The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

scientific article

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M011185200
P698PubMed publication ID11278857
P5875ResearchGate publication ID12054367

P50authorTerrence D. MulhernQ54965497
Stefan T. AroldQ37376656
Martin NobleQ37391812
John E. LadburyQ53843798
P2093author name stringCampbell ID
Ulmer TS
Werner JM
P2860cites workA Zn2+ Ion Links the Cytoplasmic Tail of CD4 and the N-terminal Region of LckQ24316020
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signalingQ24322710
Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1Q24646917
Structure of the regulatory domains of the Src-family tyrosine kinase LckQ27729362
Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†Q56453057
The importance of not saturating water in protein NMR. Application to sensitivity enhancement and NOE measurementsQ57080265
TROSY-type Triple-Resonance Experiments for Sequential NMR Assignments of Large ProteinsQ57825764
Direct Determination of Changes of Interdomain Orientation on Ligation: Use of the Orientational Dependence of15N NMR Relaxation in Abl SH(32)†Q58175506
Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free formsQ27729904
Crystal structure of the mammalian Grb2 adaptorQ27730180
Solution structure and peptide binding of the SH3 domain from human FynQ27733382
Three-dimensional structure of the tyrosine kinase c-SrcQ27734749
Crystal structure of the Src family tyrosine kinase HckQ27734750
The SH2 domain from the tyrosine kinase Fyn in complex with a phosphotyrosyl peptide reveals insights into domain stability and binding specificityQ27746601
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactionsQ27748578
The program XEASY for computer-supported NMR spectral analysis of biological macromoleculesQ27860993
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinaseQ28277700
Backbone dynamics of proteins as studied by 15N inverse detected heteronuclear NMR spectroscopy: application to staphylococcal nucleaseQ29547582
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacementQ30014848
Crosstalk between the catalytic and regulatory domains allows bidirectional regulation of Src.Q30175215
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligandQ30175264
Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.Q30175268
SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and SrcQ30176302
Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.Q30176957
A heteronuclear correlation experiment for simultaneous determination of 15N longitudinal decay and chemical exchange rates of systems in slow equilibriumQ30194094
An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosisQ30194398
Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domainQ30194432
Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.Q30194623
Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrateQ30194681
Adhesion-linked kinases in cancer; emphasis on src, focal adhesion kinase and PI 3-kinaseQ34013783
Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylationQ38612701
Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase SubfamilyQ41296563
P433issue20
P407language of work or nameEnglishQ1860
P304page(s)17199-17205
P577publication date2001-02-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases
P478volume276

Reverse relations

cites work (P2860)
Q444362791H, 13C and 15N backbone and side-chain chemical shift assignment of the Fyn SH2 domain and its complex with a phosphotyrosine peptide
Q89526875A Fyn biosensor reveals pulsatile, spatially localized kinase activity and signaling crosstalk in live mammalian cells
Q30164441A binding event converted into a folding event.
Q30157097Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.
Q33215754Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.
Q48869823Creation of Phosphotyrosine Superbinders by Directed Evolution of an SH2 Domain
Q27664248Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism
Q24318428Crystal structure analysis and solution studies of human Lck-SH3; zinc-induced homodimerization competes with the binding of proline-rich motifs
Q30009894Dancing retro: solution structure and micelle interactions of the retro-SH3-domain, retro-SHH-‘Bergerac’
Q27728152Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity
Q30155944Effect of the SH3-SH2 domain linker sequence on the structure of Hck kinase
Q54976490Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development.
Q27681534FAK dimerization controls its kinase-dependent functions at focal adhesions
Q94468439Focal adhesion kinase and Src mediate microvascular hyperpermeability caused by fibrinogen- γC- terminal fragments
Q24322697H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency
Q33988602Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes
Q27675446High-resolution crystal structure of spectrin SH3 domain fused with a proline-rich peptide
Q35597027How focal adhesion kinase achieves regulation by linking ligand binding, localization and action
Q38215562How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs
Q34792946Inhibition and activation of c-Src: the head and tail of a coin
Q30009331Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment
Q30010103Interfacial water molecules in SH3 interactions: Getting the full picture on polyproline recognition by protein-protein interaction domains
Q24338375Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains
Q24654723Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction
Q28248486Molecular dynamics and protein function
Q40175455N-acyl-3,5-bis(arylidene)-4-piperidones and related compounds which stimulate fyn kinase
Q30157892On the importance of a funneled energy landscape for the assembly and regulation of multidomain Src tyrosine kinases
Q41931642Purification, crystallization and preliminary X-ray diffraction analysis of the Fyn SH2 domain and its complex with a phosphotyrosine peptide
Q30157500Quantifying information transfer by protein domains: analysis of the Fyn SH2 domain structure
Q24302122Regulation of FynT function by dual domain docking on PAG/Cbp
Q27666303Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering
Q37635474SH2 domains: modulators of nonreceptor tyrosine kinase activity
Q30008731SH3 domains: modules of protein-protein interactions
Q30165302SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn.
Q44598483Sequence-specific 1H, 13C and 15N resonance assignments of the SH3-SH2 domain pair from the human tyrosine kinase Lck.
Q34504260Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin
Q30160827Structure and regulation of Src family kinases
Q27682496Superbinder SH2 domains act as antagonists of cell signaling
Q34101798The Microbial Receptor CEACAM3 Is Linked to the Calprotectin Complex in Granulocytes
Q24304594The adaptor protein Tom1L1 is a negative regulator of Src mitogenic signaling induced by growth factors
Q27643727The high-resolution NMR structure of a single-chain chimeric protein mimicking a SH3-peptide complex
Q27644350The high-resolution NMR structure of the R21A Spc-SH3:P41 complex: Understanding the determinants of binding affinity by comparison with Abl-SH3
Q34525887The modular logic of signaling proteins: building allosteric switches from simple binding domains
Q27684053Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin
Q30009582Two-state dynamics of the SH3-SH2 tandem of Abl kinase and the allosteric role of the N-cap

Search more.