PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors

scientific article

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1349-7006.1999.TB00763.X
P8608Fatcat IDrelease_4tuwpvxlmfaefkbbnwt2xpdvuq
P932PMC publication ID5926086
P698PubMed publication ID10363579
P5875ResearchGate publication ID12934591

P2093author name stringS Matsumoto
M Koyama
J Fujimoto
T Shiba
M Emi
H Nagai
T Tajiri
N Konishi
T Ueki
M Onda
N Kawamura
K Bando
P2860cites workP-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Mutation and cancer: statistical study of retinoblastomaQ24618185
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Antioncogenes and human cancerQ28237050
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosityQ28284646
Hepatitis B virus DNA integration in a sequence homologous to v-erb-A and steroid receptor genes in a hepatocellular carcinomaQ28287494
The 1993-94 Généthon human genetic linkage mapQ28288492
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinomaQ33493133
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinomaQ33772796
Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinomaQ34319319
Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22Q36115913
Loss of heterozygosity and analysis of mutation of p53 in hepatocellular carcinomaQ43037073
Allelotype study of primary hepatocellular carcinomaQ43578355
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomasQ48045473
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both allelesQ48379390
PTEN/MMAC1 mutations in endometrial cancers.Q53439663
Comprehensive allelotyping of human hepatocellular carcinomaQ57981015
Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancerQ67885643
Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancerQ68159719
Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomasQ69927567
Frequent genetic alterations at the distal region of chromosome 1p in human hepatocellular carcinomasQ72685147
Frequent loss of heterozygosity on chromosome 22 in hepatocellular carcinomaQ72970952
Allelotype analysis of hepatocellular carcinomaQ74029725
Five familial hypercholesterolemic kindreds in Japan with novel mutations of the LDL receptor geneQ77680094
P433issue4
P1104number of pages6
P304page(s)413-418
P577publication date1999-04-01
P1433published inJapanese Journal of Cancer ResearchQ26842384
P1476titlePTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors
P478volume90

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cites work (P2860)
Q38490789Consistent chromosome 10 rearrangements in four newly established human hepatocellular carcinoma cell lines.
Q81811800Correlation between loss of PTEN expression and PKB/AKT phosphorylation in hepatocellular carcinoma
Q39656536Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2.
Q43141122Expression of phosphatase and tensin homolog deleted on chromosome ten in liver of athymic mice with hepatocellular carcinoma and the effect of Fuzheng Jiedu Decoction
Q28204251FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ligand expression. Implications for PTEN mutation in prostate cancer
Q34611410Genetic mechanisms of hepatocarcinogenesis
Q48368105Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis
Q54503350Loss of heterozygosity on 10q23 is involved in metastatic recurrence of hepatocellular carcinoma.
Q84403214Molecular classification of hepatocellular carcinoma
Q36862768Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
Q92316075PTEN Tumor-Suppressor: The Dam of Stemness in Cancer
Q39377876PTEN: A potential prognostic marker in virus-induced hepatocellular carcinoma.
Q34966603Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
Q33392970Sequencing the full-length of the phosphatase and tensin homolog (PTEN) gene in hepatocellular carcinoma (HCC) using the 454 GS20 and Illumina GA DNA sequencing platforms
Q27002288Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
Q38635474The biology of Hepatocellular carcinoma: implications for genomic and immune therapies
Q29547860The phosphatidylinositol 3-Kinase AKT pathway in human cancer
Q24657943The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma