Determinants of evolving metabolic and cardiovascular benefit/risk profiles of rosiglitazone therapy during the natural history of diabetes: molecular mechanisms in the context of integrated pathophysiology

scientific article published on 28 February 2012

Determinants of evolving metabolic and cardiovascular benefit/risk profiles of rosiglitazone therapy during the natural history of diabetes: molecular mechanisms in the context of integrated pathophysiology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPENDO.00038.2012
P698PubMed publication ID22374753

P50authormonica montagnaniQ57436148
Maria A. PotenzaQ46406484
P2093author name stringFrancesco Addabbo
Luca Sgarra
P2860cites workEffect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular CausesQ22250883
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cellsQ22253424
PPAR attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cellsQ57892049
Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease. The Bypass Angioplasty Revascularization Investigation (BARI) InvestigatorsQ28281001
Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of HypertensionQ28301973
Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)Q28306815
Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defectsQ28509745
Peroxisome proliferator-activated receptor gamma inhibits expression of minichromosome maintenance proteins in vascular smooth muscle cellsQ28580270
Molecular regulation of vascular smooth muscle cell differentiation in development and diseaseQ29615194
TRP channelsQ29616673
The pathobiology of diabetic complications: a unifying mechanismQ29617766
The Bcl-2 protein family: arbiters of cell survivalQ29618158
Cellular mechanisms of insulin resistanceQ29619549
A central role for JNK in obesity and insulin resistanceQ29619778
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialQ29619886
Baseline characteristics of patients with diabetes and coronary artery disease enrolled in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trialQ30438736
Effect of rosiglitazone treatment on plaque inflammation and collagen content in nondiabetic patients: data from a randomized placebo-controlled trialQ31029646
The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cellsQ31921949
Troglitazone and rosiglitazone induce apoptosis of vascular smooth muscle cells through an extracellular signal-regulated kinase-independent pathwayQ32059552
Exercise training decreases store-operated Ca2+entry associated with metabolic syndrome and coronary atherosclerosisQ33573616
Rapid effect of single-dose rosiglitazone treatment on endothelial function in healthy men with normal glucose tolerance: data from a randomised, placebo-controlled, double-blind studyQ33575808
Rosiglitazone via upregulation of Akt/eNOS pathways attenuates dysfunction of endothelial progenitor cells, induced by advanced glycation end productsQ33595290
High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytesQ33750707
Impaired peroxisome proliferator-activated receptor-gamma contributes to phenotypic modulation of vascular smooth muscle cells during hypertensionQ33810041
Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug AdministrationQ33819486
A randomized trial of therapies for type 2 diabetes and coronary artery diseaseQ33827504
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009Q33880303
Endothelial dysfunction in diabetes.Q33959485
Risk of acute myocardial infarction, stroke, heart failure, and death in elderly Medicare patients treated with rosiglitazone or pioglitazoneQ34123137
Rosiglitazone revisited: an updated meta-analysis of risk for myocardial infarction and cardiovascular mortalityQ34127761
Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetesQ34150577
Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide releaseQ34185006
Assessment and treatment of cardiovascular risk in prediabetes: impaired glucose tolerance and impaired fasting glucoseQ34204855
Health status after treatment for coronary artery disease and type 2 diabetes mellitus in the Bypass Angioplasty Revascularization Investigation 2 Diabetes trialQ34242531
Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic AgentQ34256957
ThiazolidinedionesQ34346862
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitroQ34452063
Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cellsQ34509942
Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosisQ37731651
Management of diabetes mellitus in patients with cardiovascular disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trialQ37763363
Role of peroxisome proliferator-activated receptor-γ in atherosclerosis: an update.Q37843184
Cardiovascular complications in diabetes: lessons from animal models.Q37861826
Implementing cardiovascular risk reduction in patients with cardiovascular disease and diabetes mellitusQ37908528
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gammaQ38354039
Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cQ38375360
Rapid and contrasting effects of rosiglitazone on transient receptor potential TRPM3 and TRPC5 channelsQ39575691
Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.Q39648063
Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound studyQ39876880
Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosisQ40397866
Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.Q40470341
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance.Q40480010
MAP kinase cascades are activated in astrocytes and preadipocytes by 15-deoxy-Delta(12-14)-prostaglandin J(2) and the thiazolidinedione ciglitazone through peroxisome proliferator activator receptor gamma-independent mechanisms involving reactive oxQ40726966
Insulin-stimulated activation of eNOS is independent of Ca2+ but requires phosphorylation by Akt at Ser(1179).Q40799734
Nitric oxide modulates expression of cell cycle regulatory proteins: a cytostatic strategy for inhibition of human vascular smooth muscle cell proliferationQ40884375
PPARgamma agonists enhance human vascular endothelial adhesiveness by increasing ICAM-1 expressionQ40924711
Peroxisome proliferators activate extracellular signal-regulated kinases in immortalized mouse liver cellsQ41109889
Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerosisQ41491513
Expression and function of PPARgamma in rat and human vascular smooth muscle cellsQ41725857
Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cellsQ41734805
Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathwayQ42477113
Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthaseQ42482576
Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetesQ42487904
Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistanceQ34577169
Optimal medical therapy with or without PCI for stable coronary diseaseQ34612445
Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker ratsQ34630250
Rosiglitazone evaluated for cardiovascular outcomes--an interim analysisQ34634794
Diabetes and atherosclerosis: epidemiology, pathophysiology, and managementQ34646074
The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetesQ34655580
Uncertain effects of rosiglitazone on the risk for myocardial infarction and cardiovascular deathQ34659938
Long-term risk of cardiovascular events with rosiglitazone: a meta-analysisQ34686103
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trialQ34766176
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trialQ34985342
Pleiotropic effects of glitazones: a double edge sword?Q35025858
AKT phosphorylation is essential for insulin-induced relaxation of rat vascular smooth muscle cellsQ35131182
Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetesQ35140825
Metabolic and molecular basis of insulin resistanceQ35148800
Antidiabetic thiazolidinediones inhibit invasiveness of pancreatic cancer cells via PPARgamma independent mechanismsQ35596926
Dyslipidemia in the metabolic syndrome and type 2 diabetes mellitusQ35609174
Peroxisome proliferator-activated receptor gamma: implications for cardiovascular diseaseQ35633275
Vascular smooth muscle cell migration: current research and clinical implicationsQ35647930
Pathogenesis of type 2 diabetes mellitusQ35861736
Molecular mechanisms of insulin resistance that impact cardiovascular biologyQ35927757
Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of HypertensionQ36015782
Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms.Q36450952
The insulin resistance syndrome: physiological considerationsQ36806509
Cardiovascular actions of insulinQ36831533
Diabetes mellitus as a prothrombotic conditionQ36889156
Diabetes mellitus and macrovascular disease: mechanisms and mediatorsQ36934274
Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men.Q37103503
Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studiesQ37172727
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscleQ37175187
Increased rhythmicity in hypertensive arterial smooth muscle is linked to transient receptor potential canonical channels.Q37295391
Effect of rosiglitazone on progression of atherosclerosis: insights using 3D carotid cardiovascular magnetic resonance.Q37303369
Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculatureQ37337305
A multicentre, randomized, double-blind placebo-controlled trial evaluating rosiglitazone for the prevention of atherosclerosis progression after coronary artery bypass graft surgery in patients with type 2 diabetes. Design and rationale of the VeInQ37429296
Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis.Q37485515
Vascular actions of insulin with implications for endothelial dysfunctionQ37505788
Thiazolidinediones suppress endothelin-1 secretion from bovine vascular endothelial cells: a new possible role of PPARgamma on vascular endothelial function.Q42536498
Risk of thrombosis in human atherosclerotic plaques: role of extracellular lipid, macrophage, and smooth muscle cell contentQ42578006
Treatment with rosiglitazone reduces hyperinsulinemia and improves arterial elasticity in patients with type 2 diabetes mellitusQ42604247
The effects of rosiglitazone on atherosclerotic progression in patients with Type 2 diabetes at high cardiovascular riskQ42831071
PPAR-gamma dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammationQ42832963
Revisiting the rosiglitazone story--lessons learnedQ42957422
Cardiometabolic effects of rosiglitazone in patients with type 2 diabetes and coronary artery bypass grafts: A randomized placebo-controlled clinical trialQ42995214
Thiazolidinedione drugs and cardiovascular risks: a science advisory from the American Heart Association and American College Of Cardiology FoundationQ43088578
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motilityQ43138558
The inhibition of insulin-stimulated proliferation of vascular smooth muscle cells by rosiglitazone is mediated by the Akt-mTOR-P70S6K pathwayQ43211170
Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patientsQ43292964
Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasiaQ43684759
Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cellsQ43798535
Peroxisome proliferator-activated receptor-gamma ligands inhibit nuclear but not cytosolic extracellular signal-regulated kinase/mitogen-activated protein kinase-regulated steps in vascular smooth muscle cell migrationQ43798813
PPAR activators inhibit endothelial cell migration by targeting Akt.Q44020948
Insulin inhibits PDGF-directed VSMC migration via NO/ cGMP increase of MKP-1 and its inactivation of MAPKsQ44101856
Antiinflammatory and antiarteriosclerotic effects of pioglitazoneQ44201670
Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cellsQ44275923
Rosiglitazone (PPARgamma-agonist) attenuates atherogenesis with no effect on hyperglycaemia in a combined diabetes-atherosclerosis mouse modelQ44287903
Arterial stiffness increases with deteriorating glucose tolerance status: the Hoorn StudyQ44403585
Fas and Fas-associated death domain protein regulate monocyte chemoattractant protein-1 expression by human smooth muscle cells through caspase- and calpain-dependent release of interleukin-1alpha.Q44567717
Antioxidative, Antinitrative, and Vasculoprotective Effects of a Peroxisome Proliferator–Activated Receptor-γ Agonist in HypercholesterolemiaQ44650457
In type 2 diabetes, rosiglitazone therapy for insulin resistance ameliorates endothelial dysfunction independent of glucose controlQ44745053
Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patientsQ45285409
Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgammaQ45285602
New mechanism of rosiglitazone to reduce neointimal hyperplasia: activation of glycogen synthase kinase-3beta followed by inhibition of MMP-9.Q46129148
Predictive factors for in-stent late loss and coronary lesion progression in patients with type 2 diabetes mellitus randomized to rosiglitazone or placeboQ46137342
Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production.Q46406338
Rosiglitazone promotes atherosclerotic plaque stability in fat-fed ApoE-knockout miceQ46500891
Rapid effects of rosiglitazone treatment on endothelial function and inflammatory biomarkersQ46588893
Rosiglitazone attenuates atherosclerosis in a model of insulin insufficiency independent of its metabolic effectsQ46601696
Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanismsQ46601702
Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.Q46731659
Reduced plaque formation induced by rosiglitazone in an STZ-diabetes mouse model of atherosclerosis is associated with downregulation of adhesion molecules.Q46841200
Effect of rosiglitazone on plasma adiponectin levels and arterial stiffness in subjects with prediabetes or non-diabetic metabolic syndrome.Q46960665
Rosiglitazone reduces glucose-induced oxidative stress mediated by NAD(P)H oxidase via AMPK-dependent mechanism.Q46966126
Peroxisome proliferator-activated receptor gamma agonist improves arterial stiffness in patients with type 2 diabetes mellitus and coronary artery diseaseQ46989695
Coculture with endothelial cells enhances vascular smooth muscle cell adhesion and spreading via activation of beta1-integrin and phosphatidylinositol 3-kinase/Akt.Q51098540
Pioglitazone for diabetes prevention in impaired glucose tolerance.Q51161029
Carotid arterial stiffness is marginally higher in the metabolic syndrome and markedly higher in type 2 diabetes mellitus in patients with manifestations of arterial disease.Q51475362
Treatment of spontaneously hypertensive rats with rosiglitazone and/or enalapril restores balance between vasodilator and vasoconstrictor actions of insulin with simultaneous improvement in hypertension and insulin resistance.Q51484642
Chronic physiologic hyperinsulinemia impairs suppression of plasma free fatty acids and increases de novo lipogenesis but does not cause dyslipidemia in conscious normal rats.Q51564567
Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis.Q51972429
Regulation of vascular smooth muscle cell proliferation: role of NF-kappaB revisited.Q52939122
Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis.Q53606830
High glucose and insulin inhibit VSMC MKP-1 expression by blocking iNOS via p38 MAPK activation.Q54064851
Troglitazone suppresses intimal formation following balloon injury in insulin-resistant Zucker fatty rats.Q54136935
Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus.Q54346849
P433issue10
P921main subject(RS)-rosiglitazoneQ424771
pathophysiologyQ1135939
P304page(s)E1171-82
P577publication date2012-02-28
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleDeterminants of evolving metabolic and cardiovascular benefit/risk profiles of rosiglitazone therapy during the natural history of diabetes: molecular mechanisms in the context of integrated pathophysiology
P478volume302

Reverse relations

cites work (P2860)
Q50154239Beneficial effects of rosiglitazone and losartan combination in diabetic rats
Q35121959Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells
Q27000731Role of lipotoxicity in endothelial dysfunction
Q36672866The endothelium in diabetes: its role in insulin access and diabetic complications

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