Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3

scientific article (publication date: 5 April 2002)

Lateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M108727200
P698PubMed publication ID11812775

P2093author name stringSanford J Shattil
Jerry Ware
Patrizia Marchese
Zaverio M Ruggeri
Ana Kasirer-Friede
Lijun Leng
P2860cites workA CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational statesQ22010453
Human platelet glycoprotein V: characterization of the polypeptide and the related Ib-V-IX receptor system of adhesive, leucine-rich glycoproteinsQ24310691
Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factorQ24317407
von Willebrand factor conformation and adhesive function is modulated by an internalized water moleculeQ27627304
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificityQ27765263
Echicetin, a GPIb-binding snake C-type lectin from Echis carinatus, also contains a binding site for IgMkappa responsible for platelet agglutination in plasma and inducing signal transductionQ28181482
Platelet activation by von Willebrand factor requires coordinated signaling through thromboxane A2 and Fc gamma IIA receptorQ28183240
Interaction of calmodulin with the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complexQ63681818
Interaction between GPIbalpha and FcgammaIIA receptor in human plateletsQ73226299
Signaling across the platelet adhesion receptor glycoprotein Ib-IX induces alpha IIbbeta 3 activation both in platelets and a transfected Chinese hamster ovary cell systemQ73827470
Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3. Studies in human platelets ans transfected Chinese hamster ovary cellsQ74248188
Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shearQ74485103
The platelet cytoskeleton regulates the affinity of the integrin alpha(IIb)beta(3) for fibrinogenQ78177309
Purification of botrocetin from Bothrops jararaca venom. Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib-IX complexQ28255295
Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complexQ28258514
Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizersQ28275567
Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membraneQ28291722
Increased thrombin responsiveness in platelets from mice lacking glycoprotein VQ28586401
On the association of glycoprotein Ib and actin-binding protein in human plateletsQ28609736
Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAKQ30442274
Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3Q30448362
Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib.Q31835076
Unusually large plasma factor VIII:von Willebrand factor multimers in chronic relapsing thrombotic thrombocytopenic purpuraQ33481821
Platelets have more than one binding site for von Willebrand factorQ33821754
Dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flowQ33943026
von Willebrand factor binding to platelet GpIb initiates signals for platelet activationQ34208569
Controlling Signal Transduction with Synthetic LigandsQ34306937
Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregationQ34624945
Integrin cytoplasmic domains mediate inside-out signal transductionQ36233869
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3Q36256128
Glanzmann thrombasthenia: deficient binding of von Willebrand factor to thrombin-stimulated plateletsQ36314768
Analysis of the roles of 14-3-3 in the platelet glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3) using a reconstituted mammalian cell expression modelQ36316299
Adhesive properties of the isolated amino-terminal domain of platelet glycoprotein Ibalpha in a flow fieldQ36407260
A versatile synthetic dimerizer for the regulation of protein-protein interactionsQ36590017
The cytoplasmic domain of glycoprotein (GP) Ibalpha constrains the lateral diffusion of the GP Ib-IX complex and modulates von Willebrand factor bindingQ36892126
Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregationQ37554183
Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibodyQ37609861
Conformational changes in the A1 domain of von Willebrand factor modulating the interaction with platelet glycoprotein IbalphaQ38359108
Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalphaQ41132374
Distinct structural attributes regulating von Willebrand factor A1 domain interaction with platelet glycoprotein Ibalpha under flowQ41609653
Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s)Q41954139
Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunitQ42066333
Regulation of von Willebrand factor binding to the platelet glycoprotein Ib-IX by a membrane skeleton-dependent inside-out signalQ43559368
Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domainsQ43806424
Specific triggering of the Fas signal transduction pathway in normal human keratinocytesQ44057904
Characterization of the unique mechanism mediating the shear-dependent binding of soluble von Willebrand factor to plateletsQ44139530
Expression of platelet glycoprotein (GP) V in heterologous cells and evidence for its association with GP Ib alpha in forming a GP Ib-IX-V complex on the cell surface.Q45962782
Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow.Q45967882
Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membraneQ46043210
Collagen receptor signalling in platelets: extending the role of the ITAM.Q47927817
Effects of toluene on platelet membrane glycoprotein Ib and actin-binding protein.Q51708957
A novel ligand-binding site in the zeta-form 14-3-3 protein recognizing the platelet glycoprotein Ibalpha and distinct from the c-Raf-binding site.Q52532830
The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells.Q53814684
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)11949-56
P577publication date2002-04-05
P1433published inJournal of Biological ChemistryQ867727
P1476titleLateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3
P478volume277

Reverse relations

cites work (P2860)
Q42092628A critical role for 14-3-3zeta protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications
Q41824616A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
Q36370457A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
Q58608626Akt-mediated platelet apoptosis and its therapeutic implications in immune thrombocytopenia
Q34186139Beta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.
Q44854423DDAVP infusion can modify VASP phosphorylation in human platelets
Q33424537Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia
Q44941572GPIb potentiates GPVI-induced responses in human platelets.
Q28193834Glycoprotein Ib cross-linking/ligation on echicetin-coated surfaces or echicetin-IgMkappa in stirred suspension activates platelets by cytoskeleton modulated calcium release
Q44518759Glycoprotein Ib-IX-mediated activation of integrin alpha(IIb)beta(3): effects of receptor clustering and von Willebrand factor adhesion
Q89820694Imaging Platelet Processes and Function-Current and Emerging Approaches for Imaging in vitro and in vivo
Q39596996Improved platelet survival after cold storage by prevention of glycoprotein Ibα clustering in lipid rafts.
Q38991048Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments
Q35065172Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shear
Q37273226Platelet interaction with von Willebrand factor is enhanced by shear-induced clustering of glycoprotein Ibα.
Q37486621Platelet interactions as therapeutic targets for prevention of atherothrombosis
Q38117745Platelet receptors activated via mulitmerization: glycoprotein VI, GPIb-IX-V, and CLEC-2.
Q35119428Platelets and von Willebrand factor
Q36328825Platelets in inflammation and atherogenesis.
Q37540219Rolling cell adhesion
Q40374409Shear stress induced release of von Willebrand factor and thrombospondin-1 in HUVEC extracellular matrix enhances breast tumour cell adhesion
Q36266049Targeting shear stress-induced platelet activation: is lesion-specific antiplatelet therapy a realistic clinical goal?
Q36065255The Transmembrane Domains of β and IX Subunits Mediate the Localization of the Platelet Glycoprotein Ib-IX Complex to the Glycosphingolipid-enriched Membrane Domain
Q34323610The organizing principle of the platelet glycoprotein Ib-IX-V complex.
Q52013892The relationship of von Willebrand factor binding to activated platelets from healthy neonates and adults.
Q73690479Tweezing apart von Willebrand factor-glycoprotein Ib-IX adhesive signaling
Q35181571Von Willebrand factor, platelets and endothelial cell interactions

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