Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines

scientific article

Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/EMMM.201101140
P932PMC publication ID3494077
P698PubMed publication ID22745041
P5875ResearchGate publication ID228088904

P2093author name stringShuyuan Yeh
Chawnshang Chang
Kuo-Pao Lai
Chiung-Kuei Huang
Shinichi Yamashita
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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Inflammation and cancerQ24649640
Pten dose dictates cancer progression in the prostateQ24791909
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
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Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptorQ28512229
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systemsQ28586004
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancerQ28590839
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangementQ28594711
Paradoxical roles of the immune system during cancer developmentQ29614305
NF-kappaB: linking inflammation and immunity to cancer development and progressionQ29614597
Smoldering and polarized inflammation in the initiation and promotion of malignant diseaseQ29618034
TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epitheliaQ29618875
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of PtenQ30524175
Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer modelQ33450599
PTEN, a unique tumor suppressor geneQ33974014
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis.Q34014956
Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissuesQ34159764
CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β.Q34236851
Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiationQ34298595
Androgen receptor promotes hepatitis B virus-induced hepatocarcinogenesis through modulation of hepatitis B virus RNA transcriptionQ34546701
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- miceQ34693888
Role of stroma in carcinogenesis of the prostate.Q35030656
Role of the stromal microenvironment in carcinogenesis of the prostateQ35202528
PTEN: tumour suppressor, multifunctional growth regulator and moreQ35203208
Suppressed prostate epithelial development with impaired branching morphogenesis in mice lacking stromal fibromuscular androgen receptorQ35640720
Prostatic intraepithelial neoplasia in genetically engineered miceQ35747658
Prostate carcinogenesis and inflammation: emerging insights.Q35925066
Identification of a tumour suppressor network opposing nuclear Akt functionQ35991130
Hormonal, cellular, and molecular regulation of normal and neoplastic prostatic developmentQ36017017
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expressionQ36067596
Expression of the SM22alpha promoter in transgenic mice provides evidence for distinct transcriptional regulatory programs in vascular and visceral smooth muscle cellsQ36236547
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisQ36384467
Innate immunity gone awry: linking microbial infections to chronic inflammation and cancerQ36404654
Androgen receptor is a tumor suppressor and proliferator in prostate cancerQ36858442
Targeting the stromal androgen receptor in primary prostate tumors at earlier stagesQ36858449
The role of inflammation and infection in the pathogenesis of prostate carcinoma.Q36896013
Inflammation, atrophy, and prostate carcinogenesisQ36934776
Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma.Q37365527
Pten in stromal fibroblasts suppresses mammary epithelial tumoursQ37399478
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in miceQ37452281
Monocyte/macrophage androgen receptor suppresses cutaneous wound healing in mice by enhancing local TNF-alpha expressionQ37452288
Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer failsQ37741773
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTENQ39711051
Tumor-promoting phenotype of CD90hi prostate cancer-associated fibroblastsQ39876078
Sexually transmitted diseases and carcinogenesisQ40141361
ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptorQ40164058
Hic-5/ARA55, a LIM domain-containing nuclear receptor coactivator expressed in prostate stromal cellsQ40253969
Steroid hormones stimulate human prostate cancer progression and metastasisQ40343113
B-cell-derived lymphotoxin promotes castration-resistant prostate cancerQ40440899
Malignant transformation in a nontumorigenic human prostatic epithelial cell line.Q40766949
A human prostatic stromal myofibroblast cell line WPMY-1: a model for stromal-epithelial interactions in prostatic neoplasiaQ40945599
Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesisQ41899984
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastasesQ44521056
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.Q46127843
Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomasQ47814647
Promotion of bladder cancer development and progression by androgen receptor signals.Q51758123
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in miceQ58378937
Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasiaQ73164189
Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouseQ73435294
P433issue8
P921main subjectinflammationQ101991
P304page(s)791-807
P577publication date2012-06-29
P1433published inEMBO Molecular MedicineQ15817279
P1476titleLoss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines/chemokines
P478volume4

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