human platelet proteome - the molecular blueprint for illustrating multi-functional platelets and cross-species function evolution. |
| Q28513571 | Granulocyte function in grancalcin-deficient mice |
| Q52128241 | Identification and characterization of two novel calpain large subunit genes. |
| Q33572036 | Identification and optimization of a novel inhibitor of mitochondrial calpain 10 |
| Q37879317 | Impact of genetic insights into calpain biology |
| Q41970355 | Inhibit the calpain to climb the mountain |
| Q49789558 | Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. |
| Q40580527 | Involvement of micro-calpain (CAPN 1) in muscle cell differentiation |
| Q40527089 | Isoform specific function of calpain 2 in regulating membrane protrusion |
| Q37177242 | Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity |
| Q37029897 | Mechanistic role of calpains in postischemic neurodegeneration |
| Q24538576 | Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling |
| Q36146335 | Membrane Repair: Mechanisms and Pathophysiology. |
| Q27318452 | Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed |
| Q40599716 | Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization. |
| Q40037129 | N terminus of calpain 1 is a mitochondrial targeting sequence |
| Q30354158 | Otoprotective effects of ethosuximide in NOD/LtJ mice with age-related hearing loss |
| Q37728307 | PTP1B: a double agent in metabolism and oncogenesis |
| Q44161523 | Pepducin-based intervention of thrombin-receptor signaling and systemic platelet activation |
| Q43916572 | Peptidyl alpha-keto amide inhibitor of calpain blocks excitotoxic damage without affecting signal transduction events |
| Q37812402 | Physiologic and pathophysiologic role of calpain: implications for the occurrence of atrial fibrillation |
| Q47637050 | Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth |
| Q27693902 | Protein degradation systems in platelets |
| Q36156010 | Proteolytic mechanisms in necrotic cell death and neurodegeneration |
| Q33912914 | RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia |
| Q34168662 | Receptor-Independent Cardiac Protein Kinase Cα Activation by Calpain-Mediated Truncation of Regulatory Domains |
| Q28711159 | Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain |
| Q37438390 | Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon |
| Q36749161 | Role of mu-calpain in proteolytic cleavage of brain L-glutamic acid decarboxylase |
| Q36934614 | SMN complex localizes to the sarcomeric Z-disc and is a proteolytic target of calpain |
| Q30711945 | SNAP-23 is a target for calpain cleavage in activated platelets. |
| Q37706113 | Signaling regulation and role of filamin A cleavage in Ca2+-stimulated migration of androgen receptor-deficient prostate cancer cells |
| Q37301499 | Significant role of μ-calpain (CANP1) in proliferation/survival of bovine skeletal muscle satellite cells |
| Q40021155 | Specific knockdown of m-calpain blocks myogenesis with cDNA deduced from the corresponding RNAi |
| Q48934150 | Subcellular elevation of cytosolic free calcium is required for osteoclast migration. |
| Q44319476 | Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain. |
| Q35921561 | Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress |
| Q37641872 | Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading |
| Q41790608 | Targeting individual calpain isoforms for neuroprotection |
| Q39268482 | The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets |
| Q28214119 | The calpain family and human disease |
| Q30499832 | The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration |
| Q37867486 | The calpain system and cancer. |
| Q34658476 | The calpain/calpastatin system has opposing roles in growth and metastatic dissemination of melanoma. |
| Q36672357 | The calpains: modular designs and functional diversity |
| Q37656447 | The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems |
| Q28594194 | The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation |
| Q42116882 | The relative role of PLCbeta and PI3Kgamma in platelet activation |
| Q37798968 | The role of calpain in diabetes-associated platelet hyperactivation. |
| Q37994503 | The role of calpains in myocardial remodelling and heart failure |
| Q34717790 | The β isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in αII b β3 integrin signaling. |
| Q44433340 | Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphaIIbbeta3 by its extracellular domain |
| Q37670929 | Tissue transglutaminase (TG2) facilitates phosphatidylserine exposure and calpain activity in calcium-induced death of erythrocytes |
| Q44965408 | Vinculin is proteolyzed by calpain during platelet aggregation: 95 kDa cleavage fragment associates with the platelet cytoskeleton. |
| Q35273962 | Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival |
| Q25256686 | m-Calpain is required for preimplantation embryonic development in mice. |
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