| scholarly article | Q13442814 |
| P2093 | author name string | K Ozawa | |
| H Hirai | |||
| R Sakai | |||
| T Nakamoto | |||
| Y Yazaki | |||
| P2860 | cites work | Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein | Q24310026 |
| The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling | Q24337017 | ||
| Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases | Q24558683 | ||
| Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications | Q24561689 | ||
| Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins | Q30450390 | ||
| Src homology region 2 domains direct protein-protein interactions in signal transduction | Q30454167 | ||
| Rat cell line 3y1 and its virogenic polyoma- and SV40-transformed derivatives | Q39937350 | ||
| Methods for increasing the resolution of two-dimensional protein electrophoresis | Q42210406 | ||
| Cloning of ASH, a ubiquitous protein composed of one Src homology region (SH) 2 and two SH3 domains, from human and rat cDNA libraries | Q24563818 | ||
| Multiple SH2-mediated interactions in v-src-transformed cells | Q24606832 | ||
| Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains | Q24611670 | ||
| A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps | Q24616538 | ||
| Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3 | Q24616611 | ||
| Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1 | Q24646917 | ||
| Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions | Q27729407 | ||
| Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms | Q27729904 | ||
| SH2 domains recognize specific phosphopeptide sequences | Q27860748 | ||
| SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins | Q28131774 | ||
| Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho | Q28187867 | ||
| Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites | Q28238659 | ||
| Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases | Q28303117 | ||
| A novel viral oncogene with structural similarity to phospholipase C | Q28307371 | ||
| Catalytic specificity of protein-tyrosine kinases is critical for selective signalling | Q29616451 | ||
| C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains | Q29618334 | ||
| Structural basis for the binding of proline-rich peptides to SH3 domains | Q29620408 | ||
| A target for Src in mitosis. | Q30194396 | ||
| An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis | Q30194398 | ||
| Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate | Q30194681 | ||
| The v-Src SH3 Domain Binds Phosphatidylinositol 3'-Kinase | Q30194840 | ||
| Identification and Characterization of a High-Affinity Interaction Between v-Crk and Tyrosine-Phosphorylated Paxillin in CT10-Transformed Fibroblasts | Q30194902 | ||
| The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels | Q30195199 | ||
| Activation of c-Src in cells bearing v-Crk and its suppression by Csk | Q30195267 | ||
| Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins | Q30195712 | ||
| Mutations in src homology regions 2 and 3 of activated chicken c-src that result in preferential transformation of mouse or chicken cells | Q30195788 | ||
| Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins | Q30195844 | ||
| Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src | Q30195875 | ||
| Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex | Q30450356 | ||
| P433 | issue | 15 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | SH3 domain | Q24771787 |
| P304 | page(s) | 8959-65 | |
| P577 | publication date | 1996-04-12 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase | |
| P478 | volume | 271 |
| Q30009284 | A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region |
| Q52563622 | A Link Between Alzheimer's and Type II Diabetes Mellitus? Ca+2 -Mediated Signal Control and Protein Localization. |
| Q38917298 | A ligand-independent integrin β1 mechanosensory complex guides spindle orientation. |
| Q24798129 | A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling |
| Q37339820 | AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern |
| Q28215657 | Activation of Wiskott-Aldrich syndrome protein and its association with other proteins by stromal cell-derived factor-1alpha is associated with cell migration in a T-lymphocyte line |
| Q28259748 | Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro |
| Q41103833 | Activation of pp60c-src depending on cell density in PC12h cells |
| Q44022389 | Analysis of gene expression profile in p130(Cas)-deficient fibroblasts |
| Q28143730 | Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry |
| Q22011095 | BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells |
| Q30433442 | BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling |
| Q54065301 | Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment |
| Q28209463 | Biochemical signals and biological responses elicited by the focal adhesion kinase |
| Q30164299 | Blockade of v-Src-stimulated tumor formation by the Src homology 3 domain of Crk-associated substrate (Cas). |
| Q30010068 | Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas) |
| Q44992747 | CAS promotes invasiveness of Src-transformed cells |
| Q24630247 | CAS proteins in normal and pathological cell growth control |
| Q30306838 | CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells |
| Q28144485 | CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases |
| Q58260610 | Carboxy-terminal domain of Cas differentially modulates c-Jun expression, DNA synthesis, and membrane ruffling induced by insulin, EGF, and IGF-1 |
| Q30175350 | Cas mediates transcriptional activation of the serum response element by Src. |
| Q30454461 | Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells |
| Q24315726 | Cell Cycle-Regulated Processing of HEF1 to Multiple Protein Forms Differentially Targeted to Multiple Subcellular Compartments |
| Q22008792 | Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins |
| Q36258255 | Cellular mechanisms of bacterial internalization counteracted by Yersinia |
| Q33891506 | Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways |
| Q30454300 | Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases |
| Q30176626 | Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs |
| Q91983566 | Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane |
| Q30157882 | Cooperative activation of Src family kinases by SH3 and SH2 ligands |
| Q28199365 | Cortactin: coupling membrane dynamics to cortical actin assembly |
| Q33582805 | CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas |
| Q30159892 | Crystallization of the SH2-binding site of p130Cas in complex with Lck, a Src-family kinase |
| Q30453323 | Cytoplasmic Death Signal Triggered by Src-Mediated Phosphorylation of the Adenovirus E4orf4 Protein |
| Q34407283 | Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle |
| Q30471376 | Detection of Distinct Pools of the Adapter Protein pl30CASUsing a Panel of Monoclonal Antibodies |
| Q35155736 | Determinants of substrate recognition in nonreceptor tyrosine kinases |
| Q28567205 | Differential regulation of cell migration, actin stress fiber organization, and cell transformation by functional domains of Crk-associated substrate |
| Q24315764 | Direct Binding of p130Cas to the Guanine Nucleotide Exchange Factor C3G |
| Q24322881 | Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas) |
| Q40598627 | Disruption of Ca2+-dependent cell-matrix adhesion enhances c-Src kinase activity, but causes dissociation of the c-Src/FAK complex and dephosphorylation of tyrosine-577 of FAK in carcinoma cells |
| Q50878657 | Dissecting Kinase Effector Signaling Using the RapRTAP Methodology. |
| Q30581120 | Dissecting motility signaling through activation of specific Src-effector complexes |
| Q34756529 | Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK |
| Q30156887 | Dynamics and mechanism of p130Cas localization to focal adhesions |
| Q78431424 | Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas |
| Q47982538 | Enhanced Phosphorylation of Src Family Kinase Substrates Containing SH2 Domain Binding Sites |
| Q62604103 | Epidermal Growth Factor-induced DNA Synthesis |
| Q28581924 | Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton |
| Q30176064 | Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex |
| Q39984335 | Expression and tyrosine phosphorylation of Crk-associated substrate lymphocyte type (Cas-L) protein in human neutrophils |
| Q43851769 | FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v‐Src, but is not a critical determinant of v‐Src transformation |
| Q92661891 | FAK-Dependent Cell Motility and Cell Elongation |
| Q24647075 | Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins |
| Q35402392 | Focal Adhesion Kinase–Related Nonkinase Inhibits Vascular Smooth Muscle Cell Invasion by Focal Adhesion Targeting, Tyrosine 168 Phosphorylation, and Competition for p130 Cas Binding |
| Q24320223 | Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src |
| Q36382511 | Focal adhesion kinase-dependent focal adhesion recruitment of SH2 domains directs SRC into focal adhesions to regulate cell adhesion and migration |
| Q34300201 | Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion |
| Q30176135 | Formation of a stable src–AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif |
| Q24291815 | Functions of the adapter protein Cas: signal convergence and the determination of cellular responses |
| Q42824083 | Growth hormone stimulates the formation of a multiprotein signaling complex involving p130(Cas) and CrkII. Resultant activation of c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK). |
| Q28281874 | HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells |
| Q30165044 | How SH3 domains recognize proline |
| Q28218689 | Identification of UNC119 as a novel activator of SRC-type tyrosine kinases |
| Q24298086 | Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1 |
| Q24647903 | Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. |
| Q24318859 | Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration |
| Q33886658 | Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions |
| Q30168560 | Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas). |
| Q24649740 | Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. |
| Q33940349 | Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas |
| Q22253193 | Integrin signalling: a new Cas(t) of characters enters the stage |
| Q30448862 | Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes |
| Q28209614 | Interaction domains: from simple binding events to complex cellular behavior |
| Q28214605 | Interaction of the SH2 domain of Fyn with a cytoskeletal protein, beta-adducin |
| Q30157613 | Interactions between the Fyn SH3-domain and adaptor protein Cbp/PAG derived ligands, effects on kinase activity and affinity. |
| Q40933654 | Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling |
| Q38423864 | Intracellular signaling of cardiac fibroblasts |
| Q40725068 | Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1. |
| Q24317734 | Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells |
| Q24311406 | Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas‐related docking protein family, and its subsequent binding to the Src homology 2 domain of c‐Crk |
| Q24292258 | MICAL, a novel CasL interacting molecule, associates with vimentin |
| Q30453539 | Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src |
| Q43845007 | Mesoderm-independent regulation of gastrulation movements by the Src tyrosine kinase in Xenopus embryo |
| Q24292723 | Molecular basis for regulation of Src by the docking protein p130Cas |
| Q30406093 | N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. |
| Q35784907 | NNK promotes migration and invasion of lung cancer cells through activation of c-Src/PKCι/FAK loop |
| Q41444653 | Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association. |
| Q34301367 | Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer |
| Q27318059 | P130Cas Src-Binding and Substrate Domains Have Distinct Roles in Sustaining Focal Adhesion Disassembly and Promoting Cell Migration |
| Q24301092 | P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading |
| Q35194986 | Paxillin alpha and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation |
| Q28189293 | Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin |
| Q50291132 | Phosphorylation of BCAR1 by SRC-PTK2 complex |
| Q30441108 | Phosphorylation of p130Cas initiates Rac activation and membrane ruffling |
| Q30168137 | Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions |
| Q74088882 | Protein Kinase C-dependent Tyrosine Phosphorylation of p130 in Differentiating Neuroblastoma Cells |
| Q28204790 | Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics |
| Q30175264 | Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand |
| Q73449253 | Reduction of tyrosine-phosphorylated proteins in involuted thymuses of stressed rats: a study using immunological methods |
| Q30157090 | Reengineering the signaling properties of a Src family kinase |
| Q24302122 | Regulation of FynT function by dual domain docking on PAG/Cbp |
| Q30168872 | Regulation of c-SRC activity and function by the adapter protein CAS |
| Q28295462 | Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST |
| Q28241124 | Regulation of integrin-mediated p130(Cas) tyrosine phosphorylation in human B cells. A role for p59(Fyn) and SHP2 |
| Q30176494 | Requirements for localization of p130cas to focal adhesions |
| Q31473281 | Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation |
| Q33834442 | Roles of protein tyrosine phosphatases in cell migration and adhesion |
| Q30176302 | SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src |
| Q30457060 | SRChing for the substrates of Src. |
| Q30157711 | Signaling properties of a non-metazoan Src kinase and the evolutionary history of Src negative regulation |
| Q28198051 | Signaling through focal adhesion kinase |
| Q22010727 | Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes |
| Q30175148 | Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes |
| Q36443406 | Src Points the Way to Biomarkers and Chemotherapeutic Targets |
| Q33887568 | Src and Ras are involved in separate pathways in epithelial cell scattering |
| Q33959239 | Src in cancer: deregulation and consequences for cell behaviour |
| Q51804915 | Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site. |
| Q30441486 | Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells |
| Q30175877 | Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone |
| Q30310839 | Synergistic promotion of c-Src activation and cell migration by Cas and AND-34/BCAR3. |
| Q33737718 | Synthesis of functional signaling domains by combinatorial polymerization of phosphorylation motifs |
| Q30164215 | The C terminus of c-Src inhibits breast tumor cell growth by a kinase-independent mechanism |
| Q30155858 | The Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation |
| Q30168471 | The Crk signaling pathway contributes to the bombesin-induced activation of the small GTPase Rap1 in Swiss 3T3 cells |
| Q36119357 | The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways |
| Q34434204 | The Related Adhesion Focal Tyrosine Kinase Differentially Phosphorylates p130Cas and the Cas-like Protein, p105HEF1 |
| Q30156800 | The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas |
| Q30175265 | The SH3 and SH2 domains are capable of directing specificity in protein interactions between the non-receptor tyrosine kinases cSrc and cYes |
| Q30175936 | The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway |
| Q21093356 | The conservation pattern of short linear motifs is highly correlated with the function of interacting protein domains |
| Q34698265 | The docking protein Cas links tyrosine phosphorylation signaling to elongation of cerebellar granule cell axons |
| Q30157512 | The evolutionarily conserved arrangement of domains in SRC family kinases is important for substrate recognition |
| Q30175889 | The functional role of CrkII in actin cytoskeleton organization and mitogenesis |
| Q35920891 | The interplay between Src and integrins in normal and tumor biology |
| Q45989111 | The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway. |
| Q37257352 | The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration |
| Q30304275 | The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation |
| Q30008749 | The role of focal adhesion anchoring domains of CAS in mechanotransduction |
| Q24301273 | The role of protein-tyrosine phosphatase 1B in integrin signaling |
| Q27630908 | The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases |
| Q28242010 | The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle |
| Q33737241 | The tranquilizing injection of Yersinia proteins: a pathogen's strategy to resist host defense |
| Q30168345 | The v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase |
| Q24317383 | Transformation Suppression by Protein Tyrosine Phosphatase 1B Requires a Functional SH3 Ligand |
| Q52530335 | Tyrosine Phosphorylation of p130Cas Is Involved in Actin Organization in Osteoclasts |
| Q74518496 | Tyrosine phosphorylation and association of p130Casand c-Crk II by ANG II in vascular smooth muscle cells |
| Q24324381 | Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates |
| Q40426949 | Tyrosine phosphorylation of paxillin affects the metastatic potential of human osteosarcoma |
| Q41570591 | Visualizing Tyrosine Kinase Activity with Bipartite Tetracysteine Display |
| Q24301820 | XB130, a novel adaptor protein for signal transduction |
| Q28388581 | XB130: A novel adaptor protein in cancer signal transduction |
| Q28145949 | alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase |
| Q30308392 | c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes |
| Q30168758 | c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase |
| Q30303932 | c-Src, receptor tyrosine kinases, and human cancer |
| Q28290078 | p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene |
| Q44495344 | p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration |
| Q50752062 | p130Cas, Crk-Associated Substrate, Plays Important Roles in Osteoclastic Bone Resorption |
| Q28576145 | p130Cas, Crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration |
Search more.