| scholarly article | Q13442814 |
| P50 | author | Mark R. Boothby | Q91454598 |
| P2860 | cites work | Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 | Q24336199 |
| CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms | Q24534904 | ||
| Regulating mammalian target of rapamycin to tune vaccination-induced CD8(+) T cell responses for tumor immunity | Q24610550 | ||
| Safety, activity, and immune correlates of anti-PD-1 antibody in cancer | Q24633070 | ||
| mTOR signaling in growth control and disease | Q24634174 | ||
| mTOR regulates memory CD8 T-cell differentiation | Q24648624 | ||
| T cell activation | Q24658051 | ||
| Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation | Q24675931 | ||
| Regulation of mTORC1 by amino acids | Q27025586 | ||
| Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues | Q27310781 | ||
| Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer | Q27860857 | ||
| Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation | Q28141339 | ||
| Development of antibodies against p53 in lung cancer patients appears to be dependent on the type of p53 mutation | Q41612390 | ||
| T cell receptor dwell times control the kinase activity of Zap70. | Q41809472 | ||
| Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. | Q41957299 | ||
| Stability of the regulatory T cell lineage in vivo. | Q42060265 | ||
| Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation | Q42060819 | ||
| Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways | Q42099912 | ||
| PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells | Q42419970 | ||
| Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. | Q42492769 | ||
| Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia | Q42542192 | ||
| The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment | Q42593305 | ||
| Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling | Q42602502 | ||
| Protein kinase C-theta mediates negative feedback on regulatory T cell function | Q42728050 | ||
| The dynamics of protein kinase B regulation during B cell antigen receptor engagement | Q42797373 | ||
| A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity | Q42841189 | ||
| Breakthrough of the year 2013. Cancer immunotherapy | Q43822796 | ||
| Induction of T helper type 2 immunity by a point mutation in the LAT adaptor | Q44029002 | ||
| Deficient T cell fate specification in mice with an induced inactivation of Notch1. | Q45345200 | ||
| Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling | Q47607371 | ||
| The plasticity and stability of regulatory T cells. | Q50987847 | ||
| Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. | Q51908453 | ||
| In vivo depletion of CD4+CD25+ regulatory T cells enhances the antigen-specific primary and memory CTL response elicited by mature mRNA-electroporated dendritic cells. | Q51987584 | ||
| Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation. | Q52423315 | ||
| T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome. | Q54352817 | ||
| PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ. | Q54494791 | ||
| Dynamic regulation of Th17 differentiation by oxygen concentrations. | Q54539948 | ||
| A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively | Q55888521 | ||
| CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation | Q59387555 | ||
| Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand | Q67903498 | ||
| Inefficient ZAP-70 phosphorylation and decreased thymic selection in vivo result from inhibition of NF-kappaB/Rel | Q77136887 | ||
| Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 | Q95814547 | ||
| Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice | Q28201627 | ||
| CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones | Q28209894 | ||
| The B7 family revisited | Q28240070 | ||
| Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17 | Q28256601 | ||
| PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | Q28262647 | ||
| Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1 | Q28585931 | ||
| Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression | Q28594263 | ||
| Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch | Q28594879 | ||
| Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression | Q29617473 | ||
| Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals | Q29619598 | ||
| Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes | Q29620381 | ||
| Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice | Q29622850 | ||
| Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter | Q30498133 | ||
| Novel Foxo1-dependent transcriptional programs control T(reg) cell function | Q30544655 | ||
| T follicular helper cell dynamics in germinal centers | Q30573316 | ||
| Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development. | Q30583549 | ||
| CD28-CD80 interactions control regulatory T cell motility and immunological synapse formation | Q30605826 | ||
| Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes | Q32024520 | ||
| CTLA-4 activation of phosphatidylinositol 3-kinase (PI 3-K) and protein kinase B (PKB/AKT) sustains T-cell anergy without cell death | Q33389175 | ||
| Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses | Q33423703 | ||
| Enhancing CD8 T-cell memory by modulating fatty acid metabolism | Q33577204 | ||
| Foxo transcription factors control regulatory T cell development and function | Q33774905 | ||
| Molecular interactions between extracellular components of the T-cell receptor signaling complex | Q33815380 | ||
| Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation | Q33819026 | ||
| Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins | Q34115639 | ||
| Modulating numbers and phenotype of CD8+ T cells in secondary immune responses | Q34357154 | ||
| Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. | Q34390325 | ||
| The nervous system and innate immunity: the neuropeptide connection | Q34420533 | ||
| Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice | Q34581371 | ||
| Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. | Q34655006 | ||
| Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells | Q34760201 | ||
| Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens | Q34788858 | ||
| The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. | Q34801853 | ||
| A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity | Q34876814 | ||
| Stochastic cytokine expression induces mixed T helper cell States | Q34916338 | ||
| Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. | Q37578833 | ||
| T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming | Q37701913 | ||
| The LAT story: a tale of cooperativity, coordination, and choreography | Q37770817 | ||
| The ERK Cascade: Distinct Functions within Various Subcellular Organelles | Q37903694 | ||
| Visualizing how T cells collect activation signals in vivo | Q38189926 | ||
| Manipulation of regulatory T cells and antigen-specific cytotoxic T lymphocyte-based tumour immunotherapy | Q38253084 | ||
| PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines | Q38264346 | ||
| Early T cell activation: integrating biochemical, structural, and biophysical cues | Q38415272 | ||
| Leptin-induced mTOR activation defines a specific molecular and transcriptional signature controlling CD4+ effector T cell responses | Q39294928 | ||
| Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. | Q39538410 | ||
| Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade | Q40050501 | ||
| Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation | Q40484358 | ||
| Notch 1 signaling regulates peripheral T cell activation | Q40566978 | ||
| Genetic compensation induced by deleterious mutations but not gene knockdowns. | Q40744194 | ||
| Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase | Q41006886 | ||
| CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase | Q41270812 | ||
| Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches | Q41464299 | ||
| Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins | Q34925938 | ||
| Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation | Q35041145 | ||
| An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. | Q35097239 | ||
| ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. | Q35101189 | ||
| HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells | Q35102340 | ||
| Peripheral education of the immune system by colonic commensal microbiota. | Q35341308 | ||
| TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression | Q35354812 | ||
| mTORC1 and mTORC2 selectively regulate CD8⁺ T cell differentiation | Q35719914 | ||
| Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells | Q35851748 | ||
| The Neonatal CD4+ T Cell Response to a Single Epitope Varies in Genetically Identical Mice | Q35988534 | ||
| Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8(+) T cell response to infection. | Q36008100 | ||
| Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor | Q36082833 | ||
| Polar opposites: Erk direction of CD4 T cell subsets | Q36084223 | ||
| HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. | Q36177924 | ||
| PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. | Q36244792 | ||
| Aire controls gene expression in the thymic epithelium with ordered stochasticity | Q36247031 | ||
| Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa | Q36339991 | ||
| Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo | Q36353340 | ||
| Single-cell transcriptome analysis reveals coordinated ectopic gene-expression patterns in medullary thymic epithelial cells | Q36363466 | ||
| Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses | Q36376333 | ||
| The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells | Q36509846 | ||
| The Molecular Basis of T-Cell Specificity | Q36576195 | ||
| MyD88 is essential to sustain mTOR activation necessary to promote T helper 17 cell proliferation by linking IL-1 and IL-23 signaling | Q36598193 | ||
| Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells | Q36603536 | ||
| Compartmentalization of ITAM and integrin signaling by adapter molecules | Q36877284 | ||
| Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation | Q36903810 | ||
| Systematic identification of signal-activated stochastic gene regulation | Q37116090 | ||
| mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function | Q37137541 | ||
| Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. | Q37155667 | ||
| Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulation | Q37233454 | ||
| TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway | Q37342131 | ||
| The different faces of Notch in T-helper-cell differentiation | Q37376021 | ||
| Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. | Q37453462 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P577 | publication date | 2016-01-01 | |
| P1433 | published in | F1000Research | Q27701587 |
| P1476 | title | Signaling in T cells - is anything the m(a)TOR with the picture(s)? | |
| P478 | volume | 5 |
| Q39223057 | Fine tuning of immunometabolism for the treatment of rheumatic diseases |
| Q93110790 | Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity |
| Q92712487 | T cell metabolism: new insights in systemic lupus erythematosus pathogenesis and therapy |
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