Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism

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Crystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.145102
P932PMC publication ID2975169
P698PubMed publication ID20810664

P50authorJamie A MorocoQ58774054
P2093author name stringJoanne I Yeh
Laurie Betts
Thomas E Smithgall
John J Alvarado
P2860cites workHematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosisQ24319772
The protein kinase complement of the human genomeQ24324497
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
PROCHECK: a program to check the stereochemical quality of protein structuresQ26778411
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Crystal structures of c-Src reveal features of its autoinhibitory mechanismQ27618504
Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitorQ27618507
The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinasesQ27630908
Structural basis for the autoinhibition of c-Abl tyrosine kinaseQ27640773
Structure of the regulatory domains of the Src-family tyrosine kinase LckQ27729362
Three-dimensional structure of the tyrosine kinase c-SrcQ27734749
Crystal structure of the Src family tyrosine kinase HckQ27734750
The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactionsQ27748578
Coot: model-building tools for molecular graphicsQ27860505
Structure validation by Calpha geometry: phi,psi and Cbeta deviationQ27860657
ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteinsQ27860818
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacementQ30014848
Structure and dynamic regulation of Src-family kinasesQ30157661
HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interactionQ30159721
Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinaseQ30159870
An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometryQ30160036
Activation of the Src family kinase Hck without SH3-linker releaseQ30160117
Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinasesQ30160119
Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinasesQ30160127
The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activationQ30160222
Structure and regulation of Src family kinasesQ30160827
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domainQ30165193
SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivoQ30165458
Dynamic coupling between the SH2 and SH3 domains of c-Src and Hck underlies their inactivation by C-terminal tyrosine phosphorylationQ30168286
Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligandQ30175264
SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.Q30175357
SH2- and SH3-mediated interactions between focal adhesion kinase and Src.Q30176302
SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.Q30176471
Phage display selection of ligand residues important for Src homology 3 domain binding specificityQ30192920
Chemical library screens targeting an HIV-1 accessory factor/host cell kinase complex identify novel antiretroviral compoundsQ33508889
Src kinases as therapeutic targets for cancerQ37604891
Direct Determination of Changes of Interdomain Orientation on Ligation: Use of the Orientational Dependence of15N NMR Relaxation in Abl SH(32)†Q58175506
P433issue46
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
crystal structureQ895901
SH3 domainQ24771787
P304page(s)35455-61
P577publication date2010-11-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleCrystal Structure of the Src Family Kinase Hck SH3-SH2 Linker Regulatory Region Supports an SH3-dominant Activation Mechanism
P478volume285

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cites work (P2860)
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Q30009331Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment
Q30009855Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry
Q30009300SH2-catalytic domain linker heterogeneity influences allosteric coupling across the SFK family.
Q30008731SH3 domains: modules of protein-protein interactions
Q30155826Structure, dynamics, and Hck interaction of full-length HIV-1 Nef.
Q30009091Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor
Q30009028The SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function
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