Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities

scientific article published on 09 January 2019

Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/BIOM9010017
P932PMC publication ID6359508
P698PubMed publication ID30634501

P50authorLexie HollidayQ88375828
P2093author name stringJian Zuo
Guanghong Han
P2860cites workInterstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclastsQ78775543
Novel mutations in the TCIRG1 gene encoding the a3 subunit of the vacuolar proton pump in patients affected by infantile malignant osteopetrosisQ78847227
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pumpQ24291313
Podosomes display actin turnover and dynamic self-organization in osteoclasts expressing actin-green fluorescent proteinQ24550787
Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortexQ24674103
Osteoclasts: what do they do and how do they do it?Q24683898
The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding siteQ28142113
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formationQ28206691
Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexityQ28236433
Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclastsQ28274068
Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+Q28584035
WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector functionQ28589609
Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in miceQ29547898
Regulation of actin filament assembly by Arp2/3 complex and forminsQ29615161
A nucleator arms race: cellular control of actin assemblyQ29616146
Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zoneQ30175877
Cortactin has an essential and specific role in osteoclast actin assemblyQ30477461
The formin FRL1 (FMNL1) is an essential component of macrophage podosomesQ30505923
Antagonism of the osteoclast vitronectin receptor with an orally active nonpeptide inhibitor prevents cancellous bone loss in the ovariectomized rat.Q32006878
Actin binding activity of subunit B of vacuolar H+-ATPase is involved in its targeting to ruffled membranes of osteoclastsQ33245114
The Beneficial Effects of Bisphosphonate-enoxacin on Cortical Bone Mass and Strength in Ovariectomized RatsQ33770077
Control of actin assembly and disassembly at filament endsQ33840299
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screeningQ33927719
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclastsQ33939357
Podosome organization drives osteoclast-mediated bone resorption.Q34344623
Cofilin activation during podosome belt formation in osteoclastsQ34438566
Osteoclastic bone resorption by a polarized vacuolar proton pumpQ34441726
Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expressionQ34451146
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosisQ35018231
Bis-enoxacin blocks rat alveolar bone resorption from experimental periodontitisQ35123218
Organization of osteoclast microfilaments during the attachment to bone surface in vitro.Q35938974
Enoxacin directly inhibits osteoclastogenesis without inducing apoptosisQ36006859
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptivesQ36019860
Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitorQ36131284
Actin-like filaments in bone cells of cultured mouse calvaria as demonstrated by binding to heavy meromyosinQ36197493
Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structuresQ36211236
The physiological significance of beta -actin mRNA localization in determining cell polarity and directional motilityQ36290552
Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts.Q36301037
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strengthQ36316394
Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9.Q36324006
The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclastsQ36325944
Are nonresorbing osteoclasts sources of bone anabolic activity?Q36709511
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclastsQ36800896
Bis-enoxacin inhibits bone resorption and orthodontic tooth movementQ37177844
CD44 and EpCAM: cancer-initiating cell markersQ37347302
A peptidomimetic antagonist of the alpha(v)beta3 integrin inhibits bone resorption in vitro and prevents osteoporosis in vivoQ37366963
Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclastsQ37396367
WIP: WASP-interacting proteins at invadopodia and podosomes.Q38028648
Actin dynamics, architecture, and mechanics in cell motilityQ38175137
c-Src is required for stimulation of gelsolin-associated phosphatidylinositol 3-kinaseQ38336689
Human Macrophages Utilize the Podosome Formin FMNL1 for Adhesion and MigrationQ38696503
Energy metabolism in osteoclast formation and activityQ38824770
The effect of enoxacin on osteoclastogenesis and reduction of titanium particle-induced osteolysis via suppression of JNK signaling pathwayQ39001188
The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cellsQ39643346
Actin polymerization and its regulation by proteins from nonmuscle cellsQ40128974
Critical role of cortactin in actin ring formation and osteoclastic bone resorption.Q40238899
Apatite-mediated actin dynamics in resorbing osteoclastsQ40521404
The Actin-Binding Protein Cofilin and Its Interaction With Cortactin Are Required for Podosome Patterning in Osteoclasts and Bone Resorption In Vivo and In VitroQ40720435
Discovery of orally active nonpeptide vitronectin receptor antagonists based on a 2-benzazepine Gly-Asp mimeticQ40906361
Physiology and biochemistry of the kidney vacuolar H+-ATPaseQ41117727
Cytoskeletal changes in osteoclasts during the resorption cycleQ41142562
Mitochondria-rich, proton-secreting epithelial cellsQ41441116
Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzymeQ42064898
Kindlin-3-mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorptionQ42197118
LIM kinase 1 deficient mice have reduced bone massQ42272866
Evidence for the presence of a proton pump of the vacuolar H(+)-ATPase type in the ruffled borders of osteoclastsQ42762796
Osteoadsorptive bisphosphonate derivatives of fluoroquinolone antibacterialsQ43996444
Effects of echistatin and an RGD peptide on orthodontic tooth movementQ44562197
Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B.Q44684932
The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPaseQ44691509
Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPaseQ45369144
A novel Rho-mDia2-HDAC6 pathway controls podosome patterning through microtubule acetylation in osteoclastsQ46565040
Bis‑enoxacin blocks alveolar bone resorption in rats with ovariectomy‑induced osteoporosisQ47235148
Cortactin function in invadopodiaQ47367433
Actin-related protein 2/3 complex is required for actin ring formationQ47893344
Reconsidering an active role for G-actin in cytoskeletal regulation.Q48043765
The Vacuolar ATPase - A Nano-scale Motor That Drives Cell Biology.Q49721315
PGC1β Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation.Q52665238
Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.Q53214048
Differentiation dependent expression of tensin and cortactin in chicken osteoclasts.Q54185912
Kinetics of the osteoclast cytoskeleton during the resorption cycle in vitro.Q54258542
WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorptionQ61053891
Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclastQ61905401
Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cellsQ62500726
The distribution of podosomes in osteoclasts cultured on bone laminae: effect of retinolQ67975369
Rat osteoclasts adhere to a wide range of RGD (Arg-Gly-Asp) peptide-containing proteins, including the bone sialoproteins and fibronectin, via a beta 3 integrinQ68125207
Beta 3 subunit of vitronectin receptor is present in osteoclast adhesion structures and not in other monocyte-macrophage derived cellsQ69126379
Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing proteinQ70577758
Actobindin induces the accumulation of actin dimers that neither nucleate polymerization nor self-associateQ72724348
Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosisQ73091483
Initiation of osteoclast bone resorption by interstitial collagenaseQ73617945
Peptidomimetic antagonists of alphavbeta3 inhibit bone resorption by inhibiting osteoclast bone resorptive activity, not osteoclast adhesion to boneQ73828847
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectactinQ185269
bone remodelingQ952019
cellQ7868
cytoskeletal proteinsQ66563066
contractile proteinsQ69633297
macromolecular substanceQ75174158
P304page(s)17
P577publication date2019-01-09
P1433published inBiomoleculesQ23929963
P1476titleSpecialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities
P478volume9

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Q91743168Integrins: Moonlighting Proteins in Invadosome Formationcites workP2860

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