p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.

scientific article published in December 2013

p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JBMR.1936
P698PubMed publication ID23526406

P50authorSachiko SeoQ89093501
P2093author name stringShigeaki Kato
Mineo Kurokawa
Hiroaki Honda
Hidefumi Fukushima
Mariko Takahashi
Ichiro Nakamura
Kazuhiro Aoki
Yuji Seta
Hisataka Yasuda
Eijiro Jimi
Kenshi Maki
Kenji Osawa
Keiichi Ohya
Hisako Hikiji
Yukihiko Tamura
Yoshie Nagai
P2860cites workNew insights into osteoclastogenic signaling mechanismsQ38019255
Lysyl oxidase regulates actin filament formation through the p130(Cas)/Crk/DOCK180 signaling complexQ40324343
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src.Q40918530
A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled bordersQ42557625
Vav3 regulates osteoclast function and bone massQ45265424
Wortmannin, a specific inhibitor of phosphatidylinositol-3 kinase, blocks osteoclastic bone resorption.Q52511692
Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.Q52530335
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro.Q54258542
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.Q24642555
Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenanceQ28271116
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclastsQ28274068
Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinaseQ28277700
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130CasQ28279024
p130Cas: a versatile scaffold in signaling networksQ28304929
Integral roles of a guanine nucleotide exchange factor, FARP2, in osteoclast podosome rearrangementsQ28591497
Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130CasQ29030077
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factorsQ29547630
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Mammalian Rho GTPases: new insights into their functions from in vivo studiesQ29615191
Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zoneQ30175877
c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanismQ30193362
Paxillin contracts the osteoclast cytoskeletonQ30416067
Phosphorylation of p130Cas initiates Rac activation and membrane rufflingQ30441108
Signaling to actin dynamicsQ33699981
Blimp1-mediated repression of negative regulators is required for osteoclast differentiationQ33733731
The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.Q33794960
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclastsQ34679499
Rac deletion in osteoclasts causes severe osteopetrosisQ35576455
Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in miceQ35607627
The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclastsQ36268888
Regulation of cell contraction and membrane ruffling by distinct signals in migratory cellsQ36316697
Decreased c-Src expression enhances osteoblast differentiation and bone formationQ36366926
Arp2/3 complex from Acanthamoeba binds profilin and cross-links actin filamentsQ36865428
Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesisQ37370702
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinaseQ37384701
Regulation of bone mass by serotonin: molecular biology and therapeutic implicationsQ37809075
Regulation of osteoclast functionQ37939688
P433issue12
P304page(s)2449-2462
P577publication date2013-12-01
P1433published inJournal of Bone and Mineral ResearchQ15750941
P1476titlep130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.
P478volume28

Reverse relations

cites work (P2860)
Q28242737CAS proteins in health and disease: an update
Q35238440CD147 promotes Src-dependent activation of Rac1 signaling through STAT3/DOCK8 during the motility of hepatocellular carcinoma cells
Q28646036Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Q38196631Insights into the biological functions of Dock family guanine nucleotide exchange factors
Q89653987Integrin-associated molecules and signalling cross talking in osteoclast cytoskeleton regulation
Q61443977L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts
Q90450301Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity
Q26851553Modulation of osteoclast differentiation and bone resorption by Rho GTPases
Q47391362NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis
Q90548593Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts
Q34344623Podosome organization drives osteoclast-mediated bone resorption.
Q30009052Role of CrkII Signaling in RANKL-Induced Osteoclast Differentiation and Function
Q38982601Tensins are versatile regulators of Rho GTPase signalling and cell adhesion
Q47381565The actin-binding protein PPP1r18 regulates maturation, actin organization, and bone resorption activity of osteoclasts.
Q93031545The interaction of p130Cas with PKN3 promotes malignant growth
Q38366424p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis

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