Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

scientific article published on January 1997

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV.IMMUNOL.15.1.297
P698PubMed publication ID9143690

P2093author name stringBottomly K
Constant SL
P2860cites workCTLA-4 can function as a negative regulator of T cell activationQ28235866
P304page(s)297-322
P577publication date1997-01-01
P1433published inAnnual Review of ImmunologyQ567362
P1476titleInduction of Th1 and Th2 CD4+ T cell responses: the alternative approaches
P478volume15

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cites work (P2860)
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Q51977261Induction of a Th1 response from Th2-polarized T cells by activated dendritic cells: dependence on TCR:peptide-MHC interaction, ICAM-1, IL-12, and IFN-gamma.
Q40518160Infection of human dendritic cells by dengue virus activates and primes T cells towards Th0-like phenotype producing both Th1 and Th2 cytokines.
Q35968707Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I).
Q36951646Influence of aggregation on immunogenicity of recombinant human Factor VIII in hemophilia A mice
Q37060662Influence of bovine lactoferrin on expression of presentation molecules on BCG-infected bone marrow derived macrophages
Q63494109Influence of dose and immunization route on the serum Ig G antibody response to BSA loaded PLGA microspheres
Q33825562Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa
Q33669243Inheritable defects in interleukin-12- and interferon-gamma-mediated immunity and the TH1/TH2 paradigm in man.
Q44620895Inhibition of Hydroxymethylglutaryl-Coenzyme A Reductase Reduces Th1 Development and Promotes Th2 Development
Q41837371Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells
Q56899149Inhibition of Th1 Differentiation by IL-6 Is Mediated by SOCS1
Q35043799Inhibition of interleukin-12 production by auranofin, an anti-rheumatic gold compound, deviates CD4(+) T cells from the Th1 to the Th2 pathway
Q56892691Inhibition of tumor angiogenesis in lung cancer by T4 phage surface displaying mVEGFR2 vaccine
Q40879552Injection with interleukin-4-secreting fibroblasts efficiently induces T helper type 2 cell-dominated immune response
Q51797595Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals.
Q42419570Interactions Between the Immune and the Renin-Angiotensin Systems in Hypertension
Q35064764Intercellular adhesion molecule-1 inhibits interleukin 4 production by naive T cells
Q36368977Interferon gamma signaling alters the function of T helper type 1 cells.
Q45861356Interferon-gamma- and interleukin-4-targeted gene therapy for atopic allergic disease
Q51999239Interleukin (IL)-4-independent maintenance of histone modification of the IL-4 gene loci in memory Th2 cells.
Q95721788Interleukin-10-secreting Peyer's patch cells are responsible for active suppression in low-dose oral tolerance
Q33783694Interleukin-12 p40 mRNA expression in bovine leukemia virus-infected animals: increase in alymphocytosis but decrease in persistent lymphocytosis.
Q53971163Interleukin-12-induced cytotoxicity against syngeneic B cell lymphomas of SJL/J mice.
Q40187803Interleukin-33 promoting Th1 lymphocyte differentiation dependents on IL-12.
Q53657136Interleukin-4 gene transfer into rat pancreas by recombinant adenovirus.
Q39605511Interleukin-4 up-regulates mouse mammary tumor virus expression yet is not required for in vivo virus spread
Q38017393Intradermal immunization using coated microneedles containing an immunoadjuvant
Q37423165Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2
Q50096437Intraspecies variability in the dose-response relationship for Salmonella Enteritidis associated with genetic differences in cellular immune response
Q33604497Involvement of IL-18 in the expansion of unique hepatic T cells with unconventional cytokine profiles during Schistosoma mansoni infection
Q34987949Jaks, STATs, Cytokines, and Sepsis
Q40819518Kinetics of GATA-3 gene expression in early polarizing and committed human T cells
Q73035410Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells
Q42134087Lactoferrin Augmentation of the BCG Vaccine Leads to Increased Pulmonary Integrity
Q34043199Lactoferrin as a natural immune modulator
Q37360501Lactoferrin modulation of BCG-infected dendritic cell functions.
Q47222659Lamin A/C augments Th1 differentiation and response against vaccinia virus and Leishmania major.
Q33180616Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
Q81623674Linkage analysis of the genetic determinants of T-cell IL-4 secretion, and identification of Flj20274 as a putative candidate gene
Q39831157Lipopeptides of Borrelia burgdorferi outer surface proteins induce Th1 phenotype development in alphabeta T-cell receptor transgenic mice.
Q37084615Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo
Q42052572Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells
Q46976694Long oligonucleotide microarrays for African green monkey gene expression profile analysis
Q36399080Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells
Q38546530Low-dose antigen promotes induction of FOXP3 in human CD4+ T cells
Q39338146Low-strength T-cell activation promotes Th17 responses.
Q40128467Lymphocyte subsets and the role of TH1/TH2 balance in stressed chronic pain patients
Q24336392Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells
Q35219029Lymphotoxin/light, lymphoid microenvironments and autoimmune disease
Q50335825Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice.
Q33547800MHC multimerization, antigen expression and the induction of APC amnesia in the developing immune response.
Q53915050Macrophage distinguishes Vibrio cholerae hemolysin from its protease insensitive oligomer by time dependent and selective expression of CD80-CD86.
Q42099912Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways
Q53583385Mannosylated niosomes as adjuvant-carrier system for oral mucosal immunization.
Q46654414Mannosylated niosomes as carrier adjuvant system for topical immunization
Q35048389Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep
Q52103692Maturation of adult peripheral blood CD38(+)CD4(+) T cells demonstrated by cytokine production in response to a superantigen, TSST-1.
Q36730395Measurement of antigen specific immune responses: 2006 update
Q42507772Mechanism for maintenance of dominant T helper 1 immune responses in Lewis rats
Q37641941Mechanisms of Cholera Toxin in the Modulation of TH17 Responses
Q36081654Memory CD4+ T cells: fate determination, positive feedback and plasticity
Q38105259Mesoporous silica nanoparticles as antigen carriers and adjuvants for vaccine delivery.
Q44789010Microfold-cell targeted surface engineered polymeric nanoparticles for oral immunization
Q38243170Modeling the T cell immune response: a fascinating challenge
Q35076771Modified vaccinia virus Ankara-infected dendritic cells present CD4+ T-cell epitopes by endogenous major histocompatibility complex class II presentation pathways
Q38330864Modulating the Th1/Th2 balance in inflammatory arthritis
Q73827213Molecular and cellular basis for designing gene vaccines against inflammatory autoimmune disease
Q28291455Molecular cloning of FKHRL1P2, a member of the developmentally regulated fork head domain transcription factor family
Q33833187Molecular mechanisms in T helper phenotype development
Q40953830Molecular mimicry of MAGE-A6 and Mycoplasma penetrans HF-2 epitopes in the induction of antitumor CD8(+) T-cell responses
Q24619604Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling
Q33607430Molecular regulation of cytokine gene expression during the immune response
Q35168204Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo
Q34212495Mouse models of allergic airway disease
Q34118373Mucosal immunity against parasitic gastrointestinal nematodes
Q33508792Mucosal immunization with iron receptor antigens protects against urinary tract infection
Q29619125Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major
Q34224183Multiple sclerosis: current pathophysiological concepts
Q30925110Multiplexed particle-based flow cytometric assays
Q77149828Mutation of Tec family kinases alters T helper cell differentiation
Q33714813MyD88-dependent induction of allergic Th2 responses to intranasal antigen.
Q64897869Naked Oat (Avena nuda L.) Oligopeptides:Immunomodulatory Effects on Innate and AdaptiveImmunity in Mice via Cytokine Secretion, AntibodyProduction, and Th Cells Stimulation.
Q33833181Natural and induced regulation of Th1/Th2 balance
Q83204981Nematode infection in Alymphoplasia (aly) mice: worm species-dependent differential effect of defects of the gut-associated lymphatic tissue system
Q36526442Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype
Q35561690Neurotrophins in inflammatory lung diseases: modulators of cell differentiation and neuroimmune interactions
Q34009625Nippocystatin, a cysteine protease inhibitor from Nippostrongylus brasiliensis, inhibits antigen processing and modulates antigen-specific immune response
Q33508227Non-redundant role for IL-12 and IL-27 in modulating Th2 polarization of carcinoembryonic antigen specific CD4 T cells from pancreatic cancer patients
Q33356044Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
Q73028963Novel aggregate structure adjuvants modulate lymphocyte proliferation and Th1 and Th2 cytokine profiles in ovalbumin immunized mice
Q47954878Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity
Q35000685Novel role of CD8(+) T cells and major histocompatibility complex class I genes in the generation of protective CD4(+) Th1 responses during retrovirus infection in mice
Q35583526Optimal modes and targets of gene therapy in transplantation
Q47572355Oral administration of aqueous extract of Carthami Flos induces macrophage activation and preferentially potentiates type 1 helper T-cell response in vivo.
Q38878721Oral lichen planus: a literature review and update
Q52120141Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response.
Q37401020PU.1 regulates TCR expression by modulating GATA-3 activity.
Q39708596Paclitaxel acts as an adjuvant to promote both Th1 and Th2 immune responses induced by ovalbumin in mice
Q28743498Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin
Q34284473Peptide-MHC class II complex stability governs CD4 T cell clonal selection
Q34567730Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities
Q46291128Peptides from Colochirus robustus Enhance Immune Function via Activating CD3ζ- and ZAP-70-Mediated Signaling in C57BL/6 Mice
Q34285649Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors.
Q35609871Pharmacological evidence supporting a role for IL-1, IL-2 and serotonin in the inflammation induced by Schistosoma mansoni soluble egg antigen (SEA) in rat paws
Q51142804Phenotyping CD4+ hTh2 Cells by Flow Cytometry: Simultaneous Detection of Transcription Factors, Secreted Cytokines, and Surface Markers.
Q28344883Phenytoin promotes Th2 type immune response in mice
Q34643623Piecing together the family portrait of TCR-CD3 complexes
Q46907814Pinpointing IL-4-independent acquisition and IL-4-influenced maintenance of Th2 activity by CD4 T cells
Q36369264Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis
Q36702429Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for?
Q36084223Polar opposites: Erk direction of CD4 T cell subsets
Q73388196Polarization of Porphyromonas gingivalis-specific helper T-cell subsets by prior immunization with Fusobacterium nucleatum
Q45409580Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) is a potent enhancer of mixed Th1/Th2 immune responses in mice immunized with influenza virus antigens
Q37684900Polymer blend particles with defined compositions for targeting antigen to both class I and II antigen presentation pathways
Q28488158Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment
Q45116110Polyphenolic antioxidants enhance IgE production
Q57952426Porin of Shigella dysenteriae enhances Toll-like receptors 2 and 6 of mouse peritoneal B-2 cells and induces the expression of immunoglobulin M, immunoglobulin G2a and immunoglobulin A
Q54739900Porin of Shigella dysenteriae enhances mRNA levels for Toll-like receptor 2 and MyD88, up-regulates CD80 of murine macrophage, and induces the release of interleukin-12.
Q59282464Potential of mannan or dextrin nanogels as vaccine carrier/adjuvant systems
Q41008285Potentiation of antigen-specific, Th1 immune responses by multiple DNA vaccination with an ovalbumin/interferon-gamma hybrid construct
Q36020045Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses
Q80205931Pravastatin reverses the down-regulating effect of inflammation on beta-adrenergic receptors: a disease-drug interaction between inflammation, pravastatin, and propranolol
Q33706043Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees
Q74215779Prenatal immune priming with helminth infections: parasite-specific cellular reactivity and Th1 and Th2 cytokine responses in neonates
Q55188486Prevention of Cyclophosphamide-Induced Immunosuppression in Mice with the Antimicrobial Peptide Sublancin.
Q61472009Prevention of adjuvant arthritis by the W3/25 anti-CD4 monoclonal antibody is associated with a decrease of blood CD4(+)CD45RC(high) T cells
Q34350303Prevention of type I diabetes transfer by glutamic acid decarboxylase 65 peptide 206-220-specific T cells
Q52651330Primary atopic disorders.
Q51080272Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells.
Q38965182Priming with high and low respiratory allergen dose induces differential CD4+ T helper type 2 cells and IgE/IgG1 antibody responses in mice.
Q34964324Proanthocyanidins from grape seeds inhibit UV-radiation-induced immune suppression in mice: detection and analysis of molecular and cellular targets
Q45863881Prolonged exposure of dendritic cells to maturation stimuli favors the induction of type-2 cytotoxic T lymphocytes.
Q73208596Prostaglandin E(1) protects against liver injury induced by Escherichia coli infection via a dominant Th2-like response of liver T cells in mice
Q35558599Prostanoids and MPO–halide system products as a link between innate and adaptive immunity
Q33727055Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid.
Q35247822Protective response to Leishmania major in BALB/c mice requires antigen processing in the absence of DM.
Q45072385Pyriproxyfen enhances the immunoglobulin G immune response in mice
Q50637492Quantitative events determine the differentiation and function of helper T cells.
Q24650980Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation
Q28509186ROG, repressor of GATA, regulates the expression of cytokine genes
Q37084889Real-time imaging of the cellular interactions underlying tolerance, priming, and responses to infection
Q53933577Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation.
Q34121084Recombinant Ochrobactrum anthropi expressing Brucella abortus Cu,Zn superoxide dismutase protects mice against B. abortus infection only after switching of immune responses to Th1 type
Q40908512Recruitment and activation of natural killer (NK) cells in vivo determined by the target cell phenotype. An adaptive component of NK cell-mediated responses
Q39770778Reduced TCR-dependent activation through citrullination of a T-cell epitope enhances Th17 development by disruption of the STAT3/5 balance
Q35022580Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseases
Q35559953Regulation of IFN-gamma signaling is essential for the cytotoxic activity of CD8(+) T cells
Q77206882Regulation of IL-4 expression by activation of individual alleles
Q24533533Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation
Q27026243Regulation of T helper cell subsets by cyclooxygenases and their metabolites
Q42083177Regulation of T helper type 2 cell differentiation by murine Schnurri-2.
Q34087999Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene
Q34495061Regulation of cytokine gene transcription in the immune system
Q33942014Regulation of development and function of memory CD4 subsets
Q73406631Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene
Q36232198Regulation of inflammation by interleukin-4: a review of "alternatives"
Q38505120Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+ T-cells
Q45399737Regulatory T cells in hepatitis C virus infection
Q39352954Regulatory effects of IL‐12 and IL‐18 on Onchocerca volvulus‐ and Entamoeba histolytica‐specific cellular reactivity and cytokine profiles
Q34826220Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
Q96641747Resistance Profiles of Staphylococcus aureus and Immunological Status in Pregnant Women at Bafang, West Region of Cameroon: A Cross-Sectional Study
Q35042298Retinoid-mediated inhibition of interleukin-12 production in mouse macrophages suppresses Th1 cytokine profile in CD4(+) T cells
Q34099106Review article: molecular signals and genetic reprogramming in peripheral T-cell differentiation
Q35125091Review: Environmental exposure to mercury and its toxicopathologic implications for public health
Q49887794Review: The potential of seminal fluid mediated paternal-maternal communication to optimise pregnancy success.
Q38211585Rho-GTPases as key regulators of T lymphocyte biology
Q91931818Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host
Q35628016Role of T cell co-stimulation in murine models of allergic asthma
Q34243622Role of dendritic cells and Th2 lymphocytes in asthma: lessons from eosinophilic airway inflammation in the mouse
Q37009660Role of interleukin-4 (IL-4) and IL-10 in serum immunoglobulin G antibody responses following mucosal or systemic reovirus infection
Q33835324Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection
Q39311661SJSZ glycoprotein (38 kDa) modulates expression of IL-2, IL-12, and IFN-γ in cyclophosphamide-induced Balb/c
Q34185042SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells
Q47649812Safety and efficacy of immunotherapy with the recombinant B-cell epitope-based grass pollen vaccine BM32.
Q50263539Sea cucumber (Codonopsis pilosula) oligopeptides: immunomodulatory effects based on stimulating Th cells, cytokine secretion and antibody production
Q26795580Selected Aspects in the Pathogenesis of Autoimmune Diseases
Q41001482Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells.
Q42233344Self-assembly of virus-like particles of canine parvovirus capsid protein expressed from Escherichia coli and application as virus-like particle vaccine
Q39123130Serum IgE levels of tuberculosis patients in a tropical setup with high prevalence of HIV and intestinal parasitoses
Q59139144Serum concentrations of GM-CSF and G-CSF correlate with the Th1/Th2 cytokine response in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
Q57240705Shaping the T cell response to influenza virus
Q42430103Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthma
Q33951021Signal transduction by MAP kinases in T lymphocytes
Q26767443Signaling in T cells - is anything the m(a)TOR with the picture(s)?
Q35951832Signaling pathways in Th2 development
Q78016158Signals involved in the early TH1/TH2 polarization of an immune response depending on the type of antigen
Q58662838Similar inflammatory DC maturation signatures induced by TNF or Trypanosoma brucei antigens instruct default Th2-cell responses
Q30771030Simultaneous quantitation of 15 cytokines using a multiplexed flow cytometric assay
Q73863578Skewing of the Th1/Th2 responses in mice due to variation in the level of expression of an antigen in a recombinant BCG system
Q47101123Skin Immune Landscape: Inside and Outside the Organism
Q47608487Skin scratching switches immune responses from Th2 to Th1 type in epicutaneously immunized mice
Q51745429Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis.
Q44430606Spleen lymphocyte function modulated by a cocoa-enriched diet
Q44972574Starch microparticles as an adjuvant in immunisation: effect of route of administration on the immune response in mice
Q91584719Statins can suppress DC-mediated Th2 responses through the repression of OX40-ligand and CCL17 expression
Q77911230Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis
Q35972503Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide
Q37374269Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice
Q34084883Susceptibility to development of Mycobacterium ulcerans disease: review of possible risk factors
Q61823403Systemic mycobacterial infection inhibits antigen-specific immunoglobulin E production, bronchial mucus production and eosinophilic inflammation induced by allergen
Q34296494T cell effector subsets: extending the Th1/Th2 paradigm
Q36375972T cell receptor complementarity determining region 3 length analysis reveals the absence of a characteristic public T cell repertoire in neonatal tolerance. The response in the "tolerant" mouse within the residual repertoire is quantitatively simila
Q41911811T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
Q34537828T helper subset development: roles of instruction, selection, and transcription
Q36228628T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent
Q74591322T lymphocyte differentiation in the periphery
Q42094910T-bet is required for protection against vaccinia virus infection
Q74053500T-cell activation follows Th1 rather than Th2 pattern in haemodialysis patients
Q36378601T-cell responses before and after the fifth consecutive acellular pertussis vaccination in 4-year-old Dutch children
Q33989214T-cell subsets (Th1 versus Th2).
Q46027701T-cell subsets: chemokine receptors guide the way.
Q41651076T-cell subsets: transcriptional control in the Th1/Th2 decision
Q26772704TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation
Q55511380TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease.
Q42212300TCR Signaling Emerges from the Sum of Many Parts
Q37280987TLR2 and TLR4 as Potential Biomarkers of Environmental Particulate Matter Exposed Human Myeloid Dendritic Cells
Q36819179TSLP in epithelial cell and dendritic cell cross talk
Q42972510TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.
Q36327367Targeting the TCR: T-cell receptor and peptide-specific tolerance-based strategies for restoring self-tolerance in CNS autoimmune disease
Q24610908Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates
Q54785070Temporal changes in cytokine expression of foals during the first month of life.
Q45887423Th1 response in BALB/c mice immunized with Dirofilaria immitis soluble antigens: a possible role for Wolbachia?
Q34319955Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways
Q33949267Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infection
Q33833214Th1/Th2 balance in atopy
Q61522641Th1/Th2 balance in human disease
Q33833220Th1/Th2 balance in infection
Q28138975Th1/Th2 cells
Q33753434Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation
Q42110155Th2 polarization enhanced by oral administration of higher doses of antigen
Q37175971Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4.
Q51091221The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance.
Q26866318The Differentiation of CD4(+) T-Helper Cell Subsets in the Context of Helminth Parasite Infection
Q64954353The E3 ligases Itch and WWP2 cooperate to limit TH2 differentiation by enhancing signaling through the TCR.
Q33989837The JNK and P38 MAP kinase signaling pathways in T cell-mediated immune responses
Q33716018The Pseudomonas aeruginosa quorum-sensing molecule N-3-(oxododecanoyl)-L-homoserine lactone inhibits T-cell differentiation and cytokine production by a mechanism involving an early step in T-cell activation
Q34004824The SA85-1.1 protein of the Trypanosoma cruzi trans-sialidase superfamily is a dominant T-cell antigen
Q34750002The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
Q34429440The Th1/Th2 paradigm
Q54453675The contribution of Toll-like receptor 2 to the innate recognition of a Leishmania infantum silent information regulator 2 protein.
Q35294476The critical role of antigen-presentation-induced cytokine crosstalk in the central nervous system in multiple sclerosis and experimental autoimmune encephalomyelitis
Q34184752The dendritic cell in allergic airway diseases: a new player to the game
Q33723102The development of CD4+ T effector cells during the type 2 immune response.
Q33577949The dichotomy (generation of MAbs with functional heterogeneity) in antimalarial immune response in vaccinated/protected mice: a new concept in our understanding of the protective immune mechanisms in malaria
Q84923161The dynamic changes of T-bet(+)/GATA-3(+) and RORgammat(+)/FOXP3(+) cells in recipient spleens and grafts after rat orthotopic liver transplantation
Q35040624The effect of aging on immune responses
Q39037797The effect of helper epitopes and cellular localization of an antigen on the outcome of gene gun DNA immunization
Q47570341The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise: a randomised controlled trial.
Q34338802The immune tolerance network and rheumatic disease: immune tolerance comes to the clinic
Q35143136The immunogenic peptide for Th1 development
Q39684626The immunogenicity and protective efficacy of bovine herpesvirus 1 glycoprotein D plus Emulsigen are increased by formulation with CpG oligodeoxynucleotides
Q74093901The immunological synapse
Q42875123The increase in intra-macrophage thiols induced by new pro-GSH molecules directs the Th1 skewing in ovalbumin immunized mice.
Q36163783The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review
Q33719159The macroimportance of the pulmonary immune microenvironment
Q46691118The modulatory effects of lipopolysaccharide-stimulated B cells on differential T-cell polarization
Q34106569The molecular basis of T helper 1 and T helper 2 cell differentiation
Q52015425The mouse immune response to carrier erythrocyte entrapped antigens.
Q46260438The new nano-complex, Hep-c, improves the immunogenicity of the hepatitis B vaccine
Q33784067The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy
Q30329411The past, present and future of HIV-vaccine development: a critical view.
Q36600376The potential role of fowlpox virus in rational vaccine design
Q74187442The primary IgM antibody repertoire: a source of potent idiotype immunogens
Q40831490The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers
Q36474320The role of CD4+ T-cells in the development of MS.
Q36380567The role of IL-10 in regulating immunity to persistent viral infections
Q36747499The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
Q35624731The role of activation-induced cell death in the differentiation of T-helper-cell subsets.
Q51822897The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.
Q34255268The role of cutaneous dendritic cells in the immunopathogenesis of atopic dermatitis
Q36165896The role of interferon-gamma on immune and allergic responses
Q77430756The triggering signal dictates the effect of docosahexaenoic acid on lymphocyte function in vitro
Q34996767The two faces of IL-6 on Th1/Th2 differentiation
Q36229651Thymic selection pathway regulates the effector function of CD4 T cells
Q36375911Thymic stromal lymphopoietin: master switch for allergic inflammation
Q36959215Thymic versus induced regulatory T cells - who regulates the regulators?
Q33220331Tim-2 regulates T helper type 2 responses and autoimmunity
Q51970090Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritis.
Q29547305Toll-like receptor control of the adaptive immune responses
Q37800529Toward managing chronic rejection after lung transplant: The fate and effects of inhaled cyclosporine in a complex environment
Q34619808Transcription: tantalizing times for T cells
Q34079315Transcriptional regulation of Th1/Th2 polarization
Q47815861Transcriptional regulation of th2 differentiation by inducible costimulator
Q36015482Transcriptional regulatory networks for CD4 T cell differentiation
Q35180160Transforming growth factor-beta as a regulator of site-specific T-cell inflammatory response
Q41640555Transplantation immunology: a brief update
Q40790202Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice
Q44371551Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido-reductase activity
Q40678768Tumour necrosis factor-alpha but not lipopolysaccharide enhances preference of murine dendritic cells for Th2 differentiation
Q52948843Tumour-induced polarization of tumour vaccine-draining lymph node T cells to a type 1 cytokine profile predicts inherent strong immunogenicity of the tumour and correlates with therapeutic efficacy in adoptive transfer studies.
Q35884184Turning it on and off: regulation of dendritic cell function in Toxoplasma gondii infection
Q34105379Type 1/Type 2 immunity in infectious diseases
Q30305830Type 2 cytokines predominate in the human CD4(+) T-lymphocyte response to Epstein-Barr virus nuclear antigen 1.
Q35072871Unique T cells with unconventional cytokine profiles induced in the livers of mice during Schistosoma mansoni infection
Q51063368Upregulated expression of Tim-3 involved in the process of toxoplasmic encephalitis in mouse model.
Q33206148Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization
Q28572455VLA-4 integrin concentrates at the peripheral supramolecular activation complex of the immune synapse and drives T helper 1 responses
Q37476759Vaccines against Toxoplasma gondii: challenges and opportunities
Q36903787Vesicular carrier constructs for topical immunisation
Q37103943What can transgenic parasites tell us about the development of Plasmodium-specific immune responses?
Q84600803[Infectious agents in the etiopathogenesis of rheumatic diseases]
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