| scholarly article | Q13442814 |
| P50 | author | Bernard Malissen | Q2898273 |
| Marie Malissen | Q30503772 | ||
| Enrique Aguado | Q58668237 | ||
| Arkadiusz Miazek | Q58812167 | ||
| Sylvie Richelme | Q125340709 | ||
| Anne-Marie Mura | Q125341434 | ||
| Mireille Richelme | Q125341657 | ||
| P2093 | author name string | Hai-Tao He | |
| Danielle Sainty | |||
| Xiao-Jun Guo | |||
| Selene Nuñez-Cruz | |||
| P433 | issue | 5575 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 2036-2040 | |
| P577 | publication date | 2002-06-01 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | Induction of T helper type 2 immunity by a point mutation in the LAT adaptor | |
| P478 | volume | 296 |
| Q58803375 | A Mechanistic Computational Model Reveals That Plasticity of CD4 T Cell Differentiation Is a Function of Cytokine Composition and Dosage |
| Q49884904 | A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling |
| Q42496680 | A negatively charged domain of LAT mediates its interaction with the active form of Lck. |
| Q64262849 | A novel model for treatment of hypertrophic pachymeningitis |
| Q36487572 | A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. |
| Q36732637 | A retrospective on the requirements for gammadelta T-cell development |
| Q36822312 | A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity |
| Q37604357 | Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes. |
| Q36677953 | Activation of T lymphocytes and the role of the adapter LAT. |
| Q35145762 | Adaptor proteins in lymphocyte activation. |
| Q35055629 | Adaptors as central mediators of signal transduction in immune cells |
| Q37833777 | Altered T-cell receptor signaling in the pathogenesis of allergic disease |
| Q34180840 | An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors |
| Q35076666 | An evolutionary and structural perspective on T cell antigen receptor function |
| Q37397652 | Antigen receptor signaling in the rheumatic diseases |
| Q78449519 | Antigen receptor signaling under the Tuscan sun |
| Q44478560 | Appearance of the LAT protein at an early stage of B-cell development and its possible role |
| Q34224554 | Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1. |
| Q37681287 | Balanced approach of gammadelta T cells to type 2 immunity |
| Q34038396 | Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression |
| Q26865509 | Beneficial autoimmunity at body surfaces - immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer |
| Q57275414 | CD3 ITAMs count! |
| Q56899674 | CD4(+) T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids |
| Q24657562 | CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche |
| Q28275215 | Central tolerance: learning self-control in the thymus |
| Q35005875 | Changes in actin dynamics at the T-cell/APC interface: implications for T-cell anergy? |
| Q36877284 | Compartmentalization of ITAM and integrin signaling by adapter molecules |
| Q35072158 | Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses |
| Q36781465 | Cytokines of the γ(c) family control CD4+ T cell differentiation and function |
| Q46964999 | Deletion of the LIME adaptor protein minimally affects T and B cell development and function |
| Q43093293 | Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2. |
| Q35927542 | Dominant Role of CD80-CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells |
| Q24642248 | Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance |
| Q37047281 | Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT. |
| Q27026592 | Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets |
| Q52572927 | Eleven loci with new reproducible genetic associations with allergic disease risk. |
| Q44625716 | Ex vivo fludarabine exposure inhibits graft-versus-host activity of allogeneic T cells while preserving graft-versus-leukemia effects |
| Q34522144 | Examining multiprotein signaling complexes from all angles |
| Q30354566 | FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy |
| Q37321256 | Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice |
| Q38151950 | Genetic regulation of immunoglobulin E level in different pathological states: integration of mouse and human genetics |
| Q28647161 | Hematopoietic Adaptors in T-Cell Signaling: Potential Applications to Transplantation |
| Q40084461 | Herpes simplex virus remodels T-cell receptor signaling, resulting in p38-dependent selective synthesis of interleukin-10. |
| Q45957471 | Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity. |
| Q38212818 | Immune diseases caused by mutations in kinases and components of the ubiquitin system |
| Q36403942 | Inactivation of c-Cbl reverses neonatal lethality and T cell developmental arrest of SLP-76-deficient mice |
| Q38241273 | Integrative biology of T cell activation |
| Q35049534 | Itk: the rheostat of the T cell response |
| Q36056599 | K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis |
| Q35076707 | Known and potential functions for the SLP-76 adapter protein in regulating T-cell activation and development |
| Q34417567 | LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes? |
| Q44582785 | LAT regulates gammadelta T cell homeostasis and differentiation |
| Q42875306 | LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic. |
| Q36227859 | LAT-mediated signaling in CD4+CD25+ regulatory T cell development |
| Q55279826 | LatY136F knock-in mouse model for human IgG4-related disease. |
| Q57752507 | Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT |
| Q35131486 | Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response |
| Q36982685 | Lymphocyte signaling: beyond knockouts. |
| Q35568601 | Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease |
| Q37682639 | Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes |
| Q34806889 | Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. |
| Q34060500 | Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production |
| Q37801270 | Molecular and genetic parameters defining T-cell clonal selection |
| Q34974604 | Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection |
| Q82872924 | Natural IgE production in the absence of MHC Class II cognate help |
| Q35836197 | Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT. |
| Q42912126 | Negative regulation of immunoreceptor signaling by protein adapters: Shc proteins join the club |
| Q35136005 | Negative selection--clearing out the bad apples from the T-cell repertoire |
| Q36472034 | Negative signaling in Fc receptor complexes |
| Q35184781 | Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. |
| Q50732612 | Peripheral Thy1+ lymphocytes rearranging TCR-gammadelta genes in LAT-deficient mice |
| Q33656136 | Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance |
| Q35729204 | Positive and negative adaptors in T-cell signalling |
| Q36399317 | Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL |
| Q50637492 | Quantitative events determine the differentiation and function of helper T cells |
| Q35035235 | Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3ζ and ZAP-70 tyrosine phosphorylation |
| Q35164678 | Quantitative reduction of the TCR adapter protein SLP-76 unbalances immunity and immune regulation. |
| Q43621359 | Rapid in vivo analysis of mutant forms of the LAT adaptor using Pax5-Lat double-deficient pro-B cells |
| Q37376338 | Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. |
| Q37381720 | Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies. |
| Q36382766 | Recent insights into the signals that control alphabeta/gammadelta-lineage fate. |
| Q37631692 | Regulation of lymphocyte development and activation by the LAT family of adapter proteins |
| Q35084280 | Regulation of thymocyte development: only the meek survive |
| Q92913113 | Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis |
| Q36231103 | Role of the LAT adaptor in T-cell development and Th2 differentiation |
| Q36686379 | Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma |
| Q40645299 | SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients |
| Q42057283 | Secondary immunologic consequences in chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). |
| Q35832518 | Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell development |
| Q35760853 | Sequential class switching is required for the generation of high affinity IgE antibodies |
| Q39645153 | Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction |
| Q33790442 | Shb deficient mice display an augmented TH2 response in peripheral CD4+ T cells. |
| Q30441611 | ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development |
| Q26767443 | Signaling in T cells - is anything the m(a)TOR with the picture(s)? |
| Q35951832 | Signaling pathways in Th2 development |
| Q42839859 | Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function |
| Q90704129 | Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination |
| Q39337201 | T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway |
| Q21146439 | T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression |
| Q30495288 | T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering |
| Q55511380 | TCR Signaling Abnormalities in Human Th2-Associated Atopic Disease. |
| Q37219806 | TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma |
| Q36085610 | TEC-family kinases: regulators of T-helper-cell differentiation |
| Q36754365 | TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter |
| Q37252710 | Tailoring T-cell receptor signals by proximal negative feedback mechanisms |
| Q35769460 | Th2 cells: orchestrating barrier immunity |
| Q48204335 | The Adaptor Protein Rai/ShcC Promotes Astrocyte-Dependent Inflammation during Experimental Autoimmune Encephalomyelitis. |
| Q35816023 | The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity |
| Q34285036 | The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells |
| Q37770817 | The LAT story: a tale of cooperativity, coordination, and choreography |
| Q38059682 | The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation. |
| Q37724190 | The balancing act of autoimmunity: central and peripheral tolerance versus infection control. |
| Q34919049 | The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells. |
| Q37166773 | The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage |
| Q36371668 | The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation |
| Q36543613 | The importance of the Erk pathway in the development of linker for activation of T cells-mediated autoimmunity |
| Q24304913 | The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB |
| Q28506492 | The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells |
| Q54465531 | The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion. |
| Q40490479 | The molecular requirements for LAT-mediated differentiation and the role of LAT in limiting pre-B cell expansion |
| Q37633727 | The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis |
| Q35076690 | The role of Tec family kinases in T cell development and function |
| Q36822300 | The role of the LAT-PLC-gamma1 interaction in T regulatory cell function |
| Q36453343 | The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. |
| Q40188158 | Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells |
| Q46680134 | Tonic Signals: Why Do Lymphocytes Bother? |
| Q33801454 | Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development |
| Q37752795 | Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice |
| Q35076700 | Transmembrane adapters: attractants for cytoplasmic effectors |
| Q37682611 | Transmembrane adaptor proteins positively regulating the activation of lymphocytes |
| Q35852278 | Transmembrane adaptor proteins: organizers of immunoreceptor signalling |
| Q37190443 | Unravelling the association of partial T-cell immunodeficiency and immune dysregulation |
| Q24298531 | ZAP70: a master regulator of adaptive immunity |
| Q35676981 | miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways |
| Q34794213 | miRNA signature of mouse helper T cell hyper-proliferation |
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