Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma

scientific article

Hypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1044845609
P356DOI10.1038/SJ.ONC.1210461
P698PubMed publication ID17452981
P5875ResearchGate publication ID6376037

P2093author name stringF Sato
T Ito
E Montgomery
J Yang
Y Cheng
Y Mori
Z Jin
J M Abraham
S J Meltzer
J P Hamilton
R Agarwal
S David
T Kan
D Beer
A Olaru
B Paun
P2860cites workTwo genetic hits (more or less) to cancerQ22251289
Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeatsQ24309127
Craniosynostosis in transgenic mice overexpressing Nell-1Q24553230
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression riskQ28244692
Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial developmentQ28569383
Involvement of epidermal growth factor-like domain of NELL proteins in the novel protein-protein interaction with protein kinase CQ28581222
The meaning and use of the area under a receiver operating characteristic (ROC) curveQ29547182
Gene silencing in cancer in association with promoter hypermethylationQ29617274
Cancer statistics, 2005Q29617572
Specialized intestinal metaplasia, dysplasia, and cancer of the esophagus and esophagogastric junction: prevalence and clinical dataQ31919142
Roles of cell division and gene transcription in the methylation of CpG islands.Q33959680
Cancer as a disease of epithelial-mesenchymal interactions and extracellular matrix regulationQ35030679
Allelotype analysis of oesophageal adenocarcinoma: loss of heterozygosity occurs at multiple sitesQ36115450
Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine).Q36279309
Targeted induction of apoptosis in cancer management: the emerging role of tumor necrosis factor-related apoptosis-inducing ligand receptor activating agentsQ36345472
New gene, nel, encoding a Mr 93 K protein with EGF‐like repeats is strongly expressed in neural tissues of early stage chick embryosQ36692178
Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia.Q40458280
Barrett's oesophagus: microsatellite analysis provides evidence to support the proposed metaplasia-dysplasia-carcinoma sequenceQ42671396
Oesophageal cancer incidence and mortality in patients with long-segment Barrett's oesophagus after a mean follow-up of 12.7 yearsQ44291344
Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development.Q45962386
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinomaQ46062133
Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defectsQ46282179
A genome-wide search identifies epigenetic silencing of somatostatin, tachykinin-1, and 5 other genes in colon cancer.Q53342370
Effect of segment length on risk for neoplastic progression in patients with Barrett esophagus.Q53411176
Aberrant methylation of Fragile Histidine Triad gene is associated with poor prognosis in early stage esophageal squamous cell carcinomaQ82967811
P433issue43
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
hypermethylationQ106875739
P304page(s)6332-6340
P577publication date2007-04-23
P1433published inOncogeneQ1568657
P1476titleHypermethylation of the nel-like 1 gene is a common and early event and is associated with poor prognosis in early-stage esophageal adenocarcinoma
P478volume26

Reverse relations

cites work (P2860)
Q41897097A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus
Q85637871Aberrant TIG1 methylation associated with its decreased expression and clinicopathological significance in hepatocellular carcinoma
Q92539287Age dependent effects of NELL-1 isoforms on bone marrow stromal cells
Q38213141Biomarkers for dysplastic Barrett's: ready for prime time?
Q91289594Clinical advantages and disadvantages of anabolic bone therapies targeting the WNT pathway
Q44067402Clinical significance of RECK promoter methylation in pancreatic ductal adenocarcinoma
Q45017704DLC-1 is a candidate biomarker methylated and down-regulated in pancreatic ductal adenocarcinoma
Q89896747Detection of LINE-1 hypomethylation in cfDNA of Esophageal Adenocarcinoma Patients
Q26825349Early events during neoplastic progression in Barrett's esophagus
Q37228130Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer
Q37992481Epigenetic biomarkers in esophageal cancer
Q49663292Epigenetic biomarkers in gastrointestinal cancers: The current state and clinical perspectives
Q35674241Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma.
Q35666522Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma
Q37037246Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers
Q39993768Genome-wide profiling of DNA methylation in human cancer cells
Q55024946Identification of crucial genes associated with esophageal squamous cell carcinoma by gene expression profile analysis.
Q36725997Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
Q29617664Landscape of somatic retrotransposition in human cancers
Q35668216MALDI-TOF Mass Array Analysis of Nell-1 Promoter Methylation Patterns in Human Gastric Cancer
Q36336519Matching cancer genomes to established cell lines for personalized oncology
Q33840504Molecular karyotypes of Hodgkin and Reed-Sternberg cells at disease onset reveal distinct copy number alterations in chemosensitive versus refractory Hodgkin lymphoma
Q24309477NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation
Q36699479NELL-1 expression in tumors of cartilage
Q36018565NELL-1 in the treatment of osteoporotic bone loss.
Q33798085NELL-1 induces Sca-1+ mesenchymal progenitor cell expansion in models of bone maintenance and repair.
Q39314285NELL-1-dependent mineralisation of Saos-2 human osteosarcoma cells is mediated via c-Jun N-terminal kinase pathway activation
Q33779367NELL1, whose high expression correlates with negative outcomes, has different methylation patterns in alveolar and embryonal rhabdomyosarcoma
Q90698512Nell-1 Is a Key Functional Modulator in Osteochondrogenesis and Beyond
Q38149245Novel diagnostic and prognostic biomarkers in esophageal cancer
Q37354050Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma
Q30857110Qualitative analysis of Adenomatous Polyposis Coli promoter: hypermethylation, engagement and effects on survival of patients with esophageal cancer in a high risk region of the world, a potential molecular marker.
Q24632246Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma
Q26750641The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma
Q39380189The over-expression of cell migratory genes in alveolar rhabdomyosarcoma could contribute to metastatic spread
Q37812294The value of epigenetic markers in esophageal cancer
Q50176590Whole genome DNA methylation profiling of oral cancer in ethnic population of Meghalaya, North East India reveals novel genes
Q33869648Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis

Search more.