scholarly article | Q13442814 |
P50 | author | Ana Banito | Q55130865 |
Jesus Gil | Q55472013 | ||
Marzia Fumagalli | Q56488663 | ||
Fabrizio Daddadifagagna | Q67717903 | ||
Jonathan Melamed | Q38546667 | ||
Ana O'Loghlen | Q40036913 | ||
Eva Hernando | Q40230064 | ||
David Bernard | Q44039079 | ||
Juan Carlos Acosta | Q55130864 | ||
P2093 | author name string | Arnaud Augert | |
Nikolay Popov | |||
Selina Raguz | |||
Maria V Guijarro | |||
Yoshihiro Takatsu | |||
Celia Brown | |||
Marco Da Costa | |||
P2860 | cites work | The serial cultivation of human diploid cell strains | Q29547356 |
Tumour biology: senescence in premalignant tumours | Q42802962 | ||
P433 | issue | 6 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | 1006-1018 | |
P577 | publication date | 2008-06-01 | |
P1433 | published in | Cell | Q655814 |
P1476 | title | Chemokine signaling via the CXCR2 receptor reinforces senescence | |
P478 | volume | 133 |
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Q36665466 | Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration |
Q37054523 | Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries |
Q34485057 | Ageing induced vascular smooth muscle cell senescence in atherosclerosis |
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Q37268683 | Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix |
Q38936312 | Aging of the Liver: What This Means for Patients with HIV. |
Q34199776 | Aging, cellular senescence, and cancer |
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Q34361976 | An essential role for the immune system in the mechanism of tumor regression following targeted oncogene inactivation |
Q38275613 | An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. |
Q33819277 | Analysis of Gene Expression in Human Dermal Fibroblasts Treated with Senescence-Modulating COX Inhibitors |
Q35007125 | Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence |
Q39034212 | Anti-Apoptotic Signature in Thymic Squamous Cell Carcinomas - Functional Relevance of Anti-Apoptotic BIRC3 Expression in the Thymic Carcinoma Cell Line 1889c |
Q38924590 | Anti-angiogenic activity of macrolactin A and its succinyl derivative is mediated through inhibition of class I PI3K activity and its signaling |
Q37234146 | Antioxidant-rich leaf extract of Barringtonia racemosa significantly alters the in vitro expression of genes encoding enzymes that are involved in methylglyoxal degradation III |
Q64119661 | Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies |
Q64965022 | Astrocyte senescence: Evidence and significance. |
Q85076664 | Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis |
Q24320401 | Autophagy mediates the mitotic senescence transition |
Q43138014 | Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis |
Q92418482 | Autophagy, Cellular Aging and Age-related Human Diseases |
Q38776637 | BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance |
Q39817654 | Bacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling |
Q54962852 | Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence. |
Q50025483 | Baicalin induces cellular senescence in human colon cancer cells via upregulation of DEPP and the activation of Ras/Raf/MEK/ERK signaling. |
Q37322071 | Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms |
Q36799307 | Bclaf1 is an important NF-κB signaling transducer and C/EBPβ regulator in DNA damage-induced senescence |
Q89578028 | Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy |
Q34341006 | Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis |
Q58712798 | Biomarkers of Cellular Senescence and Skin Aging |
Q50455443 | Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. |
Q54602312 | Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo. |
Q37763785 | Bypassing cellular senescence by genetic screening tools |
Q37122948 | C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ |
Q38831684 | CBX7 and miR-9 are part of an autoregulatory loop controlling p16(INK) (4a). |
Q36069139 | CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells |
Q34983912 | CCAAT/enhancer-binding protein beta: its role in breast cancer and associations with receptor tyrosine kinases |
Q34236851 | CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β. |
Q56474401 | CD36 initiates the secretory phenotype during the establishment of cellular senescence |
Q34346803 | CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation |
Q47968104 | CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas. |
Q39549719 | CPEB control of NF-kappaB nuclear localization and interleukin-6 production mediates cellular senescence |
Q35945009 | CX3CL1 promotes breast cancer via transactivation of the EGF pathway |
Q36041701 | CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma |
Q37061263 | CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities |
Q36028820 | CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. |
Q35324646 | CXCR2 and its related ligands play a novel role in supporting the pluripotency and proliferation of human pluripotent stem cells |
Q36544886 | CXCR2 expression in tumor cells is a poor prognostic factor and promotes invasion and metastasis in lung adenocarcinoma |
Q36802150 | CXCR2 inhibition suppresses acute and chronic pancreatic inflammation |
Q52728031 | CXCR2 is a negative regulator of p21 in p53-dependent and independent manner via Akt-mediated Mdm2 in ovarian cancer. |
Q34095143 | CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis |
Q36210826 | CXCR2-CXCL1 axis is correlated with neutrophil infiltration and predicts a poor prognosis in hepatocellular carcinoma. |
Q27021588 | CXCR2: a target for pancreatic cancer treatment? |
Q51551651 | Cancer Cell Death-Inducing Radiotherapy: Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity. |
Q64075355 | Cancer-Associated Fibroblasts' Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma |
Q43639734 | Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling. |
Q41953731 | Cell biology. The TASCC of secretion |
Q35207826 | Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury |
Q37836231 | Cell cycle arrest is not senescence |
Q28301290 | Cell fusion induced by ERVWE1 or measles virus causes cellular senescence |
Q33893832 | Cell senescence in myxoid/round cell liposarcoma |
Q38214929 | Cell senescence: role in aging and age-related diseases |
Q37385995 | Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network |
Q27306356 | Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition |
Q92987473 | Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways |
Q92992735 | Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging |
Q45314176 | Cellular Senescence |
Q96303231 | Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions |
Q90417537 | Cellular Senescence as a Therapeutic Target for Age-Related Diseases: A Review |
Q89997239 | Cellular Senescence in the Kidney |
Q37721188 | Cellular Senescence is a Common Characteristic Shared by Preneoplasic and Osteo-Arthritic Tissue |
Q36096239 | Cellular features of senescence during the evolution of human and murine ductal pancreatic cancer |
Q38180648 | Cellular senescence and its effector programs |
Q33953067 | Cellular senescence and protein degradation: breaking down cancer |
Q91679739 | Cellular senescence and senescence-associated secretory phenotype via the cGAS-STING signaling pathway in cancer |
Q64081019 | Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease |
Q34035882 | Cellular senescence and the senescent secretory phenotype: therapeutic opportunities |
Q24602488 | Cellular senescence controls fibrosis in wound healing |
Q37678205 | Cellular senescence in osteoarthritis pathology. |
Q36483484 | Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling |
Q42031434 | Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease |
Q49069786 | Cellular senescence: Implications for metabolic disease. |
Q38012873 | Cellular senescence: a double-edged sword in the fight against cancer |
Q38359181 | Cellular senescence: a hitchhiker's guide. |
Q34028588 | Cellular senescence: a link between cancer and age-related degenerative disease? |
Q64272067 | Cellular senescence: a promising strategy for cancer therapy |
Q38383224 | Cellular senescence: from growth arrest to immunogenic conversion |
Q34041305 | Cellular senescence: from physiology to pathology |
Q37419484 | Cellular senescence: its role in tumor suppression and aging |
Q34777425 | Cellular senescence: putting the paradoxes in perspective |
Q37556144 | Cellular senescence: unravelling complexity |
Q26778013 | Changes in Regenerative Capacity through Lifespan |
Q35214469 | Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1. |
Q34662291 | Characterization of novel markers of senescence and their prognostic potential in cancer. |
Q39123428 | Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence in response to DNA damage. |
Q34010429 | Chemokine signaling in cancer: Implications on the tumor microenvironment and therapeutic targeting |
Q42258079 | Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis |
Q37773282 | Chemokine-chemokine receptors in cancer immunotherapy |
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Q37694068 | Chemokines and chemokine receptors: new insights into cancer-related inflammation. |
Q37455497 | Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology |
Q36906094 | Chemokines and their receptors in lung cancer progression and metastasis |
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Q37816561 | Chemokines in cancer related inflammation |
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Q34206508 | Cholangiocyte senescence by way of N-ras activation is a characteristic of primary sclerosing cholangitis |
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Q36707105 | Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression |
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Q64951418 | Coenzyme Q10 Prevents Senescence and Dysfunction Caused by Oxidative Stress in Vascular Endothelial Cells. |
Q37479882 | Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells |
Q36342896 | Combining an Aurora Kinase Inhibitor and a Death Receptor Ligand/Agonist Antibody Triggers Apoptosis in Melanoma Cells and Prevents Tumor Growth in Preclinical Mouse Models |
Q64963036 | Comparing progression molecular mechanisms between lung adenocarcinoma and lung squamous cell carcinoma based on genetic and epigenetic networks: big data mining and genome-wide systems identification. |
Q36007231 | Conserved Senescence Associated Genes and Pathways in Primary Human Fibroblasts Detected by RNA-Seq |
Q34238582 | Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation |
Q36964327 | Context-dependent effects of cellular senescence in cancer development |
Q35493953 | Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity |
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Q64106508 | Critical role of miR-10b in B-RafV600E dependent anchorage independent growth and invasion of melanoma cells |
Q60921672 | Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation |
Q39791621 | Cytokine expression and signaling in drug-induced cellular senescence. |
Q81725661 | Cytokine loops driving senescence |
Q34362994 | Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes |
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Q55255696 | DUOX1 Silencing in Mammary Cell Alters the Response to Genotoxic Stress. |
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Q39216101 | Detecting the Senescence-Associated Secretory Phenotype (SASP) by High Content Microscopy Analysis |
Q47887396 | Detection of Senescence Markers During Mammalian Embryonic Development |
Q41283621 | Developing senescence to remodel the embryo |
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Q47138550 | Dissecting cellular senescence and SASP in Drosophila |
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Q38875168 | Effect of cellular senescence on the growth of HER2-positive breast cancers. |
Q34331057 | Effects of CD14 macrophages and proinflammatory cytokines on chondrogenesis in osteoarthritic synovium-derived stem cells |
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Q90350293 | Galactose-modified duocarmycin prodrugs as senolytics |
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Q51508722 | Genome wide expression analysis of radiation-induced DNA damage responses in isogenic HCT116 p53+/+ and HCT116 p53-/- colorectal carcinoma cell lines. |
Q90242283 | Genome-wide screening identifies novel genes implicated in cellular sensitivity to BRAFV600E expression |
Q47690650 | Ginsenoside Rg3 Prevents Oxidative Stress-Induced Astrocytic Senescence and Ameliorates Senescence Paracrine Effects on Glioblastoma. |
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Q41711113 | Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer |
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Q37727739 | How to become immortal: let MEFs count the ways |
Q92853946 | Human Skin Keratinocytes on Sustained TGF-β Stimulation Reveal Partial EMT Features and Weaken Growth Arrest Responses |
Q36924396 | Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells |
Q36220716 | Human regulatory T cells induce T-lymphocyte senescence |
Q37850873 | Hypoxia and senescence: the impact of oxygenation on tumor suppression |
Q37372976 | Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression |
Q38873861 | IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2. |
Q39385037 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells |
Q38719376 | IL-15 enhances the antitumor effect of human antigen-specific CD8+ T cells by cellular senescence delay |
Q37421825 | IL-6-STAT3 signaling and premature senescence |
Q39198938 | IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. |
Q39162935 | ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth |
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Q57866862 | Identification and expression analysis of miR-144-5p and miR-130b-5p in dairy cattle |
Q35921720 | Identification and profiling of novel α1A-adrenoceptor-CXC chemokine receptor 2 heteromer. |
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Q47235526 | Identifying hub genes and potential mechanisms associated with senescence in human annulus cells by gene expression profiling and bioinformatics analysis |
Q56890107 | Immune Checkpoint Inhibition for Pancreatic Ductal Adenocarcinoma: Current Limitations and Future Options |
Q35677347 | Immune aging, dysmetabolism, and inflammation in neurological diseases |
Q37999302 | Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies |
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Q37974936 | Immunology in the clinic review series; focus on cancer: multiple roles for the immune system in oncogene addiction |
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Q39207614 | Impact of CXCL1 overexpression on growth and invasion of prostate cancer cell |
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Q58752509 | Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol |
Q37200457 | Inflammatory cytokine tumor necrosis factor alpha confers precancerous phenotype in an organoid model of normal human ovarian surface epithelial cells |
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Q38878851 | JAK-STAT signaling in cancer: From cytokines to non-coding genome. |
Q41897299 | Keeping your senescent cells under control |
Q54611511 | Klotho suppresses RIG-I-mediated senescence-associated inflammation. |
Q37138581 | Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape |
Q37492907 | Lessons from senescence: Chromatin maintenance in non-proliferating cells |
Q57285536 | Linking cellular stress responses to systemic homeostasis |
Q58697773 | Liver regeneration in aged mice: new insights |
Q37198572 | Living on a break: cellular senescence as a DNA-damage response |
Q90205004 | Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons |
Q55361477 | Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema. |
Q37299696 | Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis. |
Q36405926 | MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation |
Q35994479 | MacroH2A1 and ATM Play Opposing Roles in Paracrine Senescence and the Senescence-Associated Secretory Phenotype |
Q37125884 | Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability. |
Q42254401 | Mcl-1 regulates reactive oxygen species via NOX4 during chemotherapy-induced senescence |
Q52334786 | Mechanisms and functions of cellular senescence. |
Q38341214 | Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD. |
Q91864633 | Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling |
Q47171898 | Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective. |
Q37279893 | Mesenchymal differentiation mediated by NF-κB promotes radiation resistance in glioblastoma. |
Q39582286 | Metadherin enhances the invasiveness of breast cancer cells by inducing epithelial to mesenchymal transition. |
Q35645149 | Metformin and the ATM DNA damage response (DDR): accelerating the onset of stress-induced senescence to boost protection against cancer |
Q37225031 | MicroRNAs and lncRNAs in senescence: A re-view |
Q24652474 | MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8 |
Q35031045 | MicroRegulators come of age in senescence |
Q35718244 | Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice |
Q35430806 | Microbiome and cancer |
Q34046100 | Mitochondria are required for pro-ageing features of the senescent phenotype. |
Q38885570 | Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link? |
Q89453242 | Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence |
Q96303473 | Mitochondrial Bioenergetics and Dynamics in Secretion Processes |
Q38836727 | Mitochondrial dysfunction in inflammatory responses and cellular senescence: pathogenesis and pharmacological targets for chronic lung diseases |
Q38610456 | Modeling DNA damage-induced pneumopathy in mice: insight from danger signaling cascades |
Q92761412 | Molecular Mechanisms of Intervertebral Disc Degeneration |
Q38684604 | Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis |
Q26764941 | Molecular mechanisms of biological aging in intervertebral discs |
Q38098383 | Molecular mechanisms of natural killer cell activation in response to cellular stress |
Q38435673 | Molecular pathology endpoints useful for aging studies. |
Q92689931 | Molecular pathways of senescence regulate placental structure and function |
Q26853406 | Molecular turnover, the H3.3 dilemma and organismal aging (hypothesis) |
Q40837123 | Multidrug resistance protein 3 loss promotes tumor formation by inducing senescence escape. |
Q33591673 | Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer |
Q91661493 | Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway |
Q24298750 | NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling |
Q37995696 | NF-κB and the link between inflammation and cancer |
Q27007045 | NF-κB in cellular senescence and cancer treatment |
Q39600628 | NF-κB-dependent cytokine secretion controls Fas expression on chemotherapy-induced premature senescent tumor cells |
Q91657956 | NF-κB/Rel Transcription Factors in Pancreatic Cancer: Focusing on RelA, c-Rel, and RelB |
Q49150464 | NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. |
Q36455196 | NF90 coordinately represses the senescence-associated secretory phenotype |
Q90680882 | NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination |
Q36681455 | NKG2D ligands mediate immunosurveillance of senescent cells |
Q30806890 | NOTCH1 mediates a switch between two distinct secretomes during senescence. |
Q43167021 | NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation |
Q39007737 | Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma |
Q39179651 | Neuroendocrine differentiation of prostate cancer |
Q37874368 | Never-ageing cellular senescence |
Q38672946 | New concept: cellular senescence in pathophysiology of cholangiocarcinoma |
Q55312849 | Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy. |
Q30541182 | Non-cell-autonomous tumor suppression by p53. |
Q37877162 | Non-cell-autonomous tumor suppression: oncogene-provoked apoptosis promotes tumor cell senescence via stromal crosstalk. |
Q36931816 | Noncanonical roles of the immune system in eliciting oncogene addiction |
Q64096532 | Notch Signaling Mediates Secondary Senescence |
Q35810716 | Novel ARF/p53-independent senescence pathways in cancer repression. |
Q35203291 | Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy |
Q64231545 | Nuclear pore density controls heterochromatin reorganization during senescence |
Q27025985 | Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging |
Q33987633 | Oncogene withdrawal engages the immune system to induce sustained cancer regression |
Q59034476 | Oncogene- and oxidative stress-induced cellular senescence shows distinct expression patterns of proinflammatory cytokines in vascular endothelial cells |
Q40159365 | Oncogene-Expressing Senescent Melanocytes Up-Regulate MHC Class II, a Candidate Melanoma Suppressor Function |
Q37890974 | Oncogene-induced senescence and its role in tumor suppression. |
Q37948288 | Oncogene-induced senescence and melanoma: where do we stand? |
Q35954897 | Oncogene-induced senescence results in marked metabolic and bioenergetic alterations |
Q52331301 | Oncogene-induced senescence: a double edged sword in cancer. |
Q37784324 | Oncogene-induced senescence: the bright and dark side of the response |
Q36098160 | Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells |
Q47273596 | Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets |
Q42245179 | Oncogenic RAS-induced senescence in human primary thyrocytes: molecular effectors and inflammatory secretome involved. |
Q35493964 | Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations |
Q51762655 | Overcoming Barriers of Age to Enhance Efficacy of Cancer Immunotherapy: The Clout of the Extracellular Matrix. |
Q43074197 | Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence |
Q33709728 | Overexpression of CXCR2 predicts poor prognosis in patients with colorectal cancer |
Q35571285 | Overexpression of the transcription factor Sp1 activates the OAS-RNAse L-RIG-I pathway |
Q38043545 | Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases |
Q35080296 | Oxidative stress-induced inhibition of Sirt1 by caveolin-1 promotes p53-dependent premature senescence and stimulates the secretion of interleukin 6 (IL-6) |
Q35093045 | PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation |
Q39095801 | PKCη promotes senescence induced by oxidative stress and chemotherapy |
Q63979688 | PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells |
Q92308016 | PTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function |
Q52727520 | Paracrine cellular senescence exacerbates biliary injury and impairs regeneration. |
Q33960475 | Paracrine potential of fibroblasts exposed to cigarette smoke extract with vascular growth factor induction |
Q36206304 | Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway |
Q47927484 | Pathways from senescence to melanoma: focus on MITF sumoylation. |
Q37777015 | Pathways of oncogene-induced senescence in human melanocytic cells |
Q37345878 | Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. |
Q36350770 | Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence |
Q38235660 | Physiological and pathological consequences of cellular senescence. |
Q39112101 | Platelet-derived growth factor B induces senescence and transformation in normal human fibroblasts |
Q36453190 | Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression |
Q38578680 | Premature aging/senescence in cancer cells facing therapy: good or bad? |
Q56442935 | Primary Sclerosing Cholangitis |
Q31170968 | Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies |
Q37893959 | Pro-senescence therapy for cancer treatment |
Q38573503 | Progeria, rapamycin and normal aging: recent breakthrough |
Q37390493 | Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells |
Q33694680 | Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation |
Q39939523 | Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases |
Q37762358 | Quality and quantity control of proteins in senescence |
Q31081600 | Quantitative model of cell cycle arrest and cellular senescence in primary human fibroblasts |
Q34081008 | RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects |
Q36382580 | RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence |
Q26995531 | Radiation-Induced Bystander Response: Mechanism and Clinical Implications |
Q37780778 | Ras-induced senescence and its physiological relevance in cancer |
Q37219345 | RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence |
Q34821265 | Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice |
Q92825323 | Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window |
Q28074230 | Redox control of senescence and age-related disease |
Q41502851 | Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression. |
Q55238540 | Regulation of DNA damage repair and lipid uptake by CX3CR1 in epithelial ovarian carcinoma. |
Q39612304 | Regulation of E2Fs and senescence by PML nuclear bodies. |
Q50286962 | Regulation of IL6 transcription |
Q39125504 | Regulation of normal and leukemic stem cells through cytokine signaling and the microenvironment |
Q38028793 | Regulation of oncogene-induced cell cycle exit and senescence by chromatin modifiers |
Q37801346 | Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. |
Q39563697 | RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis |
Q34306322 | Removing all obstacles: a critical role for p53 in promoting tissue renewal |
Q39411571 | Repeated lipopolysaccharide stimulation induces cellular senescence in BV2 cells |
Q26785908 | Replication Stress: A Lifetime of Epigenetic Change |
Q35119267 | Response of human prostate cancer cells and tumors to combining PARP inhibition with ionizing radiation |
Q38030311 | Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD |
Q26999018 | Roles and mechanisms of cellular senescence in regulation of tissue homeostasis |
Q33897910 | Roles of CXCL5 on migration and invasion of liver cancer cells |
Q27311403 | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents |
Q61810906 | S100A13 promotes senescence-associated secretory phenotype and cellular senescence via modulation of non-classical secretion of IL-1α |
Q34945503 | SASP reflects senescence. |
Q39305388 | SASP regulation by noncoding RNA. |
Q39456823 | SASP: Tumor Suppressor or Promoter? Yes! |
Q53379943 | SASPense and DDRama in cancer and ageing. |
Q26829351 | SIRT1 as a therapeutic target in inflammaging of the pulmonary disease |
Q36005375 | SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice |
Q35032227 | SIRT1 suppresses the senescence-associated secretory phenotype through epigenetic gene regulation |
Q47135757 | SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes |
Q39858269 | SOCS1, a novel interaction partner of p53 controlling oncogene-induced senescence |
Q35846096 | Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program |
Q38071216 | Secretion of microvesicular miRNAs in cellular and organismal aging. |
Q37589120 | Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype |
Q42060137 | Senescence and NFκB: A trojan horse in tumors? |
Q48347290 | Senescence and aging: Causes, consequences, and therapeutic avenues |
Q34619554 | Senescence and apoptosis: dueling or complementary cell fates? |
Q38603571 | Senescence and cancer: An evolving inflammatory paradox |
Q47106101 | Senescence and tumor suppression. |
Q96431462 | Senescence as a therapeutically relevant response to CDK4/6 inhibitors |
Q37168870 | Senescence at a glance |
Q38132245 | Senescence bypass in mesenchymal stem cells: a potential pathogenesis and implications of pro-senescence therapy in sarcomas |
Q39346510 | Senescence in Health and Disease. |
Q26742060 | Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy |
Q98771761 | Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds |
Q90271850 | Senescence in post-mitotic cells: a driver of ageing? |
Q36903843 | Senescence in tumours: evidence from mice and humans |
Q53206297 | Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. |
Q37372370 | Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action |
Q36707656 | Senescence-Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells |
Q45314181 | Senescence-Associated Secretory Phenotype (SASP) |
Q38704813 | Senescence-associated IL-6 and IL-8 cytokines induce a self- and cross-reinforced senescence/inflammatory milieu strengthening tumorigenic capabilities in the MCF-7 breast cancer cell line |
Q37726658 | Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. |
Q51353487 | Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. |
Q29615559 | Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor |
Q37614869 | Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. |
Q37365177 | Senescence-messaging secretome: SMS-ing cellular stress |
Q35080496 | Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis |
Q89969652 | Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy |
Q34206082 | Senescent cells and their secretory phenotype as targets for cancer therapy. |
Q33833881 | Senescent cells as a source of inflammatory factors for tumor progression |
Q30641176 | Senescent cells communicate via intercellular protein transfer |
Q35080064 | Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS) |
Q92626901 | Senescent cells in the development of cardiometabolic disease |
Q93204940 | Senescent cells: A new Achilles' heel to exploit for cancer medicine? |
Q38248803 | Senescent cells: SASPected drivers of age-related pathologies |
Q39449103 | Senescent cells: an emerging target for diseases of ageing |
Q34750592 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration |
Q92705326 | Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells |
Q89967176 | Senolytics (DQ) Mitigates Radiation Ulcers by Removing Senescent Cells |
Q91987095 | Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases |
Q64286784 | Senolytics and senostatics as adjuvant tumour therapy |
Q98612686 | Senotherapeutic drugs for human intervertebral disc degeneration and low back pain |
Q37716132 | Shining the Light on Senescence Associated LncRNAs |
Q33563633 | Silencing of the small GTPase DIRAS3 induces cellular senescence in human white adipose stromal/progenitor cells |
Q93047618 | Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3 |
Q42208698 | Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2. |
Q37480197 | Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion. |
Q49654084 | Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. |
Q37475506 | Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis. |
Q50286965 | Stimulation of IL8 transcription in senescent cells |
Q52613750 | Strategies targeting cellular senescence. |
Q35983853 | Stress responses affecting homeostasis of the alveolar capillary unit |
Q26797288 | Stromal Fibroblast in Age-Related Cancer: Role in Tumorigenesis and Potential as Novel Therapeutic Target |
Q36761505 | Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. |
Q47778719 | Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. |
Q44539245 | T-helper-1-cell cytokines drive cancer into senescence |
Q37423519 | TGF-β and NF-κB signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response |
Q37370810 | TNF-α augments CXCR2 and CXCR3 to promote progression of renal cell carcinoma |
Q47120758 | TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion |
Q34477412 | Tackling the tumor microenvironment: what challenge does it pose to anticancer therapies? |
Q58547123 | Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance |
Q37191935 | Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia |
Q93165473 | Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression |
Q36602188 | Targeting aurora kinases limits tumour growth through DNA damage-mediated senescence and blockade of NF-κB impairs this drug-induced senescence. |
Q38755341 | Targeting the SASP to combat ageing: Mitochondria as possible intracellular allies? |
Q38182713 | Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence? |
Q39630639 | The BH3 mimetic ABT-737 induces cancer cell senescence. |
Q38162225 | The Chemokine CXCL8 in Carcinogenesis and Drug Response |
Q92093282 | The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer |
Q51038697 | The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State? |
Q47132545 | The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy. |
Q37050807 | The Effect of MCP-1/CCR2 on the Proliferation and Senescence of Epidermal Constituent Cells in Solar Lentigo |
Q26746986 | The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance |
Q42380380 | The Immortal Senescence |
Q30235520 | The Impacts of Cellular Senescence in Elderly Pneumonia and in Age-Related Lung Diseases That Increase the Risk of Respiratory Infections. |
Q38346325 | The Intricate Interplay between Mechanisms Underlying Aging and Cancer |
Q90513427 | The JAK1/2 inhibitor ruxolitinib delays premature aging phenotypes |
Q24336758 | The M-type receptor PLA2R regulates senescence through the p53 pathway |
Q58123198 | The Neuro-Immuno-Senescence Integrative Model (NISIM) on the Negative Association Between Parasympathetic Activity and Cellular Senescence |
Q39018419 | The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence |
Q51800912 | The Role of Kinase Modulators in Cellular Senescence for Use in Cancer Treatment. |
Q92964915 | The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis |
Q26778930 | The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation |
Q49988025 | The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway. |
Q38932691 | The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging |
Q88286449 | The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer |
Q92918403 | The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism |
Q38912661 | The cerebral cavernous malformation 3 gene is necessary for senescence induction |
Q37300974 | The cullin7 E3 ubiquitin ligase: a novel player in growth control |
Q51495293 | The double knockout of Bach1 and Bach2 in mice reveals shared compensatory mechanisms in regulating alveolar macrophage function and lung surfactant homeostasis. |
Q90854400 | The dynamic nature of senescence in cancer |
Q34263645 | The emerging role of CXC chemokines and their receptors in cancer |
Q38494393 | The emerging role of senescent cells in tissue homeostasis and pathophysiology |
Q34288983 | The essence of senescence |
Q34627786 | The expression and prognostic impact of CXC-chemokines in stage II and III colorectal cancer epithelial and stromal tissue |
Q39363274 | The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. |
Q40394481 | The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. |
Q26825221 | The impact of cellular senescence in cancer therapy: is it true or not? |
Q33807763 | The inflammatory network: bridging senescent stroma and epithelial tumorigenesis |
Q92647000 | The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype |
Q24633454 | The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing |
Q33835864 | The molecular basis for ethnic variation and histological subtype differences in prostate cancer |
Q38074014 | The mutant p53 mouse as a pre-clinical model |
Q43118045 | The nuclear receptor NR2E1/TLX controls senescence. |
Q47104071 | The potential of targeting Sin3B and its associated complexes for cancer therapy |
Q35770438 | The prognostic significance of CXCL1 hypersecretion by human colorectal cancer epithelia and myofibroblasts |
Q89999051 | The role of lamin B receptor in the regulation of senescence-associated secretory phenotype (SASP) |
Q37661677 | The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration |
Q53689773 | The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1. |
Q29620106 | The senescence-associated secretory phenotype: the dark side of tumor suppression |
Q46316735 | The senescent bystander effect is caused by ROS-activated NF-κB signalling |
Q47971896 | The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells |
Q57580223 | The tumor suppressor ING1 contributes to epigenetic control of cellular senescence |
Q30426400 | The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence |
Q27027457 | Therapeutic targeting of replicative immortality |
Q38756772 | Therapy-induced microenvironmental changes in cancer |
Q34212773 | Therapy-induced senescence in cancer |
Q37200843 | Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors |
Q51304904 | Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. |
Q38512280 | Tissue formation and tissue engineering through host cell recruitment or a potential injectable cell-based biocomposite with replicative potential: Molecular mechanisms controlling cellular senescence and the involvement of controlled transient telo |
Q38896940 | To clear, or not to clear (senescent cells)? That is the question |
Q50088224 | To stay young, kill zombie cells. |
Q44203711 | Transcriptional factor HBP1 targets P16(INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence |
Q49959175 | Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence. |
Q35226557 | Transcriptional repression of Sin3B by Bmi-1 prevents cellular senescence and is relieved by oncogene activation |
Q38291542 | Transcriptomic analyses of the radiation response in head and neck squamous cell carcinoma subclones with different radiation sensitivity: time-course gene expression profiles and gene association networks. |
Q34085659 | Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes |
Q44368039 | Transmitting senescence to the cell neighbourhood |
Q38218886 | Transplantation and inflammation: implications for the modification of chemokine function |
Q34292287 | Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. |
Q34836052 | Trefoil factor 1 acts to suppress senescence induced by oncogene activation during the cellular transformation process |
Q57285758 | Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment |
Q42617375 | Tumor dormancy, oncogene addiction, cellular senescence, and self-renewal programs |
Q24658224 | Tumor self-seeding by circulating cancer cells |
Q35378363 | Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype |
Q36625669 | Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence |
Q52562886 | Tumor-independent host secretomes induced by angiogenesis and immune-checkpoint inhibitors. |
Q88731404 | Two-Step Senescence-Focused Cancer Therapies |
Q93101367 | Type 2 diabetes is associated with the accumulation of senescent T cells |
Q93110569 | Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role |
Q93000927 | Unmasking senescence: context-dependent effects of SASP in cancer |
Q57162862 | Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology |
Q90384644 | Vimentin Plays a Crucial Role in Fibroblast Ageing by Regulating Biophysical Properties and Cell Migration |
Q24324021 | WNT16B is a new marker of cellular senescence that regulates p53 activity and the phosphoinositide 3-kinase/AKT pathway |
Q33869648 | Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis |
Q39289687 | Wnt antagonist SFRP1 functions as a secreted mediator of senescence |
Q53271766 | [Cellular senescence and the myth of Janus]. |
Q33790789 | cGAS is essential for cellular senescence |
Q51523352 | hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability. |
Q33962054 | mTOR Signaling from Cellular Senescence to Organismal Aging |
Q36336689 | mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis. |
Q50130565 | mTOR pathway activation drives lung cell senescence and emphysema. |
Q36110081 | mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype |
Q24617309 | miR-17-92 cluster: ups and downs in cancer and aging |
Q38700519 | p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling |
Q35007977 | p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype |
Q33576299 | p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence |
Q89783061 | p53's Extended Reach: The Mutant p53 Secretome |
Q37194949 | p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells |
Q39677755 | p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase |
Q36842068 | p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes |
Q27851827 | p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. |
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