SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation

scientific article published on 23 December 2015

SOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/0008-5472.CAN-15-1868
P932PMC publication ID4779598
P698PubMed publication ID26701805

P50authorCarlos S MorenoQ41853265
P2093author name stringDaniel Metzger
Birdal Bilir
Demetri D Spyropoulos
W David Martin
Adeboye O Osunkoya
Veronique Lefebvre
Soma Sannigrahi
W Guy Wiles
P2860cites workSox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cellsQ24294207
Genome-wide promoter analysis of the SOX4 transcriptional network in prostate cancer cellsQ24317198
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitorsQ24629179
Outcomes of localized prostate cancer following conservative managementQ24647380
Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinaseQ24682825
Cancer statistics, 2015Q27860576
Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicatorsQ28143448
Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growthQ28187862
Linking beta-catenin to androgen-signaling pathwayQ28215632
PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancerQ28292541
Comprehensive molecular characterization of urothelial bladder carcinomaQ28306864
Pten is essential for embryonic development and tumour suppressionQ28509238
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancerQ28590839
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
GenePattern 2.0Q29614171
Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progressionQ29615223
Endogenous human microRNAs that suppress breast cancer metastasisQ29617352
The Sex-determining region Y-box 4 and homeobox C6 transcriptional networks in prostate cancer progression: crosstalk with the Wnt, Notch, and PI3K pathwaysQ33597010
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencingQ33693912
Genome-wide CRISPR screen in a mouse model of tumor growth and metastasisQ34043392
Molecular genetics of prostate cancer: new prospects for old challengesQ34127462
Studies on Prostatic Cancer: I. The Effect of Castration, Of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the ProstateQ34215208
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancerQ35134003
PTEN: from pathology to biologyQ35208577
Transcriptional control of early B cell developmentQ35698401
Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinomaQ36497352
SOX4 enables oncogenic survival signals in acute lymphoblastic leukemiaQ36512597
Tenets of PTEN tumor suppressionQ37154214
Activation of the Wnt pathway through AR79, a GSK3β inhibitor, promotes prostate cancer growth in soft tissue and boneQ37407566
The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?Q38068040
Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapyQ39093621
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogrammingQ39140073
Syntenin-mediated regulation of Sox4 proteasomal degradation modulates transcriptional outputQ39460417
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTENQ39711051
The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancerQ39893596
Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cellsQ40291759
Akt participation in the Wnt signaling pathway through DishevelledQ40817549
Activation of β-catenin signaling in androgen receptor-negative prostate cancer cellsQ40834731
Nkx3.1; Pten mutant mice develop invasive prostate adenocarcinoma and lymph node metastasesQ44521056
Generation of mice harboring a Sox4 conditional null alleleQ80159032
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1112-1121
P577publication date2015-12-23
P1433published inCancer ResearchQ326097
P1476titleSOX4 Is Essential for Prostate Tumorigenesis Initiated by PTEN Ablation
P478volume76

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cites work (P2860)
Q38973005Amplification of SOX4 promotes PI3K/Akt signaling in human breast cancer
Q54974720Epigenetic Regulation in Prostate Cancer Progression.
Q37590870Histological and Pathological Assessment of miR-204 and SOX4 Levels in Gastric Cancer Patients.
Q90569453Identification of Hub Genes in Hepatocellular Carcinoma Related to Progression and Prognosis by Weighted Gene Co-Expression Network Analysis
Q57475174Identification of the Transcription Factor Relationships Associated with Androgen Deprivation Therapy Response and Metastatic Progression in Prostate Cancer
Q47295311Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast-like synoviocytes in arthritic disease
Q90307891LINC01133 inhibits breast cancer invasion and metastasis by negatively regulating SOX4 expression through EZH2
Q49415848Long noncoding RNA lncBRM facilitates the proliferation, migration and invasion of ovarian cancer cells via upregulation of Sox4.
Q49986924MicroRNA-320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4.
Q99544101MicroRNA-92a Inhibits the Cell Viability and Metastasis of Prostate Cancer by Targeting SOX4
Q90020747Molecular determinants of response to high-dose androgen therapy in prostate cancer
Q100526071Molecular tracing of prostate cancer lethality
Q92410975Neural Transcription Factors in Disease Progression
Q47189377Promoter hypermethylation of SOX11 correlates with adverse clinicopathological features of human prostate cancer.
Q38719688Propofol Suppresses Esophageal Squamous Cell Carcinoma Cell Migration and Invasion by Down-Regulation of Sex-Determining Region Y-box 4 (SOX4)
Q37133681SOX4 Promotes Progression in OLP-Associated Squamous Cell Carcinoma
Q90325674SOX4 is activated by C-MYC in prostate cancer
Q50430901SOX4: Joining the Master Regulators of Epithelial-to-Mesenchymal Transition?
Q64233013SOX5 promotes breast cancer proliferation and invasion by transactivation of EZH2
Q41431023STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4.
Q42150559Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity
Q37688454Subpathway-LNCE: Identify dysfunctional subpathways competitively regulated by lncRNAs through integrating lncRNA-mRNA expression profile and pathway topologies
Q93015985The SOX4/miR-17-92/RB1 Axis Promotes Prostate Cancer Progression
Q88506869The essential role of WD repeat domain 77 in prostate tumor initiation induced by Pten loss
Q47818549WNT signalling in prostate cancer.

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