scholarly article | Q13442814 |
review article | Q7318358 |
P50 | author | Jack E. Dixon | Q21165173 |
P2093 | author name string | G S Taylor | |
J T Slama | |||
M J Wishart | |||
P2860 | cites work | Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains | Q22003889 |
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region | Q22010498 | ||
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y | Q22010933 | ||
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domain | Q22253383 | ||
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase | Q22253438 | ||
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 | Q22253866 | ||
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 | Q22254000 | ||
Phosphorylation of the PTEN tail regulates protein stability and function | Q22254305 | ||
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate | Q22254632 | ||
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1 | Q22254699 | ||
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation | Q24290417 | ||
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human | Q24313350 | ||
Serine/threonine protein kinases and apoptosis. | Q33876765 | ||
Phosphoinositide signaling and the regulation of membrane trafficking in yeast | Q33899382 | ||
Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2. | Q33901232 | ||
Sac phosphatase domain proteins. | Q33914389 | ||
Cellular signaling: pivoting around PDK-1. | Q34073383 | ||
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene | Q35063217 | ||
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway | Q36396479 | ||
A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase. | Q38289397 | ||
The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila | Q39120031 | ||
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. | Q39457088 | ||
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway | Q40852967 | ||
Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression | Q40877541 | ||
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressor | Q40892936 | ||
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene | Q40896708 | ||
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. | Q40911230 | ||
Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways | Q47070325 | ||
A functional PtdIns(3)P-binding motif | Q47713511 | ||
Impaired Fas response and autoimmunity in Pten+/- mice | Q73019160 | ||
A sensitive assay for phosphoinositide phosphatases | Q73520782 | ||
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN | Q77342895 | ||
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate | Q24317714 | ||
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase | Q24322705 | ||
Association of SET domain and myotubularin-related proteins modulates growth control | Q24323057 | ||
SMART: a web-based tool for the study of genetically mobile domains | Q24515301 | ||
The PI3K-PDK1 connection: more than just a road to PKB | Q24531972 | ||
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association | Q27620298 | ||
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | Q27860985 | ||
SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. | Q27930732 | ||
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains | Q27933286 | ||
SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases | Q27934132 | ||
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation | Q28139447 | ||
Signalling through phosphoinositide 3-kinases: the lipids take centre stage | Q28141934 | ||
GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins | Q28142204 | ||
MTM1 mutations in X-linked myotubular myopathy | Q28143326 | ||
FYVE fingers bind PtdIns(3)P | Q28279043 | ||
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeast | Q28279868 | ||
Protein tyrosine phosphatases: mechanisms of catalysis and regulation | Q28288979 | ||
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | Q28306997 | ||
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN | Q28513537 | ||
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity | Q28567201 | ||
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway | Q28588309 | ||
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway | Q29616144 | ||
C2-domains, structure and function of a universal Ca2+-binding domain | Q29619459 | ||
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways. | Q30169019 | ||
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway | Q30829981 | ||
Intracellular signalling: PDK1--a kinase at the hub of things | Q33533793 | ||
PTEN: a tumour suppressor that functions as a phospholipid phosphatase | Q33594251 | ||
Pathways for phosphoinositide synthesis | Q33652651 | ||
Phosphoinositides in membrane traffic | Q33712456 | ||
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. | Q33777555 | ||
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. | Q33783562 | ||
The multiple roles of PTEN in tumor suppression | Q33849727 | ||
Protein kinases: six degrees of separation? | Q33860462 | ||
P433 | issue | 2 | |
P921 | main subject | bioinformatics | Q128570 |
P304 | page(s) | 172-181 | |
P577 | publication date | 2001-04-01 | |
P1433 | published in | Current Opinion in Cell Biology | Q13505682 |
P1476 | title | PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench | |
P478 | volume | 13 |
Q44083052 | A novel higher plant protein tyrosine phosphatase interacts with SNF1-related protein kinases via a KIS (kinase interaction sequence) domain |
Q44692371 | Analysis of the regulation of protein tyrosine phosphatases in vivo by reversible oxidation |
Q24291835 | Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity |
Q27642841 | Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome |
Q34148061 | Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4 |
Q27003427 | Defective membrane remodeling in neuromuscular diseases: insights from animal models |
Q34786070 | Disease-related Myotubularins Function in Endocytic Traffic inCaenorhabditis elegans |
Q38687390 | Dysregulation of ErbB Receptor Trafficking and Signaling in Demyelinating Charcot-Marie-Tooth Disease |
Q44467158 | Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans |
Q38275632 | Identification of intrinsically disordered regions in PTEN and delineation of its function via a network approach |
Q28486859 | Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis |
Q24532011 | Mutations in MTMR13, a new pseudophosphatase homologue of MTMR2 and Sbf1, in two families with an autosomal recessive demyelinating form of Charcot-Marie-Tooth disease associated with early-onset glaucoma |
Q24291963 | Myotubularin and MTMR2, phosphatidylinositol 3-phosphatases mutated in myotubular myopathy and type 4B Charcot-Marie-Tooth disease |
Q28218655 | PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease |
Q33862413 | Phosphoinositide phosphatases in cell biology and disease |
Q44973981 | Phosphotyrosine phosphatase SHP-1, somatostatin and prostate cancer |
Q36646389 | Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions |
Q39555144 | Receptor mediated endocytosis 8 is a novel PI(3)P binding protein regulated by myotubularin-related 2. |
Q24299014 | Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase |
Q50335998 | Specificity of the myotubularin family of phosphatidylinositol-3-phosphatase is determined by the PH/GRAM domain |
Q27670687 | Structural and functional analysis of PTPMT1, a phosphatase required for cardiolipin synthesis |
Q27701466 | Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation |
Q30482505 | The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals |
Q47731938 | The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome 2. |
Q28592271 | The lipid phosphatase myotubularin is essential for skeletal muscle maintenance but not for myogenesis in mice |
Q34002685 | The membrane and lipids as integral participants in signal transduction: lipid signal transduction for the non-lipid biochemist |
Q24300087 | The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1 |