Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading

scientific article published on June 2012

Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1538-7836.2012.04715.X
P932PMC publication ID3956748
P698PubMed publication ID22458296
P5875ResearchGate publication ID223994186

P2093author name stringA H Chishti
I M Herman
M Marinkovic
A J Wieschhaus
S M Kuchay
P2860cites workA differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.Q46728083
Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.Q53602922
Identification of a novel, actin-rich structure, the actin nodule, in the early stages of platelet spreadingQ62014624
Protease-activating Receptor-4 Induces Full Platelet Spreading on a Fibrinogen MatrixQ62665022
Positive regulation of mu-calpain action by polyphosphoinositidesQ67866484
Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood plateletsQ69952539
Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human plateletsQ71692364
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clotsQ71984999
Cytoskeletal proteins and platelet signalingQ74314920
PTP-1B is an essential positive regulator of platelet integrin signalingQ24317102
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombinQ24563384
m-Calpain is required for preimplantation embryonic development in mice.Q25256686
The calpain systemQ28185062
Protease-activated receptors in cardiovascular diseasesQ28261926
Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesionQ28280504
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 SubunitQ28291851
Regulation of cell migration by the calcium-dependent protease calpainQ29391186
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow.Q30476950
Calpain regulates neutrophil chemotaxisQ30477730
Estimating intracellular calcium concentrations and buffering without wavelength ratioingQ30861250
On the role of calpain and Rho proteins in regulating integrin-induced signaling.Q33800075
Indo-1 fluorescence signals elicited by membrane depolarization in enzymatically isolated mouse skeletal muscle fibersQ33907241
Disruption of the mouse mu-calpain gene reveals an essential role in platelet functionQ33967742
Calpain regulation of integrin alpha IIb beta 3 signaling in human plateletsQ34000203
Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets.Q34064456
Role of thrombin signalling in platelets in haemostasis and thrombosisQ34090283
Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes.Q35346534
Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in plateletsQ35950307
A molecular switch that controls cell spreading and retractionQ36119672
Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIaQ36233149
Calpain regulates actin remodeling during cell spreadingQ36255313
Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become activeQ36342597
Inhibition of calpain blocks platelet secretion, aggregation, and spreadingQ37307187
Platelet activation by extracellular matrix proteins in haemostasis and thrombosisQ37438455
Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreadingQ38290020
The protein tyrosine phosphatase Shp-2 regulates RhoA activityQ40837843
Calpain mediates integrin-induced signaling at a point upstream of Rho family membersQ40941467
Indirect association of ezrin with F-actin: isoform specificity and calcium sensitivityQ42053540
Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatasesQ42816004
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpainQ42983314
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation.Q43613710
Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets.Q46206704
P433issue6
P304page(s)1120-1132
P577publication date2012-06-01
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleTargeted gene inactivation reveals a functional role of calpain-1 in platelet spreading
P478volume10

Reverse relations

cites work (P2860)
Q35044845Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity
Q37638858Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology
Q47666229Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Q37716754Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis.
Q36832592Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets
Q36194061Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets
Q30300686Involvement of calpains in adult neurogenesis: implications for stroke
Q28546748Platelet mechanosensing of collagen matrices
Q40317987Quantitative analysis of platelets aggregates in 3D by digital holographic microscopy
Q28711159Regulation of cell adhesion and migration by Kindlin-3 cleavage by calpain
Q38057431Rho GTPases in platelet function
Q51569791Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model.
Q39268482The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets

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