Podosome organization drives osteoclast-mediated bone resorption.

scientific article

Podosome organization drives osteoclast-mediated bone resorption. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4161/CAM.27840
P932PMC publication ID4198343
P698PubMed publication ID24714644

P50authorAnne BlangyQ42875386
Irma Machuca-GayetQ77948733
P2093author name stringPierre Jurdic
Dan Georgess
P2860cites workOsteoclasts express high levels of pp60c-src in association with intracellular membranesQ41774224
CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabeculesQ42135720
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorptionQ42197118
Podosome formation in cultured A7r5 vascular smooth muscle cells requires Arp2/3-dependent de-novo actin polymerization at discrete microdomains.Q42453022
Rho and Rac exert antagonistic functions on spreading of macrophage-derived multinucleated cells and are not required for actin fiber formation.Q42804776
Podosomes are dispensable for osteoclast differentiation and migrationQ43962644
Genome-wide expression analyses establish dendritic cells as a new osteoclast precursor able to generate bone-resorbing cells more efficiently than monocytesQ44159309
Vav3 regulates osteoclast function and bone massQ45265424
A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclastsQ46565040
Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesisQ46961300
Crosstalk between cell adhesion molecules: vinculin as a paradigm for regulation by conformationQ47986621
p130Cas, Crk-associated substrate, plays important roles in osteoclastic bone resorption.Q50752062
Internal dynamics of actin structures involved in the cell motility and adhesion: Modeling of the podosomes at the molecular levelQ51637846
The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts.Q52509359
Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures.Q54137269
Energy-filtered electron microscopy reveals that talin is a highly flexible protein composed of a series of globular domains.Q54397824
Blood leukocytes and macrophages of various phenotypes have distinct abilities to form podosomes and to migrate in 3D environmentsQ57911537
The origin of dendritic cellsQ62658253
Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1Q68325243
Pediatric bone marrow transplantation for leukemia and aplastic anemia. Report of 222 cases transplanted in a single centerQ69532318
Biochemical characterization of human osteoclast integrins. Osteoclasts express alpha v beta 3, alpha 2 beta 1, and alpha v beta 1 integrinsQ72865482
Rho-A is critical for osteoclast podosome organization, motility, and bone resorptionQ73680599
Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptakeQ78859808
Immature dendritic cell transdifferentiation into osteoclasts: a novel pathway sustained by the rheumatoid arthritis microenvironmentQ80445625
Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclastsQ81924328
The architecture of the adhesive apparatus of cultured osteoclasts: from podosome formation to sealing zone assemblyQ21144466
Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASPQ24294671
Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusionQ24296813
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent proteinQ24550787
Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundleQ24563216
CD44 cell adhesion moleculesQ24568164
RANK is essential for osteoclast and lymph node developmentQ24598872
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cellsQ24605499
Dynamics of podosome stiffness revealed by atomic force microscopyQ24630297
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophagesQ24655851
Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortexQ24674103
Paxillin: a new vinculin-binding protein present in focal adhesionsQ24678834
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLQ24682139
Flt3+ macrophage precursors commit sequentially to osteoclasts, dendritic cells and microgliaQ24794597
Human primary osteoclasts: in vitro generation and applications as pharmacological and clinical assayQ24806517
Gelsolin-independent podosome formation in dendritic cellsQ27334216
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophagesQ28143279
Degrading devices: invadosomes in proteolytic cell invasionQ28244432
TGFbeta-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vesselsQ28263571
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclastsQ28274068
The molecular dynamics of osteoclast adhesionsQ28287398
Wiskott-Aldrich syndrome protein and the cytoskeletal dynamics of dendritic cellsQ28288791
The leukocyte podosomeQ28302732
SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclastsQ28510858
Rac-GTPase, osteoclast cytoskeleton and bone resorptionQ28569794
Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorptionQ28592760
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
The pathogenesis of rheumatoid arthritisQ29614957
β1A integrin is a master regulator of invadosome organization and function.Q30497504
Podosome rings generate forces that drive saltatory osteoclast migrationQ30503864
The formin FRL1 (FMNL1) is an essential component of macrophage podosomesQ30505923
Involvement of actin polymerization in podosome dynamicsQ30513979
Supervillin couples myosin-dependent contractility to podosomes and enables their turnoverQ30514839
Dynamic visualization of RANKL and Th17-mediated osteoclast function.Q30533914
Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillationsQ30533956
Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and peripheryQ30538833
Microtubule dynamic instability controls podosome patterning in osteoclasts through EB1, cortactin, and Src.Q30570530
Hck contributes to bone homeostasis by controlling the recruitment of osteoclast precursorsQ30579948
Bone Is Not Essential for Osteoclast ActivationQ33700392
Osteopetrosis and osteoporosis: two sides of the same coinQ33724069
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.Q33835366
Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activityQ33877069
Osteoclasts and monocytes have similar cytoskeletal structures and adhesion property in vitroQ33891374
Osteoclast motility: putting the brakes on bone resorption.Q33925042
Integrins and signaling in osteoclast functionQ33936574
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolismQ34021680
Integrin activation.Q34293939
Cofilin activation during podosome belt formation in osteoclastsQ34438566
Leptin-dependent serotonin control of appetite: temporal specificity, transcriptional regulation, and therapeutic implicationsQ34501447
Osteoclastic acidification pathways during bone resorptionQ34588909
Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.Q35083626
Intracellular membrane trafficking in bone resorbing osteoclastsQ35184299
Rac deletion in osteoclasts causes severe osteopetrosisQ35576455
WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP).Q35612381
Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressorsQ35617591
TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritisQ35788463
The origins of osteoclastsQ35808029
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentinQ35913720
Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signalingQ36117371
Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) miceQ36119294
CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclastsQ36173877
Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structuresQ36211236
Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled borderQ36213974
The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclastsQ36268888
Substrate recognition by osteoclast precursors induces C-src/microtubule association.Q36274033
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strengthQ36316394
Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by beta3 integrinQ36323030
The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and functionQ36324937
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclastsQ36325944
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
Podosome and sealing zone: specificity of the osteoclast modelQ36424995
Osteocyte control of osteoclastogenesisQ36514172
Talin1 and Rap1 are critical for osteoclast functionQ36606984
WASP-interacting protein (WIP): working in polymerisation and much moreQ36976223
The role of NFAT in osteoclast formationQ37033696
TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesisQ37066493
Rho GTPases in cancer cell biologyQ37156024
Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclastsQ37233413
Vesicular trafficking in osteoclastsQ37259741
c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomesQ37346002
Protein tyrosine phosphatase epsilon regulates integrin-mediated podosome stability in osteoclasts by activating Src.Q37387988
Comparative transcriptomics reveals RhoE as a novel regulator of actin dynamics in bone-resorbing osteoclasts.Q37533689
Invadosomes: intriguing structures with promise.Q37770272
Role of WASP in cell polarity and podosome dynamics of myeloid cellsQ37770648
New regulation mechanisms of osteoclast differentiationQ37987556
Rho family GTPasesQ38061989
Bone research in 2012: the ups and downs of bone in health and rheumatic diseaseQ38072313
The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cellsQ39643346
A comparison of osteoclast resorption pits on bone with titanium and zirconia surfacesQ39683325
The actin treadmillQ39829443
Actin can reorganize into podosomes in aortic endothelial cells, a process controlled by Cdc42 and RhoA.Q39887636
Murine dendritic cell transdifferentiation into osteoclasts is differentially regulated by innate and adaptive cytokinesQ40241909
Apatite-mediated actin dynamics in resorbing osteoclastsQ40521404
Resorbability of bone substitute biomaterials by human osteoclastsQ40521993
Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.Q41075059
Identification of gelsolin, a Ca2+-dependent regulatory protein of actin gel-sol transformation, and its intracellular distribution in a variety of cells and tissuesQ41438170
P433issue3
P304page(s)191-204
P577publication date2014-05-01
P1433published inCell Adhesion and MigrationQ15817193
P1476titlePodosome organization drives osteoclast-mediated bone resorption
P478volume8

Reverse relations

cites work (P2860)
Q47693586A 15-amino acid C-terminal peptide of beta-defensin-3 inhibits bone resorption by inhibiting the osteoclast differentiation and disrupting podosome belt formation.
Q92702961A Sub-Clone of RAW264.7-Cells Form Osteoclast-Like Cells Capable of Bone Resorption Faster than Parental RAW264.7 through Increased De Novo Expression and Nuclear Translocation of NFATc1
Q34774525Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts
Q49790704Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss
Q64066842Bone morphogenetic proteins: Their role in regulating osteoclast differentiation
Q38679996CCL11, a novel mediator of inflammatory bone resorption
Q38997942Cellular and Molecular Pathways Leading to External Root Resorption
Q57050981Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis
Q36753847Coordination of Actin- and Microtubule-Based Cytoskeletons Supports Transport of Spermatids and Residual Bodies/Phagosomes During Spermatogenesis in the Rat Testis
Q52646985Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors.
Q36350166Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation
Q53158015Dendrobium moniliforme Exerts Inhibitory Effects on Both Receptor Activator of Nuclear Factor Kappa-B Ligand-Mediated Osteoclast Differentiation in Vitro and Lipopolysaccharide-Induced Bone Erosion in Vivo.
Q42316781Dynamics of the sealing zone in cultured osteoclasts
Q34982269EB1 regulates tubulin and actin cytoskeletal networks at the sertoli cell blood-testis barrier in male rats: an in vitro study
Q64939376Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro.
Q90473534Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells
Q91743168Integrins: Moonlighting Proteins in Invadosome Formation
Q61959522Intravital microscopy of osteolytic progression and therapy response of cancer lesions in the bone
Q87884121Invadosomes in real life
Q93015610L-Plastin deficiency produces increased trabecular bone due to attenuation of sealing ring formation and osteoclast dysfunction
Q61443977L-caldesmon alters cell spreading and adhesion force in RANKL-induced osteoclasts
Q91655458L-plastin phosphorylation regulates the early phase of sealing ring formation by actin bundling process in mouse osteoclasts
Q64120770MicroRNAs: Key Regulators to Understand Osteoclast Differentiation?
Q41579307Microbial biofilms are able to destroy hydroxyapatite in the absence of host immunity in vitro.
Q91291852Modular actin nano-architecture enables podosome protrusion and mechanosensing
Q90548593Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts
Q93102422PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation
Q38675617Potassium citrate prevents increased osteoclastogenesis resulting from acidic conditions: Implication for the treatment of postmenopausal bone loss.
Q92189011Profilin 1 Negatively Regulates Osteoclast Migration in Postnatal Skeletal Growth, Remodeling, and Homeostasis in Mice
Q39448315Recent advances in understanding the role of protein-tyrosine phosphatases in development and disease
Q89599165Regulation of Osteoclast Differentiation at Multiple Stages by Protein Kinase D Family Kinases
Q50188819Selective regulation of osteoclast adhesion and spreading by PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling
Q57807005Signaling Mechanisms and Physiological Functions of G-protein Gα in Blood Vessel Formation, Bone Homeostasis, and Cancer
Q61798890Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities
Q61808707Sphingosine-1-Phosphate Receptor 2 Controls Podosome Components Induced by RANKL Affecting Osteoclastogenesis and Bone Resorption
Q104569990Surface distribution of heterogenous clathrin assemblies in resorbing osteoclasts
Q48527868TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42.
Q38744505The F-actin modulator SWAP-70 controls podosome patterning in osteoclasts
Q47381565The actin-binding protein PPP1r18 regulates maturation, actin organization, and bone resorption activity of osteoclasts.
Q61443001The potential risks of C-C chemokine receptor 5-edited babies in bone development
Q33830438Time-lapse reveals that osteoclasts can move across the bone surface while resorbing
Q38258542Tools of the trade: podosomes as multipurpose organelles of monocytic cells
Q92241958[Research progress on the pathogenesis of inflammatory external root resorption]