| scholarly article | Q13442814 |
| P2093 | author name string | S J Shattil | |
| T Hato | |||
| N Pampori | |||
| P2860 | cites work | Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor | Q24317407 |
| Aggregation of complement receptors on human neutrophils in the absence of ligand | Q24680114 | ||
| Affinity modulation of platelet integrin alphaIIbbeta3 by beta3-endonexin, a selective binding partner of the beta3 integrin cytoplasmic tail | Q24683804 | ||
| Rho GTPases and the actin cytoskeleton | Q27860579 | ||
| Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule | Q28115147 | ||
| Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia | Q28118972 | ||
| Signaling through scaffold, anchoring, and adaptor proteins | Q28131792 | ||
| Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling | Q28256301 | ||
| Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment | Q28258881 | ||
| Integrins: emerging paradigms of signal transduction | Q28283614 | ||
| Focal adhesions, contractility, and signaling | Q28299775 | ||
| Integrins and signal transduction pathways: the road taken | Q29547895 | ||
| Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation | Q68940569 | ||
| Self-association of bound fibrinogen on platelet surfaces | Q71404032 | ||
| Regulation of platelet aggregation by post-fibrinogen binding events. Insights provided by dithiothreitol-treated platelets | Q71543649 | ||
| Effect of cytoplasmic domain mutations on the agonist-stimulated ligand binding activity of the platelet integrin alphaIIbbeta3 | Q71825191 | ||
| Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3 | Q72808954 | ||
| Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands | Q72854737 | ||
| alpha IIb beta 3 redistribution triggered by receptor cross-linking | Q73966010 | ||
| A novel integrin-activated pathway forms PKB/Akt-stimulatory phosphatidylinositol 3,4-bisphosphate via phosphatidylinositol 3-phosphate in platelets | Q73995779 | ||
| RhoA and the function of platelet integrin alphaIIbbeta3 | Q74576925 | ||
| Integrin function: molecular hierarchies of cytoskeletal and signaling molecules | Q29618843 | ||
| Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK | Q30442274 | ||
| Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3 | Q30448362 | ||
| Platelets have more than one binding site for von Willebrand factor | Q33821754 | ||
| A humanized system for pharmacologic control of gene expression | Q34394730 | ||
| Bound fibrinogen distribution on stimulated platelets. Examination by confocal scanning laser microscopy | Q35798423 | ||
| Integrin cytoplasmic domains mediate inside-out signal transduction | Q36233869 | ||
| Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding | Q36380699 | ||
| The molecular biology of platelet membrane proteins | Q36578155 | ||
| A versatile synthetic dimerizer for the regulation of protein-protein interactions | Q36590017 | ||
| Long range propagation of conformational changes in integrin alpha IIb beta 3 | Q36697562 | ||
| Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. | Q37354696 | ||
| Cell adhesion in vascular biology. New insights into integrin-ligand interaction | Q37367042 | ||
| Nitric oxide released from activated platelets inhibits platelet recruitment | Q37369997 | ||
| Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex | Q37374506 | ||
| Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins | Q37597345 | ||
| Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function | Q38346505 | ||
| Platelet GPIIb/IIIa antagonists: the first anti-integrin receptor therapeutics | Q39781545 | ||
| The dynamic regulation of integrin adhesiveness | Q40629952 | ||
| Activation and inactivation of adhesion molecules. | Q40817333 | ||
| Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion. | Q41115251 | ||
| Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization | Q41187958 | ||
| Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation | Q41237399 | ||
| Adhesion-growth factor interactions during differentiation: an integrated biological response | Q41256483 | ||
| Molecular interactions in cell adhesion complexes | Q41334430 | ||
| Extracellular Ca2+ modulates leukocyte function-associated antigen-1 cell surface distribution on T lymphocytes and consequently affects cell adhesion | Q41485936 | ||
| Circulating integrins: alpha 5 beta 1, alpha 6 beta 4 and Mac-1, but not alpha 3 beta 1, alpha 4 beta 1 or LFA-1 | Q41515400 | ||
| The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering | Q41517769 | ||
| Are changes in integrin affinity and conformation overemphasized? | Q41710125 | ||
| Integrin signaling: the platelet paradigm | Q41733864 | ||
| The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases | Q41984711 | ||
| Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3. | Q42068185 | ||
| Mechanisms of actin rearrangements mediating platelet activation | Q42087428 | ||
| Capture by chemical crosslinkers provides evidence that integrin alpha IIb beta 3 forms a complex with protein tyrosine kinases in intact platelets | Q42821524 | ||
| Controlling mammalian gene expression with small molecules | Q45888368 | ||
| Complementation of dominant suppression implicates CD98 in integrin activation. | Q45939363 | ||
| Integrin activation by R-ras. | Q45995226 | ||
| Suppression of integrin activation: a novel function of a Ras/Raf-initiated MAP kinase pathway | Q46217115 | ||
| Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa | Q46581809 | ||
| On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. | Q46799641 | ||
| A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa). | Q52513845 | ||
| Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. | Q52524567 | ||
| The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin. | Q53990149 | ||
| Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK | Q57446983 | ||
| Evidence that changes in platelet cyclic AMP levels regulate the fibrinogen receptor on human platelets | Q67246264 | ||
| Anti-idiotypic antibodies against an antibody to the platelet glycoprotein (GP) IIb-IIIa complex mimic GP IIb-IIIa by recognizing fibrinogen | Q67894995 | ||
| Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex | Q67986716 | ||
| Modulation of platelet function through adhesion receptors. A dual role for glycoprotein IIb-IIIa (integrin alpha IIb beta 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor | Q68142029 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 1685-1695 | |
| P577 | publication date | 1998-06-01 | |
| P1433 | published in | Journal of Cell Biology | Q1524550 |
| P1476 | title | Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3 | |
| P478 | volume | 141 |
| Q44117315 | A Ser752-->Pro substitution in the cytoplasmic domain of beta3 in a Glanzmann thrombasthenia variant fails to prevent interactions between the alphaIIbbeta3 integrin and the platelet granule pool of fibrinogen. |
| Q43576574 | A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. |
| Q34827141 | A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins |
| Q33817633 | A push-pull mechanism for regulating integrin function |
| Q33621616 | ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding |
| Q46746804 | Actin S-nitrosylation inhibits neutrophil beta2 integrin function |
| Q36278857 | Activation of alpha(v)beta3-vitronectin binding is a multistage process in which increases in bond strength are dependent on Y747 and Y759 in the cytoplasmic domain of beta3. |
| Q36328589 | Activation of alphaVbeta3 on vascular cells controls recognition of prothrombin |
| Q44242590 | Activation of integrin alphaIIbbeta3 expressed in Chinese hamster ovary cells is required for interaction with solid-phase von Willebrand factor. |
| Q28348367 | Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment |
| Q40789696 | AlphaIIb's cytoplasmic domain is not required for ligand-induced clustering of integrin alphaIIbbeta3. |
| Q28208648 | Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state |
| Q27682746 | Atomic Basis for the Species-specific Inhibition of V Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of V 3 Ectodomain-17E6 Fab Complex |
| Q34026256 | Avidity regulation of integrins: the driving force in leukocyte adhesion |
| Q40734187 | Beta 1 integrin activation mediates adhesive differences between trisomy 21 and non-trisomic fibroblasts on type VI collagen |
| Q34186139 | Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering. |
| Q30709189 | Binding strength and activation state of single fibrinogen-integrin pairs on living cells |
| Q51407489 | Blood vessel occlusion in peri-burn tissue is secondary to erythrocyte aggregation and mitigated by a fibronectin-derived peptide that limits burn injury progression. |
| Q37184898 | CD98 activation increases surface expression and clusteringof beta1 integrins in MCF-7 cells through FAK/Src- and cytoskeleton-independent mechanisms |
| Q35079180 | Calpain activator dibucaine induces platelet apoptosis |
| Q33938437 | Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly |
| Q39283965 | Cell surface-expressed phosphatidylserine as therapeutic target to enhance phagocytosis of apoptotic cells |
| Q43797745 | Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation. |
| Q42276295 | Clustering of integrin α5 at the lateral membrane restores epithelial polarity in invasive colorectal cancer cells |
| Q44518865 | Concurrent signaling from Galphaq- and Galphai-coupled pathways is essential for agonist-induced alphavbeta3 activation on human platelets |
| Q58057915 | Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement |
| Q37631266 | Conformational changes and signaling in cell and matrix physics |
| Q28679173 | Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers |
| Q46824116 | Cooperative role of the membrane-proximal and -distal residues of the integrin beta3 cytoplasmic domain in regulation of talin-mediated alpha IIb beta3 activation |
| Q24293554 | Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton |
| Q37184491 | Correlation of integrin beta3 mRNA and vascular endothelial growth factor protein expression profiles with the clinicopathological features and prognosis of gastric carcinoma |
| Q34173183 | Cross-linking of cell surface receptors enhances cooperativity of molecular adhesion |
| Q39804477 | Cryo-electron microscopy structure of an adenovirus-integrin complex indicates conformational changes in both penton base and integrin |
| Q47565331 | Cryopreserved platelets demonstrate reduced activation responses and impaired signaling after agonist stimulation |
| Q33719178 | Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium. |
| Q73861811 | Cytoplasmic regions of the beta3 subunit of integrin alphaIIbbeta3 involved in platelet adhesion on fibrinogen under flow conditions |
| Q33426579 | Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombasthenia |
| Q31114092 | Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils |
| Q43494874 | Detection of integrin alpha IIbbeta 3 clustering in living cells |
| Q36796913 | Differences in regulation of Drosophila and vertebrate integrin affinity by talin |
| Q36941098 | Directly Activating the Integrin αIIbβ3 Initiates Outside-In Signaling by Causing αIIbβ3 Clustering |
| Q24324657 | Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha |
| Q57998264 | Divalent Cations Differentially Regulate Integrin αIIbCytoplasmic Tail Binding to β3and to Calcium- and Integrin-binding Protein |
| Q39226715 | Dual role of H-Ras in regulation of lymphocyte function antigen-1 activity by stromal cell-derived factor-1alpha: implications for leukocyte transmigration |
| Q38479194 | Effects of I domain deletion on the function of the beta2 integrin lymphocyte function-associated antigen-1. |
| Q37215693 | Endothelium-platelet interactions in inflammatory lung disease |
| Q73193128 | Evidence of platelet activation during treatment with a GPIIb/IIIa antagonist in patients presenting with acute coronary syndromes |
| Q30442078 | Evidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM. |
| Q34143363 | Excess fibrinogen adsorption to monolayers of mixed lipids |
| Q41154240 | Factors Associated with Nitric Oxide-mediated β2 Integrin Inhibition of Neutrophils |
| Q33828617 | G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets |
| Q44518759 | Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion |
| Q37331064 | Gonadotropin-releasing hormone (GnRH)-I and GnRH-II induce cell growth inhibition in human endometrial cancer cells: involvement of integrin beta3 and focal adhesion kinase. |
| Q28343605 | Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding |
| Q77649221 | Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1 |
| Q74026242 | Immobilised echistatin promotes platelet adhesion and protein tyrosine phosphorylation |
| Q37307187 | Inhibition of calpain blocks platelet secretion, aggregation, and spreading |
| Q58992474 | Integrin Signaling as a Cancer Drug Target |
| Q36370009 | Integrin activation by regulated dimerization and oligomerization of platelet endothelial cell adhesion molecule (PECAM)-1 from within the cell |
| Q36230871 | Integrin activation by talin |
| Q77203120 | Integrin affinity modulation |
| Q28610108 | Integrin alpha(IIb)beta(3) signaling in platelet adhesion and aggregation |
| Q42917596 | Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2. |
| Q33581938 | Integrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity |
| Q38024314 | Integrin bi-directional signaling across the plasma membrane |
| Q28509937 | Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane rafts |
| Q38644725 | Integrin αIIbβ3 outside-in signaling. |
| Q43511406 | Integrin-independent tyrosine phosphorylation of p125(fak) in human platelets stimulated by collagen |
| Q35181671 | Integrins, cations and ligands: making the connection |
| Q27860700 | Integrins: bidirectional, allosteric signaling machines |
| Q34073857 | Intermolecular transmembrane domain interactions activate integrin αIIbβ3. |
| Q40629835 | Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction. |
| Q36876257 | Kindlin-3 Is Essential for the Resting α4β1 Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions |
| Q33952812 | L718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotype |
| Q28216733 | Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3 |
| Q44212493 | Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3. |
| Q30479586 | Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading |
| Q73082500 | Maintenance of GPIIb-IIIa avidity supporting "irreversible" fibrinogen binding is energy-dependent |
| Q30974687 | Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins. |
| Q45878046 | Mapping critical sites in collagen II for rational design of gene-engineered proteins for cell-supporting materials |
| Q40939852 | Mechanisms and consequences of affinity modulation of integrin alpha(V)beta(3) detected with a novel patch-engineered monovalent ligand |
| Q24538576 | Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling |
| Q34063691 | Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils |
| Q34032702 | Noninvasive measurements of integrin microclustering under altered membrane cholesterol levels |
| Q40589353 | Novel activating and inactivating mutations in the integrin beta1 subunit A domain. |
| Q24291812 | Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains |
| Q34603261 | P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces |
| Q40943762 | PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells |
| Q36877378 | Platelet integrins and immunoreceptors |
| Q37807427 | Platelet physiology and antiplatelet agents |
| Q43715868 | Platelet-derived growth factor inhibits smooth muscle cell adhesion to fibronectin by ERK-dependent and ERK-independent pathways. |
| Q30442042 | Primary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signaling |
| Q36322119 | Proximal, selective, and dynamic interactions between integrin alphaIIbbeta3 and protein tyrosine kinases in living cells |
| Q44133275 | Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2. |
| Q42815652 | Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton |
| Q36007725 | Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling |
| Q28366833 | Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands |
| Q37780680 | Spatial organization of transmembrane receptor signalling |
| Q22009172 | Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domains |
| Q46171254 | Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain |
| Q41994968 | Suppression of integrin activation by the membrane-distal sequence of the integrin alphaIIb cytoplasmic tail |
| Q39640546 | Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation |
| Q43812332 | Synergistic outside-in regulation of platelet activation by GPIIb/IIIa ligand-induced conformation and oligomerization |
| Q36430287 | Synthetic multivalent ligands as probes of signal transduction |
| Q29617809 | Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation |
| Q38183284 | Talin and kindlin: the one-two punch in integrin activation |
| Q37787083 | Target: ligand interactions of the vascular endothelium. Implications for molecular imaging in inflammation |
| Q33417854 | Targeting integrin and integrin signaling in treating thrombosis |
| Q34503113 | Tests of Integrin Transmembrane Domain Homo-oligomerization during Integrin Ligand Binding and Signaling |
| Q33381441 | The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend |
| Q92698849 | The Inflammatory Response After Ischemic Stroke: Targeting β2 and β1 Integrins |
| Q57976978 | The lateral diffusion and fibrinogen induced clustering of platelet integrin αIIbβ3 reconstituted into physiologically mimetic GUVs |
| Q37552184 | The mechanism of kindlin-mediated activation of integrin αIIbβ3. |
| Q40777745 | The microtubule cytoskeleton participates in control of beta2 integrin avidity |
| Q31673052 | The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton. |
| Q38156780 | The platelet fibrinogen receptor: from megakaryocyte to the mortuary |
| Q34405516 | The role of the adapter molecule SLP-76 in platelet function |
| Q30521733 | The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling |
| Q27312098 | The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clustering |
| Q53902852 | Tuning chemotactic responses with synthetic multivalent ligands. |
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