PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.

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PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7. is …
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P819ADS bibcode2016NatCo...710689S
P6179Dimensions Publication ID1003629904
P356DOI10.1038/NCOMMS10689
P932PMC publication ID4754336
P698PubMed publication ID26869029
P5875ResearchGate publication ID294277213

P2093author name stringSubbareddy Maddika
Swapnil Rohidas Shinde
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia diseaseQ24295739
Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B diseaseQ24313349
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligaseQ24321736
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomesQ24672025
PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migrationQ24677034
EGF receptor trafficking: consequences for signaling and cancerQ27021340
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7.Q27930701
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanismsQ28181035
PTEN: one gene, many syndromesQ28203387
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTENQ28513537
Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphataseQ28567492
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.Q55476352
Regulation of the EGF transcriptional response by endocytic sortingQ83642076
Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN.Q29568322
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosisQ29618143
Rab7: a key to lysosome biogenesisQ29620369
Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cellsQ30433374
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activityQ33774967
The multiple roles of PTEN in tumor suppressionQ33849727
Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptorQ33886791
Functional analysis of the protein phosphatase activity of PTENQ34194118
Cullin-3 regulates late endosome maturation.Q35735068
A model for Rab GTPase localizationQ36206360
Rab7 regulates late endocytic trafficking downstream of multivesicular body biogenesis and cargo sequestrationQ37169470
WWP2 is an E3 ubiquitin ligase for PTEN.Q37588182
The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting.Q37599802
Endocytic Rabs in membrane trafficking and signalingQ38155426
Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signalingQ38962630
Toward a comprehensive characterization of a human cancer cell phosphoproteome.Q39237219
PTEN protein phosphatase activity correlates with control of gene expression and invasion, a tumor-suppressing phenotype, but not with AKT activityQ39388363
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migrationQ40002542
rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosomeQ40352439
PTEN functions by recruitment to cytoplasmic vesiclesQ40404987
Role of the small GTPase Rab7 in the late endocytic pathway.Q41127805
Control of EGF receptor signaling by clathrin-mediated endocytosis.Q45345953
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)10689
P577publication date2016-02-12
P1433published inNature CommunicationsQ573880
P1476titlePTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.
P478volume7