| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1196/ANNALS.1372.011 |
| P698 | PubMed publication ID | 17151322 |
| P2093 | author name string | Jaipaul Singh | |
| David A Phoenix | |||
| Frederick Harris | |||
| Suman Biswas | |||
| Sarah Dennison | |||
| P2860 | cites work | Genetic prediction of future type 2 diabetes | Q21563435 |
| The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium | Q22011092 | ||
| Evidence that an isoform of calpain-10 is a regulator of exocytosis in pancreatic beta-cells | Q24306602 | ||
| RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets | Q24320352 | ||
| Calpain facilitates GLUT4 vesicle translocation during insulin-stimulated glucose uptake in adipocytes | Q24322954 | ||
| Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom | Q24535833 | ||
| Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association | Q24535890 | ||
| The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states | Q24643397 | ||
| Crystal structure of calpain reveals the structural basis for Ca(2+)-dependent protease activity and a novel mode of enzyme activation | Q27620740 | ||
| Mechanisms of intracellular protein transport | Q28131681 | ||
| Redox regulation in the lens | Q28191230 | ||
| The structure of calcium-free human m-calpain: implications for calcium activation and function | Q28201809 | ||
| The calpain family and human disease | Q28214119 | ||
| Advanced glycation: an important pathological event in diabetic and age related ocular disease | Q28365776 | ||
| Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes | Q28369463 | ||
| Linkage of type 2 diabetes to the glucokinase gene | Q44684909 | ||
| Calpain system regulates muscle mass and glucose transporter GLUT4 turnover | Q44795466 | ||
| The in vitro retardation of porcine cataractogenesis by the calpain inhibitor, SJA6017. | Q45054932 | ||
| A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus | Q45112494 | ||
| Inhibition of calpain blocks pancreatic beta-cell spreading and insulin secretion | Q46398330 | ||
| Biochemical properties of lens-specific calpain Lp85. | Q46626479 | ||
| Calpain: a protease in search of a function? | Q47923112 | ||
| Protein for Lp82 calpain is expressed and enzymatically active in young rat lens | Q48024530 | ||
| Human-mouse differences in the embryonic expression patterns of developmental control genes and disease genes. | Q52172267 | ||
| Release of alpha-A sequence 158-173 correlates with a decrease in the molecular chaperone properties of native alpha-crystallin. | Q52215524 | ||
| A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2. | Q53780537 | ||
| Comment: CAPN10 alleles are associated with polycystic ovary syndrome. | Q53962914 | ||
| Calpain-10 gene polymorphism is associated with reduced beta(3)-adrenoceptor function in human fat cells. | Q53965731 | ||
| Variation in the calpain-10 gene is associated with elevated triglyceride levels and reduced adipose tissue messenger ribonucleic acid expression in obese Swedish subjects. | Q54535619 | ||
| Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains | Q56591899 | ||
| Variation within the Type 2 Diabetes Susceptibility Gene Calpain-10 and Polycystic Ovary Syndrome | Q56866495 | ||
| No evidence for involvement of the calpain-10 gene `high-risk' haplotype combination for non-insulin-dependent diabetes mellitus in early onset obesity | Q57285626 | ||
| Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans | Q57308002 | ||
| Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese | Q44273286 | ||
| A 48-hour exposure of pancreatic islets to calpain inhibitors impairs mitochondrial fuel metabolism and the exocytosis of insulin | Q44449208 | ||
| Differential influence of proteolysis by calpain 2 and Lp82 on in vitro precipitation of mouse lens crystallins | Q44533953 | ||
| Association of the SNP-19 genotype 22 in the calpain-10 gene with elevated body mass index and hemoglobin A1c levels in Japanese | Q44590441 | ||
| Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization | Q28576163 | ||
| Contribution of distinct structural elements to activation of calpain by Ca2+ ions | Q28577523 | ||
| Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release | Q28609861 | ||
| Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus | Q28771769 | ||
| Global and societal implications of the diabetes epidemic | Q29614551 | ||
| SNARE-mediated membrane fusion | Q29619234 | ||
| Tracking pathology with proteomics: identification of in vivo degradation products of alphaB-crystallin | Q30885316 | ||
| Association of calpain-10 gene with microvascular function | Q31095830 | ||
| Activation of calpain by Ca2+: roles of the large subunit N-terminal and domain III-IV linker peptides | Q33288888 | ||
| Insulin resistance and antidiabetic drugs | Q33760266 | ||
| Are variants in the CAPN10 gene related to risk of type 2 diabetes? A quantitative assessment of population and family-based association studies | Q33909587 | ||
| Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates | Q33935231 | ||
| Potential new treatments for type 2 diabetes | Q33953263 | ||
| Calpain function in the modulation of signal transduction molecules | Q34087813 | ||
| Role of calpain-10 gene variants in familial type 2 diabetes in Caucasians | Q34113437 | ||
| Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese | Q34118064 | ||
| Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells | Q34122336 | ||
| Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population | Q34125864 | ||
| Investigations into the membrane interactions of m-calpain domain V. | Q34189891 | ||
| SNAREs and the specificity of membrane fusion | Q34221149 | ||
| Pharmacological prevention of diabetic cataract | Q34317801 | ||
| Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene | Q34416738 | ||
| SNARE complex structure and function | Q34430515 | ||
| Calpain-10: from genome search to function. | Q34435033 | ||
| Understanding autoimmune diabetes: insights from mouse models. | Q34498188 | ||
| Ca2+ dependency of calpain 3 (p94) activation | Q34501577 | ||
| Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus | Q34679108 | ||
| Genetic control of autoimmunity in Type I diabetes and associated disorders | Q34728213 | ||
| Calpain function in the differentiation of mesenchymal stem cells | Q34728827 | ||
| The role of angiotensin II antagonism in type 2 diabetes mellitus: a review of renoprotection studies | Q34786560 | ||
| Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets | Q34796756 | ||
| Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus | Q34856870 | ||
| Role of calpain in adipocyte differentiation | Q34987400 | ||
| Obesity and liver disease | Q35018205 | ||
| Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets | Q35023612 | ||
| Diabetic retinopathy: more than meets the eye. | Q35036623 | ||
| The search for type 2 diabetes genes | Q35073459 | ||
| The adipocyte in insulin resistance: key molecules and the impact of the thiazolidinediones | Q35096896 | ||
| Polycystic ovary syndrome--a systemic disorder? | Q35131923 | ||
| Ischemic neuronal death in the rat hippocampus: the calpain-calpastatin-caspase hypothesis | Q35163757 | ||
| Insulin granule dynamics in pancreatic beta cells | Q35184211 | ||
| Candidate genes for type 2 diabetes | Q35711997 | ||
| Endothelial dysfunction, inflammation and diabetes | Q35813629 | ||
| Interaction of calpastatin with calpain: a review | Q35837217 | ||
| Calpain-related diseases | Q35874276 | ||
| Role of calpains in diabetes mellitus: a mini review | Q35885049 | ||
| Diabetes and inflammation | Q35984546 | ||
| Genetics of type 2 diabetes mellitus: status and perspectives | Q36044750 | ||
| Type 2 diabetes: principles of pathogenesis and therapy | Q36095054 | ||
| Genetics of Type 2 diabetes. | Q36103109 | ||
| Type 2 diabetes mellitus: a cardiovascular perspective | Q36166429 | ||
| Calpains in muscle wasting. | Q36241898 | ||
| Calpain inhibition: a therapeutic strategy targeting multiple disease states. | Q36393620 | ||
| HLA and autoimmune diseases: Type 1 diabetes (T1D) as an example | Q36399107 | ||
| Endothelial dysfunction in type 2 diabetes mellitus. | Q36418471 | ||
| A statistical method for identification of polymorphisms that explain a linkage result | Q37605240 | ||
| Downregulation of IRS-1 protein in thapsigargin-treated human prostate epithelial cells | Q40633484 | ||
| Insulin-dependent diabetes mellitus as an autoimmune disease | Q40648707 | ||
| Somatostatin increases glucocorticoid binding and signaling in macrophages by blocking the calpain-specific cleavage of Hsp 90. | Q40911630 | ||
| The insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes is mediated by a calcium-dependent thiol protease | Q41173254 | ||
| Activation of calpain in lens: a review and proposed mechanism | Q41534912 | ||
| Multiple interactions of the 'transducer' govern its function in calpain activation by Ca2+ | Q41822723 | ||
| Roles of individual EF-hands in the activation of m-calpain by calcium | Q41981605 | ||
| Diabetic state-induced regulation of glucose uptake to skeletal muscle by insulin: a possible mechanism of its enhancement and autoinhibition | Q42145911 | ||
| Lp82 is the dominant form of calpain in young mouse lens | Q42598749 | ||
| Domain II of m-calpain is a Ca(2+)-dependent cysteine protease | Q42655298 | ||
| GLUT4 expression in 3T3-L1 adipocytes is repressed by proteasome inhibition, but not by inhibition of calpains | Q42817648 | ||
| Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility | Q42927967 | ||
| Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain. | Q43511057 | ||
| Defining a link between gap junction communication, proteolysis, and cataract formation | Q43632134 | ||
| Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus | Q43737821 | ||
| Purification and characterization of lens specific calpain (Lp82) from bovine lens | Q43826188 | ||
| Changes in membrane microenvironment and signal transduction in platelets from NIDDM patients-a pilot study | Q43868661 | ||
| Common single nucleotide polymorphisms in intron 3 of the calpain-10 gene influence hirsutism | Q43901242 | ||
| Prevalence of impaired glucose tolerance among children and adolescents with marked obesity | Q43917576 | ||
| alpha-Crystallin chaperone function in diabetic rat and human lenses. | Q43950045 | ||
| Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain | Q44219947 | ||
| Contribution of ubiquitous calpains to cataractogenesis in the spontaneous diabetic WBN/Kob rat. | Q44233421 | ||
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 452-480 | |
| P577 | publication date | 2006-11-01 | |
| P1433 | published in | Annals of the New York Academy of Sciences | Q2431664 |
| P1476 | title | Calpains and their multiple roles in diabetes mellitus | |
| P478 | volume | 1084 |
| Q37964383 | A review of statistical methods for prediction of proteolytic cleavage |
| Q24293645 | Advanced glycation end-products induce calpain-mediated degradation of ezrin |
| Q33894681 | Calpain cleavage prediction using multiple kernel learning. |
| Q37857282 | Calpain inhibitors: a survey of compounds reported in the patent and scientific literature |
| Q90398287 | Calpain-10 drives podocyte apoptosis and renal injury in diabetic nephropathy |
| Q47370941 | Calpain-2 as a therapeutic target for acute neuronal injury |
| Q38330991 | Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury |
| Q27652953 | Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains |
| Q26771736 | Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors |
| Q36232747 | Detection of CAPN10 copy number variation in Thai patients with type 2 diabetes by denaturing high performance liquid chromatography and real-time quantitative polymerase chain reaction |
| Q37074296 | Genetic links between diabetes mellitus and coronary atherosclerosis |
| Q37365437 | Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder |
| Q30843714 | Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells |
| Q64998890 | Involvement of calpain in the neuropathogenesis of Alzheimer's disease. |
| Q37234084 | OGG1 is degraded by calpain following oxidative stress and cisplatin exposure |
| Q35389878 | Osmostress-induced apoptosis in Xenopus oocytes: role of stress protein kinases, calpains and Smac/DIABLO. |
| Q37812402 | Physiologic and pathophysiologic role of calpain: implications for the occurrence of atrial fibrillation |
| Q33912118 | Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death |
| Q28729955 | The emergence of human-evolutionary medical genomics |
Search more.