Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion

scientific article published on 22 March 2005

Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00006.2005
P698PubMed publication ID15784646
P5875ResearchGate publication ID7949862

P2093author name stringDomenico Bosco
Dominique G Rouiller
Eva Hammar
Géraldine Parnaud
P2860cites workAssociation of the calpain/calpastatin network with subcellular organellesQ24297820
Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cellsQ24306602
Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretionQ24550152
The calpain systemQ28185062
The calpain family and human diseaseQ28214119
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitusQ28771769
Integrin connections map: to infinity and beyondQ30309413
Degraded collagen fragments promote rapid disassembly of smooth muscle focal adhesions that correlates with cleavage of pp125(FAK), paxillin, and talinQ30442047
Calpain regulation of integrin alpha IIb beta 3 signaling in human plateletsQ34000203
Cutting to the chase: calpain proteases in cell motilityQ34537620
CalpainQ34598139
The calpains in aging and aging-related diseasesQ35548609
Calpain regulates actin remodeling during cell spreadingQ36255313
Formation of hemidesmosomes in vitro by a transformed rat bladder cell lineQ36529093
Islet Cell Surface Antibodies from Insulin-dependent Diabetics Bind Specifically to Pancreatic B CellsQ36984935
Inhibition of calpain blocks platelet secretion, aggregation, and spreadingQ37307187
Calpain cleaves RhoA generating a dominant-negative form that inhibits integrin-induced actin filament assembly and cell spreadingQ38290020
Mastoparan-induced insulin secretion from insulin-secreting betaTC3 and INS-1 cells: evidence for its regulation by Rho subfamily of G proteinsQ40637060
Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesionQ40681825
Reduced cell migration and disruption of the actin cytoskeleton in calpain-deficient embryonic fibroblastsQ40774527
Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrixQ40808554
Membrane proximal ERK signaling is required for M-calpain activation downstream of epidermal growth factor receptor signaling.Q40810412
Importance of cell-matrix interactions in rat islet beta-cell secretion in vitro: role of alpha6beta1 integrinQ40871552
Calpain mediates integrin-induced signaling at a point upstream of Rho family membersQ40941467
Calpain: a cytosolic proteinase active at the membranesQ41384525
Inhibition of secretion from isolated rat alveolar epithelial type II cells by the cell permeant calpain inhibitor II (N-acetyl-leucyl-leucyl-methioninal)Q41671897
Differences in aggregation properties and levels of the neural cell adhesion molecule (NCAM) between islet cell typesQ41711720
The effect of calpain 3 deficiency on the pattern of muscle degeneration in the earliest stages of LGMD2A.Q42107163
Calpains play a role in insulin secretion and actionQ43719952
Expression and regulation of calpain in rat pancreatic acinar cellsQ43821011
A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulinQ44449208
Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activationQ44799532
Selective localization of calpain I (the low-Ca2+-requiring form of Ca2+-dependent cysteine proteinase) in B-cells of human pancreatic isletsQ44819126
P433issue2
P304page(s)E313-21
P577publication date2005-03-22
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleInhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion
P478volume289

Reverse relations

cites work (P2860)
Q34472484Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla
Q33494516Calpain-10 expression is elevated in pancreatic islets from patients with type 2 diabetes
Q36675894Calpains and their multiple roles in diabetes mellitus
Q37716754Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis.
Q30300686Involvement of calpains in adult neurogenesis: implications for stroke
Q30543225hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2

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