PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench

scientific article

PTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0955-0674(00)00195-2
P698PubMed publication ID11248551
P5875ResearchGate publication ID12082963

P50authorJack E. DixonQ21165173
P2093author name stringG S Taylor
J T Slama
M J Wishart
P2860cites workGathering STYX: phosphatase-like form predicts functions for unique protein-interaction domainsQ22003889
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal regionQ22010498
A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and YQ22010933
FYVE-DSP1, a dual-specificity protein phosphatase containing an FYVE domainQ22253383
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinaseQ22253438
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2Q22253866
AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1Q22254000
Phosphorylation of the PTEN tail regulates protein stability and functionQ22254305
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphateQ22254632
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1Q22254699
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradationQ24290417
Characterization of the myotubularin dual specificity phosphatase gene family from yeast to humanQ24313350
Serine/threonine protein kinases and apoptosis.Q33876765
Phosphoinositide signaling and the regulation of membrane trafficking in yeastQ33899382
Charcot-Marie-Tooth type 4B is caused by mutations in the gene encoding myotubularin-related protein-2.Q33901232
Sac phosphatase domain proteins.Q33914389
Cellular signaling: pivoting around PDK-1.Q34073383
Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor geneQ35063217
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathwayQ36396479
A single mutation converts a novel phosphotyrosine binding domain into a dual-specificity phosphatase.Q38289397
The conserved PI3'K/PTEN/Akt signaling pathway regulates both cell size and survival in DrosophilaQ39120031
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathwayQ40852967
Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expressionQ40877541
Transcriptional activation of p21WAF1 by PTEN/MMAC1 tumor suppressorQ40892936
Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor geneQ40896708
PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.Q40911230
Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathwaysQ47070325
A functional PtdIns(3)P-binding motifQ47713511
Impaired Fas response and autoimmunity in Pten+/- miceQ73019160
A sensitive assay for phosphoinositide phosphatasesQ73520782
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTENQ77342895
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Association of SET domain and myotubularin-related proteins modulates growth controlQ24323057
SMART: a web-based tool for the study of genetically mobile domainsQ24515301
The PI3K-PDK1 connection: more than just a road to PKBQ24531972
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane associationQ27620298
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases.Q27930732
Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domainsQ27933286
SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatasesQ27934132
AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylationQ28139447
Signalling through phosphoinositide 3-kinases: the lipids take centre stageQ28141934
GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteinsQ28142204
MTM1 mutations in X-linked myotubular myopathyQ28143326
FYVE fingers bind PtdIns(3)PQ28279043
A gene mutated in X-linked myotubular myopathy defines a new putative tyrosine phosphatase family conserved in yeastQ28279868
Protein tyrosine phosphatases: mechanisms of catalysis and regulationQ28288979
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activityQ28567201
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayQ28588309
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayQ29616144
C2-domains, structure and function of a universal Ca2+-binding domainQ29619459
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.Q30169019
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathwayQ30829981
Intracellular signalling: PDK1--a kinase at the hub of thingsQ33533793
PTEN: a tumour suppressor that functions as a phospholipid phosphataseQ33594251
Pathways for phosphoinositide synthesisQ33652651
Phosphoinositides in membrane trafficQ33712456
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.Q33777555
The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.Q33783562
The multiple roles of PTEN in tumor suppressionQ33849727
Protein kinases: six degrees of separation?Q33860462
P433issue2
P921main subjectbioinformaticsQ128570
P304page(s)172-181
P577publication date2001-04-01
P1433published inCurrent Opinion in Cell BiologyQ13505682
P1476titlePTEN and myotubularin phosphoinositide phosphatases: bringing bioinformatics to the lab bench
P478volume13

Reverse relations

cites work (P2860)
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Q27003427Defective membrane remodeling in neuromuscular diseases: insights from animal models
Q34786070Disease-related Myotubularins Function in Endocytic Traffic inCaenorhabditis elegans
Q38687390Dysregulation of ErbB Receptor Trafficking and Signaling in Demyelinating Charcot-Marie-Tooth Disease
Q44467158Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans
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Q28486859Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
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Q24300087The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1