The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells

scientific article published on 22 April 2019

The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells is …
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scholarly articleQ13442814

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P356DOI10.1038/S41590-019-0376-3
P932PMC publication ID6724213
P698PubMed publication ID31011187

P50authorMark ShlomchikQ29887913
P2093author name stringWei Luo
Florian Weisel
Nikita Trivedi
Richard T Cattley
Laura Conter
William Hawse
Daniel Wikenheiser
P2860cites workNIH Image to ImageJ: 25 years of image analysisQ23319322
Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent mannerQ24298269
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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
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SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificityQ28262782
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
B cell receptor signal transduction in the GC is short-circuited by high phosphatase activityQ28680673
Universal sample preparation method for proteome analysisQ29615662
Src family kinases: regulation of their activities, levels and identification of new pathwaysQ30157744
Germinal center B cells recognize antigen through a specialized immune synapse architecture.Q30784700
Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteinsQ33769047
B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells.Q49361450
PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones.Q50546858
Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase.Q50931710
The FOXO1 Transcription Factor Instructs the Germinal Center Dark Zone Program.Q53259671
Putting on the Brakes: Regulatory Kinases and Phosphatases Maintaining B Cell Anergy.Q55223778
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cellsQ56901500
T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reactionQ59071961
Antigen receptor-induced signal transduction imbalances associated with the negative selection of immature B cellsQ74595851
Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZQ33854063
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BTK regulates PtdIns-4,5-P2 synthesis: importance for calcium signaling and PI3K activity.Q34276397
Large-scale gene function analysis with the PANTHER classification systemQ34358449
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Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergyQ35596278
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).Q35879604
B cell expression of the SH2-containing inositol 5-phosphatase (SHIP-1) is required to establish anergy to high affinity, proteinacious autoantigensQ35930409
Cutting Edge: Redox Signaling Hypersensitivity Distinguishes Human Germinal Center B CellsQ35931403
PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.Q36244792
Germinal center initiation, variable gene region hypermutation, and mutant B cell selection without detectable immune complexes on follicular dendritic cellsQ36368941
A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma CellsQ36494525
Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cellsQ36863105
New insights into the early molecular events underlying B cell activationQ37164839
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory responseQ37322165
Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.Q37529252
PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domainsQ37596231
BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesisQ37761495
The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.Q38341764
Germinal Center B Cell DynamicsQ38960786
Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate DecisionsQ40225596
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center.Q40228154
Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control RegionQ41159372
Cutting edge: An in vivo reporter reveals active B cell receptor signaling in the germinal center.Q41976378
The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligationQ42528491
Autonomous membrane IgE signaling prevents IgE-memory formationQ42808939
The proto-oncogene MYC is required for selection in the germinal center and cyclic reentryQ43091743
Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cellsQ43097047
Membrane cholesterol content accounts for developmental differences in surface B cell receptor compartmentalization and signalingQ46477086
A PIP2-derived amplification loop fuels the sustained initiation of B cell activationQ47390412
ICAMs support B cell interactions with T follicular helper cells and promote clonal selection.Q47759018
B cell development under the condition of allelic inclusion.Q48053216
Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells.Q48222701
Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and functionQ48276336
TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation ProgramsQ48297997
P4510describes a project that usesImageJQ1659584
P433issue6
P304page(s)736-746
P577publication date2019-04-22
P1433published inNature ImmunologyQ1071725
P1476titleThe AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells
P478volume20