DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation

scientific article published on 14 January 2020

DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ISCI.2020.100838
P932PMC publication ID7000804
P698PubMed publication ID32058953

P2093author name stringCatrin Pritchard
Peter D Adams
Tony McBryan
Karen Blyth
Andrew Hodges
Douglas J MacKenzie
Claire Reid
Neil A Robertson
Gintare Sendzikaite
Hazel Cruickshanks
Iqbal Rather
P2860cites workComprehensive molecular characterization of human colon and rectal cancerQ24630415
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.Q27852431
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory networkQ27863386
Creation of human tumour cells with defined genetic elementsQ28141602
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotypeQ28247866
Chemokine signaling via the CXCR2 receptor reinforces senescenceQ28283948
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortalQ28288215
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencingQ28505145
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancerQ29614277
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomasQ29616243
BRAFE600-associated senescence-like cell cycle arrest of human naeviQ29619550
Non-Cell-Autonomous Tumor Suppression by p53Q30541182
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancerQ33837632
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and agingQ33946993
Enumeration of the simian virus 40 early region elements necessary for human cell transformationQ34117528
Suppression of intestinal neoplasia by deletion of Dnmt3bQ34563186
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancerQ34876473
A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumorsQ35649378
B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P.Q35677252
Genome-scale analysis of aberrant DNA methylation in colorectal cancerQ35694387
Epigenetics and colorectal cancerQ36081553
The consensus molecular subtypes of colorectal cancerQ36258187
Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanomaQ36563162
The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium.Q36673761
Genomic Correlates of Immune-Cell Infiltrates in Colorectal CarcinomaQ36850230
Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancerQ36891683
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancerQ37185561
Wnt signaling potentiates nevogenesisQ37218527
Regulation of RAF protein kinases in ERK signallingQ38439535
Senescent cells harbour features of the cancer epigenome.Q39056256
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancerQ39066439
Senescence in Health and Disease.Q39346510
V600EBraf induces gastrointestinal crypt senescence and promotes tumour progression through enhanced CpG methylation of p16INK4aQ42059658
Tumour biology: senescence in premalignant tumoursQ42802962
Tissue-specific and inducible Cre-mediated recombination in the gut epitheliumQ44999476
Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancerQ46578998
Oncogene-induced senescence as an initial barrier in lymphoma developmentQ46634165
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomasQ47306076
Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E.Q47932420
Senescence and aging: Causes, consequences, and therapeutic avenuesQ48347290
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal CancerQ50116991
Senescence surveillance of pre-malignant hepatocytes limits liver cancer developmentQ53206297
Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancerQ53260087
Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancerQ54614277
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progressionQ58613225
Poor Survival Associated with theBRAFV600E Mutation in Microsatellite-Stable Colon CancersQ60673656
BRAF and KRAS Mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation statusQ80873452
Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylationQ81001994
The Origin of CIMP, At LastQ91503270
DNA Hypermethylation Encroachment at CpG Island Borders in Cancer Is Predisposed by H3K4 Monomethylation PatternsQ91503309
Aging-like Spontaneous Epigenetic Silencing Facilitates Wnt Activation, Stemness, and BrafV600E-Induced TumorigenesisQ91503317
Targeting Alterations in the RAF-MEK PathwayQ91632717
P433issue2
P921main subjectintestinal cancerQ18553796
P304page(s)100838
P577publication date2020-01-14
P1476titleDNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation
P478volume23

Search more.