| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Deborah H Anderson | |
| Dielle E Whitecross | |||
| Jeremy D S Marshall | |||
| Paul Mellor | |||
| P2860 | cites work | Insight into the PTEN - p85α interaction and lipid binding properties of the p85α BH domain | Q60960584 |
| Oncogenic mutations of PIK3CA in human cancers | Q80826963 | ||
| Caveolin-1 activates Rab5 and enhances endocytosis through direct interaction | Q82626493 | ||
| OncoKB: A Precision Oncology Knowledge Base | Q88952320 | ||
| Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases - potentially novel therapeutic targets | Q91389819 | ||
| PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma | Q93159544 | ||
| The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms | Q21146412 | ||
| Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function | Q24295164 | ||
| The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins | Q24304389 | ||
| The role of receptor internalization in CD95 signaling | Q24305510 | ||
| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
| Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins | Q24338894 | ||
| A landscape of driver mutations in melanoma | Q24603357 | ||
| Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma | Q24607661 | ||
| COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer | Q24608391 | ||
| Targeting the PI3K signaling pathway in cancer | Q24647554 | ||
| Regulation of small GTPases by GEFs, GAPs, and GDIs | Q26825750 | ||
| Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
| Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit | Q27646654 | ||
| The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations | Q27649316 | ||
| A frequent kinase domain mutation that changes the interaction between PI3K and the membrane | Q27657679 | ||
| p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. | Q39820138 | ||
| CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells | Q39959143 | ||
| Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration | Q39963386 | ||
| Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells | Q40033649 | ||
| Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility | Q40033725 | ||
| Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells | Q40147034 | ||
| Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit | Q27734201 | ||
| Cell migration: a physically integrated molecular process | Q27860682 | ||
| The phosphoinositide 3-kinase pathway | Q27860738 | ||
| Rab proteins as membrane organizers | Q27860861 | ||
| Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B | Q28116107 | ||
| Rab GTPases as coordinators of vesicle traffic | Q28131746 | ||
| High frequency of mutations of the PIK3CA gene in human cancers | Q28131776 | ||
| Signalling through the lipid products of phosphoinositide-3-OH kinase | Q28241516 | ||
| The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data | Q28266682 | ||
| Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas | Q28271306 | ||
| Oncogenic mutations of PIK3CA in human cancers | Q28284802 | ||
| Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal | Q28288215 | ||
| A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. | Q28305284 | ||
| Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit | Q28379354 | ||
| Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha | Q28616168 | ||
| Rac GTPase interacts specifically with phosphatidylinositol 3-kinase | Q28646209 | ||
| A gene expression signature predicts survival of patients with stage I non-small cell lung cancer | Q28764568 | ||
| The mutational landscape of head and neck squamous cell carcinoma | Q29614654 | ||
| PI3K pathway alterations in cancer: variations on a theme | Q29615530 | ||
| Targeting the phosphoinositide 3-kinase pathway in cancer | Q29615809 | ||
| RHO-GTPases and cancer | Q29616099 | ||
| Assembly and Molecular Architecture of the Phosphoinositide 3-Kinase p85α Homodimer | Q30009083 | ||
| Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium | Q30009133 | ||
| Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase | Q30156937 | ||
| Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase. | Q30175781 | ||
| Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. | Q30276221 | ||
| Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells. | Q30581938 | ||
| A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination | Q30584664 | ||
| Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85. | Q33292328 | ||
| Rho Family GTPases Bind to Phosphoinositide Kinases | Q33292549 | ||
| Rab5 mediates caspase-8-promoted cell motility and metastasis | Q33597844 | ||
| GTPase activating protein function of p85 facilitates uptake and recycling of the beta1 integrin | Q33615852 | ||
| Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design | Q33653223 | ||
| Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase | Q33895741 | ||
| Caspase-8 promotes cell motility and calpain activity under nonapoptotic conditions | Q40291610 | ||
| Differential expression of RAB5A in human lung adenocarcinoma cells with different metastasis potential | Q40938132 | ||
| Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton | Q41334369 | ||
| Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion. | Q41432611 | ||
| Functional analysis of PIK3CA gene mutations in human colorectal cancer | Q42814030 | ||
| Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking | Q42825426 | ||
| Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles | Q42825650 | ||
| A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells | Q42834760 | ||
| Oncogenic signaling of class I PI3K isoforms | Q46902768 | ||
| Consequences of Rab GTPase dysfunction in genetic or acquired human diseases | Q47294747 | ||
| α5β1 integrin trafficking and Rac activation are regulated by APPL1 in a Rab5-dependent manner to inhibit cell migration. | Q48183671 | ||
| The EGFR odyssey - from activation to destruction in space and time. | Q48228631 | ||
| Accelerating Discovery of Functional Mutant Alleles in Cancer | Q49790712 | ||
| Comprehensive Characterization of Cancer Driver Genes and Mutations. | Q52602398 | ||
| Systematic Functional Annotation of Somatic Mutations in Cancer. | Q52658141 | ||
| Patient-derived mutations within the N-terminal domains of p85α impact PTEN or Rab5 binding and regulation. | Q55312107 | ||
| Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia | Q57220263 | ||
| Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha | Q34100548 | ||
| Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex | Q34101673 | ||
| Biogenesis of the sorting endosome: the role of Rab5. | Q34156726 | ||
| Phosphatidylinositol 3-kinase: the oncoprotein | Q34203861 | ||
| PIK3R1 underexpression is an independent prognostic marker in breast cancer | Q34478129 | ||
| Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane | Q34574432 | ||
| Structure of small G proteins and their regulators | Q34627883 | ||
| The PTEN-PI3K pathway: of feedbacks and cross-talks | Q34828662 | ||
| Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. | Q34882666 | ||
| Identification of mutations in distinct regions of p85 alpha in urothelial cancer | Q35075756 | ||
| MicroRNA-130a inhibits cell proliferation, invasion and migration in human breast cancer by targeting the RAB5A. | Q35144855 | ||
| Membrane-binding and activation mechanism of PTEN. | Q35145882 | ||
| Knockdown of Rab5a expression decreases cancer cell motility and invasion through integrin-mediated signaling pathway | Q35231177 | ||
| High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability | Q35275603 | ||
| The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling | Q35479152 | ||
| Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases | Q35579635 | ||
| Not just a sink: endosomes in control of signal transduction | Q35840127 | ||
| Increased expression of Rab5A predicts metastasis and poor prognosis in colorectal cancer patients. | Q35919227 | ||
| Rho GTPase expression in tumourigenesis: evidence for a significant link | Q36126283 | ||
| The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signaling | Q36294561 | ||
| An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway | Q36320962 | ||
| Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1. | Q36323102 | ||
| Role of the PI3K regulatory subunit in the control of actin organization and cell migration | Q36366957 | ||
| New insights into PTEN. | Q37011116 | ||
| Caspase 8 promotes peripheral localization and activation of Rab5. | Q37021567 | ||
| Rho GTPases in cancer cell biology | Q37156024 | ||
| Class I PI3K in oncogenic cellular transformation. | Q37270450 | ||
| Drug discovery approaches targeting the PI3K/Akt pathway in cancer | Q37270455 | ||
| Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis. | Q37301875 | ||
| Phosphoinositide 3-kinases in cell migration | Q37340915 | ||
| Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants | Q37453427 | ||
| The structural basis of PI3K cancer mutations: from mechanism to therapy | Q37586861 | ||
| Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression | Q37707088 | ||
| The regulation of class IA PI 3-kinases by inter-subunit interactions | Q37764745 | ||
| Rab5 in the regulation of cell motility and invasion. | Q37824479 | ||
| Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking | Q37968309 | ||
| Cell adhesion and its endocytic regulation in cell migration during neural development and cancer metastasis. | Q38011157 | ||
| Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment. | Q38710557 | ||
| Expression of Rab5a correlates with tumor progression in pancreatic carcinoma | Q38714543 | ||
| FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly | Q38780893 | ||
| Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway | Q38829853 | ||
| Down-regulation of Rab5 decreases characteristics associated with maintenance of cell transformation | Q38853683 | ||
| Identification of a critical tyrosine residue in caspase 8 that promotes cell migration | Q39647109 | ||
| Molecular ordering of the initial signaling events of CD95. | Q39676008 | ||
| Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation | Q39766760 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | neoplasm | Q1216998 |
| enzyme | Q8047 | ||
| Rab5 | Q29716990 | ||
| P304 | page(s) | 29 | |
| P577 | publication date | 2019-01-15 | |
| P1433 | published in | Biomolecules | Q23929963 |
| P1476 | title | Impact of p85α Alterations in Cancer | |
| P478 | volume | 9 |
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