| P50 | author | Maciej Wiznerowicz | Q90207653 |
| | Alan B. Northrup | Q108812188 |
| P2093 | author name string | An Chi | |
| | Youwei Yan | |
| | Sanjeev K Munshi | |
| | Anke Klippel | |
| | Lixia Li | |
| | Manfred Kraus | |
| | Ekaterina V Bobkova | |
| | Heike Keilhack | |
| | Uwe Mueller | |
| | Sriram Sathyanarayanan | |
| | Jannik N Andersen | |
| | Alexander A Szewczak | |
| | Bart A Lutterbach | |
| | Bo-Sheng Pan | |
| | Brian Dolinski | |
| | Kumiko Nagashima | |
| | Albert H Chen | |
| | Peter Blume-Jensen | |
| | Sujal Deshmukh | |
| | Zangwei Xu | |
| | Youyuan Xu | |
| | Thi Nguyen | |
| | Stuart D Shumway | |
| | Victoria Richon | |
| | Cloud Paweletz | |
| | Roy Pollock | |
| | Timothy Allison | |
| P2860 | cites work | PDK1, the master regulator of AGC kinase signal transduction | Q24297416 |
| | Survival of cancer cells is maintained by EGFR independent of its kinase activity | Q24309274 |
| | Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B | Q24309564 |
| | P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 |
| | The protein kinase complement of the human genome | Q24324497 |
| | 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase | Q24336639 |
| | The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 |
| | A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation | Q24534951 |
| | PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase | Q24563328 |
| | The selectivity of protein kinase inhibitors: a further update | Q24654622 |
| | Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity | Q24676926 |
| | Structural mechanism for STI-571 inhibition of abelson tyrosine kinase | Q27627097 |
| | Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site | Q27638349 |
| | Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition | Q27641764 |
| | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity | Q27644970 |
| | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517 | Q27645157 |
| | Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance | Q27650096 |
| | Small Molecule Recognition of c-Src via the Imatinib-Binding Conformation | Q27652602 |
| | Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF | Q28251989 |
| | Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition | Q28474624 |
| | Scaffolding function of PAK in the PDK1-Akt pathway | Q28570522 |
| | The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Q29547302 |
| | mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt | Q29547767 |
| | PI3K pathway alterations in cancer: variations on a theme | Q29615530 |
| | Rational design of inhibitors that bind to inactive kinase conformations | Q29617558 |
| | Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity | Q29618117 |
| | 3-phosphoinositide-dependent protein kinase-1 (PDK1) promotes invasion and activation of matrix metalloproteinases | Q33237192 |
| | UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium | Q33375423 |
| | Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1. | Q33509961 |
| | Efficient identification of novel leads by dynamic focused screening: PDK1 case stud | Q33538837 |
| | ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini | Q34187916 |
| | Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis | Q34789986 |
| | Small-molecule inhibitors of PDK1. | Q34869089 |
| | AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer | Q34990362 |
| | Signalling by PI3K isoforms: insights from gene-targeted mice. | Q36092041 |
| | Building mammalian signalling pathways with RNAi screens | Q36404147 |
| | Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells | Q36508937 |
| | Tuning silence: conditional systems for RNA interference | Q36575390 |
| | Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer | Q36614997 |
| | Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells | Q36865347 |
| | Drug discovery approaches targeting the PI3K/Akt pathway in cancer | Q37270455 |
| | 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma | Q37307044 |
| | Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases | Q38525479 |
| | Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation | Q39869345 |
| | OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma | Q39916403 |
| | PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. | Q40023259 |
| | Activation of PI3K-Akt signaling pathway promotes prostate cancer cell invasion | Q40123342 |
| | Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis | Q40231706 |
| | In vivo role of the phosphate groove of PDK1 defined by knockin mutation | Q40362971 |
| | Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. | Q40445871 |
| | Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi. | Q40469795 |
| | Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells | Q40494536 |
| | From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors | Q40543789 |
| | GeneBlocs are powerful tools to study and delineate signal transduction processes that regulate cell growth and transformation | Q40712978 |
| | Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure | Q41824865 |
| | Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation | Q42823745 |
| | Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator | Q43786822 |
| | Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor | Q43948616 |
| | The survival pathways phosphatidylinositol-3 kinase (PI3-K)/phosphoinositide-dependent protein kinase 1 (PDK1)/Akt modulate liver regeneration through hepatocyte size rather than proliferation. | Q46208944 |
| | Highly prevalent genetic alterations in receptor tyrosine kinases and phosphatidylinositol 3-kinase/akt and mitogen-activated protein kinase pathways in anaplastic and follicular thyroid cancers | Q46585245 |
| | Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model | Q46595969 |
| | The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor | Q46713383 |
| | Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice | Q46768791 |
| | The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells | Q57272881 |
| | Application of a human tumor colony-forming assay to new drug screening | Q70084884 |
| | Clonogenic assay with established human tumour xenografts: correlation of in vitro to in vivo activity as a basis for anticancer drug discovery | Q80032618 |
| | Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors | Q80249404 |
| P4510 | describes a project that uses | ImageQuant | Q112270642 |
| P433 | issue | 8 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| | pharmacology | Q128406 |
| | allosteric inhibitor | Q70361704 |
| P304 | page(s) | 6433-48 | |
| P577 | publication date | 2011-02-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells: CHARACTERIZATION OF A SELECTIVE ALLOSTERIC KINASE INHIBITOR | |
| P478 | volume | 286 | |