Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells

scientific article

Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.164.12.6503
P932PMC publication ID4231715
P698PubMed publication ID10843708
P5875ResearchGate publication ID12474081

P50authorNikolaus MarxQ112515387
P2093author name stringP Libby
A D Luster
M N Sarafi
R M Ransohoff
J Plutzky
F Mach
A Sauty
J H Leung
P2860cites workGamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteinsQ24300179
HuMig: a new human member of the chemokine family of cytokinesQ24324494
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytesQ24336187
Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cellsQ24563090
Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3Q24647146
Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimersQ28238970
Mechanism of action of fibrates on lipid and lipoprotein metabolismQ28288187
Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivoQ28371943
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and deltaQ28379553
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gammaQ29615221
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)Q29615693
Chemokines--chemotactic cytokines that mediate inflammationQ29616433
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiationQ29619212
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokinesQ29620217
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activationQ29620219
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory responseQ33857617
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinaseQ33886831
Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitroQ35753181
A unique palindromic element mediates gamma interferon induction of mig gene expressionQ36645205
Activation of peroxisome proliferator-activated receptor gamma does not inhibit IL-6 or TNF-alpha responses of macrophages to lipopolysaccharide in vitro or in vivoQ40908023
The T cell-specific CXC chemokines IP-10, Mig, and I-TAC are expressed by activated human bronchial epithelial cells.Q40964781
A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcriptionQ41005077
Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptorQ41105715
The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinedionesQ41229841
Cooperative interaction between interferon (IFN) stimulus response element and kappa B sequence motifs controls IFN gamma- and lipopolysaccharide-stimulated transcription from the murine IP-10 promoterQ41565223
PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cellsQ42267879
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.Q42536498
Induction of beta-R1/I-TAC by interferon-beta requires catalytically active TYK2.Q47994257
Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines.Q55477373
PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular diseaseQ74598459
p48/STAT-1alpha-containing complexes play a predominant role in induction of IFN-gamma-inducible protein, 10 kDa (IP-10) by IFN-gamma alone or in synergy with TNF-alphaQ77483953
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)6503-6508
P577publication date2000-06-01
P1433published inJournal of ImmunologyQ3521441
P1476titlePeroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells
P478volume164

Reverse relations

cites work (P2860)
Q4419819415-Deoxy-D12,14-prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells
Q4460189315-Deoxy-delta 12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide
Q33746963A PPARγ-dependent miR-424/503-CD40 axis regulates inflammation mediated angiogenesis
Q36536205A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes
Q47953655Activation of PPARbeta/delta inhibits leukocyte recruitment, cell adhesion molecule expression, and chemokine release.
Q36634314Adiponectin inhibits macrophage tissue factor, a key trigger of thrombosis in disrupted atherosclerotic plaques
Q37211800Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease
Q40610269Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
Q35298513Anti-inflammatory properties of lipid oxidation products
Q36611745Antineoplastic effects of rosiglitazone and PPARgamma transactivation in neuroblastoma cells
Q35023612Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets
Q44590445Atorvastatin reduces interleukin-6 plasma concentration and adipocyte secretion of hypercholesterolemic rabbits
Q36458462Bexarotene in the treatment of cutaneous T-cell lymphoma
Q80432110CXCL9 and 11 in patients with pulmonary sarcoidosis: a role of alveolar macrophages
Q58246532Chemokines and atherosclerosis
Q35747641Complement and dilated cardiomyopathy: a role of sublytic terminal complement complex-induced tumor necrosis factor-alpha synthesis in cardiac myocytes
Q42497785Constitutive and regulated expression and secretion of interferon-gamma-inducible protein 10 (IP-10/CXCL10) in human adipocytes
Q24684054Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation
Q58229736Determinants of evolving metabolic and cardiovascular benefit/risk profiles of rosiglitazone therapy during the natural history of diabetes: molecular mechanisms in the context of integrated pathophysiology
Q57067440Diet-Modulated Lipoprotein Metabolism and Vascular Inflammation Evaluated by F-fluorodeoxyglucose Positron Emission Tomography
Q45987160Dietary n-3 fatty acids attenuate cardiac allograft vasculopathy via activating peroxisome proliferator-activated receptor-gamma.
Q51042965Early increase in alveolar macrophage prostaglandin 15d-PGJ2 precedes neutrophil recruitment into lungs of cytokine-insufflated rats.
Q44633202Effect of 15-deoxy-Δ12,14-prostaglandin J2 on IL-1β-induced expression of epithelial neutrophil-activating protein-78 in human endothelial cells
Q40251913Effect of 15d-PGJ2 on the expression of CD40 and RANTES induced by IFN-gamma and TNF-alpha on renal tubular epithelial cells (HK-2).
Q43108533Effect of rosiglitazone on cisplatin-induced nephrotoxicity
Q40208687Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs
Q35044388Effects of peroxisome proliferator-activated receptor-gamma agonists on central nervous system inflammation
Q33642053Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency.
Q37624930Endothelium as a gatekeeper of fatty acid transport
Q57373134Fatty Acid Regulation of Gene Transcription
Q35115458Free Radicals and Lipid Signaling in Endothelial Cells
Q35014033HO-1 Induced by Cilostazol Protects Against TNF-α-associated Cytotoxicity via a PPAR-γ-dependent Pathway in Human Endothelial Cells
Q40652063High Glucose-Induced Expression of Proinflammatory Cytokine and Chemokine Genes in Monocytic Cells
Q61638147High serum levels of CXC chemokine ligand 10 in untreated essential hypertension
Q81683808Hormone regulation of microglial cell activation: relevance to multiple sclerosis
Q34871916Immunomodulatory actions of leptin
Q46740652Immunosuppression in cardiac graft rejection: a human in vitro model to study the potential use of new immunomodulatory drugs.
Q46626095Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease
Q36202581Inflammation, dyslipidaemia, diabetes and PPars: pharmacological interest of dual PPARalpha and PPARgamma agonists
Q39797885Influence of apple polyphenols on inflammatory gene expression
Q37557746Influence of conjugated linoleic acids on functional properties of vascular cells
Q39980108Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway.
Q36890231Inhibition of 12/15-lipoxygenase by baicalein induces microglia PPARβ/δ: a potential therapeutic role for CNS autoimmune disease
Q43059312Inhibition of MMP-9 expression by PPARgamma activators in human bronchial epithelial cells
Q33967999Inhibition of cellular proliferation through IkappaB kinase-independent and peroxisome proliferator-activated receptor gamma-dependent repression of cyclin D1.
Q34962291Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions
Q36510633Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction
Q34348648Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells
Q33243924Microarray analysis identifies a set of CXCR3 and CCR2 ligand chemokines as early IFNbeta-responsive genes in peripheral blood lymphocytes in vitro: an implication for IFNbeta-related adverse effects in multiple sclerosis
Q36393212Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer
Q42135532Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.
Q40043011NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines
Q33815718NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
Q34309219Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics
Q35670502Novel pituitary ligands: peroxisome proliferator activating receptor-gamma
Q36733873Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors
Q33644094Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple sclerosis
Q34024668Nuclear receptors and inflammation control: molecular mechanisms and pathophysiological relevance
Q42263066Omega-3 fatty acids and/or fluvastatin in hepatitis C prior non-responders to combination antiviral therapy - a pilot randomised clinical trial
Q40778017Oxidized low density lipoprotein exposure alters the transcriptional response of macrophages to inflammatory stimulus
Q21342822PPAR-gamma: Therapeutic Potential for Multiple Sclerosis
Q26863678PPAR-γ -- a possible drug target for complicated pregnancies
Q48247479PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia.
Q43872427PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells
Q37002797PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells
Q36154953PPARalpha in atherosclerosis and inflammation
Q35768913PPARgamma as a new therapeutic target in inflammatory bowel diseases
Q36791361PPARs and molecular mechanisms of transrepression
Q24642728PPARs and the cardiovascular system
Q36889164PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?
Q38132128PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?
Q37777055PPARγ and chronic kidney disease
Q37115840Pathophysiological roles of microvascular alterations in pulmonary inflammatory diseases: possible implications of tumor necrosis factor-alpha and CXC chemokines
Q27022369Peroxisome Proliferator-Activated Receptor- γ in Thyroid Autoimmunity
Q33816291Peroxisome proliferator-activated receptor (PPAR)gamma can inhibit chronic renal allograft damage
Q43760306Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells
Q44247093Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis
Q34492831Peroxisome proliferator-activated receptor gamma and atherosclerosis
Q57975195Peroxisome proliferator-activated receptor α agonists modulate Th1 and Th2 chemokine secretion in normal thyrocytes and Graves' disease
Q47739408Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Q57244326Peroxisome proliferator-activated receptor γ activators inhibit interleukin-12 production in murine dendritic cells
Q34365179Peroxisome proliferator-activated receptor γ agonists reduce cell proliferation and viability and increase apoptosis in systemic sclerosis fibroblasts
Q40147302Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells
Q44060078Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis
Q44848225Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element
Q37861955Peroxisome proliferator-activated receptors and atherosclerosis.
Q35173859Peroxisome proliferator-activated receptors and the cardiovascular system
Q34290988Peroxisome proliferator-activated receptors in atherosclerosis and inflammation--an update
Q36510464Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications
Q35539448Peroxisome proliferator-activated receptors: new targets for the pharmacological modulation of macrophage gene expression and function
Q40343418Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells
Q38469591Pioglitazone modulates vascular inflammation in atherosclerotic rabbits noninvasive assessment with FDG-PET-CT and dynamic contrast-enhanced MR imaging
Q33406281Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation
Q38112106Pre- and posttherapy assessment of intestinal soluble mediators in IBD: where we stand and future perspectives.
Q45309412Prolactin stimulates integrin-mediated adhesion of circulating mononuclear cells to endothelial cells
Q42008239Protective Actions of PPAR-gamma Activation in Renal Endothelium
Q34178976Pulmonary hypertension and metabolic syndrome: Possible connection, PPARγ and Caveolin-1
Q46117356Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models
Q37114625Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation
Q35027759Regulation of chemokine expression in atherosclerosis
Q34724089Role of CXCL1 in tumorigenesis of melanoma.
Q27000731Role of lipotoxicity in endothelial dysfunction
Q34992771Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases
Q41570973Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation
Q43239098Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'.
Q35101529The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria
Q37337997The Role of PPARs in the Endothelium: Implications for Cancer Therapy
Q35212555The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis
Q90235289The protective effect of myo-inositol on human thyrocytes
Q34838209The role of PPARs in atherosclerosis
Q34207434The role of chemokines in atherosclerosis
Q40858470The role of the Th1 chemokine CXCL10 in vitiligo
Q97076303The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review
Q53580895Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.
Q36632030Thiazolidinediones and risk for atherosclerosis: pleiotropic effects of PPar gamma agonism
Q41681579Thiazolidinediones inhibit airway smooth muscle release of the chemokine CXCL10: in vitro comparison with current asthma therapies
Q45281571Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism
Q34075896Tumor necrosis factor (TNF)-α induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-κB p65 methylation
Q46475661Upregulation of LPS-induced chemokine KC expression by 15-deoxy-delta12,14-prostaglandin J2 in mouse peritoneal macrophages
Q79387298Upregulation of MIP-2 (CXCL2) expression by 15-deoxy-Delta(12,14)-prostaglandin J(2) in mouse peritoneal macrophages
Q33959265VLDL hydrolysis by hepatic lipase regulates PPARδ transcriptional responses
Q34790065Vascular effects of GI262570X (PPAR-gamma agonist) in the brown adipose tissue of Han Wistar rats: a review of 1-month, 13-week, 27-week and 2-year oral toxicity studies

Search more.