Progress in understanding the molecular pathogenesis of human lung cancer

scientific article published on August 19, 1998

Progress in understanding the molecular pathogenesis of human lung cancer is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0304-419X(98)00010-9
P953full work available at URLhttps://api.elsevier.com/content/article/PII:S0304419X98000109?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0304419X98000109?httpAccept=text/xml
P698PubMed publication ID9739759

P2093author name stringJ. D. Minna
Y. Sekido
K. M. Fong
P2860cites workHuman DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21 WAF1Q22299424
Familial risk of lung cancer among nonsmokers and their relativesQ23923032
Opioid and nicotine receptors affect growth regulation of human lung cancer cell linesQ24303652
Sequence analysis of a 685-kb genomic region on chromosome 3p22-p21.3 that is homozygously deleted in a lung carcinoma cell lineQ24309163
hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during ImmortalizationQ24310670
Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patternsQ24311901
The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger proteinQ24314868
Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancerQ24319164
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppressionQ24321439
Widely dispersed p53 mutation in respiratory epithelium. A novel mechanism for field carcinogenesisQ24561466
3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene regionQ24650774
Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancerQ69373028
Overexpression of oncoproteins in non-small cell lung carcinomas of smokersQ70459086
Reconstitution of the RB gene suppresses the growth of small-cell lung carcinoma cells carrying multiple genetic alterationsQ70466865
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patientsQ70472514
Multiple mechanisms of p16INK4A inactivation in non-small cell lung cancer cell linesQ70786926
Sequential molecular genetic changes in lung cancer developmentQ70851318
Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell linesQ70866395
Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancerQ70866448
Alterations of CDKN2 (p16) in non-small cell lung cancerQ70970949
Microsatellite instability in primary and metastatic lung carcinomasQ71010040
K-ras oncogene activation in atypical alveolar hyperplasias of the human lungQ71046892
Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical studyQ71058135
Intragenic mutations of the p16(INK4), p15(INK4B) and p18 genes in primary non-small-cell lung cancersQ71081134
Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancersQ71093043
p21 RNA and protein expression in non-small cell lung carcinomas: evidence of p53-independent expression and association with tumoral differentiationQ71124144
Tumor induction and tissue atrophy in mice lacking E2F-1Q71129252
Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancersQ71184934
Prognostic significance of germ line polymorphisms of the CYP1A1 and glutathione S-transferase genes in patients with non-small cell lung cancerQ71254262
Lung tumors in mice expressing an antisense RARbeta2 transgeneQ71520382
Expression of bcl-2 oncogene protein is prevalent in small cell lung carcinomasQ71566389
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1Q71644976
Expression of bcl-2--protein in small cell lung cancerQ71671044
Allelic losses in human chromosome 11 in lung cancersQ71700579
Specific Association of Human Telomerase Activity with Immortal Cells and CancerQ27860801
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
p53, the cellular gatekeeper for growth and divisionQ27860990
Mutation of a mutL homolog in hereditary colon cancerQ28114939
A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancerQ28116430
Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in primary and metastatic lung cancerQ28235895
An achaete-scute homologue essential for neuroendocrine differentiation in the lungQ28236555
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ SignalingQ28243202
Functional significance of different human CYP1A1 genotypesQ28243236
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressorQ28251328
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2Q28254119
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrestQ28270478
Altered cJUN expression: an early event in human lung carcinogenesisQ28272085
Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSGQ28276270
Mutation analysis of the PTEN/MMAC1 gene in lung cancerQ28287144
Ras signalling linked to the cell-cycle machinery by the retinoblastoma proteinQ28305440
Opioids induce while nicotine suppresses apoptosis in human lung cancer cellsQ28306814
Bax suppresses tumorigenesis and stimulates apoptosis in vivoQ28506493
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesisQ29547178
Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human CancersQ29616471
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursQ29618396
Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neuronsQ29618538
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARFQ29619663
Isolation of DNA sequences deleted in lung cancer by genomic difference cloningQ33191672
A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinomaQ33509666
Replacement of Fhit in cancer cells suppresses tumorigenicityQ33726007
A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein bindingQ33779824
Abnormalities in structure and expression of the human retinoblastoma gene in SCLC.Q33825340
Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric originQ33968610
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.Q34124421
v-rasH induces non-small cell phenotype, with associated growth factors and receptors, in a small cell lung cancer cell lineQ34252335
Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines.Q34295864
Aberrant upregulation of a novel integrin alpha subunit gene at 3p21.3 in small cell lung cancerQ34348374
Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorinQ34382506
Microsatellite alterations in plasma DNA of small cell lung cancer patients.Q34394739
Cigarette Smoking and Changes in the Histopathology of Lung CancerQ38503712
Platelet-derived endothelial cell growth factor expression correlates with tumour angiogenesis and prognosis in non-small-cell lung cancerQ39714055
Expression and autoregulation of transforming growth factor beta receptor mRNA in small-cell lung cancer cell linesQ39992153
Evidence for impaired retinoic acid receptor-thyroid hormone receptor AF-2 cofactor activity in human lung cancerQ40016745
Lung Cancer and CYP2D6 (the debrisoquine polymorphism): sources of heterogeneity in the proposed associationQ40426573
Complex intrachromosomal rearrangement in the process of amplification of the L-myc gene in small-cell lung cancerQ40678571
Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesisQ40694250
Protein Expression and Functional Analysis of the FHIT Gene in Human Tumor CellsQ41055843
Conversion of Bcl-2 to a Bax-like Death Effector by CaspasesQ41073693
p73 is a simian [correction of human] p53-related protein that can induce apoptosisQ41091013
Effect of cohort differences in smoking prevalence on models of lung cancer susceptibilityQ41096228
Retinoids in lung development.Q41108334
Involvement of signal transduction pathways in lung cancer biology.Q41111794
Three distinct regions involved in 3p deletion in human lung cancerQ41123112
Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutionsQ41133775
Structural and functional analysis of beta2 microglobulin abnormalities in human lung and breast cancerQ41167050
Deletion mapping of chromosome 2 in human lung carcinomaQ41193680
Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stageQ41273144
Basic science of small cell lung cancerQ41321254
Loss of heterozygosity of chromosome 3p markers in small-cell lung cancerQ41332396
Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancerQ41362569
In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small cell lung cancersQ41373277
Bombesin-like peptides and airway repair: a recapitulation of lung development?Q41384707
Stem cells in lung development, disease, and therapyQ41442268
A homozygous deletion in a small cell lung cancer cell line involving a 3p21 region with a marked instability in yeast artificial chromosomesQ41451226
Myc target genesQ41491682
Homozygous deletion at chromosome 2q33 in human small-cell lung carcinoma identified by arbitrarily primed PCR genomic fingerprintingQ41503197
Non-small cell lung cancer: clinical value of new biological predictorsQ41523353
Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.Q41524948
A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activityQ41543902
The interaction of Ras with GTPase‐activating proteinsQ41554070
The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactionsQ41554100
Biological consequences of overexpression of a transfected c-erbB-2 gene in immortalized human bronchial epithelial cellsQ41558427
Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2.Q41559408
Recombinant human stem cell factor mediates chemotaxis of small-cell lung cancer cell lines aberrantly expressing the c-kit protooncogeneQ41564993
Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: a strategy for cloning the putative tumor suppressor geneQ41605894
Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutationQ41612390
Characterization of the submicroscopic deletion in the small-cell lung carcinoma (SCLC) cell line U2020Q41616459
Expression of the epidermal growth factor receptor in human small cell lung cancer cell linesQ41623159
Polymorphic sites within the MCC and APC loci reveal very frequent loss of heterozygosity in human small cell lung cancerQ41633055
Implication of RARB in epidermoid (Squamous) lung cancerQ41668039
Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumorsQ41952934
Genesis of squamous cell lung carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expressionQ42050081
Induction of Apoptosis in Small-Cell Lung Cancer Cells by an Antisense Oligodeoxynucleotide Targeting the Bcl-2 Coding SequenceQ42441665
Expression and activation of erbB-2 and epidermal growth factor receptor in lung adenocarcinomasQ42479975
bcl-2 protein in non-small-cell lung carcinomaQ42508274
Bombesin receptor structure and expression in human lung carcinoma cell lines.Q42638221
The human homolog of the rodent immediate early response genes, PC4 and TIS7, resides in the lung cancer tumor suppressor gene region on chromosome 3p21.Q42651150
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles CountyQ43762018
Prognostic significance of tumoral angiogenesis in completely resected late stage lung carcinoma (stage IIIA-N2). Impact of adjuvant therapies in a subset of patients at high risk of recurrenceQ44344425
Immunohistochemical evidence of autocrine growth factors in adenocarcinoma of the human lungQ45037436
Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancerQ45066172
Increased familial risk for lung cancerQ45220819
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomasQ45345804
Impaired lung branching morphogenesis in the absence of functional EGF receptorQ46117988
Identification of novel regions of altered DNA copy number in small cell lung tumorsQ46229352
The p19INK4D Cyclin dependent kinase inhibitor gene is altered in osteosarcomaQ46665639
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptorQ46766121
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistanceQ50626711
Cigarettes, Sex, and Lung AdenocarcinomaQ50925655
Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinomaQ50944026
Prognostic value of the expression of p53, bcl-2, and bax oncoproteins, and neovascularization in patients with radically resected non-small-cell lung cancerQ50950104
Delineation of the centromeric and telomeric chromosome segment 11p15.5 lung cancer suppressor regions LOH11A and LOH11B.Q50960351
High telomerase activity in primary lung cancers: association with increased cell proliferation rates and advanced pathologic stageQ52192163
The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of lung cancer: a meta-analysisQ52892865
Primary small-cell lung carcinomas and their metastases are characterized by a recurrent pattern of genetic alterationsQ53001345
Absence of mutations in the transforming growth factor-beta type II receptor in sporadic lung cancers with microsatellite instability and rare H-ras1 alleles.Q53442031
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer riskQ53442109
Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletionsQ53443601
Mutation analysis of the coding sequences of MEK-1 and MEK-2 genes in human lung cancer cell linesQ53445143
Influence of a mutation reducing the catalytic activity of the cytochrome P450 CYP2D6 on lung cancer susceptibility.Q53450800
The FHIT gene 3p14.2 is abnormal in lung cancerQ53455201
Absence of a mutation of the p21/WAF1 gene in human lung and pancreatic cancersQ53456376
Genetic component of lung cancer: cohort study of twinsQ53470574
Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancerQ53494420
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lungQ53497397
Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cellsQ54172826
Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutationsQ54238137
Antitumor Activity of a Monoclonal Antibody Directed Against Gastrin-Releasing Peptide in Patients With Small Cell Lung CancerQ54550898
p16/CDKN2 gene and p53 gene alterations in Japanese non-smoking female lung adenocarcinoma.Q55317409
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancersQ55480673
Serum Anti-p53 Antibodies and Prognosis of Patients With Small-Cell Lung CancerQ57254237
Loss of heterozygosity at 9p23 defines a novel locus in non-small cell lung cancerQ58068871
Repression of RNA polymerase III transcription by the retinoblastoma proteinQ58450660
Frequent loss of the short arm of chromosome 9 in resected non-small-cell lung cancers from Japanese patients and its association with squamous cell carcinomaQ58454752
Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinomaQ58454772
Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancerQ59079930
Angiogenesis as a Prognostic Indicator of Survival in Non-Small-Cell Lung Carcinoma: a Prospective StudyQ59219589
High frequency of retinoic acid receptor beta abnormalities in human lung cancerQ67701783
Increased cytogenetic damage in smokers deficient in glutathione S-transferase isozyme μQ67753826
The ras gene family in human non-small-cell lung cancerQ67860660
p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchusQ67911122
Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lungQ68082107
Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesionsQ68090482
ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasisQ68119388
Expression of HLA class I and II antigens in bronchogenic carcinomas: its relationship to cellular DNA content and clinical-pathological parametersQ68254096
ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intentQ68254101
Expression of nuclear retinoic acid receptors in normal tracheobronchial cells and in lung carcinoma cellsQ68304765
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lungQ68532141
Evidence for mendelian inheritance in the pathogenesis of lung cancerQ68861237
Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancerQ73081849
bcl-2 oncoprotein in surgically resected non-small cell lung cancer: possibly favorable prognostic factor in association with low incidence of distant metastasisQ73090126
In vitro kinetics of two human CYP1A1 variant enzymes suggested to be associated with interindividual differences in cancer susceptibilityQ73154991
Apoptosis in operated small cell lung carcinoma is inversely related to tumour necrosis and p53 immunoreactivityQ73272342
Retinoic acid receptor expression abnormalities in lung cancer: important clues or major obstacles?Q73337245
Association of p53 protein expression in stage I lung adenocarcinoma with reference to cytological subtypesQ73354557
Extensive DNA methylation spanning the Rb promoter in retinoblastoma tumorsQ73424545
Patterns of chromosomal imbalances in adenocarcinoma and squamous cell carcinoma of the lungQ73436889
The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lungQ73443635
Reduced survival in patients with stage-I non-small-cell lung cancer associated with DNA-replication errorsQ73507959
Immunocytochemical markers in stage I lung cancer: relevance to prognosisQ73585186
Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomasQ73634108
The prognostic significance of p53 andbcl-2 expression in lung adenocarcinoma and its correlation with ki-67 growth fractionQ73717517
Allelotyping demonstrates common and distinct patterns of chromosomal loss in human lung cancer typesQ74480207
Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancerQ77557324
Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.Q34399850
Alterations of P16 (MTS1) in node-positive non-small cell lung carcinomasQ34423364
Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer developmentQ34426069
Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancerQ34436736
Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospectsQ34623003
Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivoQ35227133
Three tumor-suppressor regions on chromosome 11p identified by high-resolution deletion mapping in human non-small-cell lung cancerQ35477427
Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small cell and small cell lung cancerQ35666693
Differential retinoblastoma protein expression in neuroendocrine tumors of the lung. Potential diagnostic implicationsQ35764748
Bcl-2 protein expression in lung cancer and close correlation with neuroendocrine differentiationQ35774292
Microsatellite alteration at chromosome 3p loci in neuroendocrine and non-neuroendocrine lung tumors. Histogenetic and clinical relevanceQ35782638
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinomaQ35807817
Microsatellite alterations as clonal markers for the detection of human cancerQ35819311
Familial Aggregation of Lung Cancer among Hospital PatientsQ35883237
Mutations and altered expression of p16INK4 in human cancer.Q35892778
Reduction in receptors for bombesin and epidermal growth factor in xenografts of human small-cell lung cancer after treatment with bombesin antagonist RC-3095.Q35966914
Expression of the proto-oncogenes c-met and c-kit and their ligands, hepatocyte growth factor/scatter factor and stem cell factor, in SCLC cell lines and xenograftsQ35975907
Analyses of p53 antibodies in sera of patients with lung carcinoma define immunodominant regions in the p53 proteinQ35978507
Bcl-2 protein: a prognostic factor inversely correlated to p53 in non-small-cell lung cancerQ36080901
Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cellsQ36084691
A follow-up study of progression from dysplasia to squamous cell carcinoma with immunohistochemical examination of p53 protein overexpression in the bronchi of ex-chromate workersQ36116177
Association of vascular endothelial growth factor expression with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinomaQ36134259
Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancerQ36134480
Prognostic significance of CCND1 (cyclin D1) overexpression in primary resected non-small-cell lung cancerQ36134992
Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosectionsQ36135626
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas.Q36136355
MYCL genotypes and loss of heterozygosity in non-small-cell lung cancerQ36136459
Loss of the retinoblastoma protein-related p130 protein in small cell lung carcinomaQ36243414
Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastasesQ36367319
Small-cell lung cancer is characterized by a high incidence of deletions on chromosomes 3p, 4q, 5q, 10q, 13q and 17pQ36419914
Abnormal expression of CCND1 and RB1 in resection margin epithelia of lung cancer patientsQ36422016
Vascular endothelial growth factor and lymph node metastasis in primary lung cancerQ36431274
Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expressionQ36431673
MDM2 gene amplification and expression in non-small-cell lung cancer: immunohistochemical expression of its protein is a favourable prognostic marker in patients without p53 protein accumulationQ36431703
Non-ocular cancer in relatives of retinoblastoma patientsQ36467625
High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogeneQ36760672
Multiple mechanisms for transcriptional regulation of the myc gene family in small-cell lung cancerQ36793456
Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivoQ36864271
Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancerQ36869755
Mutant p53 can induce tumorigenic conversion of human bronchial epithelial cells and reduce their responsiveness to a negative growth factor, transforming growth factor beta 1Q36920336
Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID miceQ37356393
Malignant epithelial cells in primary human lung carcinomas coexpress in vivo platelet-derived growth factor (PDGF) and PDGF receptor mRNAs and their protein productsQ37599429
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cellsQ37734603
Somatic mutations of the MTS (multiple tumor suppressor) 1/CDK4l (cyclin-dependent kinase-4 inhibitor) gene in human primary non-small cell lung carcinomasQ38305358
Microsatellite Instability in Lung Cancer Patients 40 Years of Age or YoungerQ38345275
Insulin-like growth factor expression in human cancer cell linesQ38357885
Expression of CD44 standard form and variant isoforms in non-small cell lung carcinomasQ38474361
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective studyQ38476276
Extensive areas of aneuploidy are present in the respiratory epithelium of lung cancer patientsQ38479399
Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancersQ38480210
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomasQ38482358
Immunohistochemical detection of basic fibroblast growth factor as a prognostic indicator in pulmonary adenocarcinomaQ71733817
High K-ras mutation rates in goblet-cell-type adenocarcinomas of the lungsQ71743702
Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escapeQ71762882
Serum p53 antibodies as early markers of lung cancerQ71803498
Mechanism of all-trans-retinoic acid-mediated L-myc gene regulation in small cell lung cancerQ71814416
DNA sequence analysis of exons 2 through 11 and immunohistochemical staining are required to detect all known p53 alterations in human malignanciesQ71814434
Loss of heterozygosity at 9p21 loci and mutations of the MTS1 and MTS2 genes in human lung cancersQ71820098
Molecular basis for lack of expression of HLA class I antigens in human small-cell lung carcinoma cell linesQ71821499
Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutationQ71834681
Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells--a mechanism of immune evasion?Q71840957
Codeletion of p15 and p16 genes in primary non-small cell lung carcinomaQ71862654
Glutathione S-transferase and N-acetyltransferase genotypes and asbestos-associated pulmonary disordersQ71878642
Altered p16INK4 and retinoblastoma protein status in non-small cell lung cancer: potential synergistic effect with altered p53 protein on proliferative activityQ71909474
Molecular analysis of the FHIT gene at 3p14.2 in lung cancer cell linesQ71909478
Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancersQ71909483
Identification of a novel region of homozygous deletion on chromosome 9p in squamous cell carcinoma of the lung: the location of a putative tumor suppressor geneQ71955532
A hereditary genetic marker closely associated with microsatellite instability in lung cancerQ72033731
Telomerase Activity in Small-Cell and Non-Small-Cell Lung CancersQ72038585
Human Lung Carcinogen--DNA Adduct Levels Mediated by Genetic Polymorphisms In VivoQ72038588
Differential expression of the epidermal growth factor receptor and its ligands in primary non-small cell lung cancers and adjacent benign lungQ72079143
Deletion mapping of the short arm of chromosome 8 in non‐small cell lung carcinomaQ72087895
Altered imprinting in lung cancerQ72116903
Frequent loss of imprinting of the H19 gene is often associated with its overexpression in human lung cancersQ72119659
Expression of oncoproteins in primary human non-small cell lung cancer and incidence of metastasesQ72223794
Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignanciesQ72255920
Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinomaQ72365281
Microsatellite instability and other molecular abnormalities in non-small cell lung cancerQ72368568
Genetic instability of microsatellite sequences in many non-small cell lung carcinomasQ72399771
Frequent microsatellite instability in primary small cell lung cancerQ72399781
Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancerQ72610940
Absence of activating mutations of the RAF1 protooncogene in human lung cancerQ72625361
Alterations in telomeric repeat length in lung cancer are associated with loss of heterozygosity in p53 and RbQ72650504
Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndromeQ72657543
c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated propertiesQ72680125
Frequent allelic losses on chromosomes 2q, 18q, and 22q in advanced non-small cell lung carcinomaQ72710470
Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lungQ72710475
Absence of p16INK4 protein is restricted to the subset of lung cancer lines that retains wildtype RBQ72744200
Frequent loss of chromosome 9 in human primary non-small cell lung cancerQ72769107
Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)Q72916321
Neuroendocrine tumors of the lung. Pathology and molecular biologyQ72992626
Identification of three distinct tumor suppressor loci on the short arm of chromosome 9 in small cell lung cancerQ73023156
Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancerQ73023180
Immunoreactivity for hepatocyte growth factor/scatter factor and its receptor, met, in human lung carcinomas and malignant mesotheliomasQ73027878
Rare alleles at different VNTR loci among lung-cancer patients with microsatellite instability in tumoursQ73074308
Deletion of three distinct regions on chromosome 13q in human non-small-cell lung cancerQ73081843
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)F21-59
P577publication date1998-08-01
1998-08-19
P13046publication type of scholarly workreview articleQ7318358
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleProgress in understanding the molecular pathogenesis of human lung cancer
P478volume1378

Reverse relations

cites work (P2860)
Q37702708Aberrant promoter methylation of hOGG1 may be associated with increased risk of non-small cell lung cancer
Q40625644Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
Q37330746Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study
Q90095282Association of promoter methylation of RASSF1A and KRAS mutations in non-small cell lung carcinoma in Kashmiri population (India)
Q37758841Biochemical and docking analysis of substrate interactions with polyisoprenylated methylated protein methyl esterase
Q24649650Chromosomal alterations in the clonal evolution to the metastatic stage of squamous cell carcinomas of the lung
Q34572870Cigarette smoking: cancer risks, carcinogens, and mechanisms
Q35028440Clinical significance of aberrant Wnt7a promoter methylation in human non-small cell lung cancer in Koreans
Q37940375DNA Methylation and Nonsmall Cell Lung Cancer
Q36471888DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer.
Q40796958Defective caspase-3 relocalization in non-small cell lung carcinoma.
Q34997440Differential expression of critical cellular genes in human lung adenocarcinomas and squamous cell carcinomas in comparison to normal lung tissues
Q33705017Distinct Epigenetic Domains Separated by a CTCF Bound Insulator between the Tandem Genes, BLU and RASSF1A
Q36261852Down-regulation of PAX6 by promoter methylation is associated with poor prognosis in non small cell lung cancer
Q37205334EGFR and KRAS mutations in patients with adenocarcinoma of the lung
Q51794333EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification
Q24291194Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
Q39395200Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients
Q43955981Frequent and histological type-specific inactivation of 14-3-3sigma in human lung cancers
Q34935982Functional cloning of a tumor suppressor gene, TSLC1, in human non-small cell lung cancer
Q24621422Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (CACNA2D2)
Q40791017Genetic alteration of the beta-catenin gene (CTNNB1) in human lung cancer and malignant mesothelioma and identification of a new 3p21.3 homozygous deletion
Q28360366Global methylation profiling of lung cancer identifies novel methylated genes
Q40876361Infrequent mutation of the hBUB1 and hBUBR1 genes in human lung cancer
Q34792237Inhibition of mutant p53 expression and growth of DMS-153 small cell lung carcinoma by antagonists of growth hormone-releasing hormone and bombesin
Q33194582Loss of heterozygosity of chromosome 12p does not correlate with KRAS mutation in non‐small cell lung cancer
Q33972805Lung cancer * 9: Molecular biology of lung cancer: clinical implications
Q38465535M6P/IGF2R is mutated in squamous cell carcinoma of the lung
Q24610335Molecular biology of lung cancer: clinical implications
Q37511952Molecular changes in the bronchial epithelium of patients with small cell lung cancer
Q30782803Molecular characteristics of non-small cell lung cancer
Q43955974Molecular follow-up of preneoplastic lesions in bronchial epithelium of former Chernobyl clean-up workers
Q34249055Molecular genetic abnormalities in the pathogenesis of human lung cancer
Q26999068Mouse Models for Efficacy Testing of Agents against Radiation Carcinogenesis — A Literature Review
Q26747129Mouse models for radiation-induced cancers
Q23909570Mutational activation of the MAP3K8 protooncogene in lung cancer
Q44039872Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
Q37388731Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer
Q64085185Ovine Pulmonary Adenocarcinoma: A Unique Model to Improve Lung Cancer Research
Q37681630PPAR Agonists for the Prevention and Treatment of Lung Cancer
Q28068114PPARγ as a Novel Therapeutic Target in Lung Cancer
Q36359174Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays
Q36417658Peroxisome proliferator-activated receptors in lung cancer.
Q73362892Pleomorph poorly differentiated endocrine carcinoma of the rectum
Q34447423Prognostic molecular markers in non-small cell lung cancer
Q41766783Proliferation, but not apoptosis, is associated with distinct beta-catenin expression patterns in non-small-cell lung carcinomas: relationship with adenomatous polyposis coli and G(1)-to S-phase cell-cycle regulators
Q53607547Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression
Q37519430Proteomic comparison of two-dimensional gel electrophoresis profiles from human lung squamous carcinoma and normal bronchial epithelial tissues
Q35869189Quantitative fluorescence in situ hybridization in lung cancer as a diagnostic marker
Q38009322RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome?
Q40762443Silencing of HTR1B and reduced expression of EDN1 in human lung cancers, revealed by methylation-sensitive representational difference analysis
Q34963435Smoking molecular damage in bronchial epithelium
Q24648133Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer
Q40707959Sulfinosine-induced cell growth inhibition and apoptosis in human lung carcinomas in vitro
Q31121564The Ras-association domain family (RASSF) members and their role in human tumourigenesis
Q74421009The expression of DNA methyltransferases and methyl-CpG-binding proteins is not associated with the methylation status of p14(ARF), p16(INK4a) and RASSF1A in human lung cancer cell lines
Q33846232Tumor progression and metastasis
Q44184282gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth.
Q39124675hsa-miR29b, a critical downstream target of non-canonical Wnt signaling, plays an anti-proliferative role in non-small cell lung cancer cells via targeting MDM2 expression.

Search more.