Antioncogenes and human cancer

scientific article

Antioncogenes and human cancer is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P819ADS bibcode1993PNAS...9010914K
P356DOI10.1073/PNAS.90.23.10914
P3181OpenCitations bibliographic resource ID3659911
P932PMC publication ID47892
P698PubMed publication ID7902574
P5875ResearchGate publication ID15295806

P2093author name stringA G Knudson
P2860cites workUbiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesisQ22122362
The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activityQ24299515
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2Q24313491
Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)Q72916321
The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressorQ24316544
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteinsQ24324729
Mendelian inheritance of familial prostate cancerQ24562051
Mutation and cancer: statistical study of retinoblastomaQ24618185
A genetic model for colorectal tumorigenesisQ27860582
Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9Q28181962
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locusQ28236741
Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumpingQ28236877
Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locusQ28242901
Genetic mapping of a locus predisposing to human colorectal cancerQ28268634
Linkage of early-onset familial breast cancer to chromosome 17q21Q28268902
Identification of a chromosome 18q gene that is altered in colorectal cancersQ28274172
APC mutations occur early during colorectal tumorigenesisQ28274764
A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutationsQ28300121
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patientsQ28300256
The neurofibromatosis type 1 gene encodes a protein related to GAPQ28301160
WT-1 is required for early kidney developmentQ28512266
The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier systemQ28513603
The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21Q28609120
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumoursQ29547697
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC geneQ29616490
Participation of p53 protein in the cellular response to DNA damageQ29618319
Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasmsQ29618586
Identification of the von Hippel-Lindau disease tumor suppressor geneQ29618644
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaQ29618817
Effects of an Rb mutation in the mouseQ29619196
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesisQ29619200
Identification and characterization of the familial adenomatous polyposis coli geneQ29620382
Microsatellite instability in cancer of the proximal colonQ29620692
Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell linesQ30502375
Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosisQ30531015
Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.Q33825340
Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p.Q34046828
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patientsQ34166560
Mutation and cancer: a model for Wilms' tumor of the kidneyQ34207334
Deletion of genes on chromosome 1 in endocrine neoplasiaQ57436791
Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumourQ59088779
No room at the p53 innQ59093958
Proliferative patterns in colonic mucosa in familial polyposisQ66908731
Retinoblastoma: a prototypic hereditary neoplasmQ67312912
Chromosomal deletion and retinoblastomaQ67839651
Cytogenetic survey of 32 cancers of the prostateQ70732843
Homozygous deletion and frequent allelic loss of chromosome 8p22 loci in human prostate cancerQ72092571
Clonal expansion of p53 mutant cells is associated with brain tumour progressionQ34233614
p53 functions as a cell cycle control protein in osteosarcomasQ34254691
Expression of recessive alleles by chromosomal mechanisms in retinoblastomaQ34264957
Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A.Q34334980
A general theory of carcinogenesisQ34744320
Neuroblastoma consensus deletion maps to 1p36.1-2.Q35175544
Constitutional 1p36 deletion in a child with neuroblastoma.Q35194318
Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s).Q35194574
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.Q35248366
Mutation and cancer: neuroblastoma and pheochromocytomaQ35569133
Stem cell regulation, tissue ontogeny, and oncogenic eventsQ35757499
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancerQ36046507
The APC gene product in normal and tumor cellsQ36203064
Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10Q36506484
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogeneQ36760672
Homozygous deletions within human chromosome band 9p21 in melanomaQ37286548
Model for the incidence of embryonal cancers: application to retinoblastomaQ37587021
p53 and the Li-Fraumeni syndromeQ40910310
Molecular characterization of the retinoblastoma susceptibility geneQ40912798
Chromosomal aberrations in human neuroblastomasQ41057218
Loss of NF1 alleles in phaeochromocytomas from patients with type I neurofibromatosisQ41093150
Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosisQ41163434
Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis: loss of heterozygosity for chromosome 17.Q41278990
Structural evidence for the authenticity of the human retinoblastoma geneQ41344591
Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cellsQ41407134
Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndromeQ41523994
Homozygous loss of the interferon genes defines the critical region on 9p that is deleted in lung cancersQ41553700
Persistent expression of the tumor suppressor gene DCC is essential for neuronal differentiationQ41605307
Guanine nucleotide biosynthesis is regulated by the cellular p53 concentrationQ41652292
Nonrandom structural and numerical chromosome changes in non-small-cell lung cancerQ41686852
Hereditary Renal-Cell Carcinoma Associated with a Chromosomal TranslocationQ41751694
Clues to the pathogenesis of familial colorectal cancerQ42622043
Rhabdomyosarcoma in children: epidemiologic study and identification of a familial cancer syndromeQ44178518
Requirement for a functional Rb-1 gene in murine developmentQ44462954
Loss of heterozygosity for 10q loci in human gliomasQ46637661
Familial brain tumourQ48097571
Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinomaQ48100816
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressorQ48129277
Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastomaQ49170554
Sporadic bilateral retinoblastoma and 13q- chromosomal deletionQ52310601
p53: a frequent target for genetic abnormalities in lung cancer.Q52486321
Relaxation of imprinted genes in human cancer.Q52545355
Association between wild type and mutant APC gene products.Q54655882
Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP).Q54674142
Absence of IFNA and IFNB genes from human malignant glioma cell lines and lack of correlation with cellular sensitivity to interferons.Q55484718
A child with 18q- syndrome and cerebellar astrocytoma.Q55489119
A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10Q55670968
Allele losses in the region 17q12-21 in familial breast and ovarian cancer involve the wild-type chromosomeQ57266956
P433issue23
P407language of work or nameEnglishQ1860
P921main subjecttumor suppressor geneQ422445
neoplasmQ1216998
cancerQ12078
P304page(s)10914-10921
P577publication date1993-12-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAntioncogenes and human cancer
P478volume90

Reverse relations

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Q73447336RB protein expression in human endometrial carcinomas--an immunohistochemical study
Q36455160RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice
Q42789357RET proto-oncogene mutations and rearrangements in endocrine diseases
Q36359897RNA-seq analysis of lung adenocarcinomas reveals different gene expression profiles between smoking and nonsmoking patients.
Q40456228Recent advances in the molecular genetics of urogenital tumors
Q35047240Regulation of tumor suppressors by nuclear-cytoplasmic shuttling
Q77454454Replication status as a possible marker for genomic instability in cells originating from genotypes with balanced rearrangements
Q40171441Retinoblastoma and the genetic theory of cancer: an old paradigm trying to survive to the evidence
Q34002981Retinoids and ovarian cancer
Q33958096Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein
Q36624071Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
Q33896232Risk assessment for possible carcinogens: a critical look
Q35929538Role of BRCA1 and BRCA2 mutations in pancreatic cancer
Q35113329Role of homologous recombination in carcinogenesis.
Q34999035Selection and analysis of spontaneous reciprocal mitotic cross-overs in Saccharomyces cerevisiae
Q59794873Sex Chromosome Effects on Male-Female Differences in Mammals
Q91592073Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility
Q45863983Somatic mosaicism and cancer: inference based on a conditional Luria-Delbrück distribution
Q73035204Somatic mutation of the PTEN/MMAC1 gene in breast cancers with microsatellite instability
Q28188697Somatic mutation: early cancer steps depend on tissue architecture
Q54417578Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.
Q48379390Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles
Q34611082Spontaneous loss of heterozygosity in diploid Saccharomyces cerevisiae cells
Q40975396Stage-specific gene expression during hepatocarcinogenesis in the rat.
Q35596587Stem cell in gastrointestinal structure and neoplastic development
Q41526922Strategies for Approaching Retinoblastoma Tumor Suppressor Gene Therapy
Q35128582Stress alters rates and types of loss of heterozygosity in Candida albicans
Q42535984Structural analysis of aberrant chromosomes that occur spontaneously in diploid Saccharomyces cerevisiae: retrotransposon Ty1 plays a crucial role in chromosomal rearrangements
Q36553686Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene
Q36573886Subunit composition determines E2F DNA-binding site specificity
Q36001068Sunlight and skin cancer: another link revealed
Q24563504Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1
Q27026264The BRCA1 Breast Cancer Suppressor: Regulation of Transport, Dynamics, and Function at Multiple Subcellular Locations
Q46192247The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
Q22009112The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors
Q33823452The NF1 somatic mutational landscape in sporadic human cancers
Q47814736The future: genetics advances in MEN1 therapeutic approaches and management strategies.
Q35660996The gastrointestinal stem cell
Q33536033The genetic basis of breast cancer and its clinical implications
Q73918278The influence of cytogenetic aberrations on gene replication in chronic lymphocytic leukemia patients
Q40041349The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen
Q34388658The linear process of somatic evolution.
Q37388054The melanoma differentiation associated gene mda-7 suppresses cancer cell growth
Q34027887The molecular genetics of colorectal cancer
Q39551053The non-coding oncogene: a case of missing DNA evidence?
Q36862486The phenotype of polycythemia due to Croatian homozygous VHL (571C>G:H191D) mutation is different from that of Chuvash polycythemia (VHL 598C>T:R200W).
Q34235680The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
Q34636999The role of individual susceptibility in cancer burden related to environmental exposure
Q24290817The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
Q37272653The von Hippel-Lindau gene: turning discovery into therapy
Q35036600The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis.
Q24564802The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
Q39431542Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells
Q41687948Transcription factor-based drug design in anticancer drug development
Q24530637Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
Q42813262Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells
Q57636194Tumor suppressor genes
Q40568235Tumor suppressor genes in molecular medicine
Q37550949Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias
Q33890086Tumour suppressor gene mutations in humans and mice: parallels and contrasts
Q33938140Tumour suppressor genes
Q74319003Two regions of deletion in 9p22- p24 in neuroblastoma are frequently observed in favorable tumors
Q41015926Two-dimensional DNA typing: A cost-effective way of analyzing complex mixtures of DNA fragments for sequence variations
Q55470193Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice.
Q24561466Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesis
Q64997482Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins.
Q73812889[Evaluation of cancer risk through genetic analysis?]
Q83190779[Germline tp53 neomutation in a patient with Li-Fraumeni syndrome and pancreatic adenocarcinoma]
Q35609031mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokine
Q57338202p16INK4a is a Prognostic Marker in Resected Ductal Pancreatic Cancer

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