C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.

scientific article

C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI117001
P8608Fatcat IDrelease_smk3cuxzhjbmdapsvbiyoc7r64
P932PMC publication ID293872
P698PubMed publication ID7906694

P50authorJeffrey A KernQ63373813
P2093author name stringSchwartz DA
Weiner D
Rodenhuis S
Robinson RA
Slebos RJ
Lager D
Top B
P2860cites workAbnormalities in structure and expression of the human retinoblastoma gene in SCLC.Q33825340
Oncogenes and tumor suppressor genes in human lung carcinogenesisQ36404302
Dominant oncogenes and tumor suppressor genes in the pathogenesis of lung cancerQ37581342
Functional inactivation of genes by dominant negative mutationsQ38178605
A new international staging system for lung cancerQ39729989
Mechanisms of p185HER2 expression in human non-small cell lung cancer cell linesQ41633694
Absence of retinoblastoma protein expression in primary non-small cell lung carcinomasQ41684074
p185neu expression in human lung adenocarcinomas predicts shortened survivalQ41725055
Increased resistance to cis-diamminedichloroplatinum(II) in NIH 3T3 cells transformed by ras oncogenesQ42804780
The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiationQ42804813
Expression and amplification of myc gene family in small cell lung cancer and its relation to biological characteristics.Q42814628
Evidence by in situ hybridization that c-erbB-2 proto-oncogene expression is a marker of malignancy and is expressed in lung adenocarcinomasQ43680917
DNA alterations at proto-oncogene loci and their clinical significance in operable non-small cell lung cancerQ44682671
Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction productsQ44830802
A rapid and simple procedure for the routine detection of ras point mutations in formalin-fixed, paraffin-embedded tissuesQ45122872
Abnormalities of protooncogenes in non-small cell lung cancer. Correlations with tumor type and clinical characteristics.Q45946068
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell linesQ46937946
p53: a frequent target for genetic abnormalities in lung cancer.Q52486321
Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancerQ53494420
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.Q53520000
Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinomaQ58454772
Expression of the neu gene-encoded protein (P185neu) in human non-small cell carcinomas of the lungQ68082107
ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intentQ68254101
Prognostic value of nuclear DNA content and expression of the ras oncogene product in lung cancerQ68259992
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lungQ68532141
A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotidesQ69022841
Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancerQ69373028
Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lungQ69855061
Karyotypic characterization of established cell lines and short-term cultures of human lung cancersQ70078782
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lungQ70193311
Cancer statistics, 1993Q70535113
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectadenocarcinomaQ356033
P304page(s)516-520
P577publication date1994-02-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleC-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas
P478volume93

Reverse relations

cites work (P2860)
Q43173320Absence of ras gene mutations in early gastric carcinomas
Q73488908Adjuvant chemotherapy for non-small cell lung cancer
Q36072192Association of HER-2 overexpression with prognosis in nonsmall cell lung carcinoma: a metaanalysis
Q34936052Clinical impact of novel treatment strategies
Q77711290Clinical implications of molecular abnormalities in lung cancer
Q36641208Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer
Q42106918Detection of HER2 polymorphism and expression using circulating DNA and RNA as a tool in lung adenocarcinoma patients: a case control study
Q77376768Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected nonsmall cell lung cancer: impact on recurrence and Survival
Q47771319Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins
Q40405623EGFR enhances Survivin expression through the phosphoinositide 3 (PI-3) kinase signaling pathway
Q40973384Ectopic expression of pRb2/p130 suppresses the tumorigenicity of the c-erbB-2-overexpressing SKOV3 tumor cell line
Q38331804Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis
Q38456543Gene amplification and mRNA and protein overexpression of c-erbB-2 (HER-2/neu) in human intrahepatic cholangiocarcinoma as detected by fluorescence in situ hybridization, in situ hybridization, and immunohistochemistry
Q29614443Gene-expression profiles predict survival of patients with lung adenocarcinoma
Q34208895Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity.
Q33588251Genetics and pulmonary medicine. 7. Somatic mutations in the development of lung cancer
Q39729571Imaging and biodistribution of Her2/neu expression in non-small cell lung cancer xenografts with Cu-labeled trastuzumab PET.
Q38997358In vivo and in vitro activity of an immunoglobulin Fc fragment (Fcab) with engineered Her-2/neu binding sites.
Q36420159K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer
Q90633220KRAS Mutations Predict Response and Outcome in Advanced Lung Adenocarcinoma Patients Receiving First-Line Bevacizumab and Platinum-Based Chemotherapy
Q38669282KRAS-Mutant Lung Cancers in the Era of Targeted Therapy
Q36135626Lack of prognostic significance of epidermal growth factor receptor and the oncoprotein p185HER-2 in patients with systemically untreated non-small-cell lung cancer: an immunohistochemical study on cryosections
Q33972805Lung cancer * 9: Molecular biology of lung cancer: clinical implications
Q37227208MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients
Q33891465Molecular and genetic aspects of lung cancer
Q74569409Molecular biological markers and micrometastasis in resected non-small-cell lung cancer. Prognostic implications
Q34569440Molecular biology of lung cancer: clinical implications.
Q33793308Molecular pathogenesis of lung cancer
Q37913090Molecular predictors of prognosis in lung cancer
Q36642239Multiple molecular marker testing (p53, C-Ki-ras, c-erbB-2) improves estimation of prognosis in potentially curative resected non-small cell lung cancer
Q44120928Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.
Q41023437New prognostic factors in resectable non-small cell lung cancer
Q34679340Non-small cell lung cancer clinical trials with trastuzumab: their foundation and preliminary results
Q41523353Non-small cell lung cancer: clinical value of new biological predictors
Q36116240Prediction of recurrence by quantification of p185neu protein in non-small-cell lung cancer tissue
Q40864750Primary adenocarcinoma of the lung--histological subtypes and outcome after surgery, using the IASLC/ATS/ERS classification of lung adenocarcinoma
Q34384392Prognostic factors in stage I/II non-small cell lung cancer
Q73181191Prognostic impact of telomerase activity in non-small cell lung cancers
Q41519933Prognostic markers in resectable non-small cell lung cancer
Q34447423Prognostic molecular markers in non-small cell lung cancer
Q74341106Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung
Q53431081Progress in understanding the molecular pathogenesis of human lung cancer.
Q33595441Role of bronchoscopy in lung cancer research
Q71863856Serum Level and Tissue Expression of c-erbB-2 Protein in Lung Adenocarcinoma
Q36335248Soluble Human Epidermal Growth Factor Receptor 2 (sHER2) as a Potential Risk Assessment, Screening, and Diagnostic Biomarker of Lung Adenocarcinoma
Q53759964Study of prognostic predictors for non-small cell lung cancer.
Q74522923The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients
Q35216052The role of HER-2/neu expression on the survival of patients with lung cancer: a systematic review of the literature
Q24650902The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis
Q35013566The role of new agents in the treatment of non-small cell lung cancer.
Q36292265The role of transforming growth factor alpha production and ErbB-2 overexpression in induction of tumorigenicity of lung epithelial cells
Q36158717Therapeutic targeting of receptor tyrosine kinases in lung cancer
Q34325219Treatment of advanced non-small-cell lung cancer: a review of current randomized clinical trials and an examination of emerging therapies
Q34133830Trends in incidence and prognosis of the histological subtypes of lung cancer in North America, Australia, New Zealand and Europe
Q80941653[Prognostic value of ERBB2 amplification and protein expression in small cell lung cancer]
Q78844837[Study of epidermal growth factor receptor concentration (EGFR) in lung adenocarcinomas. Association with high erbB2 oncogenic protein levels]
Q74291349[Usefulness of cytosolic tissue-type plasminogen activator levels in lung adenocarcinomas]
Q52122642c-erbB-2 and c-Met expression relates to cholangiocarcinogenesis and progression of intrahepatic cholangiocarcinoma.

Search more.