Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis

scientific article published on March 31, 2011

Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PGEN.1001356
P953full work available at URLhttp://dx.plos.org/10.1371/journal.pgen.1001356
https://europepmc.org/articles/PMC3069107
https://europepmc.org/articles/PMC3069107?pdf=render
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001356&type=printable
P932PMC publication ID3069107
P698PubMed publication ID21483804
P5875ResearchGate publication ID51042568

P50authorJuan Carlos RoaQ56380840
Melissa FazzariQ61099538
Anirban MaitraQ63019787
Reid F ThompsonQ41312233
John GreallyQ42667137
P2093author name stringLi Zhou
Amit Verma
Ari Melnick
Yiting Yu
Marcia Canto
Masako Suzuki
Christina Montagna
Jean Wang
Joanna Opalinska
Davendra Sohal
Hector Alvarez
Tushar Bhagat
Elizabeth A. Montgomery
Linda Cannizzaro
Yongkai Mo
J. Mollenhauer
Kerry B. Dunbar
K. H. Ramesh
Stephen J. Meltzer
P2860cites workLUMA (LUminometric Methylation Assay)--a high throughput method to the analysis of genomic DNA methylationQ53626812
Alterations in DNA Methylation: A Fundamental Aspect of NeoplasiaQ56418625
Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancersQ67920829
Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarraysQ77580360
Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGHQ79850195
Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesisQ80998934
Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesionsQ82844125
Establishment and characterization of a bona fide Barrett esophagus-associated adenocarcinoma cell lineQ39940721
Effect of inflammation on cyclooxygenase (COX)-2 expression in benign and malignant oesophageal cells.Q40425709
CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target.Q40455557
Alterations in DNA methylation: a fundamental aspect of neoplasiaQ41617101
A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagusQ41897097
Temporal trends (1973-1997) in survival of patients with esophageal adenocarcinoma in the United States: a glimmer of hope?Q47562024
Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer.Q52038511
Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers.Q53342403
Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes in Barrett's adenocarcinomaQ53367270
APC gene mutations in the mutation cluster region are rare in esophageal cancers.Q53468433
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblastsQ24629646
Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancersQ24649562
Inflammation and cancerQ24649640
Comparative isoschizomer profiling of cytosine methylation: the HELP assayQ24685607
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression riskQ28244692
Radiofrequency ablation in Barrett's esophagus with dysplasiaQ28246453
Chemokine signaling via the CXCR2 receptor reinforces senescenceQ28283948
Hypomethylation distinguishes genes of some human cancers from their normal counterpartsQ29619217
Transcriptional oncogenomic hot spots in Barrett's adenocarcinomas: serial analysis of gene expressionQ33291071
An integrative genomic and epigenomic approach for the study of transcriptional regulationQ33325492
Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical featuresQ33326627
A pipeline for the quantitative analysis of CG dinucleotide methylation using mass spectrometryQ33567042
CpG island methylator phenotypes in aging and cancer.Q33765672
Reproducibility of the diagnosis of dysplasia in Barrett esophagus: a reaffirmationQ34238141
Dysplasia as a predictive marker for invasive carcinoma in Barrett esophagus: a follow-up study based on 138 cases from a diagnostic variability studyQ34238147
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.Q34433577
Clinical practice. Barrett's EsophagusQ34563466
Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinomaQ34621907
Role of CXCL1 in tumorigenesis of melanoma.Q34724089
DNA methylation in cancer: too much, but also too littleQ34770545
Epigenomics: beyond CpG islands.Q35778671
CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancerQ36228506
Esophageal adenocarcinoma arising in Barrett esophagusQ37169303
The Axl receptor tyrosine kinase confers an adverse prognostic influence in pancreatic cancer and represents a new therapeutic targetQ37182283
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.Q37259044
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylationQ37396081
Utility of biomarkers in prediction of response to ablative therapy in Barrett's esophagusQ37495646
Reduction to homozygosity involving p53 in esophageal cancers demonstrated by the polymerase chain reactionQ37527489
Concordant loss of MTAP and p16/CDKN2A expression in gastroesophageal carcinogenesis: evidence of homozygous deletion in esophageal noninvasive precursor lesions and therapeutic implicationsQ38440539
Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis.Q38519052
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectDNA methylationQ874745
carcinogenesisQ1637543
P304page(s)e1001356
P577publication date2011-03-31
P1433published inPLOS GeneticsQ1893441
P1476titleWidespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis
Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis
P478volume7

Reverse relations

cites work (P2860)
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