PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway.

scientific article published on January 2002

PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1053220766
P356DOI10.1038/SJ.ONC.1205054
P8608Fatcat IDrelease_sie2vlhywne7bgvcfkedngxrfe
P698PubMed publication ID11803475
P5875ResearchGate publication ID11556520

P50authorYoung WhangQ71283424
P2093author name stringXiu-Juan Yuan
P2860cites workRegulation of cell death protease caspase-9 by phosphorylationQ28288607
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
Pten is essential for embryonic development and tumour suppressionQ28509238
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membraneQ28647586
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaBQ29614706
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs.Q30654525
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer modelQ32069431
Apoptosis control by death and decoy receptorsQ33597389
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathwayQ33599964
Biochemical pathways of caspase activation during apoptosisQ33804316
Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikisQ33875874
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytesQ33888184
Progression of metastatic human prostate cancer to androgen independence in immunodeficient SCID miceQ34420980
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.Q39451375
The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c releaseQ39576439
Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activityQ40768754
A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell lineQ40784934
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cellsQ40811052
Elevated AKT activity protects the prostate cancer cell line LNCaP from TRAIL-induced apoptosisQ40817486
Involvement of FADD and caspase-8 signalling in detachment-induced apoptosisQ40925076
Cycloheximide-induced T-cell death is mediated by a Fas-associated death domain-dependent mechanismQ40969097
Lipopolysaccharide mediates endothelial apoptosis by a FADD-dependent pathwayQ41020707
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b.Q41085784
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosisQ41224805
Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistanceQ43680908
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
The lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptorsQ24310559
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosisQ24310597
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunitQ24554482
A simplified system for generating recombinant adenovirusesQ24682328
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machineryQ27860586
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Interleukin-3-induced phosphorylation of BAD through the protein kinase AktQ28255373
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosisQ28265012
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)319-327
P577publication date2002-01-01
P1433published inOncogeneQ1568657
P1476titlePTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway
P478volume21

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cites work (P2860)
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