Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas

scientific article published on December 1999

Mutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1136/MP.52.6.353
P932PMC publication ID395722
P698PubMed publication ID10748870
P5875ResearchGate publication ID12567239

P2093author name stringG Srivastava
Y C Hu
J C Tang
K Y Lam
P2860cites workThe lipid phosphatase activity of PTEN is critical for its tumor supressor functionQ22007981
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor betaQ24310394
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphateQ24317714
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTENQ24322051
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphataseQ24322705
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
PTEN1 is frequently mutated in primary endometrial carcinomasQ28250937
Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovaryQ28259645
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancersQ28306997
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndromeQ29615538
Presence of human papillomavirus in esophageal squamous cell carcinomas of Hong Kong Chinese and its relationship with p53 gene mutationQ44643303
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.Q44846579
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutationQ45345194
Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancersQ47709471
Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lungQ47720136
Germline mutations in PTEN are present in Bannayan-Zonana syndromeQ48046915
Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.Q48331127
Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors.Q48544624
Mutation of the PTEN (MMAC1) tumor suppressor gene in a subset of glioblastomas but not in meningiomas with loss of chromosome arm 10q.Q48566471
Somatic mutations of PTEN in glioblastoma multiformeQ48618632
Prevalence and predictive value of p53 mutation in patients with oesophageal squamous cell carcinomas: a prospective clinico-pathological study and survival analysis of 70 patients.Q50958133
Lack of somatic mutation in the PTEN gene in squamous cell carcinomas of human skin.Q53424406
PTEN/MMAC1 mutations in endometrial cancers.Q53439663
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.Q55477977
PTEN/MMAC1 mutations and EGFR amplification in glioblastomas.Q55478126
Frequent inactivation of PTEN/MMAC1 in primary prostate cancerQ57240096
Estimates of the worldwide frequency of sixteen major cancers in 1980Q68257962
Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignanciesQ73722520
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissuesQ74093343
Analysis of PTEN and the 10q23 region in primary prostate carcinomasQ74531155
Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomasQ77431121
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogeneQ77726383
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmutational analysisQ1955810
P304page(s)353-356
P577publication date1999-12-01
P1433published inJournal of Clinical PathologyQ6294965
P1476titleMutational analysis of the PTEN/MMAC1 gene in primary oesophageal squamous cell carcinomas
P478volume52

Reverse relations

cites work (P2860)
Q39063867Down-regulation of PTEN expression modulated by dysregulated miR-21 contributes to the progression of esophageal cancer
Q34523189Elevation of methylated DNA in KILLIN/PTEN in the plasma of patients with thyroid and/or breast cancer
Q35164689Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations
Q52831311Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines.
Q77879703Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma
Q37334261Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy
Q37609759High-incidence of PTEN mutations in Chinese patients with primary small cell carcinoma of the esophagus
Q35052873MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells
Q73271272Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas
Q39626053Mutational Analysis of the PTEN Gene and Its Effects in Esophageal Squamous Cell Carcinoma
Q53601178PTEN gene is infrequently hypermethylated in human esophageal squamous cell carcinoma.
Q43456119Prognostic significance of PTEN expression in esophageal squamous cell carcinoma from Linzhou City, a high incidence area of northern China
Q39628381Role of microRNA-21 and effect on PTEN in Kazakh’s esophageal squamous cell carcinoma
Q39178561SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway

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