Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin

scientific article published on 11 June 2012

Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/ONC.2012.234
P932PMC publication ID3671600
P698PubMed publication ID22689060
P5875ResearchGate publication ID225296815

P50authorMichele VitoloQ43170010
Edward H ChoQ56850259
P2093author name stringS S Martin
K Thompson
J R Yoon
A E Boggs
E M Balzer
M A Matrone
R A Whipple
P2860cites workSignaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinaseQ22010473
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Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusionQ24300777
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Phosphoinositide binding regulates alpha-actinin dynamics: mechanism for modulating cytoskeletal remodeling.Q40458329
Cofilin promotes actin polymerization and defines the direction of cell motilityQ40561188
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Form and function in protein dephosphorylationQ41193500
ADF/cofilin regulates actomyosin assembly through competitive inhibition of myosin II binding to F-actinQ42056524
Detection of a sequence involved in actin-binding and phosphoinositide-binding in the N-terminal side of cofilinQ42595953
Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphateQ42812246
PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancerQ43700699
PDZ proteins organize synaptic signaling pathwaysQ46332824
Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides.Q48968611
Widespread loss of gelsolin in breast cancers of humans, mice, and rats.Q51194136
Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium.Q52551217
Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion.Q52559414
Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase.Q54476575
Comparing the prognostic value of PTEN and Akt expression with the Mitotic Activity Index in adjuvant chemotherapy-treated node-negative breast cancer patients aged <55 years.Q54854233
Myosin IIA regulates cell motility and actomyosin–microtubule crosstalkQ58022519
Inhibition of the ATP-dependent interaction of actin and myosin by the catalytic domain of the myosin light chain kinase of smooth muscle: possible involvement in smooth muscle relaxationQ74526016
Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancyQ77870252
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshotQ24310778
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinaseQ24336074
Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competenceQ24538594
MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migrationQ24541390
Knockin of mutant PIK3CA activates multiple oncogenic pathwaysQ24657412
Phosphoinositides in cell regulation and membrane dynamicsQ27861051
Metastasis: a question of life or deathQ28242176
Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
Dissemination and growth of cancer cells in metastatic sitesQ29555846
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
Vimentin filaments support extension of tubulin-based microtentacles in detached breast tumor cellsQ30494216
Detyrosinated microtubule protrusions in suspended mammary epithelial cells promote reattachmentQ30502337
Microtentacles tip the balance of cytoskeletal forces in circulating tumor cellsQ30597735
Resolving the role of actoymyosin contractility in cell microrheologyQ33503632
Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cellsQ34103923
From latent disseminated cells to overt metastasis: genetic analysis of systemic breast cancer progressionQ34206149
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.Q34477787
Antimitotic chemotherapeutics promote adhesive responses in detached and circulating tumor cellsQ34991861
Tensegrity I. Cell structure and hierarchical systems biologyQ35077452
Biomechanical interactions of cancer cells with the microvasculature during hematogenous metastasisQ35477669
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.Q35757521
Regulation of Bcl-2 proteins during anoikis and amorphosis.Q35832745
Cytoskeletal regulation: rich in lipidsQ35887301
Cell migration in tumorsQ36228553
Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry.Q36285541
Cofilin phosphatases and regulation of actin dynamicsQ36336031
Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cellsQ36379962
Models, mechanisms and clinical evidence for cancer dormancyQ36844303
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancerQ37187915
Cortical F-actin, the exocytic mode, and neuropeptide release in mouse chromaffin cells is regulated by myristoylated alanine-rich C-kinase substrate and myosin IIQ37246337
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cellsQ37437827
Expression of E-cadherin and catenins in invasive mammary carcinomasQ38476194
P4510describes a project that usesImageJQ1659584
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)2200-2210
P577publication date2012-06-11
P1433published inOncogeneQ1568657
P1476titleLoss of PTEN induces microtentacles through PI3K-independent activation of cofilin
P478volume32

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cites work (P2860)
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Q55404029Overexpressing TPTE2 (TPIP), a homolog of the human tumor suppressor gene PTEN, rescues the abnormal phenotype of the PTEN-/- mutant.
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Q30408828ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells
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Q42371620Slingshot-1L, a cofilin phosphatase, induces primary breast cancer metastasis
Q36546319The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence
Q35151075α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration

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