Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

scientific article published on 2 April 2012

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1084/JEM.20111470
P932PMC publication ID3328370
P698PubMed publication ID22473959
P5875ResearchGate publication ID223986426

P50authorMark R. BoothbyQ91454598
Do-Sim ParkQ39964421
Jin ChenQ55189464
P2093author name stringJin Chen
Yoonha Hwang
Ki Taek Nam
Sung Hoon Cho
Ross Potter
Keunwook Lee
Emmanuel Volanakis
Prathyusha Gudapati
P2860cites workThe effect of rapamycin on T cell development in miceQ72285894
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte developmentQ73291757
Transgenic mice with hematopoietic and lymphoid specific expression of CreQ78842092
NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivoQ81180198
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.Q24305527
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingQ24323370
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)Q24324148
The PI3K-PDK1 connection: more than just a road to PKBQ24531972
A transforming mutation in the pleckstrin homology domain of AKT1 in cancerQ27646556
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancerQ27860985
Increased chemokine receptor CCR7/EBI1 expression enhances the infiltration of lymphoid organs by adult T-cell leukemia cellsQ28141009
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
NF-kappaB is a target of AKT in anti-apoptotic PDGF signallingQ28144330
PTEN: one gene, many syndromesQ28203387
PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activationQ28242875
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificityQ28262782
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1Q28276788
BCR/ABL-mediated downregulation of genes implicated in cell adhesion and motility leads to impaired migration toward CCR7 ligands CCL19 and CCL21 in primary BCR/ABL-positive cellsQ28304582
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viabilityQ28504594
Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitorQ28573596
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CQ28587901
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemiaQ29614269
mTOR signaling at a glanceQ29619857
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.Q30440717
Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitorQ33597663
Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Q33677433
Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.Q33965862
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cellsQ33979948
Critical roles for mTORC2- and rapamycin-insensitive mTORC1-complexes in growth and survival of BCR-ABL-expressing leukemic cellsQ34004994
The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.Q34235332
PDK2: a complex tail in one Akt.Q34467820
Requirement for ribosomal protein S6 kinase 1 to mediate glycolysis and apoptosis resistance induced by Pten deficiencyQ34572866
The two TORCs and Akt.Q34617423
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2.Q34801853
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.Q34836259
Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophyQ34891582
Dual mTORC2/mTORC1 targeting results in potent suppressive effects on acute myeloid leukemia (AML) progenitorsQ35091507
Activating Notch1 mutations in mouse models of T-ALL.Q35849320
Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signalingQ35849825
Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.Q35901256
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesisQ36384467
Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactionsQ36399587
Key factors in the organized chaos of early T cell developmentQ36715280
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemiaQ37113435
PARP-14, a member of the B aggressive lymphoma family, transduces survival signals in primary B cells.Q37129661
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemiaQ37215995
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemiaQ37268926
Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancersQ37272977
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemiaQ37420510
NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia.Q37439353
Notch signalling in solid tumours: a little bit of everything but not all the timeQ37867484
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.Q39457088
Activity of the novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 against T-cell acute lymphoblastic leukemia.Q39650704
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutationQ39831998
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemiaQ40158237
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.Q40195204
Direct role of NF-kappaB activation in Toll-like receptor-triggered HLA-DRA expressionQ40291332
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolismQ40390896
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinaseQ40533718
Persistent activation of NF-kappa B by the tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgammaQ41476010
Notch-induced T cell development requires phosphoinositide-dependent kinase 1.Q41953543
Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferationQ41981684
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathwaysQ42099912
The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell developmentQ44839270
Protein kinase C betaII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion.Q45057108
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
The pharmacology of mTOR inhibitionQ46041824
Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signalingQ47607371
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.Q51908453
Unequal Contribution of Akt Isoforms in the Double-Negative to Double-Positive Thymocyte TransitionQ62663058
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectleukemiaQ29496
thymocyteQ7799635
P304page(s)713-728
P577publication date2012-04-02
P1433published inJournal of Experimental MedicineQ3186912
P1476titleVital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia
P478volume209

Reverse relations

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