Calpain-mediated regulation of platelet signaling pathways

scientific article published on May 2007

Calpain-mediated regulation of platelet signaling pathways is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1097/MOH.0B013E3280EF68F8
P932PMC publication ID3959858
P698PubMed publication ID17414215

P50authorAthar H ChishtiQ89175184
P2093author name stringShafi M Kuchay
P2860cites workPKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formationQ24301041
PTP-1B is an essential positive regulator of platelet integrin signalingQ24317102
The calpain systemQ28185062
Inositol polyphosphate 4-phosphatase is inactivated by calpain-mediated proteolysis in stimulated human plateletsQ28235484
Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesionQ28280504
Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregationQ28286323
Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 SubunitQ28291851
Regulation of cell migration by the calcium-dependent protease calpainQ29391186
SNAP-23 is a target for calpain cleavage in activated platelets.Q30711945
Disruption of the mouse mu-calpain gene reveals an essential role in platelet functionQ33967742
Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets.Q34064456
Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.Q34070941
Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpainQ34118592
The properties of the protein tyrosine phosphatase PTPMEG.Q34406752
Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reactionQ35545284
Role of the membrane skeleton in preventing the shedding of procoagulant-rich microvesicles from the platelet plasma membraneQ36223464
Evidence that activation of platelet calpain is induced as a consequence of binding of adhesive ligand to the integrin, glycoprotein IIb-IIIaQ36233149
Evidence that beta3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become activeQ36342597
Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in plateletsQ36532167
Inhibition of calpain blocks platelet secretion, aggregation, and spreadingQ37307187
Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreadingQ38290020
UVA inactivates protein tyrosine phosphatases by calpain-mediated degradationQ40103872
Calpain mediates integrin-induced signaling at a point upstream of Rho family membersQ40941467
Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet functionQ41700251
Microvesicle release is associated with extensive protein tyrosine dephosphorylation in platelets stimulated by A23187 or a mixture of thrombin and collagenQ41975625
The relative role of PLCbeta and PI3Kgamma in platelet activationQ42116882
Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatasesQ42816004
Focal adhesion kinase (pp125FAK) cleavage and regulation by calpainQ42983314
Regulation of protein-tyrosine phosphatases alpha and epsilon by calpain-mediated proteolytic cleavageQ43655712
Activation of a calmodulin-dependent phosphatase by a Ca2+-dependent proteaseQ43775807
Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activationQ44227887
Vinculin is proteolyzed by calpain during platelet aggregation: 95 kDa cleavage fragment associates with the platelet cytoskeleton.Q44965408
Cleavage of platelet endothelial cell adhesion molecule-1 (PECAM-1) in platelets exposed to high shear stress.Q45154427
The role of calpain in stimulus-response coupling: evidence that calpain mediates agonist-induced expression of procoagulant activity in plateletsQ46045536
Dystrophin-related protein in the platelet membrane skeleton. Integrin-induced change in detergent-insolubility and cleavage by calpain in aggregating plateletsQ46311565
Proteolysis leads to the appearance of the long form of beta3-endonexin in human plateletsQ46427353
A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation.Q46728083
Purification and characterization of a Ca(2+)-activated thiol protease from Drosophila melanogasterQ48432508
Plasma membrane Ca2+-ATPase isoform 4b is phosphorylated on tyrosine 1176 in activated human platelets.Q50318700
Contribution of PAR-1, PAR-4 and GPIbalpha in intracellular signaling leading to the cleavage of the beta3 cytoplasmic domain during thrombin-induced platelet aggregation.Q50955441
Identification and characterization of two novel calpain large subunit genes.Q52128241
Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.Q53602922
Protease-activating Receptor-4 Induces Full Platelet Spreading on a Fibrinogen MatrixQ62665022
Thromboxane A2/prostaglandin H2 mobilizes calcium in human blood plateletsQ69952539
The Ca2+ -activated protease (calpain) modulates Ca2+/calmodulin dependent activity of smooth muscle myosin light chain kinaseQ70185820
Differential mobilization of tyrosine kinases in human platelets stimulated with thrombin or thrombin receptor agonist peptideQ71466799
Antibodies specific for proteolyzed forms of protein kinase C alphaQ71578021
Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptorsQ71623372
Association of the protein tyrosine phosphatase PTP1C with the protein tyrosine kinase c-Src in human plateletsQ71793268
Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clotsQ71984999
pp60src is an endogenous substrate for calpain in human blood plateletsQ72083293
Calpain-induced down-regulation of protein kinase C inhibits dense-granule secretion in human platelets. Inhibition of platelet aggregation or calpain activity preserves protein kinase C and restores full secretionQ72364986
Endogenous cleavage of phospholipase C-beta 3 by agonist-induced activation of calpain in human plateletsQ72591866
Proteolysis of platelet cortactin by calpainQ73541817
Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transductionQ73617879
Cytoskeletal proteins and platelet signalingQ74314920
Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpainQ77545456
SNARE protein degradation upon platelet activation: calpain cleaves SNAP-23Q78696375
A role for the intracellular protease calpain in the activation of store-operated calcium entry in human plateletsQ80049431
Phosphatidylinositol 4,5-bisphosphate regulates activation-induced platelet microparticle formationQ81659598
P433issue3
P304page(s)249-254
P577publication date2007-05-01
P1433published inCurrent Opinion in HematologyQ15757961
P1476titleCalpain-mediated regulation of platelet signaling pathways
P478volume14

Reverse relations

cites work (P2860)
Q37981642Abundance- and Activity-Based Proteomics in Platelet Biology
Q41880057Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury
Q37990195All cut up! The consequences of calpain activation on platelet function
Q34213253Calpain 1 knockdown improves tissue sparing and functional outcomes after spinal cord injury in rats
Q35939817Calpain 2 regulates Akt-FoxO-p27(Kip1) protein signaling pathway in mammary carcinoma
Q35157505Calpain chronicle--an enzyme family under multidisciplinary characterization
Q61810933Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets
Q37857282Calpain inhibitors: a survey of compounds reported in the patent and scientific literature
Q47666229Calpain-1 regulates platelet function in a humanized mouse model of sickle cell disease.
Q47947432Contribution of calpain to myoglobin efflux from cardiomyocytes during ischaemia and after reperfusion in anaesthetized rats
Q33991611Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
Q36832592Dual mechanism of integrin αIIbβ3 closure in procoagulant platelets
Q36139930Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets
Q41951212Insulin, insulin resistance, and platelet signaling in diabetes
Q34675826Mechanism of down-regulation of RNA polymerase III-transcribed non-coding RNA genes in macrophages by Leishmania
Q34785837Permissive and repulsive cues and signalling pathways of axonal outgrowth and regeneration
Q28546748Platelet mechanosensing of collagen matrices
Q39893258TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration
Q37798968The role of calpain in diabetes-associated platelet hyperactivation.
Q49830459Vesicle-based secretion in schistosomes: Analysis of protein and microRNA (miRNA) content of exosome-like vesicles derived from Schistosoma mansoni

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