Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing

scientific article

Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0176683
P932PMC publication ID5413031
P698PubMed publication ID28464039

P50authorTodd WaldmanQ96147120
P2093author name stringC David James
Jung-Sik Kim
Victoria K Hill
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Mechanism of activation of protein kinase B by insulin and IGF-1Q24309528
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Comprehensive genomic characterization defines human glioblastoma genes and core pathwaysQ24656128
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53Q24657532
AKT/PKB signaling: navigating downstreamQ24657857
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Integrative clinical genomics of advanced prostate cancerQ27853170
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancerQ28251814
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificityQ28262782
Integrated genomic characterization of endometrial carcinomaQ28289962
The somatic genomic landscape of glioblastomaQ28300185
Mutational landscape and significance across 12 major cancer typesQ28300353
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assayQ28611936
The functions and regulation of the PTEN tumour suppressorQ29615536
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
PTEN: a tumour suppressor that functions as a phospholipid phosphataseQ33594251
Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressorQ33863959
PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndromeQ34504165
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.Q34742581
PTEN hamartoma tumor syndromes.Q34824223
Subtle variations in Pten dose determine cancer susceptibilityQ35055350
Mechanistic analysis of a DNA damage-induced, PTEN-dependent size checkpoint in human cellsQ35096583
Mutational inactivation of STAG2 causes aneuploidy in human cancerQ36029045
Epitope tagging of endogenous genes in diverse human cell linesQ36959684
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathwaysQ37425090
PTEN function: the long and the short of it.Q38198345
A new class of cancer-associated PTEN mutations defined by membrane translocation defectsQ38952567
Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathwayQ39759975
Characterization of two new permanent glioma cell lines 8-MG-BA and 42-MG-BA.Q41038971
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.Q42807109
Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes.Q42814165
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Somatic mutations of PTEN in glioblastoma multiformeQ48618632
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectglioblastomaQ282142
P304page(s)e0176683
P577publication date2017-05-02
P1433published inPLOS OneQ564954
P1476titleCorrection of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing
P478volume12

Reverse relations

described by source (P1343)
Q5460300442-MG-BA
Q52609889T98G

cites work (P2860)
Q90641009AEBP1 down regulation induced cell death pathway depends on PTEN status of glioma cells
Q47136308Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications
Q92445464Detection and Correlation of Single and Concomitant TP53, PTEN, and CDKN2A Alterations in Gliomas
Q93052506Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene

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