Role of CXCL1 in tumorigenesis of melanoma.

scientific article

Role of CXCL1 in tumorigenesis of melanoma. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P932PMC publication ID2668262
P698PubMed publication ID12101257

P50authorAnn RichmondQ63665124
P2093author name stringPunita Dhawan
P2860cites workM-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6Q22003726
Point mutation causing constitutive signaling of CXCR2 leads to transforming activity similar to Kaposi's sarcoma herpesvirus-G protein-coupled receptorQ22003754
Involvement of chemokine receptors in breast cancer metastasisQ24290909
Novel small GTPase M-Ras participates in reorganization of actin cytoskeletonQ24312130
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaBQ24321775
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIKQ24321797
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cutQ24323994
Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinaseQ24522867
The mammalian Cut homeodomain protein functions as a cell-cycle-dependent transcriptional repressor which downmodulates p21WAF1/CIP1/SDI1 in S phaseQ24533294
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunitQ24554482
High- and low-affinity binding of GRO alpha and neutrophil-activating peptide 2 to interleukin 8 receptors on human neutrophilsQ24563339
Tumor surveillance via the ARF-p53 pathway.Q53430438
Inhibition of ras-induced proliferation and cellular transformation by p16INK4.Q53466632
Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic CellsQ58450597
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16Q59082348
Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic miceQ67863100
Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytesQ70199908
Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cellsQ70890742
CCAAT displacement protein competes with multiple transcriptional activators for binding to four sites in the proximal gp91phox promoterQ71144340
Ultraviolet B irradiation promotes tumorigenic and metastatic properties in primary cutaneous melanoma via induction of interleukin 8Q71703739
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gammaQ71970954
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude miceQ72523009
IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factorQ72901004
Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)Q73283069
Enhanced degradation of I-kappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cellsQ73526610
Stromal cells in lymph nodes attract B-lymphoma cells via production of stromal cell-derived factor-1Q73917469
Constitutive IkappaB kinase activity correlates with nuclear factor-kappaB activation in human melanoma cellsQ74020371
Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemiaQ74346508
Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude miceQ74376048
Transcriptional repression of the cystic fibrosis transmembrane conductance regulator gene, mediated by CCAAT displacement protein/cut homolog, is associated with histone deacetylationQ74602410
Chemokines and their role in tumor growth and metastasisQ77637277
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogeneQ77726383
Chemokines: not just leukocyte chemoattractants in the promotion of cancer.Q53400230
The role of CDP in the negative regulation of CXCL1 gene expressionQ24647127
Delayed wound healing in CXCR2 knockout miceQ24647498
The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanomaQ24658422
Regulation of the homeodomain CCAAT displacement/cut protein function by histone acetyltransferases p300/CREB-binding protein (CBP)-associated factor and CBPQ24682599
CDK inhibitors: positive and negative regulators of G1-phase progressionQ27860983
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylationQ28140878
Role of IKKgamma/nemo in assembly of the Ikappa B kinase complexQ28143953
Chemokine receptors and their role in inflammation and infectious diseasesQ28144282
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complexQ28145172
Identification and characterization of an IkappaB kinaseQ28245341
Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformationQ28249159
Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated cytokine beta and gamma proteinsQ28251702
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activationQ28252726
The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 ReceptorQ28284449
Melanoma growth stimulatory activity: Isolation from human melanoma tumors and characterization of tissue distributionQ28296887
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1Q28302936
A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expressionQ28345011
Cellular survival: a play in three AktsQ29547806
ChemokinesQ29616435
Chemokines and leukocyte trafficQ29618886
The biology of chemokines and their receptorsQ29619170
Regulation of protein kinase B.Q33539991
Chemokine receptors and their antagonists in allergic lung disease.Q33713498
How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complexQ33797139
Chemokines and their receptors in lymphocyte traffic and HIV infectionQ33799800
Chemokines and cell migration in secondary lymphoid organsQ33807114
The IKK complex: an integrator of all signals that activate NF-kappaB?Q33877083
Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcomaQ33889051
The role of chemokine receptors in primary, effector, and memory immune responsesQ33932742
Autocrine and paracrine regulation by cytokines and growth factors in melanomaQ33937586
CXC chemokines in angiogenesis.Q33983541
Nuclear factor-kappa B, cancer, and apoptosisQ34047210
Cellular signaling: pivoting around PDK-1.Q34073383
Ras proteins in the control of the cell cycle and cell differentiationQ34090530
The role of chemokines in atherosclerosisQ34207434
Virally encoded 7TM receptorsQ34225991
Skin cancer: a review and atlas for the medical providerQ34342201
The proteasome: a new target for novel drug therapiesQ34441064
Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cellsQ34509942
The Functional Role of the ELR Motif in CXC Chemokine-mediated AngiogenesisQ34662335
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1Q36004058
Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastasesQ36367319
MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cellsQ36644730
Expression of transcripts for two interleukin 8 receptors in human phagocytes, lymphocytes and melanoma cellsQ36768315
A cis-acting element in the promoter region of the murine c-myc gene is necessary for transcriptional blockQ36797286
MGSA/GRO-mediated melanocyte transformation involves induction of Ras expressionQ37154670
Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in cultureQ37385515
An NF-kappa B-like transcription factor mediates IL-1/TNF-alpha induction of gro in human fibroblastsQ38334326
Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.Q39451375
Poly(ADP-ribose) in the cellular response to DNA damageQ39613580
HMGI(Y) and Sp1 in addition to NF-kappa B regulate transcription of the MGSA/GRO alpha geneQ40396385
Chemokines, leukocyte trafficking, and inflammationQ40502969
Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progressionQ40853389
Both amino- and carboxyl-terminal domains of TRAF3 negatively regulate NF-kappaB activation induced by OX40 signalingQ40873064
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaksQ40930035
Recognition and processing of damaged DNA.Q41001869
Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferationQ41133441
Characterization of the role of melanoma growth stimulatory activity (MGSA) in the growth of normal melanocytes, nevocytes, and malignant melanocytesQ41192380
Constitutive and cytokine-induced expression of the melanoma growth stimulatory activity/GRO alpha gene requires both NF-kappa B and novel constitutive factorsQ41258049
Genomic cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1 alpha, and MIP-1 beta, members of the chemokine superfamily of proinflammatory cytokines.Q41549116
NF-kappaB activation: the I kappaB kinase revealed?Q41639488
Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progressionQ41640097
Effects of MGSA/GRO alpha on melanocyte transformationQ41676895
Neutrophil-activating peptide 2 and gro/melanoma growth-stimulatory activity interact with neutrophil-activating peptide 1/interleukin 8 receptors on human neutrophilsQ41857249
Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor IQ42015911
The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.Q42479390
Molecular cloning and characterization of a mouse gene with homology to the Duffy-antigen receptor for chemokinesQ42611732
Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma.Q42815905
Two structurally distinct kappa B sequence motifs cooperatively control LPS-induced KC gene transcription in mouse macrophages.Q42824047
Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.Q42991716
Epithelial cancer cell migration: a role for chemokine receptors?Q43657321
Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame.Q43806546
Positive and negative regulation of the human thymidine kinase promoter mediated by CCAAT binding transcription factors NF-Y/CBF, dbpA, and CDP/cut.Q46153400
Human non-small cell lung cancer cells express a type 2 cytokine patternQ46197942
Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in DrosophilaQ46557714
Malaria enhances expression of CC chemokine receptor 5 on placental macrophagesQ47879515
Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implicationsQ48131002
Chemokine/chemokine receptor nomenclatureQ48737954
CD30 expression on circulating memory CD4+ T cells as a Th2-dominated situation in patients with atopic dermatitis.Q52022979
The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A.Q52172349
Gene expression in melanoma cell lines and cultured melanocytes: correlation between levels of c-src-1, c-myc and p53.Q52828093
P433issue1
P304page(s)9-18
P577publication date2002-07-01
P1433published inJournal of Leukocyte BiologyQ1524048
P1476titleRole of CXCL1 in tumorigenesis of melanoma
P478volume72

Reverse relations

cites work (P2860)
Q28393278A multi-targeted approach to suppress tumor-promoting inflammation
Q33911395Adenoma formation following limited ablation of p120-catenin in the mouse intestine.
Q24301589Angiogenic expression profile of normal and neurofibromin-deficient human Schwann cells
Q64245106Anti-metastatic Properties of Naproxen-HBTA in a Murine Model of Cutaneous Melanoma
Q28276508Augmentation of therapeutic responses in melanoma by inhibition of IRAK-1,-4
Q35754264Bifidobacteria grown on human milk oligosaccharides downregulate the expression of inflammation-related genes in Caco-2 cells.
Q35101747CTLA-4 is a direct target of Wnt/beta-catenin signaling and is expressed in human melanoma tumors
Q64911156CXCL1 Derived from Mammary Fibroblasts Promotes Progression of Mammary Lesions to Invasive Carcinoma through CXCR2 Dependent Mechanisms.
Q36085855CXCL1 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer
Q37403610CXCL1 gene silencing inhibits HGC803 cell migration and invasion and acts as an independent prognostic factor for poor survival in gastric cancer
Q36234075CXCL1 is elevated in the urine of bladder cancer patients
Q89805860CXCL1/CXCR2 Paracrine Axis Contributes to Lung Metastasis in Osteosarcoma
Q30496149Cancer biomarker discovery: the entropic hallmark
Q59795953Chemokine (C-X-C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid-derived suppressor cells
Q34788410Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers
Q34010429Chemokine signaling in cancer: Implications on the tumor microenvironment and therapeutic targeting
Q83169012Chemokines in health and disease
Q38109160Chemokines, chemokine receptors and the gastrointestinal system.
Q35092571Ciglitazone negatively regulates CXCL1 signaling through MITF to suppress melanoma growth
Q40443266Constitutive expression of growth regulated oncogene (gro) in human colon carcinoma cells with different metastatic potential and its role in regulating their metastatic phenotype
Q30831587Construction of human liver cancer vascular endothelium cDNA expression library and screening of the endothelium-associated antigen genes
Q36800206Correlation of macrophage inflammatory protein-2 expression and brain edema in rats after intracerebral hemorrhage
Q60958246Cytokines, Chemokines, and Other Biomarkers of Response for Checkpoint Inhibitor Therapy in Skin Cancer
Q64103311Detection of Inflammation-Related Melanoma Small Extracellular Vesicle (sEV) mRNA Content Using Primary Melanocyte sEVs as a Reference
Q49656814Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?
Q41458701Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling
Q35784652Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family
Q33346619ELR+ CXC chemokine expression in benign and malignant colorectal conditions
Q38902180Elevated Blood Neutrophil-to-Lymphocyte Ratio: A Readily Available Biomarker Associated with Death due to Disease in High Risk Nonmetastatic Melanoma
Q42086850Elevated expression of growth-regulated oncogene-alpha in tumor and stromal cells predicts unfavorable prognosis in pancreatic cancer.
Q36615128Elevated neutrophil and monocyte counts in peripheral blood are associated with poor survival in patients with metastatic melanoma: a prognostic model
Q90429073Elevation of CXCL1 indicates poor prognosis and radioresistance by inducing mesenchymal transition in glioblastoma
Q36182073Elucidation of Relevant Neuroinflammation Mechanisms Using Gene Expression Profiling in Patients with Amyotrophic Lateral Sclerosis
Q55505567Emerging evidence of the molecular landscape specific for hematogenous metastasis from gastric cancer.
Q28069422Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Q51382068Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression.
Q40177641Expression and migratory analysis of 5 human uveal melanoma cell lines for CXCL12, CXCL8, CXCL1, and HGF.
Q33208592From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies
Q37519157GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment
Q33858488GROα overexpression drives cell migration and invasion in triple negative breast cancer cells
Q34988788Hepatocellular proliferation correlates with inflammatory cell and cytokine changes in a murine model of nonalchoholic fatty liver disease
Q36924396Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells
Q39877618Identification of GRO1 as a critical determinant for mutant p53 gain of function
Q33595109Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes
Q33475160Identification of proteins involved in neural progenitor cell targeting of gliomas
Q34269107Interleukin-17 Induces Expression of Chemokines and Cytokines in Prostatic Epithelial Cells but Does Not Stimulate Cell Growth In Vitro
Q34995710Interleukin-19 increases angiogenesis in ischemic hind limbs by direct effects on both endothelial cells and macrophage polarization
Q37432097International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors
Q90344037Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling
Q92535678Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment
Q38994985Ladarixin, a dual CXCR1/2 inhibitor, attenuates experimental melanomas harboring different molecular defects by affecting malignant cells and tumor microenvironment
Q35224136Liposome-encapsulated CpG enhances antitumor activity accompanying the changing of lymphocyte populations in tumor via intratumoral administration
Q37226145Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo
Q35077436Melanoma cells influence the differentiation pattern of human epidermal keratinocytes
Q53493928Melanoma-derived factors alter the maturation and activation of differentiated tissue-resident dendritic cells.
Q36721063Merkel cell polyomavirus T antigens promote cell proliferation and inflammatory cytokine gene expression
Q27320784Mesenchymal transition and dissemination of cancer cells is driven by myeloid-derived suppressor cells infiltrating the primary tumor
Q60311076Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma
Q36198788Microsecond-pulsed dielectric barrier discharge plasma stimulation of tissue macrophages for treatment of peripheral vascular disease
Q36719110Muscle-to-organ cross talk mediated by myokines
Q36347158NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT
Q33889523On the theory of tumor self-seeding: implications for metastasis progression in humans
Q34304058Overexpression of Chemokine (C-X-C) ligand 1 (CXCL1) associated with tumor progression and poor prognosis in hepatocellular carcinoma
Q21245718Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells
Q36841086Platelet-cytokine Complex Suppresses Tumour Growth by Exploiting Intratumoural Thrombin-dependent Platelet Aggregation
Q37195656Protein Sialylation Regulates a Gene Expression Signature that Promotes Breast Cancer Cell Pathogenicity
Q33735558Regulation of angiogenesis by histone chaperone HIRA-mediated incorporation of lysine 56-acetylated histone H3.3 at chromatin domains of endothelial genes
Q36120825Role of chemokines in tumor growth
Q34428921Role of macrophage CCAAT/enhancer binding protein delta in the pathogenesis of rheumatoid arthritis in collagen-induced arthritic mice.
Q33833881Senescent cells as a source of inflammatory factors for tumor progression
Q34367591Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases
Q37189621Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor κB activation
Q28547113TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms
Q24519206The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells
Q39018419The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence
Q35754593The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer
Q35231687The functional role of reactive stroma in benign prostatic hyperplasia
Q37394981The good and the bad of chemokines/chemokine receptors in melanoma
Q29620106The senescence-associated secretory phenotype: the dark side of tumor suppression
Q92787633Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway
Q34001179Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development
Q35207107Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli
Q43224742Trp53 inactivation in the tumor microenvironment promotes tumor progression by expanding the immunosuppressive lymphoid-like stromal network.
Q24658224Tumor self-seeding by circulating cancer cells
Q26784415Tumor-Associated Mast Cells in Thyroid Cancer
Q64059990UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway
Q42170400Uveal melanoma: Ocular and systemic disease
Q33869648Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis
Q79334200[Chromosomal alterations in juvenile angiofibromas]
Q27851827p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

Search more.