Chemokine signaling via the CXCR2 receptor reinforces senescence

scientific article

Chemokine signaling via the CXCR2 receptor reinforces senescence is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2008.03.038
P3181OpenCitations bibliographic resource ID763710
P698PubMed publication ID18555777
P5875ResearchGate publication ID5300559

P50authorAna BanitoQ55130865
Jesus GilQ55472013
Marzia FumagalliQ56488663
Fabrizio DaddadifagagnaQ67717903
Jonathan MelamedQ38546667
Ana O'LoghlenQ40036913
Eva HernandoQ40230064
David BernardQ44039079
Juan Carlos AcostaQ55130864
P2093author name stringArnaud Augert
Nikolay Popov
Selina Raguz
Maria V Guijarro
Yoshihiro Takatsu
Celia Brown
Marco Da Costa
P2860cites workThe serial cultivation of human diploid cell strainsQ29547356
Tumour biology: senescence in premalignant tumoursQ42802962
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1006-1018
P577publication date2008-06-01
P1433published inCellQ655814
P1476titleChemokine signaling via the CXCR2 receptor reinforces senescence
P478volume133

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Q37279893Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma.
Q39582286Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition.
Q35645149Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer
Q37225031MicroRNAs and lncRNAs in senescence: A re-view
Q24652474MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
Q35031045MicroRegulators come of age in senescence
Q35718244Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice
Q35430806Microbiome and cancer
Q34046100Mitochondria are required for pro-ageing features of the senescent phenotype.
Q38885570Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Q89453242Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
Q96303473Mitochondrial Bioenergetics and Dynamics in Secretion Processes
Q38836727Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases
Q38610456Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades
Q92761412Molecular Mechanisms of Intervertebral Disc Degeneration
Q38684604Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis
Q26764941Molecular mechanisms of biological aging in intervertebral discs
Q38098383Molecular mechanisms of natural killer cell activation in response to cellular stress
Q38435673Molecular pathology endpoints useful for aging studies.
Q92689931Molecular pathways of senescence regulate placental structure and function
Q26853406Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis)
Q40837123Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape.
Q33591673Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
Q91661493Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway
Q24298750NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
Q37995696NF-κB and the link between inflammation and cancer
Q27007045NF-κB in cellular senescence and cancer treatment
Q39600628NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells
Q91657956NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB
Q49150464NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model.
Q36455196NF90 coordinately represses the senescence-associated secretory phenotype
Q90680882NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Q36681455NKG2D ligands mediate immunosurveillance of senescent cells
Q30806890NOTCH1 mediates a switch between two distinct secretomes during senescence.
Q43167021NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation
Q39007737Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma
Q39179651Neuroendocrine differentiation of prostate cancer
Q37874368Never-ageing cellular senescence
Q38672946New concept: cellular senescence in pathophysiology of cholangiocarcinoma
Q55312849Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.
Q30541182Non-cell-autonomous tumor suppression by p53.
Q37877162Non-cell-autonomous tumor suppression: oncogene-provoked apoptosis promotes tumor cell senescence via stromal crosstalk.
Q36931816Noncanonical roles of the immune system in eliciting oncogene addiction
Q64096532Notch Signaling Mediates Secondary Senescence
Q35810716Novel ARF/p53-independent senescence pathways in cancer repression.
Q35203291Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy
Q64231545Nuclear pore density controls heterochromatin reorganization during senescence
Q27025985Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging
Q33987633Oncogene withdrawal engages the immune system to induce sustained cancer regression
Q59034476Oncogene- and oxidative stress-induced cellular senescence shows distinct expression patterns of proinflammatory cytokines in vascular endothelial cells
Q40159365Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function
Q37890974Oncogene-induced senescence and its role in tumor suppression.
Q37948288Oncogene-induced senescence and melanoma: where do we stand?
Q35954897Oncogene-induced senescence results in marked metabolic and bioenergetic alterations
Q52331301Oncogene-induced senescence: a double edged sword in cancer.
Q37784324Oncogene-induced senescence: the bright and dark side of the response
Q36098160Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
Q47273596Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets
Q42245179Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved.
Q35493964Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations
Q51762655Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix.
Q43074197Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence
Q33709728Overexpression of CXCR2 predicts poor prognosis in patients with colorectal cancer
Q35571285Overexpression of the transcription factor Sp1 activates the OAS-RNAse L-RIG-I pathway
Q38043545Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases
Q35080296Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6)
Q35093045PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation
Q39095801PKCη promotes senescence induced by oxidative stress and chemotherapy
Q63979688PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
Q92308016PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function
Q52727520Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Q33960475Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction
Q36206304Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway
Q47927484Pathways from senescence to melanoma: focus on MITF sumoylation.
Q37777015Pathways of oncogene-induced senescence in human melanocytic cells
Q37345878Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
Q36350770Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence
Q38235660Physiological and pathological consequences of cellular senescence.
Q39112101Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts
Q36453190Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression
Q38578680Premature aging/senescence in cancer cells facing therapy: good or bad?
Q56442935Primary Sclerosing Cholangitis
Q31170968Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies
Q37893959Pro-senescence therapy for cancer treatment
Q38573503Progeria, rapamycin and normal aging: recent breakthrough
Q37390493Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells
Q33694680Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation
Q39939523Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases
Q37762358Quality and quantity control of proteins in senescence
Q31081600Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts
Q34081008RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects
Q36382580RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence
Q26995531Radiation-Induced Bystander Response: Mechanism and Clinical Implications
Q37780778Ras-induced senescence and its physiological relevance in cancer
Q37219345RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence
Q34821265Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice
Q92825323Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window
Q28074230Redox control of senescence and age-related disease
Q41502851Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Q55238540Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma.
Q39612304Regulation of E2Fs and senescence by PML nuclear bodies.
Q50286962Regulation of IL6 transcription
Q39125504Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment
Q38028793Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers
Q37801346Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo.
Q39563697RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis
Q34306322Removing all obstacles: a critical role for p53 in promoting tissue renewal
Q39411571Repeated lipopolysaccharide stimulation induces cellular senescence in BV2 cells
Q26785908Replication Stress: A Lifetime of Epigenetic Change
Q35119267Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation
Q38030311Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD
Q26999018Roles and mechanisms of cellular senescence in regulation of tissue homeostasis
Q33897910Roles of CXCL5 on migration and invasion of liver cancer cells
Q27311403Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents
Q61810906S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α
Q34945503SASP reflects senescence.
Q39305388SASP regulation by noncoding RNA.
Q39456823SASP: Tumor Suppressor or Promoter? Yes!
Q53379943SASPense and DDRama in cancer and ageing.
Q26829351SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
Q36005375SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
Q35032227SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation
Q47135757SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes
Q39858269SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence
Q35846096Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program
Q38071216Secretion of microvesicular miRNAs in cellular and organismal aging.
Q37589120Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype
Q42060137Senescence and NFκB: A trojan horse in tumors?
Q48347290Senescence and aging: Causes, consequences, and therapeutic avenues
Q34619554Senescence and apoptosis: dueling or complementary cell fates?
Q38603571Senescence and cancer: An evolving inflammatory paradox
Q47106101Senescence and tumor suppression.
Q96431462Senescence as a therapeutically relevant response to CDK4/6 inhibitors
Q37168870Senescence at a glance
Q38132245Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas
Q39346510Senescence in Health and Disease.
Q26742060Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy
Q98771761Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
Q90271850Senescence in post-mitotic cells: a driver of ageing?
Q36903843Senescence in tumours: evidence from mice and humans
Q53206297Senescence surveillance of pre-malignant hepatocytes limits liver cancer development.
Q37372370Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action
Q36707656Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells
Q45314181Senescence-Associated Secretory Phenotype (SASP)
Q38704813Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line
Q37726658Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.
Q51353487Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.
Q29615559Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
Q37614869Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2.
Q37365177Senescence-messaging secretome: SMS-ing cellular stress
Q35080496Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis
Q89969652Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
Q34206082Senescent cells and their secretory phenotype as targets for cancer therapy.
Q33833881Senescent cells as a source of inflammatory factors for tumor progression
Q30641176Senescent cells communicate via intercellular protein transfer
Q35080064Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)
Q92626901Senescent cells in the development of cardiometabolic disease
Q93204940Senescent cells: A new Achilles' heel to exploit for cancer medicine?
Q38248803Senescent cells: SASPected drivers of age-related pathologies
Q39449103Senescent cells: an emerging target for diseases of ageing
Q34750592Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration
Q92705326Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
Q89967176Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells
Q91987095Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases
Q64286784Senolytics and senostatics as adjuvant tumour therapy
Q98612686Senotherapeutic drugs for human intervertebral disc degeneration and low back pain
Q37716132Shining the Light on Senescence Associated LncRNAs
Q33563633Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells
Q93047618Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
Q42208698Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2.
Q37480197Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.
Q49654084Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.
Q37475506Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis.
Q50286965Stimulation of IL8 transcription in senescent cells
Q52613750Strategies targeting cellular senescence.
Q35983853Stress responses affecting homeostasis of the alveolar capillary unit
Q26797288Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target
Q36761505Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2.
Q47778719Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Q44539245T-helper-1-cell cytokines drive cancer into senescence
Q37423519TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response
Q37370810TNF-α augments CXCR2 and CXCR3 to promote progression of renal cell carcinoma
Q47120758TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion
Q34477412Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies?
Q58547123Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance
Q37191935Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia
Q93165473Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression
Q36602188Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence.
Q38755341Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies?
Q38182713Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
Q39630639The BH3 mimetic ABT-737 induces cancer cell senescence.
Q38162225The Chemokine CXCL8 in Carcinogenesis and Drug Response
Q92093282The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer
Q51038697The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
Q47132545The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy.
Q37050807The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo
Q26746986The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance
Q42380380The Immortal Senescence
Q30235520The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections.
Q38346325The Intricate Interplay between Mechanisms Underlying Aging and Cancer
Q90513427The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes
Q24336758The M-type receptor PLA2R regulates senescence through the p53 pathway
Q58123198The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence
Q39018419The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence
Q51800912The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment.
Q92964915The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis
Q26778930The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation
Q49988025The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway.
Q38932691The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging
Q88286449The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer
Q92918403The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism
Q38912661The cerebral cavernous malformation 3 gene is necessary for senescence induction
Q37300974The cullin7 E3 ubiquitin ligase: a novel player in growth control
Q51495293The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis.
Q90854400The dynamic nature of senescence in cancer
Q34263645The emerging role of CXC chemokines and their receptors in cancer
Q38494393The emerging role of senescent cells in tissue homeostasis and pathophysiology
Q34288983The essence of senescence
Q34627786The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue
Q39363274The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype.
Q40394481The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.
Q26825221The impact of cellular senescence in cancer therapy: is it true or not?
Q33807763The inflammatory network: bridging senescent stroma and epithelial tumorigenesis
Q92647000The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype
Q24633454The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
Q33835864The molecular basis for ethnic variation and histological subtype differences in prostate cancer
Q38074014The mutant p53 mouse as a pre-clinical model
Q43118045The nuclear receptor NR2E1/TLX controls senescence.
Q47104071The potential of targeting Sin3B and its associated complexes for cancer therapy
Q35770438The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts
Q89999051The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP)
Q37661677The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
Q53689773The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1.
Q29620106The senescence-associated secretory phenotype: the dark side of tumor suppression
Q46316735The senescent bystander effect is caused by ROS-activated NF-κB signalling
Q47971896The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells
Q57580223The tumor suppressor ING1 contributes to epigenetic control of cellular senescence
Q30426400The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence
Q27027457Therapeutic targeting of replicative immortality
Q38756772Therapy-induced microenvironmental changes in cancer
Q34212773Therapy-induced senescence in cancer
Q37200843Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors
Q51304904Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.
Q38512280Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telo
Q38896940To clear, or not to clear (senescent cells)? That is the question
Q50088224To stay young, kill zombie cells.
Q44203711Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence
Q49959175Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence.
Q35226557Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation
Q38291542Transcriptomic analyses of the radiation response in head and neck squamous cell carcinoma subclones with different radiation sensitivity: time-course gene expression profiles and gene association networks.
Q34085659Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes
Q44368039Transmitting senescence to the cell neighbourhood
Q38218886Transplantation and inflammation: implications for the modification of chemokine function
Q34292287Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B.
Q34836052Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process
Q57285758Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment
Q42617375Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs
Q24658224Tumor self-seeding by circulating cancer cells
Q35378363Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
Q36625669Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence
Q52562886Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors.
Q88731404Two-Step Senescence-Focused Cancer Therapies
Q93101367Type 2 diabetes is associated with the accumulation of senescent T cells
Q93110569Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
Q93000927Unmasking senescence: context-dependent effects of SASP in cancer
Q57162862Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology
Q90384644Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration
Q24324021WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway
Q33869648Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis
Q39289687Wnt antagonist SFRP1 functions as a secreted mediator of senescence
Q53271766[Cellular senescence and the myth of Janus].
Q33790789cGAS is essential for cellular senescence
Q51523352hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability.
Q33962054mTOR Signaling from Cellular Senescence to Organismal Aging
Q36336689mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.
Q50130565mTOR pathway activation drives lung cell senescence and emphysema.
Q36110081mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Q24617309miR-17-92 cluster: ups and downs in cancer and aging
Q38700519p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling
Q35007977p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
Q33576299p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence
Q89783061p53's Extended Reach: The Mutant p53 Secretome
Q37194949p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
Q39677755p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase
Q36842068p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes
Q27851827p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer.

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