USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer.

scientific article published on 14 June 2019

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/S13046-019-1262-4
P932PMC publication ID6570860
P698PubMed publication ID31200745

P2093author name stringXiaolu Cui
Chiyuan Piao
Chuize Kong
Xuyong Lin
Xiaojun Man
Yuanjun Jiang
P2860cites workBladder Cancer Incidence and Mortality: A Global Overview and Recent Trends.Q38876950
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML networkQ39948774
Improving microRNA target prediction by modeling with unambiguously identified microRNA-target pairs from CLIP-ligation studiesQ40130973
Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.Q40615729
The PTEN tumor suppressor protein inhibits tumor necrosis factor-induced nuclear factor kappa B activityQ40805561
Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathwayQ40817321
Nongenomic Mechanisms of PTEN RegulationQ42218359
Molecular pathways: next-generation immunotherapy--inhibiting programmed death-ligand 1 and programmed death-1.Q44204596
MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cellsQ45872881
The tumor suppressor phosphatase and tensin homolog protein (PTEN) is negatively regulated by NF-κb p50 homodimers and involves histone 3 methylation/deacetylation in UROtsa cells chronically exposed to monomethylarsonous acidQ47930560
Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients.Q54583947
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesQ60142201
High levels of phosphatase and tensin homolog expression are associated with tumor progression, tumor recurrence, and systemic metastases in pT1 urothelial carcinoma of the bladder: a tissue microarray study of 156 patients treated by transurethralQ85804519
Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018Q90903275
Ubiquitination regulates PTEN nuclear import and tumor suppressionQ24292946
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Regulation of MITF stability by the USP13 deubiquitinaseQ24318832
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13Q24338972
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Regulation of ubiquitin-dependent processes by deubiquitinating enzymesQ28257517
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancerQ29617772
NF-kappaB at the crossroads of life and deathQ29619302
PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunitQ30308560
starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq dataQ30705717
USP13 regulates the RAP80-BRCA1 complex dependent DNA damage responseQ33770883
Suppression of PTEN expression by NF-kappa B prevents apoptosisQ35544303
The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studiesQ35638497
Focus on bladder cancerQ35868630
Urothelial tumorigenesis: a tale of divergent pathwaysQ36234720
PTEN at a glanceQ36452913
Post-translational regulation of PTEN.Q37270440
Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motifQ37403837
Higher methylation intensity induced by EBV LMP1 via NF-κB/DNMT3b signaling contributes to silencing of PTEN geneQ37457770
Amplification of USP13 drives ovarian cancer metabolismQ37465116
miR-130b, an onco-miRNA in bladder cancer, is directly regulated by NF-κB and sustains NF-κB activation by decreasing Cylindromatosis expressionQ37565531
Deubiquitylation and stabilization of PTEN by USP13Q37633952
Molecular analysis of PTEN and MXI1 in primary bladder carcinomaQ38307065
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses.Q38667837
A review on the evolution of PD-1/PD-L1 immunotherapy for bladder cancer: The future is now.Q38755773
P433issue1
P304page(s)259
P577publication date2019-06-14
P1433published inJournal of Experimental & Clinical Cancer ResearchQ13739415
P1476titleUSP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer.
P478volume38

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cites work (P2860)
Q90321041Candesartan ameliorates vascular smooth muscle cell proliferation via regulating miR-301b/STAT3 axis
Q98181672Molecular profiling of immune cell-enriched Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) interacting protein USP13
Q91634088Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway
Q98283567USP13 controls the stability of Aurora B impacting progression through the cell cycle
Q97652757Ubiquitination and deubiquitination of MCL1 in cancer: deciphering chemoresistance mechanisms and providing potential therapeutic options