Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors

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Investigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1042/BJ2740497
P932PMC publication ID1150166
P698PubMed publication ID2006912
P5875ResearchGate publication ID21148923

P2093author name stringShaw E
Anagli J
Hagmann J
P2860cites workL-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and LQ24531160
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
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The inhibition of macrophage protein turnover by a selective inhibitor of thiol proteinasesQ28367093
Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral proteaseQ34557016
Cysteinyl proteinases and their selective inactivationQ34656277
Isolation and sequence analyses of cDNA clones for the large subunits of two isozymes of rabbit calcium-dependent proteaseQ35046307
Heterogeneity in late-onset metachromatic leukodystrophy. Effect of inhibitors of cysteine proteinases.Q35198709
Synergism of platelet-aggregating agents. Role of elevation of cytoplasmic calciumQ35576249
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structuresQ36628858
Brain spectrin, calpain and long-term changes in synaptic efficacyQ39511156
Synthetic fluoropeptides as pharmacologically useful compoundsQ39544431
The role of autolysis in activity of the Ca2+-dependent proteinases (mu-calpain and m-calpain).Q41269837
Thrombin-induced platelet aggregation involves an indirect proteolytic cleavage of aggregin by calpainQ41270240
Shape change and uptake of 5-hydroxytryptamine in human blood platelets: action of neuropsychotropic drugsQ41696861
Calpain inhibition by peptide epoxidesQ41761276
Calpain I activation is not correlated with aggregation in human plateletsQ41781541
The effects of autolysis on the structure of chicken calpain II.Q41868823
The inactivation of the cysteinyl exopeptidases cathepsin H and C by affinity-labelling reagentsQ42112501
Platelet-derived growth factor-induced alterations in vinculin distribution in porcine vascular smooth muscle cellsQ42208585
Cytoplasmic free Ca2+ in human platelets: Ca2+ thresholds and Ca-independent activation for shape-change and secretionQ42464048
Fluoride-dependent calcium-induced platelet procoagulant activity shows that calpain is involved in increased phospholipid transbilayer movementQ42501910
Spectrin is associated with membrane-bound actin filaments in platelets and is hydrolyzed by the Ca2+-dependent protease during platelet activationQ44227887
Degradation of myocardial structural proteins in myocardial infarcted dogs is reduced by Ep459, a cysteine proteinase inhibitorQ45353239
Elucidation of calpain dependent phosphorylation of myosin light chain in human platelets.Q45848433
Probing of the structural stability of vimentin and desmin-type intermediate filaments with Ca2+-activated proteinase, thrombin and lysine-specific endoproteinase Lys-C.Q46539891
A new solid-state reagent to iodinate proteins. I. Conditions for the efficient labeling of antiserumQ46622394
Demonstration of a relationship between talin and P235, a major substrate of the calcium-dependent protease in plateletsQ46689898
Intracellular Ca2+-dependent protease (CALPAIN) and its high-molecular-weight endogenous inhibitor (CALPASTATIN)Q47301366
Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules.Q48120501
Correlation between calpain-mediated cytoskeletal degradation and expression of platelet procoagulant activity. A role for the platelet membrane-skeleton in the regulation of membrane lipid asymmetry?Q51784915
Calpain II involvement in mitosisQ57224475
Peptidyl diazomethyl ketones are specific inactivators of thiol proteinasesQ67267798
Ca2+-dependent protease in human platelets. Specific cleavage of platelet polypeptides in the presence of added Ca2+Q67600371
Thiolprotease inhibitor, EST, can inhibit thrombin-induced platelet activationQ68879172
Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64dQ69329203
Montreal platelet syndrome: a defect in calcium-activated neutral proteinase (calpain)Q69352975
Influence of a calcium dependent protease inhibitor on platelet activation and secretionQ69458820
Collagen-stimulated human platelet aggregation is mediated by endogenous calcium-activated neutral proteaseQ69483215
Synthesis of a new cell penetrating calpain inhibitor (calpeptin)Q69831486
Calcium-dependent proteolysis occurs during platelet aggregationQ70158655
Evidence for membrane-associated calpain I in human erythrocytes. Detection by an immunoelectrophoretic blotting method using monospecific antibodyQ72388558
Ionomycin can elevate intraplatelet Ca2+ and activate phospholipase a without activating phospholipase CQ72392374
The thiol proteinase inhibitors, Z-Phe-PheCHN2 and Z-Phe-AlaCHN2, inhibit lysosomal protein degradation in isolated rat hepatocytesQ72694707
Calcium-dependent proteins in platelets response of calcium-activated protease in normal and thrombasthenic platelets to aggregating agentsQ72858361
THE AGGREGATION OF BLOOD PLATELETSQ76530970
P407language of work or nameEnglishQ1860
P304page(s)497-502
P577publication date1991-03-01
P1433published inBiochemical JournalQ864221
P1476titleInvestigation of the role of calpain as a stimulus-response mediator in human platelets using new synthetic inhibitors
P478volume274 ( Pt 2)

Reverse relations

cites work (P2860)
Q43614765A selective cysteine protease inhibitor is non-toxic and cerebroprotective in rats undergoing transient middle cerebral artery ischemia
Q67809975Additional Peptidyl Diazomethyl Ketones, Including Biotinyl Derivatives, Which Affinity-Label Calpain and Related Cysteinyl Proteinases
Q42796434Affinity labelling of the Ca(2+)-activated neutral proteinase (calpain) in intact human platelets
Q36255313Calpain regulates actin remodeling during cell spreading
Q42132232Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases
Q41188037Development and therapeutic potential of calpain inhibitors
Q44888020Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat.
Q71131484Hepatocellular carcinoma cells resist necrosis during anoxia by preventing phospholipase-mediated calpain activation
Q33572036Identification and optimization of a novel inhibitor of mitochondrial calpain 10
Q37031593Improvement in recovery after experimental intracerebral hemorrhage using a selective cathepsin B and L inhibitor
Q37307187Inhibition of calpain blocks platelet secretion, aggregation, and spreading
Q41190407Isolation of a Chinese hamster ovary cell clone possessing decreased mu-calpain content and a reduced proliferative growth rate
Q33512916Proteomic and phospho-proteomic profile of human platelets in basal, resting state: insights into integrin signaling
Q72615845The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain
Q24311357The major calpain isozymes are long-lived proteins. Design of an antisense strategy for calpain depletion in cultured cells

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