Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

scientific article published in September 2002

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1165/RCMB.4850
P698PubMed publication ID12204892
P5875ResearchGate publication ID11183655

P50authorJeffrey A KernQ63373813
P2093author name stringJinbo Liu
P2860cites workThrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathwayQ43559449
Neuregulin-1 and human epidermal growth factor receptors 2 and 3 play a role in human lung development in vitro.Q52169558
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinaseQ22009917
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4Q24336447
Identification of heregulin, a specific activator of p185erbB2Q24338146
Humanization of an anti-p185HER2 antibody for human cancer therapyQ24561842
ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinasesQ28198475
Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2Q28609160
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
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STATs in oncogenesisQ29617571
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Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cellsQ33854194
Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in miceQ33941361
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.Q34124421
HER2/neu: mechanisms of dimerization/oligomerizationQ34130541
Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liverQ34312998
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activityQ34532143
The type 1 (EGFR-related) family of growth factor receptors and their ligandsQ35264192
Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivoQ35676433
Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activityQ35684026
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell linesQ36239779
Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent miceQ36497106
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gammaQ37432208
An epidermal growth factor receptor/Jak2 tyrosine kinase domain chimera induces tyrosine phosphorylation of Stat5 and transduces a growth signal in hematopoietic cellsQ38354196
Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer researchQ40445359
A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signalingQ40673334
How receptor tyrosine kinases activate Ras.Q40778358
Epidermal growth factor (EGF) receptor kinase-independent signaling by EGF.Q40816275
ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cellsQ40925406
IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell lineQ40937398
Regulation of heregulin beta1-induced differentiation in a human breast carcinoma cell line by the extracellular-regulated kinase (ERK) pathwayQ41013193
Growth effects of alpha-interferon but not of bombesin or angiotensin II are mediated by activation of STAT proteinsQ41029044
STAT activation by epidermal growth factor (EGF) and amphiregulin. Requirement for the EGF receptor kinase but not for tyrosine phosphorylation sites or JAK1.Q41205161
Inhibition of human lung cancer cell line growth by an anti-p185HER2 antibody.Q41524948
Mechanisms of p185HER2 expression in human non-small cell lung cancer cell linesQ41633694
Specificity within the EGF family/ErbB receptor family signaling networkQ41721612
Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling networkQ42657008
Activation of Stat3 preassembled with platelet-derived growth factor beta receptors requires Src kinase activityQ42801916
P433issue3
P304page(s)306-313
P577publication date2002-09-01
P1433published inAmerican Journal of Respiratory Cell and Molecular BiologyQ4744268
P1476titleNeuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation
P478volume27

Reverse relations

cites work (P2860)
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Q27853182Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
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Q36776754Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.
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