Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets

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Double knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets is …
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scholarly articleQ13442814

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P356DOI10.1128/MCB.00522-07
P932PMC publication ID1952154
P698PubMed publication ID17576811
P5875ResearchGate publication ID6259969

P50authorAthar H ChishtiQ89175184
P2093author name stringNayoung Kim
Shafi M Kuchay
William P Fay
Elizabeth A Grunz
P2860cites workFour genes for the calpain family locate on four distinct human chromosomesQ24297648
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequenceQ24301399
PTP-1B is an essential positive regulator of platelet integrin signalingQ24317102
The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate bindingQ24321328
Structure and physiological function of calpainsQ24530607
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient miceQ24552910
The calpain systemQ28185062
Calpain: novel family members, activation, and physiologic functionQ28273311
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 SubunitQ28291851
Disruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and divisionQ28512039
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B geneQ29618933
Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talinQ30442047
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.Q33835366
Disruption of the mouse mu-calpain gene reveals an essential role in platelet functionQ33967742
Calpain regulation of integrin alpha IIb beta 3 signaling in human plateletsQ34000203
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.Q34070941
Inhibition of calpain blocks platelet secretion, aggregation, and spreadingQ37307187
UVA inactivates protein tyrosine phosphatases by calpain-mediated degradationQ40103872
The role of autolysis in activity of the Ca2+-dependent proteinases (mu-calpain and m-calpain).Q41269837
Regulation of the calpain-calpastatin system by membranes (review).Q41443012
Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet functionQ41700251
Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagenQ41975625
Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatasesQ42816004
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpainQ42983314
Inhibition of thrombin-induced platelet activation by leupeptin. Implications for the participation of calpain in the initiation of platelet activation.Q43613710
Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavageQ43655712
Bruton's tyrosine kinase is a substrate of calpain in human plateletsQ43737352
Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent proteaseQ43775807
Evidence that agonist-induced activation of calpain causes the shedding of procoagulant-containing microvesicles from the membrane of aggregating platelets.Q46206704
Neuronal PTP1B regulates body weight, adiposity and leptin action.Q47329751
Light on plateletsQ48620238
The calpain small subunit gene is essential: its inactivation results in embryonic lethality.Q52541584
Effect of Ca2+ on binding of the calpains to calpastatinQ69358684
Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptideQ71466799
Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human plateletsQ71692364
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clotsQ71984999
Cytoskeletal proteins and platelet signalingQ74314920
Regulation of arterial thrombolysis by plasminogen activator inhibitor-1 in miceQ74405764
Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpainQ77545456
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)6038-6052
P577publication date2007-06-18
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleDouble knockouts reveal that protein tyrosine phosphatase 1B is a physiological target of calpain-1 in platelets
P478volume27

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cites work (P2860)
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Q39645763Calcium as a mediator between erythropoietin and protein tyrosine phosphatase 1B
Q28584194Calpain 1 and Calpastatin expression is developmentally regulated in rat brain
Q36491754Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.
Q33684125Calpain-1 contributes to IgE-mediated mast cell activation
Q47666229Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Q34973686Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice
Q24310309Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B
Q37505664Cell and molecular biology of the novel protein tyrosine-phosphatase-interacting protein 51.
Q92652900Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis
Q26771736Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors
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Q38214958Insights into platelet-based control of coagulation.
Q41951212Insulin, insulin resistance, and platelet signaling in diabetes
Q24318475Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics
Q37025183Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.
Q37728307PTP1B: a double agent in metabolism and oncogenesis
Q38123537PTP1B: a simple enzyme for a complex world
Q36534381Pharmacological inhibition of calpain-1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
Q39166559Protein Phosphotyrosine Phosphatase 1B (PTP1B) in Calpain-dependent Feedback Regulation of Vascular Endothelial Growth Factor Receptor (VEGFR2) in Endothelial Cells: IMPLICATIONS IN VEGF-DEPENDENT ANGIOGENESIS AND DIABETIC WOUND HEALING.
Q37094065Protein tyrosine phosphatases: regulatory mechanisms
Q33630136Reactive oxygen species play a critical role in collagen-induced platelet activation via SHP-2 oxidation
Q38847682Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization
Q33884112Regulation of platelet-activating factor-mediated protein tyrosine phosphatase 1B activation by a Janus kinase 2/calpain pathway
Q42024923Role of sodium tungstate as a potential antiplatelet agent
Q51569791Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model.
Q38205014Signalling pathways involved in paracetamol-induced hepatotoxicity: new insights on the role of protein tyrosine phosphatase 1B.
Q33811181Substrate specificity of protein tyrosine phosphatases 1B, RPTPα, SHP-1, and SHP-2.
Q35770204Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin
Q35921561Targeted gene inactivation of calpain-1 suppresses cortical degeneration due to traumatic brain injury and neuronal apoptosis induced by oxidative stress
Q37641872Targeted gene inactivation reveals a functional role of calpain-1 in platelet spreading
Q39268482The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets
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Q37656447The effects of Capn1 gene inactivation on skeletal muscle growth, development, and atrophy, and the compensatory role of other proteolytic systems
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